328 results about "Polyoxyethylene castor oil" patented technology

A pharmaceutical composition comprising, in relation to 100% by weight of a total amount of a self-emulsifying composition, 70 to 90% by weight of eicosapentaenoic acid ethyl ester as a first medicinal component, 0.5 to 6% by weight of water, 1 to 29% by weight of polyoxyethylene sorbitan fatty acid ester (optionally further comprising polyoxyethylene castor oil) as an emulsifier, 1 to 25 parts by weight of lecithin in relation to 100 parts by weight of the eicosapentaenoic acid ethyl ester, and pitavastatin, rosuvastatin, or a salt thereof as a second medicinal component. The composition is excellent in any one of self-emulsifying property, dispersibility of the composition, emulsion stability, absorbability, and storage stability of the medicinal components and a preparation.

The invention discloses a medicinal membrane spraying preparation for skin trauma and a preparation method thereof, and relates to the field of medicinal preparations. The medicinal membrane spraying preparation consists of a blank membrane spraying preparation and medicinal components dissolved in the blank membrane spraying preparation and having skin trauma treating effective concentration. The medicinal membrane spraying preparation is characterized in that the blank membrane spraying preparation comprises the following components in percentage by mass: 0.3 to 8 percent of polyvinyl alcohol PVA0588, 0.5 to 5 percent of polyvinyl alcohol PVA 1788 and/or 1 to 10 percent of polyvinyl butyral (PVB), 0 to 5 percent of humectant, 0 to 2 percent of fragrance, 0 to 10 percent of viscosity regulator and the balance of solvent; the solvent is 60 to 100 percent ethanol, ethyl acetate, acetone and/or propylene glycol; and the viscosity regulator is polyoxyethylene hydrogenated castor oil RH40or polyoxyethylene castor oil EL35. When the membrane spraying preparation is sprayed on a skin wound, a membrane is formed within one minute, the membrane maintaining time reaches 5 hours, and the preparation can quickly stop blood and clot blood; and the preparation can save the steps of dressing, replacing gauze, sterilizing and the like with injury to the skin, is favorable for wound healing and does not leave scars.

The invention relates to an anti-ultraviolet and photostable finishing liquid, a preparation method thereof, and an application thereof on fabrics. The finishing liquid is prepared from materials of: 35 to 60g/L of a paint, 2 to 4g/L of a white paint, 15 to 30g/L of an acrylic ester adhesive, 10 to 20g/L of urea, 2 to 3g/L of glycerin, 55 to 80g/L of an organic softening agent, 2.5 to 15g/L of micro-nano oxide, 2 to 5g/L of polyoxyethylene castor oil ether, 0.5 to 1g/L of a penetrant, and balance of water. The materials are mixed, such that a target product is obtained. According to the invention, a window curtain is processed from a one-bath one-step process of dying, ultraviolet resisting, and shading. The method has characteristics of short technical process and convenient application.Also, the method is water saving, energy saving and discharging reducing.

The invention discloses a coenzyme Q10 pharmaceutical composition which mainly comprises components: (1) coenzyme Q10 is active ingredient; (2) one or multiple of polyethylene 15-oxhydryl glycol stearate (Solutol HS 15), polysorbate, PEG, poloxamer, and polyoxyethylene castor oil derived products are solubilizer; (3) one or multiple of midchain monoglyceride and derived products thereof, medium saturated or unsaturated fatty acid are oil component; and (4) injection water is solvent. One or multiple of excipient, chemical inhibitor, and osmotic pressure regulator are added for preparing injection and freeze drying agent. Compared with the traditional coenzyme Q10 pharmaceutical composition, the injection administration coenzyme Q10 pharmaceutical composition has better storage and transportation stability and higher clinical application safety and patient compliance. The injection has simple preparation process, convenient quality control, lower production cost and convenient industrial production.

