1074 results about "Medicine use" patented technology

The invention provides an artificial-intelligence auxiliary interrogation diagnosis system which comprises a corpus training module, a question classification module, a chat processing module, an automatic response module for medical commonsense questions and an interrogation diagnosis interaction module, wherein the corpus training module automatically extracts a patient's illness sign information, treatment and medicine use information and diagnosis suggestion information in historical conversations between a doctor and the patient, semantic representation is conducted according to the various types of extracted information, the information is converted into numerical vectors, training learning is conducted on the numerical vectors, and a diagnosis model which contains relations between the illness sign information existing in historical doctor-patient interactions and the doctor's diagnosis suggestions is obtained; and the question classification module judges and classifies information consulted by the patient into an online interrogation diagnosis question or a question outside the interrogation diagnosis service scope or a medical commonsense question, and the questions are answered by the interrogation diagnosis interaction module, the chat processing module and the automatic response module of the medical commonsense question respectively. The system is characterized in that by various models obtained through training, an interrogation diagnosis mechanism can be learned independently and perfected; and system universality and diagnosis accuracy are increased.

The invention belongs to a biological technology field, more concretely discloses an insulin-Fc fusion protein, a preparation method and applications thereof. The insulin-Fc fusion protein provided by the invention has a long half life, can reduce interval time of insulin usage, and can reduce medicine use pain.

The invention relates to BALB / c mice that are deficient in the programmed cell death-1 receptor (PD-1), a screening method for autoimmune disease medicine using these mice, an IgG self-reactive antibody that the mice produce, a protein that specifically reacts to the antibody and is produced in heart, and a diagnostic method for dilated cardiomyopathy using the protein. Because PD-1 deficient BALB / c mice spontaneously develop autoimmune disease, and specifically dilated cardiomyopathy, they are useful for screening for medicines against these diseases.

The invention relates to a production method of traditional Chinese medicine marinated eggs with health care function, which is characterized by comprising the following steps: preparing fresh soup, preparing marinating soup, disinfecting the surfaces of the eggs, cooking the eggs, marinating the eggs, vacuum packing the marinated eggs, and sterilizing by steam in a sterilizer for 30 minutes. The main ingredients used in manufacturing the marinated eggs are a plurality of Chinese herbal medicines which have long history in China and are both medicines and foods, and after reasonable compatibility and scientific fine processing, a proper amount of the Chinese herbal medicines used can ensure the color, flavor, shape and unique alluring taste of the marinated eggs, thereby improving the food treatment efficacies of the marinated eggs for preserving health, beautifying, building the body, invigorating spleen-stomach and replenishing qi. The marinated eggs can be eaten to adjust the physiological function of the body, reduce blood fat, improve the physiological function and detoxicating capacity of the liver, activate tissues and activate cells, thereby enabling the body to restore the physiological equilibrium and improving the disease-resistant capacity and energy of the body.

A medicine management apparatus 100 includes: a medicine storage 148 which stores a plurality of medicines used at a site of medical care; a storage and retrieval detector 146 which, when a medicine handling personnel manipulates the apparatus to store or retrieve an accommodated medicine to be accommodated in the apparatus, physically detects the target accommodated medicine for which the apparatus is manipulated, differentiating it from the other accommodated medicines; and a counter 150 which counts each type of the plurality of accommodated medicines. An injection prescription receiver 152 receives injection prescription data from an external prescription analyzer 250. A retrieval determining unit 124 determines whether the accommodated medicine detected as being retrieved is the accommodated medicine directed by the injection prescription data to be retrieved. A retrieval completion notification unit 154 transmits a retrieval completion signal to the prescription analyzer 250, prompted by the completion of the retrieval of the accommodated medicine directed by the prescription data to be retrieved.

The invention relates to a prescription and a preparation method of rejoicing powder having a new dosage form and used for preventing or treating the senile dementia, and belongs to the biological medicine field. The rejoicing powder having a new dosage form is based on rejoicing powder having an ancient classic prescription and treats Radix Polygalae, Acorus gramineus and the like as primary medicines, the primary medicines are pretreated, partial or all medicines are extracted with water or an organic solvent in necessity to obtain effective components, the primary medicines or the effective components are mixed with proper medicinal auxiliary materials, and the rejoicing powder having the new dosage form is prepared through a certain preparation technology. The traditional prescription and the traditional technology for preparing the powder through simply crushing all medicines are changed in the invention, a new method and a new technology are applied against modern clinic medicine use characteristics to prepare the novel powder, and technological products have the characteristics of safety, effectiveness, controllable quality, convenient taking and the like of modern medicines, have the advantages of high biological utilization degrees of the effective components, fast effectiveness, substantial improvement of the product quality, and effective guarantee of the basic efficacies comprising qi benefiting, heart nourishing, nerve calming and tranquilizing, and have unique clinic application values in the prevention and the treatment of the senile dementia.

