1446results about How to "High measurement sensitivity" patented technology

Structural parameters of a specimen are determined by fitting models of the response of the specimen to measurements collected by different measurement techniques in a combined analysis. Models of the response of the specimen to at least two different measurement technologies share at least one common geometric parameter. In some embodiments, a model building and analysis engine performs x-ray and optical analyses wherein at least one common parameter is coupled during the analysis. The fitting of the response models to measured data can be done sequentially, in parallel, or by a combination of sequential and parallel analyses. In a further aspect, the structure of the response models is altered based on the quality of the fit between the models and the corresponding measurement data. For example, a geometric model of the specimen is restructured based on the fit between the response models and corresponding measurement data.

The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be quantitated in a proteolytic digest of a complex protein sample) and an internal standard peptide (the same chemical structure but including stable isotope labels). Upon elution into a suitable mass spectrometer, the natural (sample derived) and internal standard (isotope labeled) peptides are quantitated, and their measured abundance ratio used to calculate the abundance of the monitor peptide, and its parent protein, in the initial sample

A method of measuring an analyte, comprising a step of measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein a layered inorganic compound is caused to exist in the reaction system including the formation reaction of the detectable substance, whereby high-sensitivity measurement is made possible, the detectable substance can be stabilized to improve accuracy of the measurement, a rate of a chemical reaction is increased to enable quick measurement, and high-sensitivity measurement is made possible even in a reaction system which forms an insoluble substance. Also, it can be provided an analytical testing piece for measuring an analyte, by measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein the testing piece comprises at least one test portion having a detection portion for detecting the detectable substance and contains a layered inorganic compound at least in the test portion, whereby diffusion and elution of a dyestuff or the like is prevented, more sensitive and accurate simple analysis is made possible, and easy handling is possible.

A method of measuring an analyte, comprising a step of measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein a layered inorganic compound is caused to exist in the reaction system including the formation reaction of the detectable substance, whereby high-sensitivity measurement is made possible, the detectable substance can be stabilized to improve accuracy of the measurement, a rate of a chemical reaction is increased to enable quick measurement, and high-sensitivity measurement is made possible even in a reaction system which forms an insoluble substance. Also, it can be provided an analytical testing piece for measuring an analyte, by measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein the testing piece comprises at least one test portion having a detection portion for detecting the detectable substance and contains a layered inorganic compound at least in the test portion, whereby diffusion and elution of a dyestuff or the like is prevented, more sensitive and accurate simple analysis is made possible, and easy handling is possible.

The scanning speed of a sample in Doppler OCT, etc., is increased to enable quick measurement of blood flow rate, blood flow volume, etc. Wideband light from a light source 2 is linearly polarized by a polarization controller 3 and this linearly polarized beam is split into vertically polarized light and horizontally polarized light using a Wollaston prism 14 at a sample arm, which are then irradiated simultaneously onto two different locations of the sample in the scanning direction using a galvanometer mirror18, and reference light from a reference arm 5 and object light from a sample arm 6 are merged and caused to interfere with each other, with the resulting interference signal light passed through a diffraction grating 26 for spectroscopy, while the horizontal component and vertical component are separated by a polarized beam splitter 28, to simultaneously measure the components with two polarization-sensitive optical detectors 29, 30 and thereby obtain two tomography images of the same location at different times by one mechanical scan, thus allowing the amount of temporal change in phase to be measured using the two tomography images.

An isolating circuit for an electrosurgical generator arranged to produce radiofrequency (RF) energy and microwave energy for treating biological tissues is provided. The generator has an RF channel and a microwave channel which are combined at a signal combiner to enable the RF energy and microwave energy to be delivered into tissues along a common feed path. The isolating circuit includes a tunable wavelength isolator at a junction between the microwave channel and the signal combiner, and can include a capacitive structure between a ground conductor of the signal combiner and a conductive input section of the waveguide isolator to inhibit coupling of the RF energy and leakage of the microwave energy. The isolating circuit can combine into a single tunable unit all the necessary components to isolate the microwave and RF channels from one another while providing a high withstanding voltage.

A method for making a textile sensor and a textile sensor can include selecting a combination of variables from the group consisting of yarn variables, stitch variables, and textile variables; and knitting an electrically conductive yarn in the textile sensor in accordance with the selected combination of variables, wherein the combination of variables is selected so as to provide a controlled amount of contact resistance in the textile sensor. The method and textile can further include a capacitive textile-sensor having at least two integrally knit capacitor plate elements and having a configuration adapted for a sensing activity. Resistance in the textile sensor can automatically calibrate to a stable baseline level after the textile sensor is applied to a body.

