78 results about "Polyoxyethylated castor oil" patented technology

A lyophilized solid composition of taxane (preferably docetaxel and paclitaxel), is suitable to prepare a pharmaceutical formulation to be administered to mammals, particularly humans, comprising a taxane, a tensoactive, a lyophilizing excipient, and acid; also essentially free from organic solvents. The solid composition is free from polysorbate 80 and polyoxyethylated castor oil; it is sterile; it is soluble in aqueous solutions in the absence of organic solvent and it has an apparent density from 0.05 g / ml to 0.45 g / ml. A procedure of double lyophilization obtains a solid composition of taxane. A pharmaceutical formulation of a taxane comprises a solid composition of lyophilized taxane and a solubilizing composition. A kit comprises the compositions and a syringe.

A pharmaceutical formulation of taxane intended to be administered to mammals, preferably humans, comprises two compositions combined prior to being administered, forming a transparent solution free from precipitates, in which the compositions comprise a solid composition of lyophilized taxane, free from tensoactives, oils, polymers, solubility enhancers, preservatives and excipients; and a solubilizing composition of the lyophilized taxane solid composition that comprises at least one tensoactive. This formulation is free from polysorbate 80 and polyoxyethylated castor oil. A procedure is provided for the preparation of the solid composition by means of the lyophilization of taxane in a lyophilizing organic solvent. A kit for the injectable formulation of taxane comprises a prefilled syringe. Also a pharmaceutical taxane solution for perfusion, free from organic solvent, is provided.

The invention relates to a graphene dispersion liquid and a preparation method thereof. The graphene dispersion liquid comprises graphene, a dispersant and a solvent. The dispersant is polyoxyethylated castor oil. Through use of the dispersant in graphene, the graphene dispersion liquid having good dispersibility is prepared. The graphene dispersion liquid has good electrical conductivity and can be used in fields of conductive materials, anti-static materials, electromagnetic shielding materials of electronic products, electrode materials of lithium ion batteries, and microwave absorption materials.

The invention provides ophthalmic ciclosporin emulsion. The ophthalmic emulsion is characterized by comprising the following components by weight percent: 0.02-0.1% of ciclosporin, 2.5-4% of polyoxyethylated castor oil, 1-3% of middle-chain fatty glyceride, 2-5% of glycerin, 0.2-0.5% of sodium alginate and the balance of water.

The invention discloses a preparation method of a taxol / DNA tetrahedral drug loading system and belongs to the field of biological drugs. The preparation method includes: mixing a taxol solution with a DNA tetrahedral solution, hatching, then centrifuging, and removing supernate to obtain the taxol / DNA tetrahedral drug loading system. The preparation method has the advantages that the water solubility of PTX is increased, the anaphylactic reaction of an existing PTX solvent which is the mixture of polyoxyethylated castor oil and anhydrous ethanol, lethal dose of 50% is lowered, the resource limitation problem is relieved effectively, the drug tolerance of the PTX can be reversed, and lethality to drug-tolerant tumors is increased.

The present invention provides an injectable pharmaceutical composition containing, as an active ingredient, paclitaxel, an anti-cancer agent. The injectable pharmaceutical composition comprises an effective amount of paclitaxel, which is dissolved in polyoxyethylated castor oil, alcohol, and an injectable aqueous solution. A sufficient amount of CO2 is added to stabilize paclitaxel in the injectable pharmaceutical composition to make the injectable pharmaceutical composition to a pH about 5.0.

The invention relates to the field of daily chemicals, in particular to a licorice-extract-containing emulsion and a preparation method thereof. The licorice-extract-containing emulsion comprises the following components in parts by weight: 0.01-10 parts of a licorice extract, 1-20 parts of phospholipid, 5-25 parts of oil, 0.5-20 parts of a nonionic surfactant and 60-90 parts of a dispersion medium, wherein the nonionic surfactant is selected from one or more of span-60, span-80, polyglycerol-10 oleate, polyglycerol monooleate, tween-80, polyoxyethylated castor oil and caprylocaproyl macrogolglycerides. Due to the presence of keratoderma, the active ingredient molecules difficultly pass through the skin obstacle to be absorbed by the organism; according to the licorice extract-containing emulsion, the licorice extract is wrapped in lipid nanoemulsion, so that the water solubility of the licorice extract can be effectively increased, the transdermal absorption capacity of the licorice extract is improved and the application of the licorice extract in the field of skin external use is strengthened.

