Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Modified starch adhesive for preparing hollow capsule and starch-base hollow capsule thereof

A hollow capsule and modified starch technology, which is applied in the directions of capsule delivery, medical preparations with non-active ingredients, and pharmaceutical formulations, can solve the problems of difficulty in water removal, large amount of glue and water, and no products, and achieves increased hydrophilicity. performance, lowering the gelatinization temperature, and the effect of inhibiting regeneration

Active Publication Date: 2014-07-23
江苏崇尚生物科技有限公司
View PDF10 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the price of hydroxypropyl methylcellulose is not very expensive, in the production process of preparing hollow capsules with it as the main raw material, the glue water material is relatively large, and it is difficult to remove water, and the glue paste is long and difficult to form. Large, the disintegration time of hollow capsules prepared with it as the main raw material is relatively long, therefore, the current domestic market share is not high
The price of starch is very low, and it is very attractive to prepare hollow capsules with it. Many domestic manufacturers have also applied for patents for starch hollow capsules. However, because starch molecules are easy to form strong hydrogen bonds, the starch film is brittle and fragile. It is difficult to make hollow capsules with high strength and resistance to filling
In recent years, some American and Japanese patents have prepared hollow capsule shells with higher strength by adding high-strength gels to the starch matrix, but at the same time, it has also caused the hollow capsule shells to be difficult to disintegrate, and it is difficult to obtain rapid disintegration in the body. product
Therefore, although there are many patents, there is no product that can be pushed to the market so far.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 99.5wt% hydroxypropyl tapioca starch (degree of substitution DS = 0.1, gelatinization temperature 60°C; hydroxypropyl cornstarch is prepared by cornstarch and propylene oxide through the conventional reaction method of starch industry), 0.5wt% Konjac gum was mixed to prepare modified starch glue for preparing hollow capsules.

[0020] The above-mentioned modified starch glue used for preparing empty capsules and a small amount of KCl (about 0.05% of the weight of the modified starch glue) as a coagulation aid are mixed with water that is 8 times the weight of the modified starch glue and After gelatinization and gelatinization by heating, starch-based hollow capsules with good flexibility and good disintegration properties were prepared by conventional capsule preparation technology.

[0021] The prepared starch-based hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia in 2010, using Tianda Tianfa ZB...

Embodiment 2

[0023] With 95wt% hydroxypropyl cornstarch (degree of substitution DS = 0.93, gelatinization temperature 25 ℃, hydroxypropyl cornstarch is prepared by cornstarch and propylene oxide through the conventional reaction mode of starch industry), 5wt% karaage Glues are mixed to prepare modified starch glue for preparing hollow capsules.

[0024] The above-mentioned modified starch glue used for preparing empty capsules and a small amount of potassium citrate (about 0.15% of the weight of the modified starch glue) as a coagulation aid, and water that is 6 times the weight of the described modified starch glue After mixing and heating to gelatinize and gelatinize, starch-based hollow capsules with good flexibility and good disintegration performance are prepared by conventional capsule preparation technology.

[0025] The prepared starch-based hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition. Tiand...

Embodiment 3

[0027] With 80wt% hydroxypropyl potato starch (degree of substitution DS = 0.22, gelatinization temperature 47 ℃, hydroxypropyl potato starch is prepared by the conventional reaction mode of starch industry with propylene oxide), 20wt% melon gelatin to prepare denatured starch glue for preparing empty capsules.

[0028] The above-mentioned modified starch glue used for preparing empty capsules and a small amount of calcium chloride (about 0.2% of the weight of the modified starch glue) as a coagulation aid are mixed with water that is 5 times the weight of the modified starch glue. After mixing and heating to gelatinize and gelatinize, starch-based hollow capsules with good flexibility and good disintegration performance are prepared by conventional capsule preparation technology.

[0029] The prepared starch-based hollow capsules were disintegrated with reference to the method stipulated in Part II of the Chinese Pharmacopoeia in 2010, using Tianda Tianfa ZB-1E intelligent di...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
degree of substitutionaaaaaaaaaa
degree of substitutionaaaaaaaaaa
Login to View More

Abstract

The invention relates to a modified starch adhesive for preparing a hollow capsule and a starch-base hollow capsule prepared from the modified starch adhesive, belonging to the field of food, medicines and the like. The modified starch adhesive for preparing the hollow capsule is prepared by mixing hydroxypropyl starch or acid-treated hydroxypropyl starch with a gelatinizer. The substitution degree DS of the hydroxypropyl starch or acid-treated hydroxypropyl starch is 0.1-0.93, and the gelatinization temperature is 25-60 DEG C. The modified starch adhesive can be heated in water to be gelatinated and colloidized to obtain the starch-base hollow capsule. The hydroxypropyl functional group is introduced to the starch molecules to modify the starch, thereby overcoming the intermolecular hydrogen bonding force of the starch, performing the toughening and reinforcing functions, effectively inhibiting starch from anabiosis, increasing the hydrophilicity of the starch molecules and lowering the gelatinization temperature; and thus, the starch-base hollow capsule has favorable disintegrability.

Description

technical field [0001] The invention relates to a modified starch glue used for preparing hollow capsules used in the fields of food, medicine and the like, and a starch-based hollow capsule prepared from the modified starch glue. Background technique [0002] The use of animal-derived gelatin to make hollow capsules has a history of at least nearly 200 years. Since gelatin can mask the bad taste, smell or irritation to the stomach of many medicines, gelatin capsules are quickly promoted and used in the production of various solid preparations. Over the past 100 years, various capsules made of gelatin have been sold well in the international pharmaceutical market for a long time. At the end of the last century, the outbreak of mad cow disease finally dragged gelatin capsules into an unprecedented crisis of confidence. In April 2012, the "poisonous capsule" incident that broke out in my country undoubtedly aggravated the distrust of the Chinese people towards gelatin capsul...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08L3/08C08L5/00C08K3/16C08K5/098A61K47/36A61K9/48
Inventor 闫丰文袁国卿
Owner 江苏崇尚生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products