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Nano-emulsion in-situ gel for treating haemorrhoids

An in-situ gel and nanoemulsion technology, which is applied in the directions of plant raw materials, emulsion delivery, and medical preparations containing active ingredients, etc., can solve problems such as difficult control of dosage, short action time of lotion, and reduced compliance. , to achieve the effect of easy dose control, strong affinity, and increased compliance

Inactive Publication Date: 2014-04-23
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used traditional Chinese medicine external preparations for clinical treatment of hemorrhoids mainly include lotion, suppository, gel, etc., the lotion has a short action time, and the medication is too frequent and irritating, which brings a lot of inconvenience to the patient; the traditional suppository is in solid form. The medicine melts or softens in the cavity, which is not only inconvenient to use, but also may slide into the bottom of the rectum to cause the first-pass effect of the medicine, and cause discomfort to the patient due to water absorption and reduce compliance; the gel can improve the compliance of the patient and has A certain degree of bioadhesion can avoid the first-pass effect of the drug, but the dosage is not easy to control and it is inconvenient to use

Method used

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  • Nano-emulsion in-situ gel for treating haemorrhoids

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Experimental program
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Effect test

Embodiment 1

[0014] The nanoemulsion in situ gel for the treatment of hemorrhoids of the present embodiment is calculated by the following weights: flavescens 65g, salvia miltiorrhiza 110g, wild chrysanthemum 65g, borneol 1.7g, menthol 3.6g, polyoxyethylene castor oil 100g, dehydrated alcohol 40g, isopropyl myristate 10g, poloxamer 407120g and poloxamer 18824g; wherein,

[0015] Add 14 times the weight of wild chrysanthemum to the water of wild chrysanthemum each time, steam distill for 4 hours, extract the volatile oil of wild chrysanthemum for later use, filter to obtain water extract; add 14 times the weight of wild chrysanthemum to the mass fraction of 50% ethanol , reflux extraction twice, 1 hour each time, combined ethanol extract, recovered ethanol under reduced pressure, combined with water extract, concentrated, adjusted pH value to 5, adsorbed by AB-8 macroporous adsorption resin, and eluted with 2BV pure water Remove impurities, elute with ethanol 4BV with a mass fraction of 50%...

Embodiment 2

[0021] The nanoemulsion in situ gel for the treatment of hemorrhoids of the present embodiment is calculated by the following weights: Sophora flavescens 30g, Salvia miltiorrhiza 30g, wild chrysanthemum 100g, borneol 8g, menthol 1g, polyoxyethylene castor oil 160g, absolute ethanol 10g, Composition of isopropyl myristate 60g, poloxamer 40760g and poloxamer 1885g; wherein,

[0022] Add 14 times the weight of wild chrysanthemum to the water of wild chrysanthemum each time, steam distill for 4 hours, extract the volatile oil of wild chrysanthemum for later use, filter to obtain water extract; add 14 times the weight of wild chrysanthemum to the mass fraction of 50% ethanol , reflux extraction twice, 1 hour each time, combined ethanol extract, recovered ethanol under reduced pressure, combined with water extract, concentrated, adjusted pH value to 5, adsorbed by AB-8 macroporous adsorption resin, and eluted with 2BV pure water Remove impurities, elute with ethanol 4BV with a mass ...

Embodiment 3

[0028] The nanoemulsion in situ gel for the treatment of hemorrhoids of the present embodiment is calculated by the following weights: Sophora flavescens 100g, Salvia miltiorrhiza 120g, wild chrysanthemum 30g, borneol 1g, menthol 8g, polyoxyethylene castor oil 30g, absolute ethanol 80g, Composition of isopropyl myristate 5g, poloxamer 407160g and poloxamer 18880g; wherein,

[0029]Add 14 times the weight of wild chrysanthemum to the water of wild chrysanthemum each time, steam distill for 4 hours, extract the volatile oil of wild chrysanthemum for later use, filter to obtain water extract; add 14 times the weight of wild chrysanthemum to the mass fraction of 50% ethanol , reflux extraction twice, 1 hour each time, combined ethanol extract, recovered ethanol under reduced pressure, combined with water extract, concentrated, adjusted pH value to 5, adsorbed by AB-8 macroporous adsorption resin, and eluted with 2BV pure water Remove impurities, elute with ethanol 4BV with a mass ...

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Abstract

The invention relates to nano-emulsion in-situ gel for treating haemorrhoids. The gel comprises the following components by weight: 30-100g of sophora flavescens, 30-120g of salviae miltiorrhizae, 30-100g of wild chrysanthemum, 1-8g of borneol, 1-8g of menthol, 30-160g of polyoxyethylated castor oil, 10-80g of absolute ethyl alcohol, 5-60g of isopropyl myristate, 60-160g of poloxamer 407, and 5-80g of poloxamer 188. The nano-emulsion in-situ gel can infiltrate into a mucous membrane to play the effects of clearing heat, removing toxicity, drying dampness, relieving itching, activating blood circulation to remove stasis, diminishing edema and relieving pain, and can be used for promoting local blood circulation, and improving nutrition of peripheral tissues to achieve the aims of diminishing edema and inflammation, and relieving pain.

Description

technical field [0001] The invention relates to a nanoemulsion in-situ gel for treating hemorrhoids, which belongs to the technical field of traditional Chinese medicine. Background technique [0002] Hemorrhoids are mainly soft veins formed by expansion and varicose venous plexus under the mucous membrane of the end of the rectum, anal canal and anal margin; or skin inflammation, hypertrophy, and hyperplasia of connective tissue in the folds of the anal margin; or anal vein rupture and blood stasis formation thrombus. According to relevant data, the incidence rate of anorectal diseases is 59.1%. Hemorrhoids account for 87.25% of all rectal diseases and 52.19% of all anorectal diseases. , necrosis and infection, etc., aggravate the pain and condition. At present, Western medicine mostly adopts surgical methods to the treatment of hemorrhoids, and hormones and analgesics are mostly used in postoperative care, and these medicines have more side effects. Traditional Chinese ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/107A61K9/06A61P9/14A61P29/00A61K31/045A61K31/125
Inventor 贾永艳袁玉霞周宁祝侠丽关延彬田效志熊晶晶王佳乐
Owner HENAN UNIV OF CHINESE MEDICINE
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