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Enalapril maleate capsules and preparation method thereof

A technology of enalapril maleate and Pulee tablets, which is applied in the field of enalapril maleate tablets and its preparation, can solve problems such as increased cost and complicated preparation process, and achieve cost saving, simple process, and improved The effect of stability

Inactive Publication Date: 2017-08-18
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Though above-mentioned four kinds of methods have strengthened the stability of enalapril maleate tablet to a certain extent, also make preparation technology more complicated, increased cost

Method used

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  • Enalapril maleate capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A kind of enalapril maleate tablet, calculates according to parts by weight, comprises following raw materials:

[0018] 4 parts of enalapril maleate, 50 parts of lactose, 20 parts of starch, 1.5 parts of zinc stearate and 1.5 parts of glyceryl distearate.

[0019] Preparation:

[0020] Include the following steps:

[0021] 1) Enalapril maleate, lactose, and starch are mixed evenly in equal increments, passed through a 100-mesh sieve, and set aside;

[0022] 2) Mix the powder prepared in step 1) with the prescribed amount of zinc stearate and glyceryl distearate in equal increments, pass through a 100-mesh sieve, and dry the powder into tablets to obtain Enalapril maleate tablets.

Embodiment 2

[0024] A kind of enalapril maleate tablet, calculates according to parts by weight, comprises following raw materials:

[0025] 3.2 parts of enalapril maleate, 60 parts of lactose, 20 parts of pregelatinized starch, 3 parts of zinc stearate and 1 part of glyceryl distearate.

[0026] Preparation:

[0027] Include the following steps:

[0028] 1) Enalapril maleate, lactose, and pregelatinized starch are mixed uniformly in equal increments, passed through a 100-mesh sieve, and set aside;

[0029] 2) Mix the powder prepared in step 1) with the prescribed amount of zinc stearate and glyceryl distearate in equal increments, pass through a 100-mesh sieve, and dry the powder into tablets to obtain Enalapril maleate tablets.

Embodiment 3

[0031] A kind of enalapril maleate tablet, calculates according to parts by weight, comprises following raw materials:

[0032] 5 parts of enalapril maleate, 60 parts of lactose, 10 parts of pregelatinized starch, 0.2 parts of zinc stearate and 1 part of glyceryl distearate.

[0033] Preparation:

[0034] Include the following steps:

[0035] 1) Enalapril maleate, lactose, and pregelatinized starch are mixed uniformly in equal increments, passed through a 100-mesh sieve, and set aside;

[0036] 2) Mix the powder prepared in step 1) with the prescribed amount of zinc stearate and glyceryl distearate in equal increments, pass through a 100-mesh sieve, and dry the powder into tablets to obtain Enalapril maleate tablets.

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Abstract

The invention provides enalapril maleate capsules and a preparation method thereof. The enalapril maleate capsules comprise the following raw and auxiliary materials in parts by weight: 3-5 parts of enalapril maleate, 60-80 parts of filler, 0.2-3 parts of zinc stearate and 1-3 parts of glycerol distearate. The preparation method comprises the following steps: 1) uniformly mixing enalapril maleate and the filler in an equivalently increasingly adding manner, and screening the mixture through a 100-mesh sieve for later use; and 2) uniformly mixing the powder obtained in the step 1) with zinc stearate and glycerol distearate in prescription amounts in an equivalently increasingly adding manner, screening the mixture through a 100-mesh sieve, and tabletting the dry powder to obtain the enalapril maleate capsules. The capsules prepared from simple raw and auxiliary materials are high in stability and high in dissolving rate.

Description

technical field [0001] The invention belongs to the technical field of enalapril maleate, in particular to an enalapril maleate tablet and a preparation method thereof. Background technique [0002] Enalapril maleate belongs to angiotensin-converting enzyme inhibitors and is commonly used clinically for the treatment of hypertension, and tablets are its most widely used dosage form. The chemical stability of enalapril maleate itself is better, but because the compatibility with some excipients such as magnesium stearate, microcrystalline cellulose etc. is bad, there is certain problem in the chemical stability of its tablet, in Often degrades to enalaprilat and enalapril diketone during storage. [0003] At this stage, various manufacturers usually use the following four methods to increase the stability of enalapril maleate: ① use chemical reaction to increase the stability. Adding an alkaline substance can convert the carboxyl group of enalapril maleate into a carboxylat...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K38/05A61K47/14A61P9/12
Inventor 高煜操铖
Owner HUAYI PHARMA ANHUI CO LTD
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