The invention discloses mint-scented compound essential oil and a feed additive containing mint-scented compound essential oil and production and application thereof, and relates to the technical field of feed nutrition and feed additive production. The mint-scented compound essential oil is prepared by using Asian mint oil, cineole, cinnamaldehyde, eugenol, carvacrol, menthol and thymol as raw materials, putting the above raw materials into an enamel reaction kettle or a stainless steel reaction kettle sequentially, and evenly stirring and mixing the above raw materials. Preparation method 1:stirring and mixing the compound essential oil and anhydrous alcohol or propylene glycol in the stainless steel reaction kettle according to a weight ratio, with the addition of polyoxyethylene castor oil emulsifiers, thereby obtaining a feed additive containing liquid mint-scented compound essential oil. Preparation method 2: stirring and mixing the compound essential oil and dry starch in a high-speed mixer according to a weight ratio, thereby obtaining a feed additive containing solid mint-scented compound essential oil. Preparation method 3: stirring and mixing the compound essential oiland beta-cyclodextrin or soluble starch in the high-speed mixer according to a weight ratio, with the addition of Tween-80 emulsifiers, thereby obtaining a feed additive containing water-soluble mint-scented compound essential oil.

The invention relates to amino acid surfactant-based transparent solid soap. The amino acid surfactant-based transparent solid soap comprises, by weight, 55-75 parts of an amino acid surfactant, 3-13 parts of pure water, 3-10 parts of polyoxyethylene castor oil (15-40EO), 3-8 parts of glycerin, 3-10 parts of glucose, 2-8 parts of ethanol, 0.1-3 parts of a pH balance agent and 0.2-0.5 parts of essence. Through compounding of high-content amino acid surfactants having different structures, the pH value of the amino acid surfactant-based transparent solid soap is controlled to weak acidity and is the same to or close to a human body pH value. Through the amino acid surfactant-based transparent solid soap, skin feel is completely improved after cleaning. The amino acid surfactant-based transparent solid soap has the advantages of high transmittance of light and good durability.

The invention relates to a production process of a textile fiber color modifier. The textile fiber color modifier is prepared from the following raw materials in percentage by weight: 52%-68% of swelling agent, 10%-30% of emulsifying and dispersing agent, and 8%-20% of solvent, wherein the swelling agent is one or more of propylene glycol monomethyl ether, phenoxy-1-propanol, cyclohexanol methyl ether, N-normal-butyl-phthalimide, and N-isopropyl-phthalimide; the emulsifying and dispersing agent is one or more of styrylphenol polyoxyethylene ether sulfonate, polyoxyethylene castor oil, iso-tridecanol polyoxyethylene ether, fatty amine polyoxyethylene ether, polyoxyethylene (60) sorbitan monostearate (namely Tween-60), polyoxyethylene (80) sorbitan monostearate (namely Tween-80), and pesticide emulsifier No.600; and the solvent is one or more of water, ethanol, isopropyl alcohol, ethylene glycol, and ethylene glycol monobutyl ether. The production process comprises the following steps of adding all the materials into a reaction kettle and stirring the materials at 30 DEG C to 50 DEG C for 60 to 90 minutes, thereby obtaining the textile fiber color modifier. The textile fiber color modifier can be used for overcoming the dyeing defects of polyester and blended fabrics of the polyester in dyeing, and the dyed fabrics can meet environmental protection standards.

The invention relates to an ophthalmic flurbiprofen ester nano emulsion-in situ gel preparation and a preparation method thereof. The ophthalmic flurbiprofen ester nano-emulsion in situ gel preparation is made from oil, an emulsifier, a thickener, an osmoregulator, a bacteriostatic agent and purified water; and is characterized in that one or a plurality of safe and non-irritating lecithin, Tween60, Tween80, polyoxyethylene castor oil and polyoxyethylene hydrogenated castor oil are taken as the emulsifier; and a high molecular material with ion sensitivity characteristic is taken as the thickener. The ophthalmic flurbiprofen ester nano emulsion-in situ gel preparation is low-viscosity fluid with good fluidity in vitro, and rapidly forms hydrogel after being dropped in eyes. The ophthalmic flurbiprofen ester nano emulsion in-situ gel preparation has the advantages of increasing the residence time of the drug in eyes and increasing bioavailability, has no irritability or other toxic side effect to eyes, and has good biocompatibility and the like.