A method is provided for preparing a pharmaceutical composition comprising: taking polyoxyethylated castor oil which if diluted 1:10 in water has a pH greater than 5 and aging the polyoxyethylated castor oil by exposing the polyoxyethylated castor oil to a gas comprising oxygen for a period of time, the exposure to the gas over the period of time causing an acidity of the polyoxyethylated castor oil to increase; and forming a pharmaceutical composition comprising the aged polyoxyethylated castor oil and a pharmaceutically active agent such as paclitaxel; wherein at least 80% of the potency of the pharmaceutically active agent is retained by the pharmaceutical composition after the pharmaceutical composition is stored for at least 7 days at 40° C.

The invention discloses special rice fertilizer with a soil saline and alkaline improvement effect, and belongs to the technical field of fertilizer. The special rice fertilizer is prepared from beerwaste water treatment station sludge, peanut oil residue, poultry and livestock excrement biogas slurry, conditioning agents, phosphogypsum, medical stone powder, trace elements, potassium chloride, potassium humate, polyoxyethylated castor oil and polycaprolactone according to a certain weight proportion. The fertilizer can obviously improve the saline and alkaline land soil property and can increase the rice yield. The treated biogas slurry is also used for further fermenting a mixture of the beer wastewater treatment station sludge and the peanut oil residue; a fermentation product containsa large number of beneficial active bacteria and various ingredients; the fertilizer ingredients are supplemented; meanwhile, the soil permeability and the moisture and fertility preserving capability are also improved; the absorption of rice on nutrient elements is promoted; the disease-resistant and stress-resistant capability of the rice is improved.

The invention discloses an anti-corrosion strippable polymer antirust film added with aluminum triphosphate. The anti-corrosion strippable polymer antirust film is prepared from the following raw materials: aluminium isopropoxide,a silane coupling agent KH560, tetraethoxysilane, polyoxyethylated castor oil, polyethylene glycol, trimethyl methyl silane, polyvinyl alcohol, borax, normal octane, nonylphenol ethoxylate, phosphoric acid, sodium metaaluminate, mica iron oxide, boric acid ester, disodium hydrogen phosphate, sodium silicate, tartaric acid, triethanolamine, lauryl sodium sulfate, a proper amount of n-butyl alcohol, a proper amount of coconut oil fatty acid diethanolamide, a proper amount of nitric acid, a proper amount of hydrochloric acid, a proper amount of absolute ethyl alcohol and a proper amount of deionized water. The prepared antirust agent can form a film on the surface of a workpiece, has the advantages of good slow-release and anti-rust properties, is economical in formula and lasting in function, and can meet the antirust requirements and the market requirements of alloy steel and aluminum alloy.

The invention belongs to the technical field of medicine, and particularly relates to a paclitaxel palmitate liposome and a preparation method thereof. Paclitaxel palmitate is obtained through esterification of palmitic acid and 2'-bit hydroxyl of the paclitaxel and belongs to a paclitaxel prodrug. The prodrug overcomes the defect of poor lipid solubility of the paclitaxel, and accordingly, the problem of poor druggability of paclitaxel nano-preparations is solved substantially. Aiming at the special physicochemical property of the paclitaxel palmitate, matching between formula composition and preparation technology is researched, the paclitaxel palmitate liposome, which does not contain polyoxyethylated castor oil and is safe, stable in quality and simple to prepare, is developed in a real sense, and the solid foundation is laid for further research and application of the paclitaxel in the anti-tumor field.

