260 results about "Pentanone" patented technology

The invention relates to a color photosensitive resin composition, a color filter comprising the color photosensitive resin composition, and a display device. The color photosensitive resin composition comprises a colorant, an alkali-soluble resin, a photopolymerization compound, a photopolymerization initiator and a solvent, and is characterized in that the photopolymerization initiator comprises an oxime ester compound and the solvent comprises hydroxy-4-methyl-2-pentanone.

The present invention provides novel processes for the preparation of a cyclopentanone of Formula II and a lactone of Formula I, which are useful in the production of prostaglandins: wherein Z, R2, R3, X1, X2, and are as defined in the specification. The invention also provides novel enantiomerically enriched compounds.

The invention discloses a route and method for preparing 3-aminomethyl-5-methylhexanoic acid, namely pregabalin raceme hydrochloride. The method comprises the following steps of: performing condensation on 4-methyl-2-pentanone to obtain a compound in a formula (1), and performing reduction to obtain a compound in a formula (2); performing halogenation or esterification to obtain a compound in a formula (3a), and performing substitution to obtain a compound in a formula (4), or performing elimination on the compound in the formula (3a) to obtain a compound in a formula (3b) and performing addition to obtain a compound in the formula (4); and performing reduction and acidolysis on the compound in the formula (4) to obtain a pregabalin hydrochloride compound in a formula (6). The method is easy to operate, mild in reaction conditions, and low in cost, and is suitable for large-scale industrial production.

The present invention discloses a kind of n-hexane extract of stellera chamaejasme and the application of its further separated active compounds A and B as pesticide. Bioactivity test with cabbage worm as target pest shows the n-hexane extract of stellera chamaejasme diluted in 30 times has 72 hr corrected cabbage worm death rate of 100 %, the compound A, 1, 5-diphenyl-3-hydroxy-1-pentanone, has contact killing activity on cabbage worm of 483.4 mg / L (LC50), and the compound B, 4-hydroxy-sesquiterpene-propylene-ester, has contact killing activity on cabbage worm of 530.3 mg / L(LC50). The present invention lays foundation for developing green pesticide with stellera chamaejasme.

The invention relates to a purification method for tylosin. The invention describes the post treatment of the extraction liquid of tylosin when chloroform is used for extracting the tylosin from fermentation filter liquid, i.e. a purification method. The essential of the method is as follows: the extraction liquid is concentrated into a condition that chloroform is basically removed; a condensateis dissolved by acid water; butyl acetate or toluene or 4-methyl-2-pentanone is added; the pH value is adjusted to 7.5-9.5 by alkali liquid, and extraction and phase splitting are sequentially performed; and a tartaric acid aqueous solution or a phosphoric acid aqueous solution is added to an ester phase for performing back extraction, back extraction liquid is obtained and is sprayed and dried, or the pH value of the back extraction liquid is adjusted to 7.5-10.5, and the back extraction liquid is pressed and filtered or centrifugated to obtain the tylosin.

The invention discloses a preparation method of perfluoro-2-methyl-3-pentanone. In the presence of a fluoride salt and an ether compound, perfluoro-2, 3-epoxy-2-methylpentane undergoes a catalytic rearrangement reaction to generate perfluoro-2-methyl-3-pentanone. The method has the advantages of mild reaction conditions, fast reaction rate, high reaction selectivity and high yield, etc. The prepared perfluoro-2-methyl-3-pentanone can be used as a cleaning agent, a solvent and a fire extinguishing agent.

It is an object of the present invention to provide an inexpensive and efficient industrial method for obtaining (S)-2-pentanol, (S)-2-hexanol, 1-methylalkyl malonic acid and 3-methyl carboxylic acid at a high optical purity. The present invention provides a method of producing (S)-2-pentanol or (S)-2-hexanol which comprises allowing certain types of microorganisms or transformed cells, a product obtained by treating said microorganisms or cells, a culture solution of said microorganisms or cells, and / or a crude purified product or purified product of a carbonyl reductase fraction obtained from said microorganisms or cells, to act on 2-pentanone or 2-hexanone.

CPVC adhesives for joining CPVC substrates, pipes and articles are provided which comprise (a) about 5 to about 25 wt. % CPVC resin, (b) about 20 to about 90 wt. % of a single pentanone or blends of pentanones, (c) 0 to about 20 wt. % total heterocyclic solvent, and (d) 0 to about 45 wt. % total of non-heterocyclic solvents other than component (b) (such as MEK, acetone, cyclohexanone, and so forth). The CPVC adhesive compositions of this invention permit a reduction in the content of heterocyclic solvents to be achieved while meeting performance standards applicable to CPVC pipe joining, such as hydrostatic burst strength and hydrostatic sustained pressure test.

