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Cefixime dry suspension and preparation method thereof

A technology of cefixime and dry suspension, applied in the field of medicine, can solve the problems of unfavorable application in production, low bioavailability, unpleasant drug dissolution, etc., and achieves improved bioavailability, improved drug stability, and preparation stability. Good results

Active Publication Date: 2013-09-18
广东彼迪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cefixime preparations involved in the above-mentioned patented technologies all have the problems of poor stability and relatively low bioavailability
[0007] Chinese patents CN101972231A, CN101966166A, CN101966160A, CN101966159A and CN101966154A disclose dry suspensions, capsules, dispersible tablets, tablets and granules containing cefixime liposomes respectively, and the liposome preparations of these cefixime are stable to be further improved
Chinese patent CN101711741A discloses a submicron emulsion solid preparation of cefixime. Since there is no oil phase, the surfactant dissolves rapidly in the water phase when the dissolution rate is measured, resulting in the crystallization of the drug, so the drug is not dissolved quickly.
CN102327235B discloses a cefixime lipid nanoparticle solid preparation and a preparation method thereof. The provided solid lipid nanoparticle preparation has high drug loading, uniform particle size, long retention time of medicine in blood circulation, and better Sustained release and controlled release effect, however, liposome technology is complicated to prepare and does not take advantage of the application in production

Method used

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  • Cefixime dry suspension and preparation method thereof
  • Cefixime dry suspension and preparation method thereof
  • Cefixime dry suspension and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026]

[0027]

[0028] Preparation Process:

[0029] (1) Weigh cefixime for the prescription amount, add it to saturated caprylic triglyceride under stirring condition to dissolve, then add polyoxyethylene castor oil to the oil solution, stir to obtain a clear solution;

[0030] (2) The prescription amount weighs povidone and pregelatinized starch, and mixes them evenly to obtain a mixture;

[0031] (3) Adsorb the solution of step (1) with the mixture of step (2), and stir evenly;

[0032] (4) Subpackage on a granule packaging machine to obtain Cefixime dry suspension.

Embodiment 2

[0034]

[0035] Preparation Process:

[0036] (1) Weigh cefixime for the prescription amount, add it into saturated capric triglyceride under stirring condition to dissolve, then add polyoxyethylene castor oil into the oil solution, stir to obtain a clear solution;

[0037] (2) Weigh the lactose and sodium carboxymethyl cellulose for the prescription amount, mix them evenly, and obtain the mixture;

[0038] (3) Adsorb the solution of step (1) with the mixture of step (2), and stir evenly;

[0039](4) Subpackage on a granule packaging machine to obtain Cefixime dry suspension.

Embodiment 3

[0041]

[0042] Preparation Process:

[0043] (1) The prescription quantity weighs cefixime, and under stirring conditions, add caprylic acid to capric acid molar ratio of 1:1 saturated caprylic acid-capric acid mixed triglyceride to dissolve, and then add polyoxygen to the oil solution. Ethylene castor oil, stirred to obtain a clear solution;

[0044] (2) Pre-gelatinized starch and hydroxypropyl cellulose are weighed for the prescription amount, and mixed evenly to obtain a mixture;

[0045] (3) Adsorb the solution of step (1) with the mixture of step (2), and stir evenly;

[0046] (4) Subpackage on a granule packaging machine to obtain Cefixime dry suspension.

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Abstract

The invention discloses a cefixime dry suspension and a preparation method thereof. The preparation comprises the following components in parts by weight: 1 part of cefixime, 0.8-4 parts of polyoxyethylated castor oil, 3-6 parts of medium-chain fatty acid glyceride, 2-6 parts of a suspending agent and 8-15 parts of a filler; the preparation method comprises the flowing steps of: dissolving cefixime in the medium-chain fatty acid glyceride with the polyoxyethylated castor oil, and subsequently absorbing by using a mixture of the suspending agent and the filler. The preparation is good in stability, rapid to dissolve, simple in process and applicable to industrial large-scale production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cefixime dry suspension and a preparation method thereof. Background technique [0002] Cefixime (Cefixime) is an oral third-generation cephalosporin antibiotic, chemical name: (6R, 7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2- (Carboxymethoxyimino)acetamido]-8-oxo-3-ethylene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid trihydrate, Chem The structural formula is as follows: [0003] [0004] Cefixime is white to light yellow crystalline powder, odorless, with slight specific odor, easily soluble in methanol, dimethyl sulfoxide, slightly soluble in acetone, hardly soluble in ethanol, almost insoluble in water, ethyl acetate, ether, in hexane. As the third-generation oral cephalosporin antibiotic, cefixime has a broad antibacterial spectrum and strong antibacterial activity. , Proteus mirabilis, and Neisseria gonorrhoeae (including enzyme-producing strains) a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/14A61K47/44A61K31/546A61P31/04
Inventor 刘小兰司徒卫彤朱富根
Owner 广东彼迪药业有限公司
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