398 results about "Methyl Ketone" patented technology

Disclosed is a photo-curable conductive adhesive and method for preparation, which is prepared from light-sensitive high molecular polymer, reactive dilution monomer, conducting particles, light-summing heat initiating agent and anti-oxidant through mixing and grinding, wherein the light-sensitive high molecular polymer is epoxy acrylic resin or / and polyurethane-acrylate, the reactive dilution monomer is the single, double and multiple functional monomers of acrylic acid, the conducting particle is silver powder, copper powder or silver-plated copper powder, the light initiating agent is alpha-amine alkyl methyl ketone, benzoin (or substituted benzoin) ether or acyl phosphines, the heat initiating agent is azocompound or peralcohol, the antioxidant is hydroquinone, p-hydroxybenzene methyl ether, 2,6-ditertiary-butyl-4-methylphenol.

The invention discloses a method for preparing 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. The method comprises the following steps of: firstly, carrying out reaction on cyclopropyl methyl ketone and p-chlorobenzyl for 2-4 hours at the temperature ranging from 90 DEG C to 110 DEG C, and obtaining a compound I after post treatment, wherein the cyclopropyl methyl ketone and the p-chlorobenzyl are used as reactants, sodium hydride is used as a catalyst and toluol is used as solvent; secondly, leading the compound I to react with magnesium in a isopropanol dissolvent at the temperature ranging from 45 DEG C to 60 DEG C, and obtaining a compound II after post treatment; and thirdly, adding the compound II to DMF (Dimethyl Formamide), then adding sodium hydroxide, importing oxygen for 8 hours to15 hours under stirring for reaction, controlling the temperature to range from 10 DEG C to 25 DEG C, and finally obtaining the 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone after post treatment. The preparation method has the advantages of simple steps, cheap and easily obtained raw materials, no deadly poison, low cost; less three-waste (waste gas, waste water and industrial residue) pollution, suitability for industrial production and higher yield and content of end products.

A method for the preparation of aryl methyl ketones converts a variety of ethyl arenas to the corresponding aryl methyl ketones using a dioxygen-containing gas as the oxidant. The catalyst used for the reaction is a metal complex bearing general formulas as disclosed.

A method for manufacturing a piezoresistive material, a piezoresistive composition and a pressure sensor device are provided. The piezoresistive composition includes a conductive carbon material, a solvent, a dispersive agent, an unsaturated polyester and a crosslinking agent. The conductive carbon material is selected from a group consisting of multi-wall nanotube, single-wall carbon nanotube, carbon nanocapsule, graphene, graphite nanoflake, carbon black, and a combination thereof. The solvent is selected from a group consisting of ethyl acetate, butyl acetate, hexane, propylene glycol mono-methyl ether acetate and a combination thereof. The dispersive agent includes block polymer solution with functional groups providing the affinity. The unsaturated polyester is selected from a group consisting of an ortho-phthalic type unsaturated polyester, an iso-phthalic type unsaturated polyester, and a combination thereof. The crosslinking agent is selected from a group consisting of ethyl methyl ketone peroxide, cyclohexanone diperoxide, dibenzoyl peroxide, tert-butyl peroxybenzoate and a combination thereof.

The invention is a combination for preparing modified glass fibre reinforced plastic pull-extrude (GFRP) sectionbar including unsaturated polyester resin 92.6-64 (wt.%), nano silicon dioxide 0.5-4, calcium carbonate 5-20, benzoyl peroxide 0.2-2, methyl ketone peroxide 0.2-2, demoulding agent 0.5-2 and mill base 1-6. Batching in the above weight percents, selecting a ultrasonic wave dispersive apparatus to fully disperse the nano silicon dioxide in 2Kg resin; dispersing and blending, where the glue soluting temperature is controlled at 30 plus or minus 2 deg.C and the fully blending and dispersing time is 1 hour; adding in other additives in proportion in turn, fully blending until the mixture is uniform and meets the preset viscosity number; prepring structural sections: pouring the well-prepared glue soluting in a presoaking glue tank and keep constant temperature at 25 plus or minus 2 deg.C; placing the glass yarn felts ccording to a sectionbar perform guiding device to enter in the glue tank for fully soaking with the glue; making the yarn felts soaked with resin glue soluting enter in a well-heated mould for solidification moulding, and pulling into products by a hydraulic drag device, and at last cutting for fixed size.

