The present invention relates to a Chinese medicine compound for curing nephropathy syndrome, which is made from milk veteh, dried orange peel, salvia, dangshen, largehead atractylode, cortex eucommiae, motherwort herb, gordon euryale seed, parasite scurrula, coix seed, Chinese yam, imperatae rhizome, poria skin, epimedium powder, slenderstyle acanthopanax bark, cooked rehmannia root and / or acceptable carriers in pharmacology. The present invention also relates to a preparation method of the Chinese medicine compound. The Chinese medicine compound of the present invention has the effects of reinforcing the spleen and replenishing qi, removing heat and toxic substance, promoting diuresis and eliminating dampness, nourishing liver and kidney, etc., which is used for curing such symptoms as a large amount of albuminuria, serious edema, hypoproteinemia and hyperlipidemia caused by nephropathy syndrome.