79 results about "Normal bone" patented technology

Disclosed are compositions and methods for preventing, inhibiting, reducing and treating conditions and diseases associated with abnormal bone resorption in mammals, including for example osteoporosis. Embodiments of compositions of the invention comprise a pharmaceutically effective amount of alendronate and vitamin D3 suitable for once-weekly dosing. Compositions and methods of the invention provide vitamin D nutrition during bisphosphonate treatment to facilitate normal bone formation and mineralization while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcaemia and osteomalacia. Also disclosed are methods for manufacturing compositions of the present invention, for measuring stability and degradation of those compositions, and for measuring blood plasma levels of vitamin D.

Disclosed are a bionic bone repairing scaffold of a layered structure and a manufacturing method thereof. The scaffold is formed by at least one scaffold unit (4). The scaffold unit (4) is of a cylinder structure with a helical section, the cylinder structure is formed by continuously rolling a laminar material (2) tightly from inside to outside, and the diameter of the cylinder structure is from 0.1 mm to 50 mm. The structure is similar to the Harvard system of the natural bone, has a highly bionic effect, can well implement mechanical transfer between a defect site and normal bone tissue, can maintain good structure stability even in a degradation process, and completes the repair and function reconstruction of the bone tissue. The three-dimensional size of the bone repairing scaffold can be adjusted flexibly by controlling the thickness and height of the laminar material (2), and the number of rolling layers, so as to satisfy different use requirements.

The invention discloses a preparation technology of a PCL / GE (polycaprolactone / gelatin) electrospinning composite stent, and belongs to the technical field of biological tissue engineering stents. The preparation technology sequentially comprises a preparation technology of a PCL / GE nanometer fiber electrospinning film which is made of an artificial cell extracellular matrix (ECM) stent material, a preparation method of an electrospinning film coated with hydroxyapatite crystals, and a building method of the electrospinning composite stent. The preparation technology has the advantages that the electrospinning film coated with the hydroxyapatite crystals and the PCL / GE electrospinning film are combined to form an ECM structure which is similar to natural bone tissues; the prepared electrospinning composite stent has no obvious cell toxicity, the internal stent structure is similar to the ECM of the natural bone tissues, and the outer layer structure can block the invasion of peripheral connective tissues; the biocompatibility is good, and the regeneration of bone tissues can be effectively promoted; a stable environment is provided for the regeneration of new bones, and the structure and function of the ECM of the normal bone tissues can be simulated.

The invention discloses a hot pot flavoring capable of clearing fever, which comprises seasoning sauce and soup stock, wherein the soup stock comprises normal bone soup and chicken juice; the ratio of the seasoning sauce to the soup stock is 1: (8-10). The seasoning sauce is characterized by being prepared from the following components in percentage by weight: 10-15% of pepper, 15-18% of aniseed, 3-5% of netmeg, 3-8% of mulberry leaf, 5-8% of Foeniculum vulgare, 5-6% of chicken meal, 2-4% of lily, 2-4% of ginger powder, 0.5-1% of table salt, 2-3% of cinnamon, 2-4% of mother chrysanthemum, 2-4% of orange peel, 2-4% of radix ophiopogonis, 0.3-0.5% of white granulated sugar, 2-3% of sesame sauce, 2-5% of peanut butter, 2-3% of fish oil and the balance of edible essences. The hot pot flavoring has abundant nutritions and fresh and delicious taste and has the efficacies on appetizing, expelling cold and enhancing appetite after certain food materials capable of clearing the fever are added.

The invention discloses an in vivo degradable and absorbable metal encirclement device for bone fracture internal fixation, which consists of a single claw-shaped fixing part, or a plurality of claw-shaped fixing parts and connecting plates combined together alternately. The encirclement device is prepared from a degradable metal material. The encirclement device tightly encircles a bone fracture part through a fixed claw to realize engagement alignment of broken bones; the connecting plates of the encirclement device connect the claw-shaped fixing parts together to form a shape matched with that of a bone. When the bone fracture part is healed up, the connecting plates of the encirclement device are degraded gradually, and when the bone fracture part has the mechanical strength of a normal bone, claw-shaped fixing ends of the encirclement device lose the fixing effect, become fragments coated by muscles and fibrous tissues and finally are completely absorbed by an organism. On the premise of meeting the fixing effect of a magnesium alloy bone plate, the encirclement device can greatly improve the treatment effect of the magnesium alloy bone plate without using wedge-type fixing ends such as magnesium alloy bone pegs and the like, and simultaneously, the magnesium alloy bone plate is not needed to be taken out through a secondary operation, so that pains of the patient are alleviated and postoperative long-term risks of the patient are reduced.

