Composition for preparing empty capsules and starch-based empty capsules thereof

Abstract

The invention relates to a composition for preparing a hollow capsule and a starch-base hollow capsule prepared from the composition, belonging to the field of food, medicines and the like. The composition for preparing the hollow capsule is prepared by mixing hydroxypropyl starch or acid-treated hydroxypropyl starch with a reinforcing and toughening agent and a gelatinizer. The substitution degree DS of the hydroxypropyl starch or acid-treated hydroxypropyl starch is 0.007-0.93, and the gelatinization temperature is 30-70 DEG C. The composition can be heated in water to be gelatinated and colloidized to obtain the starch-base hollow capsule. The hydroxypropyl functional group is introduced to the starch molecules to modify the starch, thereby overcoming the intermolecular hydrogen bonding force of the starch, performing the toughening and reinforcing functions, effectively inhibiting starch from anabiosis, increasing the hydrophilicity of the starch molecules and lowering the gelatinization temperature; and thus, the starch-base hollow capsule has favorable disintegrability.

Description

technical field [0001] The invention relates to a composition for preparing hollow capsules used in the fields of food, medicine and the like, and starch matrix hollow capsules prepared from the composition. Background technique [0002] The use of animal-derived gelatin to make hollow capsules has a history of at least nearly 200 years. Since gelatin can mask the bad taste, smell or irritation to the stomach of many medicines, gelatin capsules are quickly promoted and used in the production of various solid preparations. Over the past 100 years, various capsules made of gelatin have been sold well in the international pharmaceutical market for a long time. At the end of the last century, the outbreak of mad cow disease finally dragged gelatin capsules into an unprecedented crisis of confidence. In April 2012, the "poisonous capsule" incident that broke out in my country undoubtedly aggravated the distrust of the Chinese people towards gelatin capsules. In addition, gelat...

AI Technical Summary

Problems solved by technology

Although the price of hydroxypropyl methylcellulose is not very expensive, in the production process of preparing hollow capsules with it as the main raw material, the glue water material is relatively large, and it is difficult to remove water, and the glue paste is long and difficult to form. Large, the disintegration time of hollow capsules prepared with it as the main raw material is relatively long, therefore, the current domestic market share is not high

The price of starch is very low, and it is very attractive to prepare hollow capsules with it. Many domestic manufacturers have also applied for patents for starch hollow capsules. However, because starch molecules are easy to form strong hydrogen bonds, the starch film is brittle and fragile. It is difficult to make hollow capsules with high strength and resistance to filling

In recent years, some American and Japanese patents have prepared hollow capsule shells with higher strength by adding high-strength gels to the starch matrix, but at the same time, it has also caused the hollow capsule shells to be difficult to disintegrate, and it is difficult to obtain rapid disintegration in the body. product

Therefore, although there are many patents, there is no product that can be pushed to the market so far.