The invention discloses wearable flame-retardant light calcium carbonate packing, which is prepared from the following raw materials in parts by weight: 2-3 parts of talcum powder, 0.4-0.6 part of molybdenum disulfide, 1-2 parts of copper oxide, 2-3 parts of lanthanum oxide, 0.4-0.6 part of tall oil, 1-1.5 parts of calcium stearate, 3-5 parts of decabromodiphenyl ether, 0.4-0.6 part of polyoxyethylated castor oil, 2-3 parts of methacrylate, 0.1-0.2 part of potassium peroxodisulfate, 2-4 parts of dibutyltin dilaurate, 3-4 parts of polyisobutene, 2.2-2.5 parts of stearate, 1.2-1.4 parts of silicone oil containing hydrogen, 80-85 parts of light calcium carbonate, 13-16 parts of an assistant and 120-140 parts of water. The light calcium carbonate surface of the packing is coated by an organic matter layer, so that the packing is firmly combined, the interface bonding with the PVC is enhanced, the overall performance of the material is improved, the flame-retardant property of the PVC is increased by adding of the decabromodiphenyl ether, and the dispersity and the abrasive resistance are improved.

The invention discloses a graphene battery negative electrode composite material, which is obtained by sequentially coating the surface of graphene with carbon and silicon carbide, wherein the mass ratio of graphene to carbon to silicon carbide is 1: 0.08-0.1 : 0.15-0.25. The graphene battery negative electrode composite material has higher first coulombic efficiency, reduces the amount of a positive electrode material, and further reduces the cost of an entire battery. The surface of the graphene is sequentially coated with the carbon and the silicon carbide, the graphene battery negative electrode composite material has the characteristics of high capacity and high cycle stability. Polyoxyethylated castor oil is used as a dispersing agent in dispersion of the graphene in the preparation method, the graphene is uniformly dispersed by control of the dosage of the dispersing agent, and the electrical property is improved.

The invention provides a coal combustion improver. The coal combustion improver is prepared mainly by using the following components in parts by weight: 20 parts of nanometer calcium oxide, 4 to 12 parts of activated carbon, 2 to 10 parts of chromium trioxide, 8 to 16 parts of copper nitrate, 5 to 15 parts of potassium nitrate, 4 to 10 parts of cerium nitrate, 6 to 12 parts of ferrocene, 10 to 20 parts of kieselguhr, 2 to 10 parts of ammonium hydrogen carbonate, 8 to 16 parts of diammonium phosphate and 0.2 to 0.8 parts of polyoxyethylated castor oil. Compared with the prior art, the coal combustion improver provided by the invention not only can increase the gas yield and obviously improve the combustion improving effect, but also can greatly reduce the emission of SO2 and nitrogen oxide and reduce the environmental pollution.

The invention discloses a reversed-phase microemulsion for removing harmful chloride ions from a bronze ware. The reversed-phase microemulsion comprises oil phase, aqueous phase, a mixed surfactant and cosurfactant, wherein the oil phase is cyclohexane, the aqueous phase is a silver acetate aqueous solution, the mixed surfactant comprises the following components in percent by volume: 55-65% of polyoxyethylated castor oil, 35-45% of span-80, the cosurfactant is any one of ethyl alcohol, n-butyl alcohol, isobutanol and n-amyl alcohol, the volume ratio of the cosurfactant to the surfactant is 1: (0.3-2). The reversed-phase microemulsion for removing harmful chloride ions from a bronze ware is stable and white transparent in color, has good permeability, wettability, levelling property and rheological property, easily permeates into and act on bronze cultural relics with complex surface appearance and ornamentation, effectively removes harmful chloride ions from bronze wares, does not pollute the surfaces of the bronze cultural relics, and is strong in operability.

The invention relates to a cysteine / ferroferric oxide / copper sulfide / BSA (bovine serum albumin) nano-composite particle as well as preparation and application thereof. The nano-composite particle is degraded by utilizing ultrasonic waves with comparatively high power on a water / oil mixed solution interface to form microemulsion; Fe3O4 modified by cysteine is combined with BSA by a disulfide bond to form a shell; CuS is adsorbed on the BSA by electrostatic interaction; a comparatively large internal space is used for loading hydrophobic drug PTX (paclitaxel, dissolved in polyoxyethylated castor oil) insoluble in water. Compared with the prior art, the nano-composite particle has wide application prospect in the aspects of nuclear magnetic imaging, targeted drug delivery, photothermal therapy, therapy combined with chemotherapy and the like, an anti-cancer drug and a photothermal reagent can be transmitted to cancer positions, the toxic and side effects on normal tissues and cells are reduced, meanwhile, cancer cells are effectively killed, so that the treatment effect is further improved; a preparation method is simpler (a one-step microemulsion method is adopted) and has the advantage of large-scale production.