To identify molecular determinants of lytic bone disease in multiple myeloma, the expression profiles of ˜12,000 genes in CD138-enriched plasma cells from newly diagnosed multiple myeloma patients exhibiting no radiological evidence of lytic lesions (n=28) were compared to those with ≧3 lytic lesions (n=47). Two secreted WNT signaling antagonists, soluble frizzled related protein 3 (SFRP-3 / FRZB) and the human homologue of Dickkopf-1 (DKK1), were expressed in 40 of 47 with lytic bone lesions, but only 16 of 28 lacking bone lesions (P<0.05). DKK1 and FRZB were not expressed in plasma cells from 45 normal bone marrow donors or 10 Waldenstrom's macroglobulinemia, a related plasma cells malignancy that lacks bone disease. These data indicate that these factors are important mediators of multiple myeloma bone disease, and inhibitors of these proteins may be used to block bone disease.

The invention discloses a double-nail-hook metaphysis pressurizing fixing device which comprises a first fixing part, a second fixing part and a connecting part. The connecting part is used for connecting the first fixing part and the second fixing part. The first fixing part comprises two strip-shaped objects. The strip-shaped objects are used for penetrating through the fracture part of the metaphysis and being inserted into the backbone to be fixed. The connecting part is in a forked strip-shaped hook shape attached to the surface of the bone. Forked strips of the connecting part and the strip-shaped objects of the first fixing device are connected in a one-to-one corresponding mode. A plurality of pressurizing fixing holes are formed in the second fixing part. Pressurizing screws penetrate through the pressurizing fixing holes so that the second fixing part can be fixed to the backbone connected with the metaphysis. The pressurizing fixing device is convenient to take out, low in cost, and beneficial for healing the fracture part and preventing secondary injuries to normal bone tissue.

The invention provides a method for preparing a biological scaffold by 3D printing. The method comprises the steps of grinding allogeneic bones or heterogeneous bones at a low temperature in a freezing grinder to obtain a printing material, modeling 3D printing with the aid of a computer, and then performing post treatment in a genipin solution. The prepared biological scaffold has good biological compatibility, and the bone graft material does not have toxicity, rejection, mutagenicity or antigenicity in vivo, and does not disturb bone and tissue regeneration; the prepared biological scaffold can be gradually degraded and absorbed and replaced by autologous bone tissues, can bear the pressure close to 20MPa with normal bone cortex, and has good initial mechanical properties; and the elastic modulus is gradually reduced, stress shielding is avoided, fracture, collapse and loosening of implants in the long-term healing process are avoided, bone fusion can be accelerated, and the implants can be finally completely converted into autologous bone tissues.

The invention provides a nano calcium silicate-polyetheretherketone (PEEK) composite material which is composed of nano calcium silicate and PEEK in a volume ratio of (10-30):(70-90). The nano calcium silicate-PEEK composite material maintains the excellent biomechanical characteristics of the PEEK, and greatly enhances the biological activity of the PEEK. After being implanted into the body, the nano calcium silicate-PEEK composite material can be matched with peripheral normal bones in the mechanical aspect, can be well integrated with the host bone, promotes the adhesion, proliferation and osteogenesis differentiation of the bone source cells, can keep long-term stability, can be used in clinic as a spine interbody fusion device material and a joint prosthesis material, has active practical meanings, and can generate huge social and economic benefits.

Composition and method for preventing or treating abnormal bone resorption in mammals, the composition characterized as containing, a supplementary effective amount of a non-activated metabolite of vitamin D2 and / or D3 and a pharmaceutically effective amount of bisphosphonate to provide vitamin D nutrition during treatment to facilitate normal bone formation and mineralization, while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcemia and osteomalacia. The method of preventing or treating may be further characterized by concomitantly administering the components simultaneously or alternately at dosing intervals selected from once-weekly, twice-weekly, bi-weekly, monthly, and bimonthly.