The invention discloses a method for preparing an ethyl methyl ketone by dehydrating a 2,3-butanediol, belonging to the technical field of chemical product preparation. The method is to prepare the ethyl methyl ketone by dehydrating the 2,3-butanediol under the action of molecular sieve solid acid catalyst. The method comprises the following steps: taking the 2,3-butanediol of 10-90 wt% as a raw material, pre-heating and vaporizing the raw material at a reaction temperature of 200-300 DEG C, the raw material gas after being aerified reacting through a catalyst layer with the 2,3-butanediol mass airspeed of 1.5-3.4h, and separating reactor outlet materiels by liquid-vapor separation to obtain the ethyl methyl ketone. The conversion rate of the 2,3-butanediol is 94.2-100%, and the selectivity of the ethyl methyl ketone can reach 70.1-94.2%. The catalyst adopted in the invention has high activity and high airspeed, thereby having high conversion rate of 2,3-butanediol with different concentration; the ethyl methyl ketone has high selectivity and productivity and is environmentally friendly, the process is simple and the catalyst has good stability.

The invention relates to a method for spearing butane from butylene with the multicomponent compound of ionic liquid, saline, ethyl methyl ketone and N-formylmorpholine. The content of ionic liquid in the multicomponent compound is 1.0 to 95 percent; the content of the saline in the multicomponent compound is 0.5 to 20 percent; the electropositive ion of the ionic liquid is iminazole electropositive ion, alkyl imidazole electropositive ion or alkyl quaternary ammonium ion, or the compound thereof; the electronegative ion is tetrafluoroborate electronegative ion, hexafluorophosphoric acid electronegative ion, nitrate ion, tetrachloro aluminic acid iron, heptachlor bi aluminic acid iron, chloride ion, bromine electronegative ion or the mixture; and the ionic liquid can be dimethylformamide potassium thiocyanate compound salt, dimethylformamide sodium sulfocyanate compound salt, or the compound; the saline is potassium thiocyanate, sodium sulfocyanate, ammonium thiocyanate, sodium nitrate, potassium nitrate, sodium iodide, potassium iodide, zinc chloride, copper chloride, zinc chloride, potassium bromide, or the compound thereof.

The invention relates to the technology in the field of food and beverage processing, in particular to preparation of an egg and milk essence substrate by using a dual enzymatic method in cooperation with the mailard reaction; and the prepared egg and milk essence substrate can be widely applied to various food industries. The method comprises the following steps of: hydrolyzing natural cream by using lipase and subjecting dried egg yolk to enzymolysis by using protease; mixing a hydrolysis product and an enzymolysis product based on a certain ratio, homogenizing by a homogenizer, and obtain a homogenous emulsification system by using the monoglyceride and lecithin in a mixture per se as emulsifiers; then adding reducing sugar-xylose and amino acid-methionine for producing the egg characteristic flavor, mixing to reach a uniform state, directly heating to 105-110 DEG C, reacting for 1-3 hours; and performing the mailard reaction and enzyme deactivation at the same time. A final product has the flavor mixture of free fatty acid, lactone, methyl ketone, alcohol, aldehyde, black-like essence with antioxidant activity and the like, wherein the free fatty acid is obtained through hydrolyzing the fat, the lactone, methyl ketone, alcohol and aldehyde are obtained through heating the fat, and the black-like essence is generated by the mailard reaction; and thus, the product has an intense egg and milk flavor.

