Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of chickpea sprout extract dispersible tablet

A technology of chickpea and extract, which is applied in the preparation of dispersible tablets of chickpea bean sprouts extract, medicine or auxiliary hypoglycemic health food, which can solve complex operation process, easy precipitation of isoflavone compounds, and bioavailability low level problem

Inactive Publication Date: 2013-09-11
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
View PDF5 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent ZL201010523065.6: a purification method of active ingredients of chickpea bean sprouts, ZL201010614623.X: effective parts of chickpea bean sprouts and its preparation method and application, both of which are purified by macroporous resin after adsorption by polyamide, The operation process is complicated, and when the ethanol extract is concentrated to no alcohol, the isoflavones are easy to precipitate, which brings inconvenience to the purification work, and the loss of active ingredients is also large
[0006] Since isoflavones are poorly soluble ingredients, when they are made into general tablets, their in vitro dissolution is slow and their bioavailability is low.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of chickpea sprout extract dispersible tablet
  • Preparation method and application of chickpea sprout extract dispersible tablet
  • Preparation method and application of chickpea sprout extract dispersible tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: (based on making 200 pieces)

[0017] Germinate the chickpeas after 3 days, pick the bean sprouts, dry them, crush them into coarse powder, add 15 times the weight of 50% ethanol aqueous solution, soak until thoroughly, heat to a temperature of 60°C, and reflux extraction twice, each time After 1 hour, the extracts were combined, filtered, and the filtrate was decompressed to recover ethanol until the alcohol concentration of the liquid was 5%, and was adsorbed by HPD300 macroporous adsorption resin column for 6 hours, first eluted with distilled water until the effluent was nearly colorless, and then used 50% ethanol and 95% ethanol were eluted sequentially, collected until the eluate was colorless, concentrated under reduced pressure at a concentration temperature of 40°C, pressure -0.07Mpa to -0.1Mpa, dried, crushed, and passed through a 100-mesh sieve to obtain the olecranon bean sprouts extract;

[0018] Weigh 35g of chickpea bean sprouts extract, 50...

Embodiment 2

[0019] Embodiment 2: (based on making 200 pieces)

[0020] Germinate the chickpeas after 4 days, pick the bean sprouts, dry them, crush them into coarse powder, add 20 times the weight of 60% ethanol aqueous solution, soak until thoroughly, heat to a temperature of 70°C, and reflux extraction 3 times, each time 1.5 hour, combine the extracts, filter, the filtrate decompresses and recovers ethanol until the alcohol concentration of the liquid is 10%, absorbs through HPD600 macroporous adsorption resin column for 10h, first elutes with distilled water until the effluent is nearly colorless, and then uses the concentration It is eluted with 60% ethanol, collected until the eluent is colorless, concentrated under reduced pressure, concentrated at 50°C, pressure -0.07Mpa to -0.1Mpa, dried, crushed, and passed through a 100-mesh sieve to obtain chickpea sprouts extract ;

[0021] Weigh 30 g of chickpea bean sprouts extract, 40 g of microcrystalline cellulose as filler, 18 g of cros...

Embodiment 3

[0022] Embodiment 3: (based on making 200 pieces)

[0023] Germinate the chickpeas after 3 days, pick the bean sprouts, dry them, crush them into coarse powder, add 70% ethanol aqueous solution with a concentration 30 times the weight, soak until thoroughly, heat to a temperature of 80°C, and reflux extraction 4 times, each time 1.0 hour, combine the extracts, filter, the filtrate decompresses and recovers ethanol until the alcohol concentration of the liquid is 15%, absorbs through the HPD100 macroporous adsorption resin column for 12 hours, first elutes with distilled water until the effluent is nearly colorless, and then uses the concentration It is eluted with 80% ethanol, collected until the eluent is colorless, concentrated under reduced pressure, concentrated at 65°C, pressure -0.07Mpa to -0.1Mpa, dried, crushed, and passed through a 80-mesh sieve to obtain chickpea bean sprouts extract ;

[0024]Weigh 25g of chickpea bean sprouts extract, add 20g of lactose and 20g of...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a chickpea sprout extract used for reducing blood sugar and also relates to a preparation method and application of a chickpea sprout extract dispersible tablet used for reducing blood sugar. The preparation method of the chickpea sprout extract dispersible tablet comprises the following steps of: sprouting chickpeas for 3-4 days, picking sprouts, airing and then extracting with ethyl alcohol, adsorbing by virtue of a macroporous adsorption resin, carrying out reduced pressure concentration and drying, so as to obtain the chickpea sprout extract; then adding pharmaceutically acceptable filling agent, disintegrating agent and swelling property auxiliary materials into the chickpea sprout extract, mixing uniformly, making softwood by taking an ethyl alcohol solution as a wetting agent, pelletizing, drying, straightening granules, adding a lubricating agent, uniformly mixing, and tabletting, thus the chickpea sprout extract dispersible tablet is obtained. The chickpea sprout extract dispersible tablet obtained by adopting the preparation method has the characteristics of high disintegration speed, high active ingredient dissolution rate and good dispersion uniformity and can be applied to medicine used for treating or preventing diabetes or health-care food assisting to reduce blood sugar.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a preparation method of a dispersible tablet of chickpea bean sprouts extract and a medicine for treating or preventing diabetes or a health food for assisting hypoglycemia. Background technique [0002] Diabetes mellitus (DM) is a systemic metabolic disease determined by genetics. The incidence and prevalence of diabetes in my country are increasing year by year. Its main features are hyperglycemia and diabetes. big disease. Relevant experts predict that the past ten years will be the "International Epidemic Year of Diabetes". According to the World Health Organization (WHO) report, there are as many as 125 million people with diabetes worldwide, and this number is expected to exceed 300 million by 2025. my country's epidemiological survey shows that the prevalence of diabetes in China is 3.21%, and the number of patients exceeds 30 million, ranking among the highest...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/48A61K9/20A23L1/202A23L1/29A61P3/10A61K131/00A23L11/20A23L33/00
Inventor 阿吉艾克拜尔·艾萨罗玉琴高彦华赵海清
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com