The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

The invention discloses a non-disperse infrared multi-component flue gas analyzer. In the non-disperse infrared multi-component flue gas analyzer, a light source with similar black body radiation characteristic is adopted and can cover infrared absorption bands of all component gases to be tested and interfered component gases; high-stability light source emission is realized by designing a voltage-stabilizing and current-stabilizing circuit; an optically filtering wheel is provided, so double effects of optically filtering and modulating light waves are achieved, and stability and measuring accuracy of a system are improved; concentration of various gases in the flue gas can be measured at the same time by reasonably selecting parameters of optical filters; a water vapor measuring channel is introduced on the optically filtering wheel, so an analyzer can work in the damp environment normally; a sample pool adopts a multi-time reflection pool structure, so gas absorption optical distance is increased and detection sensitivity of the system is improved; and the sample pool adopts a heating and temperature control system, so water vapor condensation and combination of the water vapor and acidic gases to be tested such as sulfur dioxide (SO2) and nitrogen dioxide (NO2) are avoided, and measuring accuracy and corrosion resistance of the system are improved.

The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be quantitated in a proteolytic digest of a complex protein sample) and an internal standard peptide (the same chemical structure but including stable isotope labels). Upon elution into a suitable mass spectrometer, the natural (sample derived) and internal standard (isotope labeled) peptides are quantitated, and their measured abundance ratio used to calculate the abundance of the monitor peptide, and its parent protein, in the initial sample.

A snapshot backscatter radiography (SBR) system and related method includes at least one penetrating radiation source, and at least one substantially transmissive radiation detector. The substantially transmissive radiation detector is interposed between an object region to be interrogated and the radiation source. The substantially transmissive radiation detector receives and detects forward radiation from the radiation source before transmitting a portion thereof to interrogate the object region, wherein a portion of backscattered radiation provided by the object region is detected by the detector. A changeable collimating grid having a plurality of spaced apart radiation absorbing features is coupled to structure changing a position of the plurality of features and is disposed in at least one of the path of the forward radiation and the path of the backscattered radiation. An image of the object can be obtained by subtracting the forward radiation detected at the detector, or an estimate thereof, from a total of all radiation detected by the detector. Integrated circuit inspection, land mine detection, and luggage or cargo screening systems can all be SBR based.

Methods and systems for small angle CD metrology with a small spot size are introduced to increase measurement sensitivity while maintaining adequate throughput necessary for modern semiconductor manufacture. A small angle CD metrology system includes a small angle spectroscopic ellipsometry (SE) subsystem combined with a small angle spectroscopic reflectometry system, both operated at small angles of incidence. The small angle SE subsystem is configured to operate in a complete Mueller Matrix mode to further improve measurement sensitivity. The small angle CD metrology system includes an objective having all reflective surfaces in the light path. In some embodiments, the all-reflective objective is a Schwartzschild objective having an axicon mirror element to further reduce measurement spot size. In some embodiments, the small angle CD metrology system includes a dynamic aperture subsystem to isolate specific ranges of angles of incidence and azimuth for improved measurement sensitivity.

The invention provides an all-fiber testing device for testing the polarization crosstalk of an optical device. The all-fiber testing device comprises a wide-spectrum light source (501), a polarizer (511), a to-be-tested polarizing device (522), an optical path correlator (530), a difference detector (550) and a photoelectric signal conversion and signal recording device (560), wherein the wide-spectrum light source (501) is connected with the to-be-tested optical fiber device (522) through the polarizer (511) and a first rotary connector (521) and is connected with the optical path correlator (530) with a polarization beam splitting Michelson structure through a second rotary connector (523); and the optical path correlator (530) is connected with the polarization difference detector (550) through a third rotary connector (541) and is connected with an interference signal detecting and processing device (560). The all-fiber testing device has the advantages of small size, high measurement accuracy, high temperature and vibration stability and the like, so that the all-fiber testing device is widely applied to high-accuracy measurement and analysis of the polarization performance of the optical device.

In order to provide a magnetic field measuring apparatus facilitating the pressure control in a gas cell, or capable of inspecting the internal pressure of the gas cell without using any special process, the magnetic field measuring apparatus is configured such that a process layer of the magnetic field measuring apparatus has such a structure that includes a first hollow portion and a second hollow portion provided opposed to first hollow portion with a first isolation wall interposed therebetween. Alternatively, a method for manufacturing the magnetic field measuring apparatus includes breaking the first isolation wall after generating alkali metal (FIG. 17 and FIG. 20).