The invention relates to a group of medical ceramic bone with different structures in the same class. The inorganic crystal grid is consistent to the normal bone with the method, it can be divided into skin bone type, loose bone type, compound type and particle type according to the structures, its primary ingredient is natural ramification of aspatite. The manufacturing method is: selects bones on different part of huge animal, and then carries on degreasing, protein eliminating, dehydrating, and baking. According to different structures, the carrier which can be used as transplanting material, medicine or growing factor and bracket material of organization project, it can form new bones with different effects.

Toona sinensis extract for suppressing the proliferation and inducing apoptosis of osteosarcoma, but not normal human osterblasts. The extraction process comprises: extracting Toona sinensis with water to obtain a first extract, and filtering the first extract by a membrane to obtain a filtrate, and the Toona sinensis extract of the invention does not cause biological damages of normal bone cells. In addition, the invention further provides a pharmaceutical composition comprising the Toona sinensis extract.

The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising a matriptase monoclonal antibody and anticancer agents such as doxorubicin (DOX) are introduced, which are equipotent to anticancer agents used in free form but exhibit significantly reduced cardiotoxicity and almost no adverse effects on normal bone marrow-derived mesenchymal stromal cells that do not express matriptase. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase. In addition, administration of a matriptase antibody or immunoconjugates of a matriptase antibody and a cytotoxic agent in combination with administration of an immunomodulatory agent, such as thalidomide or an analog thereof, provides a more effective treatment of these cancers.

To identify molecular determinants of lytic bone disease in multiple myeloma, the expression profiles of ˜12,000 genes in CD138-enriched plasma cells from newly diagnosed multiple myeloma patients exhibiting no radiological evidence of lytic lesions (n=28) were compared to those with ≧3 lytic lesions (n=47). Two secreted WNT signaling antagonists, soluble frizzled related protein 3 (SFRP-3 / FRZB) and the human homologue of Dickkopf-1 (DKK1), were expressed in 40 of 47 with lytic bone lesions, but only 16 of 28 lacking bone lesions (P<0.05). DKK1 and FRZB were not expressed in plasma cells from 45 normal bone marrow donors or 10 Waldenstrom's macroglobulinemia, a related plasma cells malignancy that lacks bone disease. These data indicate that these factors are important mediators of multiple myeloma bone disease, and inhibitors of these proteins may be used to block bone disease reduce tumor burden in multiple myeloma and to block bone disease.

The invention discloses a bone repair material with a multi-dimensional channel structure. The bone repair material has a layered matrix structure; a plurality of bosses I are formed in one surface of the matrix structure, and a plurality of bosses II are formed in another surface of the matrix structure; the bosses I and the bosses II are arrayed alternatively; grooves are formed between adjacent bosses I and adjacent bosses II; and a plurality of through holes are formed in a way of being perpendicular to the surfaces of the bosses I. The bone repair material provided by the invention adopts a three-dimensional network channel formed through the through holes in the matrix structure and the grooves, and the three-dimensional network channel is filled with collagenous fiber, which is favorable for cell attachment and growth as well as nerve ingrowth, and also is convenient for nutrient substance transfer and cell metabolite discharge, and also can enable cells to be evenly distributed in the interior of the material, and is favorable for even and uniform organizational formation in the interior of a support; the structural material can form firm biological gomphosis with regenerated new bone, and good structure stability can be maintained during a degradation process; the mechanical strength is high, and mechanical transmission between a bone defect part and normal bone tissue can be well achieved.

To identify molecular determinants of lytic bone disease in multiple myeloma, the expression profiles of ˜12,000 genes in CD138-enriched plasma cells from newly diagnosed multiple myeloma patients exhibiting no radiological evidence of lytic lesions (n=28) were compared to those with ≧3 lytic lesions (n=47). Two secreted WNT signaling antagonists, soluble frizzled related protein 3 (SFRP-3 / FRZB) and the human homologue of Dickkopf-1 (DKK1), were expressed in 40 of 47 with lytic bone lesions, but only 16 of 28 lacking bone lesions (P<0.05). DKK1 and FRZB were not expressed in plasma cells from 45 normal bone marrow donors or 10 Waldenstrom's macroglobulinemia, a related plasma cells malignancy that lacks bone disease. These data indicate that these factors are important mediators of multiple myeloma bone disease, and inhibitors of these proteins may be used to block bone disease.