The invention discloses a novel vaccine adjuvant (also called as SPO1 vaccine adjuvant) and a preparation method thereof. The vaccine adjuvant disclosed by the invention mainly comprises squalane, polyoxyethylene castor oil and polyether, and can realize immunization through injection or nasal spray, transdermal non-injection and other approaches; and the vaccination through non-injection has the characteristics of low cost, convenience for administration, avoidance of cross infection and high safety. The SPO1 vaccine adjuvant disclosed by the invention can be used for preparing vaccines along with inactivated whole pathogens, extracted components of cracked pathogen, bacterial vesicles and capsular polysaccharide or polysaccharide-binding protein, recombinant protein, recombinant VLP (Virus-like Particle), DNA (Deoxyribonucleic Acid) or RNA (Ribonucleic Acid) and other different types of antigens, can be suitable for people in different age groups and preparation of different animal vaccines and immunization, has the advantages of no complex structure, simple process, convenience for preparation and sterilization, low cost and suitability for mass production and industrialization.

The invention discloses a novel taxol lipid microsphere injection containing amphiphilic polyamino acid and a preparation method thereof. The injection contains taxol, amphiphilic polyamino acid, oil for injection, an emulsifying agent, an auxiliary emulsifying agent, a potential regulator, an antioxidant, a metal chelating agent, an iso-osmotic adjusting agent and water for injection, wherein the amphiphilic polyamino acid is a segmented copolymer consisting of a hydrophilic chain segment and racemic hydrophobic polyamino acid. The novel taxol lipid microsphere injection represents a microscopic structure different from that of a traditional lipid microsphere preparation, therefore the injection has excellent stability superior to that of the traditional lipid microsphere preparation. Inthe preparation, polyoxyethylene castor oil is not contained, VE (vitamin E) is not used massively, and no organic solvent is introduced; in addition, the injection can tolerate thermal pressure sterilization, has the advantages of no irritation, low toxicity, good stability and low cost, and is suitable for industrial production in large scale.

A disclosed novel composite metal polishing fluid is characterized by being prepared from the following raw materials in parts by weight: 11-13 parts of cerium oxide, 2-4 parts of graphene oxide, 7-9 parts of rapeseed oil, 1-2 parts of stannous octoate, 4-6 parts of polyoxyethylene sorbitan fatty acid ester, 3-5 parts of polyoxyethylene castor oil, 4-6 parts of urea, 2-4 parts of citric acid, 4-6 parts of emulsified silicone oil, 5-7 parts of an auxiliary agent, and 300 parts of deionized water. The prepared mixed polishing fluid is safe, non-toxic and reasonable in formula. Through the cooperation of the added surfactant and the abrasive, the polishing effect is improved, preferential adsorption is realized, and a long-term easily-cleaned physical adsorption surface is formed. By adding the auxiliary agent, the polishing fluid has good dispersity, lubricity and film-forming property, and is capable of forming an air-obstructing layer on a workpiece surface to prevent air from corroding a metal surface. The polishing fluid is capable of satisfying the polishing processing requirements of various products and parts, and helps to improve the polishing efficiency, cleaning effect, surface precision and the like.