The invention relates to a medicine storing / taking control system, and in particular relates to a medicine or consumable item storing / taking control system for a ward. According to the invention, medicines are quickly and accurately provided for a patient in a prescription medicine taking mode; and the taking information of the medicines and the medicine using condition of the patient are recorded automatically, so that the problem that the existing medicine storing / taking system cannot meet the managing demand of the medicines in the ward is solved, and the defect of patient condition delay due to the fact that the medicine taking time is prolonged and the medicines are taken wrongly is overcome. In addition, a medicine lacking alarm is given when the inventory shortage of the medicines and the consumable items occurs.

The invention provides a method, system and device for intelligently selecting medicine. The method comprises: establishing a multi-dimension attribute item dictionary; extracting medicine using element information; processing the medicine using element information according to the multi-dimension attribute item dictionary; extracting element information relative to patient medicine usage; processing the element information relative to patient medicine usage according to the multi-dimension attribute item dictionary; performing intelligent medicine selection matching and comparison on various pieces of attribute item information in the medicine using element information and the element information relative to patient medicine usage; and generating an intelligent medicine selection list. The method, system and device for intelligently selecting medicine may apply information technology analysis, process a large volume of medicine using data, and provide an intelligent medicine selection way.

The invention belongs to the field of feedstuff additives, and relates to a livestock and poultry meat quality modifier, and a preparation method thereof. The modifier is characterized in that: crushed and sieved tangerine peel, cinnamon, hot pepper, and clove are adopted as main materials; bean pulp, corn flour and wheat bran are adopted as auxiliary materials; the materials are processed through steps of water-steeping, pH value regulating, sterilizing, and cooling; the materials are then inoculated with probiotics for fermentation; after fermentation, the materials are dried, such that themodifier is obtained. The meat quality modifier is used as a livestock and poultry feedstuff additive. The addition amount of the modifier in the feedstuff is 0.02% to 0.5% by weight. The modifier can be used for replacing antibiotic medicines and hormone medicines used in current livestock and poultry productions. With the modifier, livestock and poultry digestions can be promoted, livestock andpoultry production performances can be improved, livestock and poultry meat qualities and flavors can be improved, and livestock and poultry product added values can be increased. The modifier also has advantages of no toxic and side effect, no pollution, no residue. The modifier causes no drug resistance. With the modifier, livestock and poultry meat production requirements of high-efficiency, high-quality and health can be satisfied.

The invention relates to tanshinone derivatives represented by a general formula (I), wherein the tanshinone derivatives are substituted by different groups on A ring, B ring, C ring, and D ring. The invention also relates to medicine compositions with the derivatives as active components, preparation methods of the medicines, and applications thereof in preparing a 1-type 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) inhibiting agent. The invention also provides applications of the compounds represented by the general formula (I) in preparations of medicines used for treating diabetes and related metabolic diseases (such as hypertension, obesity, senile dementia, and the like).

The invention belongs to the field of the tumor molecule biology, in particular to a diagnosis reagent, a reagent knit and prevention and cure drugs of endometrial carcinoma, which provides a new diagnosis reagent and medicine for the early diagnosis and the prevention of endometrial carcinoma, and also provides a new method for filtering the medicine used for preventing endometrial carcinoma. The diagnosis reagent for endometrial carcinoma of the invention contains a reagent which can test the expressing level of a human cyclophilin A protein or the content of the mRNA of genes of the human cyclophilin A protein. The medicine which can prevent endometrial carcinoma of the invention includes: the expressing carrier of a shPNA molecule which can express the human cyclophilin A, etc. can change the expressing level of the human cyclophilin A protein or the mRNA content of the genes of the human cyclophilin A protein. The diagnosis reagent of the invention can be used for the early diagnosis of endometrial carcinoma, which has a wide application prospect.

The invention relates to a method for preparing a pitavastatin calcium raw material by asymmetric hydrogenation in the technical field of medicinal chemistry. The method comprises the following steps: performing catalytic hydrogenation on 4-benzyloxy-ethyl-acetoacetate I by using a chiral catalyst to prepare (S)-4-benzyloxy-3-hydroxy-ethyl-butyrate, and then obtaining the pitavastatin calcium through a series of reactions such as Claisen condensation, reduction, hydroxyl protection, removal of benzyl, oxidation and the like. In the invention, the highly-efficient chirality added value is realized by the use of catalytic amount of the chiral catalyst (wherein the ratio of substrate to the catalyst can reach 3, 000 to 1), and by performing the asymmetric hydrogenation and the reduction on non-chiral ketones to generate chiral alcohols compounds directly (wherein the enantioselectivity can be up to 94.3 percent).

