1442results about How to "High measurement sensitivity" patented technology

The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be quantitated in a proteolytic digest of a complex protein sample) and an internal standard peptide (the same chemical structure but including stable isotope labels). Upon elution into a suitable mass spectrometer, the natural (sample derived) and internal standard (isotope labeled) peptides are quantitated, and their measured abundance ratio used to calculate the abundance of the monitor peptide, and its parent protein, in the initial sample

A method of measuring an analyte, comprising a step of measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein a layered inorganic compound is caused to exist in the reaction system including the formation reaction of the detectable substance, whereby high-sensitivity measurement is made possible, the detectable substance can be stabilized to improve accuracy of the measurement, a rate of a chemical reaction is increased to enable quick measurement, and high-sensitivity measurement is made possible even in a reaction system which forms an insoluble substance. Also, it can be provided an analytical testing piece for measuring an analyte, by measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein the testing piece comprises at least one test portion having a detection portion for detecting the detectable substance and contains a layered inorganic compound at least in the test portion, whereby diffusion and elution of a dyestuff or the like is prevented, more sensitive and accurate simple analysis is made possible, and easy handling is possible.

The scanning speed of a sample in Doppler OCT, etc., is increased to enable quick measurement of blood flow rate, blood flow volume, etc. Wideband light from a light source 2 is linearly polarized by a polarization controller 3 and this linearly polarized beam is split into vertically polarized light and horizontally polarized light using a Wollaston prism 14 at a sample arm, which are then irradiated simultaneously onto two different locations of the sample in the scanning direction using a galvanometer mirror18, and reference light from a reference arm 5 and object light from a sample arm 6 are merged and caused to interfere with each other, with the resulting interference signal light passed through a diffraction grating 26 for spectroscopy, while the horizontal component and vertical component are separated by a polarized beam splitter 28, to simultaneously measure the components with two polarization-sensitive optical detectors 29, 30 and thereby obtain two tomography images of the same location at different times by one mechanical scan, thus allowing the amount of temporal change in phase to be measured using the two tomography images.

An isolating circuit for an electrosurgical generator arranged to produce radiofrequency (RF) energy and microwave energy for treating biological tissues is provided. The generator has an RF channel and a microwave channel which are combined at a signal combiner to enable the RF energy and microwave energy to be delivered into tissues along a common feed path. The isolating circuit includes a tunable wavelength isolator at a junction between the microwave channel and the signal combiner, and can include a capacitive structure between a ground conductor of the signal combiner and a conductive input section of the waveguide isolator to inhibit coupling of the RF energy and leakage of the microwave energy. The isolating circuit can combine into a single tunable unit all the necessary components to isolate the microwave and RF channels from one another while providing a high withstanding voltage.

The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be quantitated in a proteolytic digest of a complex protein sample) and an internal standard peptide (the same chemical structure but including stable isotope labels). Upon elution into a suitable mass spectrometer, the natural (sample derived) and internal standard (isotope labeled) peptides are quantitated, and their measured abundance ratio used to calculate the abundance of the monitor peptide, and its parent protein, in the initial sample.

Methods and systems for small angle CD metrology with a small spot size are introduced to increase measurement sensitivity while maintaining adequate throughput necessary for modern semiconductor manufacture. A small angle CD metrology system includes a small angle spectroscopic ellipsometry (SE) subsystem combined with a small angle spectroscopic reflectometry system, both operated at small angles of incidence. The small angle SE subsystem is configured to operate in a complete Mueller Matrix mode to further improve measurement sensitivity. The small angle CD metrology system includes an objective having all reflective surfaces in the light path. In some embodiments, the all-reflective objective is a Schwartzschild objective having an axicon mirror element to further reduce measurement spot size. In some embodiments, the small angle CD metrology system includes a dynamic aperture subsystem to isolate specific ranges of angles of incidence and azimuth for improved measurement sensitivity.

The sequencing of individual monomers (e.g., a single nucleotide) of a polymer (e.g., DNA, RNA) is improved by reducing the motion of the polymer due to thermally-driven diffusion to reduce the spatial error in the position of the polymer within a measurement device. A major system parameter, such as average translocation velocity or measurement time, is selected based on the characteristics of the sensing system utilized, and an algorithm jointly optimizes the sequencing order error rate and the monomer identification error rate of the system.

A liquid sensor has comb-shaped electrodes, applied to a piezoelectric substrate, as interdigital transducers for generating an electroacoustic wave from a transmitting transducer to a receiving transducer. The number of finger pairs of the interdigital transducers and the material out of which the electrodes are made are so chosen that a surface shear wave generated by the transmitting transducer and a bulk shear wave generated by the transmitting transducer have different frequencies.

Methods for determining whether the brain activity of a human subject in response to a stimulus of interest or question of interest is characteristic of a state of interest, such as a deceptive state or a truthful state, are disclosed. Some methods include the use of control questions, including truthful control questions and deceptive control questions, to provide bases for comparison for responses to stimuli of interest or questions of interest. Some methods include the use of differences between two states, such as a deceptive state and a truthful state. In some methods, brain maps are generated and compared. Also disclosed are systems for detecting deception by measuring brain activity.

The invention discloses a water level-flow speed-flow rate monitoring integrated device, a water level-flow speed-flow rate monitoring system and a water level-flow speed-flow rate monitoring method. The device comprises a radar water level measuring module, a radar flow speed measuring module, a wind speed measuring module and a flow rate calculating module, wherein the radar water level measuring module, the radar flow speed measuring module and the wind speed measuring module are connected with the flow rate calculating module respectively; the radar water level measuring module is used for measuring the real-time water level data of a river course / channel in a non-contact form; the radar flow speed measuring module is used for measuring the real-time surface flow speed data of the river course / channel in the non-contact form; the wind speed measuring module is used for measuring real-time wind speed data to correct a flow speed of a water surface; the flow rate calculating module is used for calculating to obtain the size of the flow rate of a controlled section of the river course / channel at a current moment by combining with an input relevant parameter of the controlled section of the river course / channel according to the water level data, the flow speed data and the wind speed data. The device can be used for monitoring the water level and the flow speed of the river course / channel in real time, and moreover, can be used for realizing monitoring the flow rate in real time.

The present invention provides an apparatus having a sample separation unit, a Raman spectroscopy unit, and a mass spectrometry unit. The present invention further provides a method for specifying a biomolecule and a method for identifying the binding site of the biomolecule and the low-molecular-weight compound, comprising a combination of Raman spectroscopy and mass spectrometry. The present invention further provides a surface-enhanced Raman spectroscopy method with improved sensitivity.

Provided herein are devices, systems, and methods of employing the same for the performance of bioinformatics analysis. The apparatuses and methods of the disclosure are directed in part to large scale graphene FET sensors, arrays, and integrated circuits employing the same for analyte measurements. The present GFET sensors, arrays, and integrated circuits may be fabricated using conventional CMOS processing techniques based on improved GFET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense GFET sensor based arrays. Improved fabrication techniques employing graphene as a reaction layer provide for rapid data acquisition from small sensors to large and dense arrays of sensors. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes, including DNA hybridization and / or sequencing reactions. Accordingly, GFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and / or binding events associated with chemical processes relating to DNA synthesis within a gated reaction chamber of the GFET based sensor.