The invention discloses a high-grade high-speed copper wire drawing lubricant. The lubricant is prepared from following raw materials by weight: 12-15 parts of polyoxyethylated castor oil, 2-3 parts of triethanolamine borate, 1-2 parts of sodium citrate, 2-3 parts of tetradecyl trimethyl ammonium chloride, 1-2 parts of stannous mono-sulphate, 1-2 parts of sodium diisopropyl naphthalene sulfonate, 1-2 parts of carboxymethyl cellulose, 2-3 parts of an antiwear agent and 1000 parts of water. Nano aluminium nitride powder is added into the lubricant, thus promoting heat dissipation, enhancing film-forming property and increasing the processing speed. The lubricant has excellent lubricating property, thus improving the processing precision and the surface smoothness. The consumption of a wire drawing die is low. Threads or wires are protected effectively. Generation of surface quality defect and other phenomena is reduced. The service lifetime of the die can be prolonged. The lubricant has firm film formation, high-temperature resistance, no layering, no degeneration, small viscosity change and long shelf-life.

The invention relates to a cleaning agent for a printed circuit board and a preparation method. The cleaning agent for the printed circuit board is prepared from the following raw materials in parts by weight: 5 to 15 parts of an emulsifying agent, 1 to 5 parts of a solubilizing agent, 0.1 to 3 parts of an anti-foaming agent, 1 to 3 parts of a pH regulating agent, 3 to 8 parts of a surfactant, andthe balance of deionized water, wherein the emulsifying agent is selected from a TX and / or NP-series emulsifying agent; the solubilizing agent is one or a mixture of two of polyoxyethylene hardened castor oil, polyoxyethylated castor oil, fatty alcohol-polyoxyethylene ether, fatty alcohol polyoxyethylene-polyoxypropylene ether, polyoxyethylene dehydrated sorbitol aliphatic ester and polyglycerolfatty acid ester; the pH regulating agent is a mixture of ammonia water, sodium carbonate and sodium bicarbonate. The cleaning agent for the printed circuit board has the advantages that adhesive residue flushing cleanliness is improved, trace impurity residue after a dry film is developed can be effectively eliminated, normal production of a printed circuit board flow is ensured, and the yield ofthe printed circuit board production is increased.

The invention discloses a bidirectional control fertilizer specially used for rice and a preparation method thereof and belongs to the technical field of fertilizer. The bidirectional control fertilizer specially used for rice is prepared from urea, potassium chloride, diammonium phosphate, plant ash, silicon powder, trace elements, calcium superphosphate, humic acid, potassium sulfate, river mud,fish leftovers, a compound microorganism bacterium agent, oyster shell powder, a synergist, polyoxyethylated castor oil, polycaprolactone and lignin-paracresol according to a certain weight ratio. The fertilizer is scientific and reasonable in formula, rapid nutrient release and slow nutrient release are combined, fertilizer requirement laws of the rice in each growth period are really met, and fertilizer utilization rate is increased. Meanwhile, the fertilizer contains inorganic nutrients and also contains a large amount of beneficial microorganism nutrients, multiple beneficial bacteria aresynergistic, plant resistance and root nutrition absorption can be obviously improved, control effect on plant diseases and insect pests of the rice can be excellent, rice yield is effectively increased, and the bidirectional control fertilizer disclosed by the invention also has a function of improving soil.

The invention relates to the technical field of antitumor drugs, and discloses a composition containing paclitaxel and a preparation method thereof. The composition containing paclitaxel comprises 1 part by weight of paclitaxel and 1.2-15 parts by weight of egg yolk lecithin; the pH value range of the composition is 4.0-6.0. According to the composition containing paclitaxel of the invention, egg yolk lecithin is adopted as an emulsifier; the pH value of the composition is adjusted to be within a proper range; no polyoxyethylated castor oil with large toxicity is adopted; no ethanol is contained; the medication risk of the composition containing paclitaxel is reduced; and the patient compliance is improved.