The invention discloses a paint coating which contains paint powder, polyvinyl butyral, zeolite powder, a hydrosolvent, a mixture of butanol and ethyl methyl ketone, water-soluble resin, no-floating aluminium-powder slurry, acrylonitrile, methyl methacrylate, a mixture of rosin resin and linseed oil and phosphoric acid. The paint coating is prepared by the following steps: adding paint powder, polyvinyl butyral, zeolite powder, a hydrosolvent, a mixture of butanol and ethyl methyl ketone, water-soluble resin, no-floating aluminium-powder slurry, acrylonitrile and methyl methacrylate into processing equipment, and stirring to make the mixture uniform so as to form dilute paint; and adding the mixture of rosin resin and linseed oil, uniformly stirring and adding phosphoric acid. According to the invention, cost of raw materials is low; and with the addition of phosphoric acid and polyvinyl butyral, the paint dries fast, has good viscosity, will not fall off for a long time when brushed on an object, is safe and environmentally-friendly and has a water-resistant function. In addition, the manufacturing method is simple and meets people's requirements on using effect.

The invention relates to a method for preparing cyclopropyl methyl ketone, and belongs to the field of organic synthesis. The preparing method includes the following steps that metal halide and an inert solvent are added into a fixed bed reactor, the fixed bed reactor is heated to 185-195 DEG C, and then alpha-acetyl-gamma-butyrolactone is continuously added into the fixed bed reactor, and is subjected to a cleavage reaction; after the reaction is saturated, the alpha-acetyl-gamma-butyrolactone stops to be added, reaction distillation continues to be carried out till no product is distilled out, and a cyclopropyl-methyl-ketone crude product is obtained; the fixed bed reactor is connected with a rectifying tower, the prepared cyclopropyl-methyl-ketone crude product is transferred into the rectifying tower to be subjected to high tower dividing and then subjected to normal pressure rectification, the reflux ratio is adjusted, impurities are separated, and the high-purity cyclopropyl methyl ketone is obtained through distilling. The method is low in production cost, high in production efficiency, product yield and purity, small in by-product number, wastewater amount, waste material number and environment pollution and more suitable for industrial production.

The invention discloses a method for preparing long-chain alkane from biomass derivatives 5-HMF (hydroxymethyl furfural) or furaldehyde. According to the method, the biomass derivatives 5-HMF or furaldehyde are used as raw materials; a condensation product is formed after base catalysis and methyl ketone compound condensation; then, ketonic or alcoholic intermediates of tetrahydrofuran rings are obtained through hydrogenation catalysis; finally, the long-chain alkane is prepared through hydrogenation and ring opening dual catalysis preparation. The method has the advantages that the raw materials can be prepared from biological saccharides through hydrolysis and dehydration; the yield of the alkane is high; the consumption of catalysts is low; the reaction condition is mild; the process is clean and simple; in the reaction process of preparing the alkane from the condensation products, other operations and control are not needed except the program temperature rise; a new path for preparing the long-chain alkane from the biomass derivatives 5-HMF or furaldehyde by a one-pot method is opened up.

The invention relates to a preparing method of chemical leather for linings of a pair of superfine fiber water absorption breathable shoes; the method is realized by the following steps: 1. superfine fiber is adopted to make chemical leather; 2. the prepared treatment fluid is poured into a square groove provided with a sink roll; wherein, the mixture ratio (Kg) of the treatment fluid is 100Kg of demineralized water and 2-15Kg of aqueous solution of water modified silicon polymer; 3. liquid carrying rate is controlled to be 50-120% of the weight of base cloth; and the drying temperature is 60-150 DEG C; 4. dry process surface manufacturing treatment is carried out; wet end furnish (Kg) is 100 Kg of solvent type urethane resin, 2-10 Kg of hollow wood fiber, 2-20 Kg of colored powder and 5-40 Kg of ethyl methyl ketone; 5. release paper B-100 is adopted; 6. a first impasto palette knife distance is 120-300mum, and the drying temperature is 60-150 DEG C; 7. a second impasto palette knife distance is 80-250mum, and the drying temperature is 60-150 DEG C; 8. the gluing way is wet combining, the gluing pressure is 3-6 Kg, and the vehicle speed is 2-10m / min; a sample is obtained by directly and quickly stripping after drying; the obtained products have good simulation property, hand feeling and breathability.

A process for preparing saturated alcohols comprising effecting an aldol condensation of alkyl methyl ketones of 6 to 8 carbon atoms which are branched at the beta-carbon atom with aldehydes of 4 to 15 carbon atoms which are branched at the alpha-carbon atom to form alpha,beta-unsaturated ketones and subsequent hydrogenation of the alpha,beta-unsaturated ketones to obtain alcohols, wherein the aldol condensation is carried out at a temperature of 60 to 130° C. in the presence of a 30-55% strength aqueous solution of an alkali metal hydroxide resulting in very low by-product formation.

