105results about How to "High partition coefficient" patented technology

Adhesive preparations with improved percutaneous absorption of physiologically active substances, in particular, matrix adhesive preparations containing a base drug salt and an organic acid salt having an mean diameter of from 0.1 to 100 μm are provided.

The invention discloses an amphiphilic polypeptide DGRGGGAAAA and a preparation method thereof, and a novel anticancer drug delivery system and a preparation method thereof; the preparation method of the amphiphilic polypeptide DGRGGGAAAA comprises: 1) using DMF (dimethyl formamide) as a solvent, DCM (dichloromethane) as an expanding agent and DIC (diisopropyl carbodiimide) as a catalyst to synthesize DGRGGGAAAA by a solid-phase synthetic process; 2) mixing the DGRGGGAAAA and doxorubicin (DOX), dissolving the mixture in water, subjecting the system to multiple dialysis, centrifuging the dialyzed system, and removing supernate to obtain the novel anticancer drug delivery system. The novel anticancer drug delivery system has significantly improved efficiency, and has the advantages of high targeting action, small side effect, low toxicity and the like.

The invention provides a method for extracting gibberellin from ferment filtrate by a salting-out method, comprising the following steps of adding adequate sodium chloride or sodium sulfate in gibberellin-contained ferment filtrate, separating the gibberellin out of the filtrate, and obtaining the crude extract containing the gibberellin by solid-liquid separation; wherein the yield of the crude extract is more than 98%.

The invention relates to an aquaculture compound iodine solution. The solution comprises the following components in percentage by weight: 1.8-3% of iodine, 0.3-1% of iodide, 15-30% of a nonionic surfactant, 3.5-4.5% of hydrochloric acid with the concentration of 75% by weight, 16-26% of phosphoric acid with the concentration of 85% by weight and the balance of water. The invention further relates to a preparation method of the aquaculture compound iodine solution. The aquaculture compound iodine solution is ingenious in design, has high distribution coefficient and high stability and is suitable for large-scale popularization and application.

The invention provides a method for leaching and separating benzene-cyclohexane or normal heptane saliferously. Inorganic slat extraction agent is dissolved in main organic leaching agent to form saliferous organic solvent with certain concentration so as to obtain composite extraction agent. The invention is characterize in that the composite extraction agent is added according to the volume ratio of 0.5 to 2:1 of the composite extraction agent and the benzene-cyclohexane or normal heptane to form a benzene-cyclohexane or normal heptane compound system; the benzene-cyclohexane or normal heptane compound system is saliferously leached through multiple cross-flows and counter-flows so as to obtain cyclohexane with the mol concentration being larger than 96 percent, or the normal heptane with the mol concentration being larger than 73 percent; and the leaching liquid which is rich in benzene is rectified so as to obtain the benzene with the mol concentration being larger than 98 percentand the organic main extraction agent with the concentration being larger than 96 percent. The invention has the advantages that a method of adding the saliferous assistant component into the organicsolvent is adopted, so that the obtained composite leaching agent has repulsive interaction on the cyclohexane or normal heptane among the raw material components, thereby decreasing the mutual solubility and mixing the liquid layers.