Traditional Chinese medicine composition for treating children with rheumatoid arthritis and preparation method thereof
A rheumatoid and arthritis technology, which is applied in the field of traditional Chinese medicine composition for treating children with rheumatoid arthritis and its preparation, can solve the problems of high toxicity and side effects of drugs, and achieve strong targeting, convenient administration, and strong joints Effect
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preparation example Construction
[0075] The preparation method of capsule of the present invention:
[0076] Sangjisheng 1500g, Rehmannia glutinosa 1500g, Fangfeng 1500g, Angelica 1500g, Drynaria 1500g, Gentiana 1500g, Earthworm 1500g, Psoralen 1500g, Achyranthes bidentata 1500g, Geranium 1500g, Dipsacus 1500g, Danpi 1500g, Shenjincao 1500g, Clematis 1500g, Paeoniae Alba 1500g, Wood Beetle 1500g, Atractylodes 1500g, Curcuma 1500g, Corydalis 1500g, Eucommia 1500g, Polygonum cuspidatum 1500g, Duhuo 1500g, first cut all raw materials into coarse particles, and then put them into In ethanol, soak for more than 2 hours, add 8 times the amount of ethanol and 6 times the amount of the total mass of the raw drug, and heat and extract twice, the extraction time is 2 hours and 1 hour; combine the 2 extracts, and the extracts are passed through the tube Centrifuge to obtain a centrifuge, which is absorbed by D 101 macroporous resin, washed with water to remove impurities, and then eluted with 70% ethanol, collected elua...
experiment example 2
[0095] Experimental example 2: Cumulative toxicity test:
[0096] Traditional Chinese medicine preparation of the present invention is taken orally honey refined pills to mice by 7.69, 19.18 and 43.21g crude drug / kg continuous medication 15 weeks (1.0ml / 100g body weight, every day 2 times) and after drug withdrawal 3 weeks, the result shows: Chinese medicine of the present invention The preparation has no obvious effect on the hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of rats. After 1 week and 3 weeks after stopping the drug, there was no significant change in the organs of the rats. Explanation The oral capsule of the traditional Chinese medicine preparation of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.
experiment example 3
[0097] Experimental Example 3: Results of Acute Percutaneous Toxicity Test
[0098] The medicinal compound preparation for external use of the present invention has the effects of expelling wind and dampness, promoting blood circulation and dredging collaterals, and is used for treating rheumatism, rheumatoid arthritis and other diseases. Accordingly, the acute percutaneous toxicity test was first carried out to observe whether the drug's acute percutaneous toxicity to rats is actually non-toxic.
[0099] Test substance: the preparation ointment for external use of the present invention. Weigh 50g of the test substance and add distilled water to make a 50% paste for later use.
[0100] Experimental animals: 20 SD rats were provided by the Experimental Animal Center of Shandong Provincial Academy of Traditional Chinese Medicine, male and female, weighing 180-220g, first-class animals (Yidongzi No. 08-25), and the source of feed was the same as above. Animal room environment: ...
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