The invention provides a device and a method for improving polarization crosstalk measurement performance of an optical device. The device comprises a wide spectrum light source (301), a polarizer (311), a polarization device to be tested (632), an optical path correlator (640) and a polarization crosstalk detection and signal recording device (150), wherein the wide spectrum light source (301) is connected with the optical device to be tested (632) by the polarizer (311) and a first rotation connector (631) and then is connected with the optical path correlator (640) by a second rotation connector (633). By the device and the method, noise amplitude can be greatly suppressed, the sensitivity of polarization crosstalk measurement is improved, the dynamic range of polarization crosstalk measurement is expanded, and the device and the method are widely used for high-precision measurement and analysis on polarization performance of the optical device.

Structural parameters of a specimen are determined by fitting models of the response of the specimen to measurements collected by different measurement techniques in a combined analysis. X-ray measurement data of a specimen is analyzed to determine at least one specimen parameter value that is treated as a constant in a combined analysis of both optical measurements and x-ray measurements of the specimen. For example, a particular structural property or a particular material property, such as an elemental composition of the specimen, is determined based on x-ray measurement data. The parameter(s) determined from the x-ray measurement data are treated as constants in a subsequent, combined analysis of both optical measurements and x-ray measurements of the specimen. In a further aspect, the structure of the response models is altered based on the quality of the fit between the models and the corresponding measurement data.

Disclosed are compositions and methods for preventing, inhibiting, reducing and treating conditions and diseases associated with abnormal bone resorption in mammals, including for example osteoporosis. Embodiments of compositions of the invention comprise a pharmaceutically effective amount of alendronate and vitamin D3 suitable for once-weekly dosing. Compositions and methods of the invention provide vitamin D nutrition during bisphosphonate treatment to facilitate normal bone formation and mineralization while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcaemia and osteomalacia. Also disclosed are methods for manufacturing compositions of the present invention, for measuring stability and degradation of those compositions, and for measuring blood plasma levels of vitamin D.

Provided herein are devices, systems, and methods of employing the same for the performance of bioinformatics analysis. The apparatuses and methods of the disclosure are directed in part to large scale graphene FET sensors, arrays, and integrated circuits employing the same for analyte measurements. The present GFET sensors, arrays, and integrated circuits may be fabricated using conventional CMOS processing techniques based on improved GFET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense GFET sensor based arrays. Improved fabrication techniques employing graphene as a reaction layer provide for rapid data acquisition from small sensors to large and dense arrays of sensors. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes, including DNA hybridization and / or sequencing reactions. Accordingly, GFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and / or binding events associated with chemical processes relating to DNA synthesis within a gated reaction chamber of the GFET based sensor.

The sequencing of individual monomers (e.g., a single nucleotide) of a polymer (e.g., DNA, RNA) is improved by reducing the motion of the polymer due to thermally-driven diffusion to reduce the spatial error in the position of the polymer within a measurement device. A major system parameter, such as average translocation velocity or measurement time, is selected based on the characteristics of the sensing system utilized, and an algorithm jointly optimizes the sequencing order error rate and the monomer identification error rate of the system.

A liquid sensor has comb-shaped electrodes, applied to a piezoelectric substrate, as interdigital transducers for generating an electroacoustic wave from a transmitting transducer to a receiving transducer. The number of finger pairs of the interdigital transducers and the material out of which the electrodes are made are so chosen that a surface shear wave generated by the transmitting transducer and a bulk shear wave generated by the transmitting transducer have different frequencies.

The invention discloses a water level-flow speed-flow rate monitoring integrated device, a water level-flow speed-flow rate monitoring system and a water level-flow speed-flow rate monitoring method. The device comprises a radar water level measuring module, a radar flow speed measuring module, a wind speed measuring module and a flow rate calculating module, wherein the radar water level measuring module, the radar flow speed measuring module and the wind speed measuring module are connected with the flow rate calculating module respectively; the radar water level measuring module is used for measuring the real-time water level data of a river course / channel in a non-contact form; the radar flow speed measuring module is used for measuring the real-time surface flow speed data of the river course / channel in the non-contact form; the wind speed measuring module is used for measuring real-time wind speed data to correct a flow speed of a water surface; the flow rate calculating module is used for calculating to obtain the size of the flow rate of a controlled section of the river course / channel at a current moment by combining with an input relevant parameter of the controlled section of the river course / channel according to the water level data, the flow speed data and the wind speed data. The device can be used for monitoring the water level and the flow speed of the river course / channel in real time, and moreover, can be used for realizing monitoring the flow rate in real time.