The invention provides a lubricating oil composite type antifoaming agent. With composite of two or more antifoaming agents comprising silicone oil, fluorine-containing silicone oil and an acrylate copolymer and with cooperative use of two or more solvents comprising paint industry solvent oil, aviation kerosene and pentanone, the antifoaming agent is used in lubricating oil products, and improves the high-temperature antifoaming property of the oil products.

The invention discloses (E)-1-aryl-5-phenyl-2-alkene-1-pentanone compounds and the synthesis and application thereof. The structural formula of the compounds is shown as a formula I, wherein X is shown in the specification of the invention and R is F, Cl, Br, CH3O, C2H5O, NO2, C2H5 and CH3. The compounds have the advantages of simple structure and simple and feasible preparation method. The compound with the formula I has the favorable effect of preventing and controlling tetranychus cinnabarinus and has practical application values in agricultural production.

The invention discloses a composite solvent to prepare neoprene adhesive, which comprises the following parts: 130# solvent oil, dimethyl carbonate, butyl acetate or acetic ester, cyclohexyl-methane or cyclohexane, methyl ethyl ketone or pentanone. The solvent possesses aromatic smell and little toxicity, which improves adhesive strength.

The invention relates to a synthesis method and application of perfluoro(2-methyl-3-pentanone), and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps: mixing perfluoro(4-methylpent-2-ene) with a solvent; cooling to 13-17 DEG C; adding an oxidant; collecting a reaction product with the largest specific gravity to obtain a perfluoroepoxide; isomerizing the perfluoroepoxide in the presence of the solvent and an amine catalyst; collecting a reaction product with the largest specific gravity; and rectifying and collecting rectification products having a boiling point of 48 to 50 DEG C to obtain the perfluoro(2-methyl-3-pentanone), wherein the solvent comprises acetonitrile and / or dimethylformamide. The synthesis method has the advantages of simple process and relatively high product purity and synthesis yield; the synthesized perfluoro(2-methyl-3-pentanone) can be used as a fire extinguishing agent for fire extinguishing, and is good in fire extinguishing effect, green and environmentally friendly.

The invention relates to curcumin structural analogues and application thereof. Curcumin is an excellent lead compound and has a plurality of pharmacological activity. Compared to curcumin, the analogues provided in the invention have a more stable monocarbonyl intermediate joining chain, and the joining chain is cyclopentanone; substituents on a phenyl ring of the analogues have a specific combination. The invention also includes pharmaceutically acceptable salts of the analogues, medicinal preparations containing the analogues and application of the analogues in pharmacy. According to results of related research, the analogues can be used for treating inflammation and tumors.

The invention discloses a method for recovering 4-methyl-2-pentanone from tiamulin wastewater by acidification. The method comprises the following steps: inorganic salt is added to the tiamulin wastewater for carrying out salting out, part of organic substance sediment is dissolved out, the sediment is removed by filtering, and then inorganic strong acid is added to the wastewater for adjusting the pH value of the wastewater, the wastewater is enabled to be layered, and the separated organic phase is 4-methyl-2-pentanone. The invention also provides the treatment method for the tiamulin wastewater. According to the method, 4-methyl-2-pentanone is recovered from the tiamulin wastewater through salting-out and acidification, the recycle of waste is realized, the COD (Chemical Oxygen Demand)of the wastewater in which the 4-methyl-2-pentanone is recovered is greatly lowered, and the emission requirements can be achieved through common wastewater treatment procedures. Compared with the current treatment of tiamulin wastewater, the difficulty of the wastewater treatment method is low, the cost is low, the cyclic utilization of raw materials is realized, and the requirements on circulareconomy and clean production are met.

The present invention discloses process of preparing 5-methoxyl-1-(4-trifluoromehyl phenyl) pentanone as one key intermediate for preparing depression treating medicine fluvoxamine maleate with p-trifluoromethyl benzoyl chloride and magnesium 4-methoxyl butyl halide in the presence of catalyst. The process includes following four steps: 1. preparing p-trifluoromethyl benzoyl chloride with p-trifluoromethyl benzoic acid and thionyl chloride through chlorination; 2. preparing 1-halo-4-methoxyl butane; 3. preparing Grignard reagent through reaction of 1-halo-4-methoxyl butane and metal Mg; and 4. preparing 5-methoxyl-1-(4-trifluoromehyl phenyl) pentanone through reaction of p-trifluoromethyl benzoyl chloride and the Grignard reagent. The process has the features of facile material, low cost, short reaction period, high efficiency and environment friendship.