The invention relates to the technical field of biomedical tissue engineering, in particular to a novel bone tissue engineering scaffold and a preparation method thereof. The bone scaffold comprises abone material and an exosome-loaded fibrin gel compound, the bone material is provided with holes, and the gel compound is distributed in the holes. The invention researches a bone material which ishighly similar to a natural bone matrix and has osteogenesis and vascularization activities. The porous decellularized tissue engineering scaffold is closer to a normal bone, has good biomechanical properties, is suitable for bone defect repair of a load bearing area, and maximally retains inherent components of the scaffold. According to the method, cell components with most antigens in tissues can be effectively removed, the immunological rejection reaction of grafts is reduced, the approximate morphological structure of the tissues can be maintained, and most tissue matrix components and bioactive factors are retained.

The invention relates to an artificial prosthesis of a long bone diaphysis tenon and mortise structure. A protruding face I and a rectangular protrusion I of a prosthesis proximal handle connecting part I are inserted into a strip-shaped groove II and a rectangular notch II of a prosthesis far-end handle connecting part II respectively, a protruding face II and a rectangular protrusion II of the prosthesis far-end handle connecting part are inserted into a strip-shaped groove I and a rectangular notch I of the prosthesis proximal handle connecting part I respectively, after a semicircular groove I of the prosthesis proximal handle connecting part I is in butt joint with a semicircular groove II of the prosthesis far-end handle connecting part II, a cylindrical counter bore is formed, tenon is inserted into the cylindrical counter bore formed in one end of the cylinder, and the tenon locks the connecting part I and the connecting part II together. Prosthesis fixation is firm and reliable, the operation is simple and convenient, the operation time is shortened, the operation effect and efficiency are improved, and operative complications are reduced. The artificial prosthesis can be widely applied to different defects of long bone diaphysis, the minimum osteotomy amount can reach 3.0 cm, and the maximum opportunity is provided for reserving normal bone tissue and joints as much as possible.

The invention provides a traditional Chinese medicine composition for treating children with rheumatoid arthritis and a preparation method thereof. Internal medicine comprises the following raw material medicines: loranthus parasiticus, prepared rehmannia root, divaricate saposhnikovia root, angelica, rhzizoma drynariae, gentiana macrophylla, earthworms, fructus psoraleae, radix achyranthis bidentatae, erodium stephanianum willd, teasel root, cortex moutan, lycopodium clavatum, radix clematidis, radix paeoniae alba, woodlouse, rhizoma atractylodis, radix curcumae, rhizoma corydalis, eucommia, polygonum cuspidatum and radix angelicae pubescentis; and external medicine comprises the following raw material medicines: tripterygium glycosides, cassia twig, frankincense, myrrh, ligusticum wallichii, nux vomica, honeysuckle stem, scorpio, resina draconis, woodlouse, teasel root, earthworms, safflower, beefwood-like clubmoss herb, polygonum cuspidatum, tuberculate speranskia herb and homalomena occulta. The traditional Chinese medicine composition provided by the invention is orally taken and is externally used and has the functions of clearing away heat and eliminating dampness, preventing joint deformity, relieving pain and relieving swelling. The technology has the advantages of convenience in administration, direct access to lesions, strong targeting, easiness for manufacturing the medicine, low cost and the like. The internal use and external use are combined to ensure the functions of replenishing the vital essence and removing heat, dredging the collaterals by resolving damp, eliminating pain, preventing joint deformity and generating no influence of the development of children; and the traditional Chinese medicine composition can promote normal bone growth and reinforce the joints.

Apparatus and method are disclosed for assessing rotational bone kinematics. Instantaneous center of rotation (ICR) of a bone segment is derived from a digitalized image of a bone and it is compared with the normal distribution of an ICR to determine rotational bone kinematics. The apparatus and method may be used to assess kinematic status of a normal bone and pathological bone. They also may be used to design an improved artificial disc to provide an appropriate kinesis.

