The invention relates to the preparation of a stone protection treatment agent and aims to provide a method for preparing a surface lyophobic oleophobic protection treatment agent. The method comprises the following steps: mixing butyl titanate with absolute ethyl alcohol; slowly adding the mixture into an acid hydrolyzing solution; reacting for 1-12 hours at 50 DEG C, thereby acquiring a particle type nanometer titanium dioxide sol; adding a silane coupling agent and performing hydrolytic-polymeric reaction for 1-24 hours under a water-bath condition at 30-80 DEG C, thereby acquiring a compound sol; adding perfluor monomer, acrylate organic matter, amide organic matter and azodiisobutyronitrile, and then reacting for 2-10 hours under a water-bath condition at 70 DEG C; cooling to 40 DEG C and then adding a mixed solvent of ketone and alcohol; and stirring for 2 hours, thereby acquiring the surface lyophobic oleophobic protection treatment agent. After the protection treatment agent is coated on the surface of stone, the nanometer titanium dioxide permeates through the surface of the stone and is firmly loaded on the surface, thereby increasing the micro surface roughness of the stone, enhancing the lyophobic oleophobic property of fluoro acrylic copolymer, endowing the stone with ultra-lyophobic oleophobic surface property, and achieving a water-contacting angle being 147 DEGC.