The invention relates to a synthetic method of ulipristal acetate. According to the method, 3, 3-(ethylenedioxy group) steroidal estrogen-5(10), 9(11)-diene17-ketone is used as a raw material and reacted with tosylmethyl isocyanide under the condition of alkalinity to obtain 3, 3-(ethylenedioxy group) steroidal estrogen-5(10), 9(11)-diene17-cyanogen; the 3, 3-(ethylenedioxy group) steroidal estrogen-5(10), 9(11)-diene17-cyanogen and a methyl grignard reagent are reacted to obtain methyl ketone; the methyl ketone and trialkyl ester phosphate are reacted in the oxidation environment under alkalinity conditions to obtain 3, 3-ethylenedioxy group-17 alpha-hydroxyl-19-norpregna-5(10), 9(11)-diene-20-ketone; the 3, 3-ethylenedioxy group-17 alpha-hydroxyl-19-norpregna-5(10), 9(11)-diene-20-ketone uses ethylene glycol to protect 20-carbonyl under the acid catalysis to obtain a key intermediate; and the intermediate is synthesized into a target product through four steps of reaction by means of known methods. The synthetic method is concise in paths, easy to operate, convenient to post-process, low in cost, high in total yield and easy to amplify, and raw materials are easily obtained.

The invention discloses a method for effectively preparing cylopropyl ethylnen as shown in the formula (I). The method comprises the steps that firstly, cylopropyl methyl ketone shown in the formula (II) is taken as a raw material and fully reacts in an organic solvent under the effect of phosphorus pentachloride and a catalyst, a reaction solution is subjected to reduced pressure distillation to obtain 1,1-dichloro-1-cylopropyl ethane as shown in the formula (III), an elimination reaction is then carried out under the effect of alkali, and a reaction solution is subjected to rectification and purification to obtain the product cylopropyl ethylnen. The method for effectively preparing the cylopropyl ethylnen has the advantages of being mild in reaction condition, high in yield, low in cost, little in three-waste and the like, and is suitable for industrial production.

The invention discloses an industrial organic exhaust gas combustion catalyst and a preparation method thereof. Active components of the catalyst are loaded on a carrier through a dipping and roasting process, the active components comprise transition metal oxides comprising CuO, MnO, Fe2O3 and CeO2 and AgO composite oxide, and the carrier is selected from alumina coated cellular ceramic or cellular active alumina. The catalyst is suitable for industrial organic exhaust gas combustion, VOCs in the exhaust gas is one of or a mixture containing more of ethyl acetate, ethyl methyl ketone, butyl acetate isopropanol and propylene glycol methyl ether, and the catalyst is especially suitable for the catalytic combustion of industrial organic exhaust gas in the coating production of the packaging and printing industries.

The invention relates to a method for producing monascus pigment with low content of citrinin by using rice as raw material, and the process thereof consists of the following steps: (1) rice milk is prepared; (2) the rice milk is added with 0.1 percent to 0.2 percent of ammonium nitrate, 0.15 percent to 0.25 percent of potassium dihydrogenphosphate, 0.1 percent to 0.2 percent of manganese sulfate, 1 percent to 2 percent of maize pulp and 1.5 percent to 2.5 percent of soybean powder, and the obtained mixture is heated to 121 DEG C to be kept for 20 minutes, and then cooled to 35 DEG C to 40 DEG C to obtain a fermentation culture solution; (3) monascus strains are transferred to a seed culture medium to be cultivated for 50 hours under the temperature of 31 DEG C to 33 DEG C, after being cultivated on a solid slant plane, and then an enlarged monascus culture solution is obtained; (4) 8 percent to 10 percent of the enlarged monascus culture solution is fed into the fermentation culture solution, and the obtained mixture is kept under the temperature of 31 DEG C to 37 DEG C, stirred and cultivated for 20 hours, hereafter, octanoic acid with the weight equal to 0.1 percent to 0.2 percent of the weight of rice and methyl ketone with the weight equal to 0.1 percent to 0.2 percent of the weight of rice are added, then the temperature is kept, and the mixture is stirred and cultivated for 85 hours to 95 hours, while the pressure of a fermentor is kept to be 0.04MPa to 0.06MPa so as to obtain a fermentation liquor; (5) the fermentation liquor is filtered, and the obtained filtrate is treated with spray drying or freeze drying after membrane concentration. The monascus pigment obtained by the method consists of less than 0.05 mg / kg of the monascus when color value is higher than 200.