The invention relates to a method for improving a bamboo pulp reaction performance. The method comprises the following steps of (1) pre-processing a pulp board; (2) pre-processing before processing an accessory ingredient; (3) processing the accessory ingredient, wherein the accessory ingredient is one or a mixture of polyglycol ether, polyoxyethylated castor oil, Turkey red oil, polyethylene glycol diamine, polyoxyethylene and sodium tripolyphosphate. The accessory ingredient processing provided by the invention has the advantages that the reaction performance adverse impact brought by cornification effect caused by further removing hemicellulose drying at the same time is avoided, the selectivity is good, and the degradation of cellulose is avoided; under the condition of keeping the pulp viscosity, the reaction performance can be improved by 5 to 20 percent.

The invention relates to nano-emulsion in-situ gel for treating haemorrhoids. The gel comprises the following components by weight: 30-100g of sophora flavescens, 30-120g of salviae miltiorrhizae, 30-100g of wild chrysanthemum, 1-8g of borneol, 1-8g of menthol, 30-160g of polyoxyethylated castor oil, 10-80g of absolute ethyl alcohol, 5-60g of isopropyl myristate, 60-160g of poloxamer 407, and 5-80g of poloxamer 188. The nano-emulsion in-situ gel can infiltrate into a mucous membrane to play the effects of clearing heat, removing toxicity, drying dampness, relieving itching, activating blood circulation to remove stasis, diminishing edema and relieving pain, and can be used for promoting local blood circulation, and improving nutrition of peripheral tissues to achieve the aims of diminishing edema and inflammation, and relieving pain.

The invention discloses a food-grade fluorescent nano-microemulsion and a preparation method thereof. The preparation method comprises the following steps: (1) mixing isoamyl acetate with ethanol, so as to obtain a mixed oil phase, adding polyoxyethylated castor oil, and stirring; and (2) dropwise adding water while stirring, so as to obtain uniform and transparent food-grade fluorescent nano-microemulsion. The oil-in-water food-grade fluorescent nano-microemulsion prepared by virtue of the preparation method has fluorescence characteristics, belongs to the field of food-grade nano-fluorescent materials, is toxic free and biodegradable and has good biocompatibility. The food-grade fluorescent nano-microemulsion does not need to be labeled when being used as a fluorescent nano-material, and no bracket is needed. The adopted raw materials are simple and easily available, isoamyl acetate is an aromatic additive for foods, the preparation cost of the product is low, and meanwhile, the food-grade fluorescent nano-microemulsion further has special fragrance. The high-temperature and high-pressure treatment is not required in the preparation method, and the preparation method is simple, feasible and high in process efficiency and meets the concepts of energy conservation and environment protection.

The invention relates to a dexamethasone nanogel and a preparation method thereof. 1000 g of dexamethasone nanogel is prepared from 0.9-1.5 g of crude dexamethasone drug, 20-25 ml of castor oil, 20 g of polyoxyethylated castor oil-propylene glycol mixed surfactant, 10-12 g of Carbomer, 50-55 g of glycerin, 14-16 g of triethanolamine, 40-50 g of ethyl alcohol, 1-1.5 g of nipagin and the balance water. A gel matrix is used as a microcarrier, its solubility can be improved, and the transdermal efficiency of the gel matrix can be improved by utilizing the transdermal characteristic of nano-emulsion; the gel has the characteristic of slow release and accordingly has a long-acting effect; the first-pass effect of the liver can be avoided, and meanwhile the direct harm of oral medication to the gastrointestinal tract is also decreased.

A method for preparing ethanol-diesel oil mixed fuel. At least one emulsifier is obtained, wherein the emulsifier is one or more than one of lauryl amine polyoxyethylene ether, polyoxyethylene fatty acid ester, polyoxyethylene fatty amine ether, polyoxyethylated castor oil, or fatty alcohol-polyoxyethylene ether. Ethanol is added into a mixture of the emulsifier and diesel oil, and an emulsification temperature of 50-80 DEG C is maintained. The percents of the components are 15-25% of the emulsifier, 60-80% of the diesel oil, and 10-20% of the ethanol. The beneficial effects of the invention are that: good emulsification and fusion of ethanol and diesel oil is realized by using the emulsifier, and the obtained ethanol-diesel oil fuel is uniform in quality and easy to combust, and has a large fuel value.