Disclosed are a non-flammable nonaqueous electrolyte solution and a lithium ion cell using the electrolyte solution. The non-flammable nonaqueous electrolyte solution comprises a ternary or higher-order compound additive, a high concentration of lithium salt and a phosphoric ester serving as a primary solvent. The lithium ion cell comprises a positive electrode containing a lithium transition metal oxide capable of absorbing and releasing lithium, a negative electrode containing a carbon-based material capable of absorbing and releasing lithium, and the above non-flammable nonaqueous electrolyte solution. The ternary or higher-order compound additive contains at least one compound selected from each of the three compound groups consisting of: a compound group (a) of vinylene carbonate compounds; a compound group (b) of vinyl acetate compounds, alkyl methyl carbonate compounds and vinyl ethylene carbonate compounds; and a compound group (c) of 2-pyrrolidinone compounds, cyclic alkyl compounds and cyclic pentanone compounds. The non-flammable nonaqueous electrolyte solution of the present invention can provide enhanced charge / discharge characteristics to a lithium ion cell.

The invention relates to a synthesis method of cyclopropyl methyl ketone. The synthesis method includes the steps of: 1) carrying out hydrogenation hydrolysis on 2-methyl furan in the presence of a hydrogenation catalyst, hydrogen and water by one-pot process to prepare acetyl n-propanol; 2) carrying out hydrochloric acid chlorination reaction on the acetyl n-propanol prepared in step 1) to prepare 5-chloro-2-pentanone; and 3) carrying out ring closing reaction on the crude product of 5-chloro-2-pentanone prepared in step 2) under an alkaline condition to obtain the cyclopropyl methyl ketone.The synthesis method of cyclopropyl methyl ketone provided by the invention adopts 2-methyl furan as the raw material, carries out one-pot process hydrogenation hydrolysis, hydrochloric acid chlorination reaction and ring closing reaction to obtain cyclopropyl methyl ketone, the process is simple and smooth, and the reaction conditions are mild, therefore the synthesis method is suitable for industrial scale-up production; by adopting 2-methylfuran as the raw material, the method is high in atom economy, green and environment-friendly, and low in raw material cost.

The invention relates to a method for synthesizing pentanone-2 through a Bayer-Vlieger oxidation reaction. The pentanone-2 is prepared by using propionaldehyde as a raw material, performing alkaline condensation and the Bayer-Vlieger oxidation reaction on the propionaldehyde, and finally performing hydrolysis under an acid condition. The method comprises the following process steps of: (1) condensing the propionaldehyde at the temperature of 30 to 40 DEG C under the action of solution of NaOH to obtain 2-methyl-2-pentenal; (2) preparing buffer solution of acetic acid and sodium acetate from the product obtained in the step (1) by taking the acetic acid as solvent in the presence of the sodium acetate, controlling the pH of a reaction system to be between 3.7 and 6, and at the temperature of 10 to 30 DEG C, using peroxyacetic acid to perform B-V oxidation so as to obtain formic acid-2-amylene-2-alcohol ester; and (3) using H2SO4 aqueous solution to reflux and hydrolyze the product obtained in the step (2) under an acidic condition to prepare the pentanone-2. The quality of the pentanone-2 meets the requirements of preparing a flavoring essence and an essence for household and personal care chemicals. The method has the advantages of readily available raw materials, simple process, high yield, single product component, easy refining, high product quality, low cost and suitability for industrial production.

The invention provides a method for synthesizing 1, 3- disubstituted - ene- 1- pentanone. It takes iridium complex compound as catalyst and pi-allyl beta- keto acid ester as raw material to synthesize said product with large area and high enantiotropic selection. The invention is characterized by easy got raw material, high- performance catalyst, temperate reacting condition, wide suitable range for substrate, large product area and high enantiotropic selection.

The invention discloses a catalyst for continuous production of pentanone by ketene hydrogenation. The catalyst is composed of a carrier, active components attached to the carrier and an auxiliary agent, wherein the active components comprise a component A and a component B, and the auxiliary agent comprises a component C, a component D and a component E; the component A is Ni; the component B isat least one of Mo, Wu and Cr; the component C is at least one of V, Zn and Cu; the component D is at least one of lanthanide series elements; the component E is at least one of P, B and N; and the carrier is pseudo-boehmite containing amorphous silica-alumina. Meanwhile, the invention also discloses a preparation method and application of the catalyst. The catalyst is stable in activity and longin service lifetime, and when the catalyst is used for preparing pentanone through ketene hydrogenation, the molar conversion rate of raw materials is larger than 99%, and the product selectivity is larger than 98%.