The invention discloses a method for preparing an amide compound, which comprises the steps of configuration of reaction system. Methyl ketone, amine, catalyst, an oxidizing agent and solvent are use, wherein the general formula of the methyl ketone is RCOCH3, and R is selected from one kind of C6-C14 aryl group, C2-C8 alkenyl group, and five-or six-membered heterocyclic group; the amine is primary amine; the catalyst is selected from one kind of potassium iodide, iodine, tetramethyl ammonium iodide, tetrabutyl ammonium iodide, tetrahexyl ammonium iodide, bismuth iodide, lithium iodide, phenyl trimethyl ammonium iodide, benzyl trimethyl ammonium iodide or sodium iodide; the oxidizing agent is tert-butyl hydroperoxide; the solvent is selected from one kind of water, dichloromethane, ethyl acetate, toluene, 1,2-dichloroethane, 1,1,1-trichloroethane, acetonitrile, and isopropanol. The methyl ketone, the catalyst and the amine are added into the reaction system under the temperature of 0 DEG C and stirred for 5 minutes, and then the oxidizing agent is added to react for 2-48 hours to obtain the amide compound. The method provided by the invention is green, moderate, high in selectivity and wide in application range.

The invention discloses a method for separating an azeotropic mixture of ethyl methyl ketone and water through variable-pressure rectification, which belongs to the fields of chemical rectification and purification. A first rectifying tower is adopted, a near-azeotropic mixture of the ethyl methyl ketone and the water is obtained at the tower top under corresponding pressure, and wastewater containing a trace amount of ethyl methyl ketone is obtained at the tower bottom, wherein the first rectifying tower is a normal pressure tower; the near-azeotropic mixture of the ethyl methyl ketone and the water obtained at the tower top of the normal pressure tower enters a second rectifying tower, wherein the second rectifying tower is a pressurized tower, the azeotropic mixture of the ethyl methyl ketone and the water is obtained at the tower top under high pressure, the azeotropic mixture returns to the normal pressure tower for feeding, and an ethyl methyl ketone product with high purity is obtained at the tower bottom, wherein the operation pressure of the pressurized tower is 0.5MPa, the number of theoretical plates is 38, the number of rectification sections is 15, and the number of stripping sections is 23; the operation pressure of the normal pressure tower is 0.102MPa, the number of the theoretical plates is 32, the number of the rectification sections is 11, and the number of the stripping sections is 21. The invention reduces the energy consumption in the separating process, improves the purity of the product, improves the yield of the ethyl methyl ketone product and has simple process and reasonable device.

The invention discloses a preparation method of intermediate cyclopropyl acetylene of anti-AIDS (acquired immune deficiency syndrome) drug efavirenz. The preparation method comprises the steps of performing a reaction in an organic solvent by taking cyclopropyl methyl ketone as a raw material and phosphorus pentachloride as a chlorinating agent by the action of a catalyst to generate alpha, alpha-dichloroethyl cyclopropane and phosphorus oxychloride, performing decompressed rectification to remove phosphorus oxychloride, removing part of hydrogen chloride from alpha, alpha-dichloroethyl cyclopropane by the action of triethylamine to generate alpha-chlorovinyl cyclopropane, and further removing part of hydrogen chloride by the action of strong base to generate cyclopropyl acetylene. Phosphorus oxychloride is removed by the decompressed rectification; the generation of much phosphorus wastewater due to hydrolysis of phosphorus oxychloride in ice water is avoided; recovered phosphorus oxychloride can be comprehensively utilized by simple rectification; waste gas, wastewater and industrial residue are reduced; the cost is lowered; cyclopropyl acetylene is prepared from alpha-chlorovinyl cyclopropane via a reaction rectification technology; and the method has the advantages of high conversion rate, good selectivity, low energy consumption and the like, and is suitable for industrialproduction.