The invention discloses a bad-flavor-free multifunctional electric power equipment casing rust-resisting paint characterized by comprising the following components by weight: 2-3 parts of polycaprolactone, 1-2 parts of sodium benzoate, 2-4 parts of iron carbonate, 0.2-0.3 part of vanillin, 6-9 parts of silicone acrylic emulsion, 4-6 parts of precipitated barium sulfate, 4-6 parts of mica iron oxide, 0.4-0.6 part of polyoxyethylated castor oil, 1-2 parts of zinc stearate, 1-2 parts of dibutyl phthalate, 32-37 parts of epoxy resin, 3-5 parts of aluminium silicate, 1-2 parts of crosslinking agent TAIC (triallyl isocyanurate), 22-26 parts of diphenyl oxide resin, 0.5-1.0 part of dodecencylsuccinic acid, 10-14 parts of xylene, 5-7 parts of butyl acetate and 4-7 parts of an additive; the bad-flavor-free multifunctional electric power equipment casing rust-resisting paint has high adhesion and good film forming effect, the paint film is flexible and hard, the added vanillin and silicone acrylic emulsion can improve paint bad flavor to make the flavor pleasant and easy to accept, the bad-flavor-free multifunctional electric power equipment casing rust-resisting paint has good water, rust and corrosion resistance and high aging resistance, the added additive also has the noise reduction effect to improve impact of noise produced by the work of electric power equipment on the people's physical and mental health.

The invention discloses a novel detergent for printing ink. The detergent is characterized by being prepared from the following raw materials in parts by weight: 3-4 parts of white oil, 10-12 parts of ethanol, 4-5 parts of acetone, 10-12 parts of isopropanol, 3-4 parts of borax, 3-4 parts of mirabilite, 2-3 parts of sodium carbonate, 1-2 parts of sodium tripolyphosphate, 12-15 parts of polyoxyethylated castor oil, 1-2 parts of sodium laurylsulfate, 2-3 parts of triethanolamine borate, 1-2 parts of sodium dodecyl benzene sulfonate, 4-5 parts of an assistant and 100-110 parts of water. The assistant is added to improve the technical performance of the detergent and reduce the toxic and side effects and the environmental pollution. The detergent disclosed by the invention has excellent dissolving and diluting capacity to printing ink, and is free from toxicity and pollution, nonflammable and incombustible, less in damage to the rubber covered roller of a printer, convenient and safe to use, and applicable to popularization in a wide range.

The invention discloses a cefixime dry suspension and a preparation method thereof. The preparation comprises the following components in parts by weight: 1 part of cefixime, 0.8-4 parts of polyoxyethylated castor oil, 3-6 parts of medium-chain fatty acid glyceride, 2-6 parts of a suspending agent and 8-15 parts of a filler; the preparation method comprises the flowing steps of: dissolving cefixime in the medium-chain fatty acid glyceride with the polyoxyethylated castor oil, and subsequently absorbing by using a mixture of the suspending agent and the filler. The preparation is good in stability, rapid to dissolve, simple in process and applicable to industrial large-scale production.

The invention discloses a cnidium lactone foaming microemulsion with optimal mixed materials and a preparation method thereof, belonging to the technical fields of drugs and drug manufacturing. The cnidium lactone foaming microemulsion contains cnidium lactone and auxiliary materials, wherein the auxiliary materials include ethyl oleate, a mixed surfactant and deionized water; the mixed surfactantcontains polyoxyethylated castor oil 40 and diethylene glycol monoethyl ether; and the ratio of ethyl oleate to polyoxyethylene 40 hydrogenated castor oil to diethylene glycol monoethyl ether to deionized water is 8.13 to 14.81 to 6.58 to 71.44. The cnidium lactone foaming microemulsion has the beneficial effects that the solubility of cnidium lactone in an emulsifying prescription of the cnidiumlactone foaming microemulsion is increased by at least 201 times, so that a solubilizing purpose is achieved, and a certain guiding significance is provided for the later-period one-step preparationformation of the cnidium lactone foaming microemulsion.

The present invention relates to a novel intravenous formulation for a taxane chemotherapeutic agent. The agent is formulated with ethanol, polyoxyethylated castor oil and a mixture of antioxidants to prevent oxidation of the drug substance caused by the polyoxyethylated castor oil.