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Pharmaceutical composition for treating hypertension

A composition and drug technology, which is applied in the direction of drug combination, pharmaceutical formulation, cardiovascular system diseases, etc., can solve the problems of poor stability, slow absorption, high lipophilicity, etc., to enhance dispersibility and membrane permeability, and improve dissolution The effect of poor performance and enhanced stability

Active Publication Date: 2013-08-14
CHONGQING SHENGHUAXI PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through the research of a large number of patents and documents, it is found that the research on the pharmaceutical compositions of lercanidipine and enalapril is mostly solid preparations, such as tablets, capsules, etc., and there is little research on their liquid preparations
According to the characteristics of the drug itself—enalapril maleate has poor stability and is prone to hydrolysis and dehydration degradation reactions; It is almost insoluble in the medium, resulting in slow absorption and slow onset of action—especially the absorption of lercanidipine in the body, which directly affects the speed of onset of the combination of the two drugs

Method used

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  • Pharmaceutical composition for treating hypertension
  • Pharmaceutical composition for treating hypertension
  • Pharmaceutical composition for treating hypertension

Examples

Experimental program
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Effect test

Embodiment 1

[0037] prescription:

[0038]

[0039] Preparation method: mix polyethylene glycol 400 with propylene glycol. Dissolve lercanidipine hydrochloride and enalapril maleate in the mixture, and stir at 60°C until the drugs are completely dissolved. Add the polyoxyethylene castor oil at this temperature, mix well, cool the contents to room temperature, and add the caprylic / quiric acid glycerides. Finally, it is filled in soft capsules.

Embodiment 2

[0041] prescription:

[0042]

[0043] Preparation method: dissolve lercanidipine hydrochloride and enalapril maleate in a mixture of soybean oil, oleic acid, Tween 80, polyethylene glycol fatty acid glycerides, and propylene glycol, stir at 70°C until completely dissolved, and mix uniform. After cooling, fill in soft capsules.

Embodiment 3

[0045] prescription:

[0046]

[0047] Preparation method: Dissolve lercanidipine hydrochloride and enalapril maleate in caprylic acid / glyceryl quilate, polyoxyethylene castor oil, Tween 80, and propylene glycol mixture, stir at 55°C until completely dissolved, and mix well . After cooling, fill in soft capsules.

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Abstract

The invention provides a pharmaceutical composition for treating hypertension. The invention relates to a pharmaceutical composition comprising therapeutic doses of lercanidipine hydrochloride and enalapril maleate, and a proper amount of oil, a surfactant and an assisted surfactant. Preparative dosage forms particularly hard capsules and soft capsules are provided. The pharmaceutical composition increases solubility of a poorly soluble drug of lercanidipine hydrochloride and stability of enalapril maleate, and is suitable for the treatment of hypertension.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and relates to a pharmaceutical composition combined with lercanidipine hydrochloride and enalapril maleate for treating hypertension. Prepared dosage forms thereof are provided, especially hard capsules and soft capsules. Background technique [0002] Enalapril is an angiotensin-converting enzyme inhibitor, and its ethyl ester part is rapidly decomposed in the liver and converted into its effective metabolite-enalaprilat to exert its antihypertensive effect. Enalaprilat inhibits angiotensin-converting enzyme, reduces the content of angiotensin II, causes systemic vasodilation, and lowers blood pressure. It has obvious antihypertensive effect on Ⅱ renal type hypertension, Ⅰ renal type hypertension and spontaneously hypertensive rat models. [0003] Lercanidipine is a third-generation dihydropyridine calcium channel blocker, which can reversibly block the influx of calcium ions in the L...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61P9/12A61K31/4422
Inventor 贾春荣胡洁朱才华
Owner CHONGQING SHENGHUAXI PHARMA CO LTD
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