The invention provides an anti-tritium glove and a preparation method thereof. Compound latex adopted for the anti-tritium glove is prepared from, by weight, 200 parts of butyl rubber emulsion, 0.10-0.25 part of polyoxyethylated castor oil, 0-5 parts of potassium hydroxide and 20 parts of dispersoid. The butyl rubber emulsion is prepared from, by weight, 160 parts of butyl rubber, 1.0-1.5 parts of oleic acid, 4.0-7.2 parts of potassium hydroxide, 5.5-6.4 parts of monopotassium phosphate, 35-50 parts of polyvinyl alcohol, 0.8-1.0 part of polyoxyethylene castor oil potassium soap and 94-100 parts of soft water. The dispersoid is prepared from, by weight, 4 parts of sulphur, 5 parts of accelerant Px, 10 parts of accelerant ZDC, 8 parts of zinc oxide, 2 parts of antiager DBH, 0.4 part of green pigment, 5 parts of dispersant NF, 0.8 part of stabilizer KOH, 0.1 part of carbon black, 1.5-5.0 parts of anti-tritium material and 50 parts of water. Compared with the prior art, the anti-tritium glove has the advantages that the tritium permeability coefficient, air tightness, mechanical performance, hot air aging resistance, sulfuric acid solution resistance and sodium hydroxide solution resistance are excellent, and the requirements of relevant military units are met.

The invention discloses a developing solution as well as a preparation method and application thereof. The developing solution comprises the following components in percentage by weight: 1-15% of an alkaline compound, 0.5-6% of a non-ionic surface active agent and the balance of water, wherein the alkaline compound is preferably selected from at least one of tetramethylammonium hydroxide, tetraethyl ammonium hydroxide and tetrapropylammonium hydroxide. The non-ionic surface active agent is selected from at least one of coconut monoethanol amide, cocoanut fatty acid diethanolamide, polyoxyethylene castor oil (10) ether and polyoxyethylene castor oil (30) ether. In the developing solution provided by the invention, the water solution formed by the alkaline compound and the non-ionic surfaceactive agent has good intersolubility, the developing solution has the characteristics that the developing performance is good, no residue is left, the operating temperature range is wide, and the environmental pollution is less and the like, and has wide application in a development preparation process of photosensitive resin.

The invention discloses a building glass cleaner. The building glass cleaner consists of the following raw materials in parts by weight: 3-5 parts of dodecylbenzene sulfonic acid, 2-5 parts of sodium dodecyl sulfate, 3-4 parts of polyoxyethylene castor oil, 2-5 parts of fatty alcohol-polyoxyethylene ether, 8-10 parts of methyl parahydroxybenzoats, 6-8 parts of monoglyceride, 5-10 parts of glycerin monostearate, 2-5 parts of sodium carboxymethylcellulose, 2-5 parts of sodium lauryl sulfate, 2-5 parts of lauryl alcohol, 2-5 parts of triethanolamine, 5-10 parts of phenoxyethanol, 3-5 parts of 2-hydroxyethylamine, 3-10 parts of nanosilicon dioxide, 5-10 parts of talcum powder, 5-10 parts of ethyl acetate and 80-100 parts of deionized water. The building glass cleaner is capable of effectively removing and cleaning pollution and effectively preventing the glass from being polluted again, good in hydrophilicity and free from track on the surface of the glass after scrubbing.

The invention relates to a wool lubricant which is mainly used for wool textile technique; the wool lubricant needs to be diluted into emulsion when in use. The wool lubricant comprises mineral oil, oleate, anion surfactant, non-ion surfactant, emulsion, organic alcohol amine and organic acid; the weight percentage of the constituents is as follows: 55% of the mineral oil, 18% of the oleic acid methanol ester, 5% of the oleic acid butanol ester, 5% of the sodium oleate, 6% of polyoxyethylene castor oil (EO=15), 6% of nonylphenol ethoxylates (EO=10), 2% of triethanolamine, and 3% of oleic acid. The method for preparing the wool lubricant comprises the following steps of: in a reaction kettle with temperature control, orderly adding 55kg of the mineral oil, 18kg of the oleic acid methanol ester, 5kg of the oleic acid butanol ester, 5kg of the sodium oleate, 6kg of the polyoxyethylene castor oil, 6kg of the nonylphenol ethoxylates, 2kg of the triethanolamine, 3kg of the oleic acid and a certain amount of essence. The composite product is transparent yellow oily liquid and can be diluted by water into stable emulsion liquid with a pH value of 6-8.