The invention belongs to the field of medical engineering, particularly relates to a bone tissue constructed by tissue engineering. Tissue engineered bone scaffold materials are shaped according to specific defect forms of bones required to be restored. The outer layer of the shaped tissue engineered bone is a bone cortical frame, cancellous bone substitutes inoculated with bone marrow mesenchymal stem cells are filled in the middle of the shaped tissue engineered bone and substitute for cancellous bone and bone marrow compositions in the normal bone structure. The tissue engineered bone comprises cortical bone, cancellous bone and cell compositions which are similar to those of the normal bone structure. In clinical application, doctors can determine the resection range in advance according to CT (computed tomography) films of patients in operations, and shape the tissue engineered bone scaffold materials according to CT reconstruction data of the bone defect portions, thereby realizing individual treatment.

The invention provides a small sample tumor necrosis rate classification prediction device based on deep learning. The device comprises: a single image generation module configured to input a normal bone contour image and a real pre-chemotherapy tumor image with a tumor necrosis rate category label into a trained first generative adversarial network model to obtain a pre-chemotherapy tumor image with a tumor necrosis rate category label; the time sequence image generation module is configured to input the tumor image before chemotherapy generation into a trained second generative adversarial network model to obtain a tumor generation time sequence image; and the necrosis rate classification module is configured to train a deep convolutional neural network model by adopting the generated tumor time sequence image so as to obtain a tumor necrosis rate classification result of the to-be-detected tumor time sequence image. The device can solve the problems that the number of tumor samplesis small, and the missed diagnosis and misdiagnosis rate is high.

Systems and methods for generating a surgical plan for altering an abnormal bone using a generic normal bone model are discussed. For example, a system for planning a surgery on an abnormal bone can include a model receiver module (110) configured to receive a generic normal bone model (440). The generic normal bone model (440) can include a data set representing a normal bone having an anatomical origin comparable to the abnormal bone. An input interface (120) can receive an abnormal bone representation (430) including a data set representing the abnormal bone. A surgical planning module (130) can include a registration module (131) configured to register the generic normal bone model to the abnormal bone representation by creating a registered generic model. A surgical plan formation module (132) can be configured to identify one or more abnormal regions (452) of the abnormal bone (430) using the registered generic model.

The invention discloses a preparation method of a 3D printing porous root-shaped implant tooth, which comprises the following steps of: firstly, shooting medical image data of a maxillofacial part ofa patient by using CBCT, introducing the medical image data of the maxillofacial part into 3D image generation and editing processing software, editing, and converting and exporting an STL format fileof the affected tooth; obtaining an STL fitting model of the affected tooth by using the STL format file of the affected tooth; introducing the STL fitting model of the affected tooth into 3D modeling software to carry out reverse reconstruction and positive design of the implant tooth; and finally, printing the implant tooth by using a 3D printing device. The implant tooth prepared by the methodcan increase the contact area with normal bone through the pores on the surface, ensure the growth of osteoblasts, accelerate the speed of clinical bone combination and ensure that the implant toot is more stable.

The invention provides a guiding device for the pelvic tumor osteotomy, which comprises a handle and a guiding part. The guiding part is divided into a front part and a rear part which are connected; the front part is of a hook shape; the rear part is of a straight line shape; one end of the rear part is connected with the front part; the other end of the rear part is connected with the handle; a cavity running through the front part is arranged in the front part of the guiding part; the front part is provided with an inlet hole and an outlet hole which are communicated with the cavity; the inlet hole is arranged at the end of the front part, which is connected with the rear part, or is arranged on the rear part; and the outlet hole is arranged at the end of the front part, which is far away from the front part. According to the guiding device for the pelvic tumor osteotomy, which is provided by the invention, aiming at the complex anatomical features of the pelvis, the problem of difficulty in reasonably cutting bones totally according to a pre-operation plan is solved, the problem of insufficient cutting of the tumor or excessive cutting of the normal bone tissues in the operating process can also be solved, the possibility of damage to adjacent organs can also be reduced, and the unnecessary operation complications are reduced.