PCT No. PCT / US96 / 18426 Sec. 371 Date Oct. 13, 1998 Sec. 102(e) Date Oct. 13, 1998 PCT Filed Nov. 15, 1996 PCT Pub. No. WO97 / 18481 PCT Pub. Date May 22, 1997A built in current sensor circuit (BICS) for use in integrated circuit testing utilizing the Quiescent Power Supply testing technique comprised of a detecting transistor, an s-ram cell and a buffer cell electrically coupled in a cascaded configuration to perform a comparator function, a reference source comprised of a current generating transistor and a voltage level setting transistor, and an active output load comprised of a single p-MOSFET sized to draw a unique amount of current when a respective circuit under test is determined to be defective., whereby the additional current drawn by the active output load is readily observable on the bias line by an external standard off-the-shelf current monitor. The built in current sensor circuit thereby alleviates the excessive use of area overhead in deep submicron integrated circuits and the need for separately propagating a defect signal to an output pin.

A method for forming a flow sensor having self-supported heat-carrying elements is disclosed. Self-supported heat-carrying elements are capable of operating with higher thermal efficiency, enabling lower power consumption and higher sensitivity, due to a lack of heat loss into a supporting membrane. Self-supported heat-carrying elements facilitate wider operating temperature range and compatibility with harsh media.

The present invention provides an apparatus having a sample separation unit, a Raman spectroscopy unit, and a mass spectrometry unit. The present invention further provides a method for specifying a biomolecule and a method for identifying the binding site of the biomolecule and the low-molecular-weight compound, comprising a combination of Raman spectroscopy and mass spectrometry. The present invention further provides a surface-enhanced Raman spectroscopy method with improved sensitivity.

The invention relates to a method for the non-destructive examination of a test body by means of ultrasound, whereby ultrasound waves are injected into the test body by means of one or more ultrasound transducers and ultrasound waves reflected inside the test body are received by a plurality of ultrasound transducers and are converted to ultrasound signals. The ultrasound signals are detected in individual measurement intervals and are stored individually and are accessible to offline evaluation after termination of the measurements. The inventive method allows to subsequently synthesize any acoustic irradiation angle and focusing in the physically possible volume range of the test body from the stored ultrasound signals by using corresponding reconstruction algorithms, thereby eliminating the need for additional ultrasound measurements.

The invention relates to an integrated measurement system to detect a quantity of magnetic particles in a sample. The measurement system includes a substrate. An electromagnetic (EM) structure disposed on the surface of the substrate is configured to receive a sample including the magnetic particles in proximity thereof. The integrated measurement system also includes an electrical current generator disposed on the surface of the substrate which is electro-magnetically coupled to the EM structure. The electrical current generator is configured to cause an electrical current to flow in the EM structure. The integrated measurement system also includes an effective inductance sensor disposed on the surface of the substrate which is configured to measure a selected one of an effective inductance and a change in effective inductance. The invention also relates to a method to determine the number of and / or the locations of the magnetic particles in a sample.

A chemical and biological transducer is prepared by setting two long period fibre gratings, fibre covering and fibre core on one piece of fibre to form a MZ interferometer and then plating a metal film on fibre covering surface to form SPR transducer of fibre MZ interferometer structure. The sensing system comprises wide band light source, fibre, chemical and biological transducer formed as above, fibre spectrograph and computer as said transducer is set in gas or solution of chemical composition or biological molecule to be tested.

Provided herein are devices, systems, and methods of employing the same for the performance of bioinformatics analysis. The apparatuses and methods of the disclosure are directed in part to large scale graphene FET sensors, arrays, and integrated circuits employing the same for analyte measurements. The present GFET sensors, arrays, and integrated circuits may be fabricated using conventional CMOS processing techniques based on improved GFET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense GFET sensor based arrays. Improved fabrication techniques employing graphene as a reaction layer provide for rapid data acquisition from small sensors to large and dense arrays of sensors. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes, including DNA hybridization and / or sequencing reactions. Accordingly, GFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and / or binding events associated with chemical processes relating to DNA synthesis within a gated reaction chamber of the GFET based sensor.

An isolating circuit for electrosurgical generator arranged to produce radiofrequency (RF) energy and microwave energy for treating biological tissue. The generator has an RF channel and a microwave channel which are combined at signal combiner to enable the RF energy and microwave energy to be delivered into tissue along a common feed path. The isolating circuit comprises a tunable waveguide isolator at a junction between the microwave channel and signal combiner, and can include a capacitive structure between a ground conductor of the signal combiner and a conductive input section of the waveguide isolator to inhibit coupling of the RF energy and leakage of the microwave energy. The isolating circuit can combine into a single tunable unit all the necessary components to isolate the microwave and RF channels from one another whilst providing a high withstanding voltage.