The invention provides a method for determining a nickel content in soil by microwave digestion-flame atomic absorption spectrometry, wherein the method is characterized by: pretreating a soil sample by combining long-time immersion and stepedly heated microwave digestion, using polyoxyethylene castor oil glycerin ether as an activator, raising atomization efficiency of nickel atoms in flame, raising determination sensitivity, thereby raising sensitivity; based on linear relation of absorbance and nickel content determined by a flame atomic abserption spectrometer by a standard solution, measuring and calculating to obtain the content of nickel atoms in soil. The method provided by the invention solves problems that a method for determining trace elements by traditional atomic absorption spectrometry has disadvantages long time consumption, low sensitivity, large solvent consumption amount, and severe environment pollution caused by a solvent, and the method provided by the invention has advantages of good precision, high recovery rate, accuracy, reliability, rapidness and convenience.

The invention belongs to the field of oilfield chemistry, and relates to a drilling fluid lubricant prepared by taking biodiesel, a polyether compound and esters oil as base oil, adding a proper antiwear additive and surfactants and blending, and a preparation method thereof. The lubricant provided by the invention comprises the components by the weight percentage: 20%-30% of the biodiesel, 20%-30% of polyether, 20%-30% of esters base oil, 5-20% of Span-80 sorbitan oleate, 5-20% of EL-40 polyoxyethylene castor oil, 2-10% of an extreme pressure antiwear agent, and 0.5-1% of a defoaming agent. The drilling fluid lubricant provided by the invention is formed by taking the biodiesel, the polyether, esters and other good-biodegradability compounds as the base oil, adding the anionic surfactant, the non-ionic surfactant, the extreme pressure antiwear agent and the defoaming agent and blending; the drilling fluid lubricant has excellent wear resistance and biodegradability, has no significant effect on other drilling fluid properties, such as the viscosity, the water loss rate and the like, and is an environmental-friendly drilling fluid lubricant.

The invention discloses an all-trans retinoic acid-camptothecin anticancer drug conjugate as well as a preparation method and application thereof. The structural formula of the all-trans retinoic acid-camptothecin anticancer drug conjugate is shown in a formula (I), (II), (III), (IV), (V) or (VI). The all-trans retinoic acid-camptothecin anticancer drug conjugate has good solubility in Tween, polyoxyethylene castor oil, a Poly(ethylene adipate)-polylactic acid copolymer and a Poly(ethylene adipate)-poly (lactic acid-glycollic acid) copolymer, can be self assembled into nanometer grains in water, can be directly injected or taken orally or processed into other dosage forms. According to the all-trans retinoic acid-camptothecin anticancer drug conjugate disclosed by the invention, as all-trans retinoic acid and SN-38 or camptothecin take synergistic effect, compared with a conjugate only containing one of irinotecan, SN-38 and all-trans retinoic acid, the all-trans retinoic acid-camptothecin anticancer drug conjugate has good tumor suppression effect.

The present invention relates to a composite pesticide containing fipronil. Its composition includes (by wt%) 0.1%-30% of effective component A, 0.2%-10% of fipronil, 0.1%-3% of organic silicon synergistic agent, 5.0%-20% of emulsifying agent and 50%-90% of solvent, in which the described effective component is one of abamectin or profenofos or phoxim or more than one of them; the described emulsifying agent is one of sodium alkylbenzenesulfonate, polyoxyethylene castor oil ether, fatty alcohol-polyoxyethylene ether and polyoxyethylene nonylphenol ether or more than one of them; and the described solvent is one of methyl alcohol, ethyl alcohol, dimethyl benzene, dimethyl sulfoxide, dimethyl formamide, rapeseed oil, soybean oil and cotton seed oil or more than one of them.

