The invention discloses a preparation method of
enalapril maleate. The preparation method comprises the following steps of adding L-
alanine, alkali and water into a container, cooling, adding a (Boc)2O solution, performing heating, stirring and reacting to obtain an intermediate 1; adding the intermediate 1 into a
solvent, cooling, adding a chlorination
reagent under the protection of
nitrogen, and performing stirring for reaction to obtain an intermediate 2; adding L-
proline and alkali into water for reaction, then adding the intermediate 2, and carrying out heat preservation reaction to obtain an intermediate 3; adding 2-oxo-4-phenyl
ethyl butyrate, the intermediate 3, a
molecular sieve and a
reducing agent into a
solvent, and reacting under set pressure to obtain an
enalapril crude product; and dissolving the
enalapril crude product, adding
maleic acid, and stirring for reaction to obtain
enalapril maleate. The method has the advantages of safe and easily available starting materials, low price, relatively short reaction steps, avoidance of the use of toxic reagents, relatively small generation amount of three wastes, relatively simple operation, high product purity, high yield, and suitableness for industrial production.