The invention discloses a preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. The preparation method comprises the steps that: (1) cyclopropyl methyl ketone, dimethyl sulfate, dimethyl sulfide and sodium hydroxide take epoxidation reaction to obtain 2-cyclopropyl-2-methyl propylene oxide; (2) the 2-cyclopropyl-2-methyl propylene oxide is catalyzed and re-ranged by anhydrous zinc chloride at the room temperature to obtain 2-cyclopropyl propionaldehyde; (3) the 2-cyclopropyl propionaldehyde is oxidized by 40 percent oxydol at the room temperature to obtain 2-cyclopropyl monoprop; (4) the 2-cyclopropyl monoprop and thionyl chloride take reaction to obtain 2-cyclopropyl propionyl chloride; (5) the 2-cyclopropyl propionyl chloride takes reaction with chlorobenzene and anhydrous aluminum trichloride to obtain the 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone with the content being 98.0 percent to 98.7 percent, and the total yield is 80.0 percent to 83.1 percent. The preparation method has the advantages that the steps are simple, raw materials are cheap and are easy to obtain, easy-self-ignition compounds are not used, organic solvents are not used in the steps (2) and (3), three wastes are few, and the preparation method is suitable for industrialization.

A fragrant compound or fragrant composition stable for a long period of time in an acidic hard article surface cleaning liquid adjusted so as to be acidic, particularly to pH 2.0 to 3.0 with an organic acid. One or more of fragrant compounds selected from the group consisting of 2,6-dimethyl-2-heptanol, 3,3-dimethylcyclohexyl methyl ketone, o-tert-butylcyclohexanol, α-amylcinnamic aldehyde, α-damascone, γ-octalactone, γ-nonalactone, γ-decalactone, anethole, ethyl benzoate, ethyl 2,2,6-trimethylcyclohexanecarboxylate, 2,2,6-trimethyl-1-crotonylcyclohexane, 6-acetyl-1,1,2,4,4,7-hexamethyltetrahydronaphthalene, isoamyl phenylethyl ether, methyl octin carbonate, 6,7-dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone, tricyclodecenyl acetate, undecyl aldehyde, fenchyl acetate, dihydrojasmone, cedryl methyl ether, p-cresol, hexyl aldehyde, and rosephenone are stable.

The present invention relates to a synthesis method for alpha-ketoamide compounds, wherein a plurality of alpha-ketoamide compounds can be prepared through the synthesis method. According to the present invention, cheap and easily available methyl ketone and amine are adopted as raw materials, various metal salts are adopted as catalysts, no medium solvent is required (a reaction further can be performed in an organic medium solvent), and the alpha-ketoamide compound is subjected to one step synthesis under an oxygen source condition of an atmospheric pressure; other additives such as an alkali, a ligand and the like are not used; the prepared alpha-ketoamide compound has a structure general formula represented by a formula I, wherein R1 is hydrogen atom, aryl, heteroaryl, aralkyl, alkyl, cycloalkyl and other substituted groups, and R2 and R3 are independently hydrogen atom, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl and other substituted groups; and the method is an alpha-ketoamide compound synthesis method with characteristics of simpleness, efficiency, environment protection, mild conditions, high yield and no organic solvent.

The invention discloses a preparation method of alpha-keto amide, which comprises the following steps: (a), preparing a reaction system comprising methyl ketone, amine compounds, a catalysts, an oxidant and a solvent, wherein the general formula of methyl ketone is RCOCH3, and R is selected from one of C6-C14 of aryl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 alkoxy or alkyl sulphanyl, C2-C8 phenolic group as a protection group, unsubstituted five-member or six-member heterocyclic group and substituted five-member or six-member heterocyclic group, and the amine compounds are selected from primary amine or secondary amine; and (b), mixing the reaction system to react for 2-48 hours at a room temperature to obtain alpha-keto amide. The invention discloses a new preparation method of alpha-keto amide. The reaction condition is moderate, and the reaction can undergo under the air condition without a complicated operation procedure; in addition, the preparation method is environment-friendly and meets the requirement and the direction of the contemporary green chemistry development.