The invention belongs to the field of drug synthesis and particularly relates to a preparation method of regorafenib hydrate. 4-methyl-2-pentanone, 4-amino-3-fluorophenol and N-methyl-4-chloro-2-pyridine carboxamide are condensed to obtain a regorafenib intermediate 1, 4-chloro-3-(trifluoromethyl)isocyanate is added for condensation and salt-forming reactions to produce a regorafenib intermediate2, and finally, free hydration is performed in an alkaline acetone aqueous solution to obtain the regorafenib hydrate. The preparation method of the regorafenib hydrate is simple to operate and easy to monitor, has yield up to 90% or above and high efficiency and is applicable to mass industrial production. The prepared regorafenib hydrate has low impurity content, has no solvent residues basically, significantly shortens purification time, has stable properties, keeps stable in accelerated stability tests and has high safety.

The invention discloses a preparation method of quinolone, isoquinoline and methylquinolines, aiming to be short in process flow and low in cost. The preparation method comprises the following steps: placing rectified residual liquor obtained from extraction of quinolone into a urea coronary inclusion complex, and carrying quinolone and isoquinoline in a solution into the urea coronary inclusion complex according to molecule sizes; according to difference of crystallization points, separating the quinolone from isoquinoline; separating multiple solid-phase monomethylquinolone from a liquid-state mixed solvent; placing the separated multiple solid-phase monomethylquinoline and solid-phase 2,4-dimethylquinoline into a thiourea water solution for dipping to form a thiourea coronary inclusion complex; spraying anhydrous methanol, propanol, butanone and pentanone mixed solvent through a peristaltic pump; crystalizing 2,4-dimethylquinolone dissolved in the mixed solvent, separating from other trace polymethylquinolone impurities, and refining to obtain 2,4-dimethylquinoline products; and according to the difference of crystallization points, placing the thiourea coronary inclusion complex into a crystallization kettle for heating and separation.

The invention relates to a preparation method of an osimertinib intermediate, comprising: subjecting ortho-nitrotoluene and 3,3-dialkoxypropanenitrile as raw materials to alkali-catalyzed nucleophilicaddition to obtain 1-(2-nitro)phenyl-4,4-dialkoxy-2-butanone, subjecting 1-(2-nitro)phenyl-4,4-dialkoxy-2-butanone and N,N-dimethylformamide dimethyl acetal to thermal condensation to obtain 1-dimethylamino-2-(2-nitro)phenyl-5,5-dialkoxy-3-n-pentanone, subjecting the attained reaction liquid to direct catalytic hydrogenation to obtain 3-(3,3-dialkoxy)propionylindole, subjecting 3-(3,3-dialkoxy)propionylindole to reaction with a methylation reagent under alkaline conditions to generate 3-(3,3-dialkoxy)propionyl-N-methylindole, and subjecting 3-(3,3-dialkoxy)propionyl-N-methylindole and 2-methoxy-4-fluoro-5-nitrophenylguanidine to exocondensation to obtain the osimertinib intermediate. The materials herein are low in price and easy to attain, the route is short, and the preparation method is environmentally friendly and high in yield.

The present invention provides a cobalt phosphide catalyst for preparing 3-pentanone and propanal from hydrogen, carbon monoxide and ethylene. Specifically the present invention provides an active carbon supported cobalt phosphide catalyst for preparing 3-pentanone and propanal from H2, CO and ethylene under a certain temperature and pressure reaction condition. The catalyst comprises a main active component, an additive and a carrier, wherein the main active component is a cobalt phosphide, the additive is one or a plurality of alkali metals or oxides thereof, and the carrier is selected from active carbon. In a fixed bed reactor, at a creation temperature, under a certain pressure and in the presence of the catalyst, high activity and high selectivity preparation of products such as 3-pentanone and propanal by using H2, CO and ethylene can be achieved.

The invention discloses an immersed phase change cooling medium and application thereof in a cooling system of an electronic device. The cooling medium is one or a mixture of two or more of perfluoro-4-methyl-2-pentene, perfluoro-2-methyl-3-pentanone, perfluoro-2-methyl-2, 3-epoxypentane and perfluorohexanone. The immersed phase-change cooling medium provided by the invention has the characteristics of high electrical insulation property, low viscosity, lower boiling point, high gasification latent heat, good compatibility and stability, incombustibility, combustion inhibition, low global warming potential (GWP), zero ozone consumption potential (ODP) and the like.