The invention discloses a network and method for a hospital traditional Chinese medicine distribution service. Purchase, decoction and distribution services of traditional Chinese medicine of a hospital are completely contracted out to an SPD operating center. A method for the hospital traditional Chinese medicine distribution service based on SPD comprises the steps that medicine use information is determined by the SPD operating center according to patient prescription information sent by an HIS and the SPD operating center purchases raw materials of the traditional Chinese medicine in a centralized mode according to demand information; after the prescription information is classified, audited, checked and registered by the SPD operating center, the traditional Chinese medicine is decocted in a centralized mode through a traditional mode; the decocted traditional Chinese medicine is distributed by the SPD operating center in a centralized mode according to the requirements of the hospital and a patient. According to the method, professionalization capacity and professionalization resources can be fully used, the hospital puts all vigor on medical services, and a third party logistics integrated service provider has the ability to improve the quality of traditional Chinese medicine decoction pieces and reduce risks in the decoction process. Meanwhile, the traditional Chinese medicine decoction service of the hospital is completely contracted out and separated, so that the traditional Chinese medicine logistics service operating cost of the hospital is effectively reduced, and the operation efficiency is improved.

The invention provides intelligent medicine box equipment and a medicine taking management method achieved through the intelligent medicine box equipment. The intelligent medicine box equipment comprises a box cover, a medicine bin, a detecting device, a reminding device and a control system, and the control system comprises a clock unit, a central control unit and a wireless transmission unit which are sequentially connected. According to the intelligent medicine box equipment, a user can be reminded to take the preset variety and quantity of medicine at the preset time, and therefore the wrong taking and missed taking phenomena are avoided; meanwhile, the medicine using condition of a medicine box is detected in real time through the detecting device, and delayed multi-time reminding is performed through the reminding device to achieve the purpose of effectively supervising medicine taking of the user; in addition, medicine taking state records of the user are sent to an intelligent terminal through a wireless transmission unit, and the intelligent terminal can conveniently set the medicine taking variety, quantity and time of the user in time and can share the medicine taking state of the user in time and supply family member supervising and telemedicine analysis tracing.

The invention discloses a CRISPR-Cas9 system for knocking out the gene GRIN2D and its application. The CRISPR-Cas9 system comprises Cas9 and gRNA specifically targeting to the gene GRIN2D. The invention also discloses application of the CRISPR-Cas9 system to preparation of drugs used for treating cancer and application of the gene GRIN2D to diagnostic kits and medicines used for precise treatmentof stomach cancer and other tumors. In virtue of a clinical sample tissue chip of stomach cancer, the gene GRIN2D is proved to be increased in expression in stomach cancer tissue and be related to prognosis according to immunohistochemical results. The CRISPR-Cas9 system provided by the invention can highly efficiently knock out the highly-expressed gene GRIN2D in stomach cancer and inhibit the proliferation and migration / invasion of gastric cancer cells, and is simple to operate and high in knockout efficiency. The CRISPR-Cas9 system is expected to be applied to diagnosis and treatment of stomach cancer and other tumors with over-expressed GRIN2D. The CRISPR-Cas9 system is applicable to a plurality of tumors with abnormal expression of GRIN2D.

The invention discloses a home care robot. The home care robot comprises an outer shell, a head part, a door body and an intelligent bracelet. The lower end of the outer shell is connected with a base through an adjusting mechanism. Moving devices are arranged on the left side and the right side of the lower end of the base. The outer side of the upper end of the base is connected with the outer shell through a fence. A dispensing apparatus is installed on the left side of the exterior of the outer shell. The right side of the dispensing apparatus is provided with a heating pipe. A water-out button is installed on the right side of the heating pipe. Mechanical arms are installed at the left end and the right end of the back side of the outer shell. An armrest is arranged on the left side of the outer shell. Pickups are connected with the left side and the right side of the head part. The head part is located above the outer shell. An infrared sensor module and a camera are correspondingly arranged in the exterior of the head part. A radio communication module is arranged on the upper portion of the head part. According to the home care robot, the dispensing apparatus is arranged, timely and reasonable dose distribution according to the needed dose of the old can be achieved, and the condition of excessive medicine using or forgetting to take medicine cannot happen.