The invention relates to a self-lubricating wear-resistant ceramic for cutting tools, which is prepared from the following raw materials in parts by weight: 2-3 parts of bismuth sulfide, 2-3 parts of diethanolamine, 2-3 parts of ammonium sulfate, 2-3 parts of magnesium chloride, 2-3 parts of calcium carbide sludge, 2-3 parts of graphene oxide, 0.6-0.8 part of KOH, 0.2-0.3 part of polyoxyethylene castor oil, 3-4 parts of magnesium oxide, 36-40 parts of titanium boride, 4-5 parts of nano tungsten trioxide, 30-35 parts of titanium carbide, 3-5 parts of beryllium oxide, 1-2 parts of silver powder, a right amount of ethanol, a right amount of deionized water, 1-1.5 parts of polyacrylic acid, 1.2-1.6 parts of polyethyleneglycol and 4-5 parts of antiwear assistant. The added nano tungsten trioxide enhances the high temperature resistance of the ceramic. The ceramic has the characteristics of high temperature resistance, high carrying capacity, self lubrication, thermal shock resistance, high wear resistance and the like, and is suitable for manufacturing cutting tools. The antiwear assistant can enhance the wear resistance and heat resistance of the ceramic.

The invention provides albumin hydrogel. The albumin hydrogel is prepared by mixing albumin, a cross-linking agent and a solvent, the cross-linking agent comprises a repeating unit having a structureof formula (I) and an end group having a structure of formula (II). The invention develops the albumin hydrogel which is rapid in crosslinking, low in gelatinization concentrating and free of biotoxicity, and the albumin hydrogel is applied to the fields of cell culture, tissue engineering and drug delivery. Besides, as a good paclitaxel topical treatment drug carrier, the albumin hydrogel overcomes the defect of poor paclitaxel solubility, polyoxyethylene castor oil with biotoxicity is not introduced, and compared with a systemic preparation, the albumin hydrogel has the advantages that the administration frequency is effectively reduced, the drug concentration at a tumor is increased, and the systemic toxicity is reduced. Nanoparticles wrapping paclitaxel are used as gel forming components of the gel, so that uniform distribution of the paclitaxel in the gel can be realized, and stable and continuous release is realized.

The invention provides a paclitaxel composition for injection. The composition comprises the following components in percentage by weight: 0.200-1.087% of paclitaxel, 95.000-99.200% of polyoxyethylenated castor oil and ethanol as well as 0.200-1.500% of organic acid. The paclitaxel composition for injection, provided by the invention, can be directly administrated after being diluted by an infusion solution. By using the paclitaxel composition for injection, provided by the invention, the damage caused by terminal sterilization of the product to the main component is avoided because a sterile production process is adopted in the preparation process; meanwhile, the sterile level of the product is more preferably guaranteed because an polyoxyethylenated castor oil sterilizing process is additionally increased in the process. Compared with the prior art, the paclitaxel composition for injection, provided by the invention, has the advantages of reducing the content of the preparation related substances, improving the product stability, reducing the occurring rate of the adverse reaction and improving the safety in clinical use.

The present invention discloses a rabdosia rubescens extract microemulsion preparation and its preparation method. It is formed from rabdosia rubescens extract, oil phase, surfactant and assistant of surfactant. The described oil phase is one kind selected from transacylated corn oil or midchain fatty triglyceride or their mixture; the described surfactant is one kind selected from polyoxyethylenated castor oil, polyoxyethylene hydrogenated castor oil, polyglycol-8-glycerocaprylic acid/caprate or their mixture, and the assistant of surfactant is one kind selected from dicarboxyl mono-ethyl ether ester, 1-2-propylene glycol and polyethylene glycol 400 or their mixture.