The invention discloses a trifloxystrobin preparing method, including the steps as follows: (a) using ortho-methyl hypnone as raw material and using potassium permanganate to oxidize so as to obtain 2-(2'-methyl-phenyl)-2-carbonyl acetic acid; (b) making the product in step (a) react with methanol to obtain 2-(2'-methyl-phenyl)-2-carbonyl methyl acetate; (c) bromizing the product in step (b) to obtain 2-(2'-bromomethyl-phenyl)-2-carbonyl methyl acetate; (d) making the product in step (c) react with methoxy amine to obtain (E)-2-(2'-bromomethyl-phenyl)-2-carbonyl methyl acetate-O-methyl ketone oxime; (e) making the product in step (d) react with meta-trifluoromethyl hypnone oxime to obtain the product trifloxystrobin. It reduces the discharge of large amount of waste water in course of oxidization reaction, avoids esterification by adopting methyl- chloroformate, most operating conditions are moderate.

The invention discloses a synthetic method of intermediate cyclopropyl acetylene of an anti-aids drug efavirenz, and relates to the technical field of synthesis of cyclopropyl acetylene. The synthetic method comprises the following steps: reacting in an organic solvent to produce alpha, alpha-ethyl dichloride cyclopropane by taking cyclopropyl methyl ketone as a raw material and taking phosphorus pentachloride as a chlorinating agent; and obtaining the cyclopropyl acetylene by adding the alpha, alpha-ethyl dichloride cyclopropane into strong base aqueous liquor through a phase transfer catalyst. The synthetic method has the beneficial effects that the organic solvent and inorganic strong base are not needed to be adopted, expensive reagents such as the organic solvent and potassium tert-butoxide are avoided; moreover, process raw materials are easily available, process is simple, operation is convenient, cost is lowered and the three wastes are reduced, and therefore, the synthetic method is suitable for industrial production.

The invention discloses a making method of cyclopropyl methyl ketone, which comprises the following steps: adding normal aceto propyl alcohol in the alcaine solution; chlorinating; evaporating 5-chloride-2-pentanone; adopting separating coupling technique to do ringed-reaction for 5-chloride-2-pentanone; generating cyclopropyl methyl ketone.

This invention provides new catalyst with high activity to synthesize methyl isopropenyl ketone and ethanone from MEK and carbinol, its preparation method and application in ketone preparation reaction. The catalyst comprises Zr, Mn, Zn and mixed oxide of alkali metal carried a little Pd. By this product, the reaction can run at very low temperature, does not coke easily, needs less raw material and the cost is lower.

The invention discloses a synthetic method for 3-cyano group imidazo [1, 2-a] pyridine compounds and an application thereof. Materials such as 2-aminopyridine compounds, methyl ketone compounds and benzyl cyanide are used to be reacted with N-heteroaryl nitrile through cheap and efficient cuprous iodide in catalyzing, oxidizing and cyclizing modes, and a series of the 3-cyano group imidazo [1, 2-a] pyridine compounds are constructed. The synthetic method has the advantages that the materials are easy to obtain, the operation is simple and convenient, the condition is gentle, the substrate is good in universality, the economic benefit is obtained, and the efficiency is achieved, and the method can be applied to efficient and simple and convenient composition of medicine molecules such as saripidem and necopidem.

The invention relates to a method for preparing alpha-alkylated ketone by coupling alcohol with alpha-methyl / methylene ketone. The method comprises the following steps: sequentially adding alpha-methyl / methylene ketone compounds and alcohol compounds into a reaction solvent, then, adding 2mol% of catalyst bistriphenylphosphine rhodium carbonyl chloride (RhCl (CO) (PPh3) 2), finally adding an inorganic alkali, and reacting at 50-100 DEG C to obtain reaction liquid after the reaction is completed; and filtering, concentrating and column chromatography separating the reaction liquid according to a conventional method to obtain the alpha-alkylated ketone. The method provided by the invention is efficient, rapid and environmental-friendly.