The invention discloses an exosome-encapsulated nano drug-loading system for tumor treatment, and preparation thereof. The system is obtained by utilizing cell endocytosis of a drug-loading nanometermaterial and then exocytosis. The drug-loading nanometer material is loaded with an antitumor medicine including at least one of a chemotherapeutic, a medicine used for immunotherapy and a medicine used for modifying a tumor microenvironment. The composition, structure and the like of the key outer component biofilm encapsulating the nano drug-loading system are improved, and compared with the prior art, the exosome-encapsulated nano drug-loading system provides a novel route for biofilm-based biological processed nanoparticles. By utilization of the exosome-encapsulated nano drug-loading system, the composition and the structure of the exosome can be maintained greatly, and the obtained exosome-encapsulated nano drug-loading system has good stability and tumor targeting performance duringblood circulation. .

The invention discloses a multifunctional medical kit. The multifunctional medical kit comprises an upper box body, a lower box body, a built-in blood pressure measuring instrument, a power supply system, a semiconductor refrigeration component and a heating tube. The inner space of the lower box body is divided by partition plates into a refrigerating chamber, a warm-keeping chamber, a conventional medicine placing area, a medical equipment placing area and a control area. The semiconductor refrigeration component is installed on the lower portion of the refrigerating chamber, and the heating tube is installed on the lower portion of the warm-keeping chamber. The inner space of the multifunctional medical kit is reasonably divided, medical equipment can be prevented from being damaged, medicine can be prevented from being damaged and contaminated, medicine with special storage conditions can be carried conveniently by the adoption of the refrigerating chamber and the warm-keeping chamber, the problem that medicine use is difficult in remote areas can be solved to a great extent, and doctors who visit patients at home can have medicine for use.

The invention belongs to the field of imaging medicines, and relates to a cross-blood-brain-barrier (cross-BBB) targeting multimodal nano-medicine used in brain tumor diagnosis. The invention especially relates to the synthesis of magnetic / fluorescent nano-diagnostic medicines with cross-BBB receptor active targeting effect and intermediate thereof. The invention also relates to an application of the medicine and the intermediate in living noninvasive brain tumor multimodal imaging. The multimodal nano-diagnostic medicine provided by the invention is respectively marked with tumor new vessel targeting group, cross-BBB transporting group, and magnetic and optical imaging group. The medicine is first targeted to tumor peripheral new vessels, then is delivered into brain with a receptor-mediated cross-BBB transportation effect, and is secondarily targeted to tumor cells. With magnetic resonance imaging / optical multimodal imaging techniques, and with the medicine, noninvasive high SNR tracing of brain tumor and especially BBB-undamaged brain tumor can be realized. The medicine provided by the invention can provide a novel reference approach for brain tumor preoperative localization and brain tumor resection under real-time image guidance.

The invention discloses a double-formula medicine used for treating insomnia, and a preparation method thereof. With existing insomnia-treating medicines, a simultaneous kidney invigorating, liver soothing and tranquilizing function can hardly be achieved. The medicine assists in solving the problem. With the medicine, various depressive insomnias can be treated with multiple targets, multiple links and multiple approaches. The double-formula medicine provided by the invention is composed by a formula A and a formula B. The formula A is composed of a Tiantai radix linderae extract, a corydalis tuber extract, panax notoginseng powder, a Chinese clematis root and rhizome extract, black common monkshood daughter root, an eucommia extract, and the like. The formula B is composed of a white mulberry root-bark extract, a psoralea corylifolia extract, a dipsacus asper extract, a silktree albizia bark extract, an oriental waterplantain tuber extract, an asiatic plantain seed extract, a Chinese arborvilae seed extract, a thinleaf milkwort root extract, a spine date seed extract, a common cnidium fruit extract, and the like. The invention also provides a preparation method of the double-formula medicine. With the method, various depressive insomnias can be treated with multiple targets, multiple links and multiple approaches. The medicine is advantaged in safe treatment, no toxic or side effect, fast effect, and thorough treatment.

The invention discloses novel lactobacilli and a composition thereof, and an application thereof in preparing medicines used for ameliorating diabetes and complications thereof. The composition comprises an effective amount of at least one lactobacillus selected from: lactobacillus reuteri GMNL-89, lactobacillus gasseri GMNL-205, and lactobacillus reuteri GMNL-263; and a pharmaceutically acceptable carrier. The lactobacillus gasseri GMNL-205 and the lactobacillus reuteri GMNL-263 are novel lactobacilli. The composition and novel lactobacilli provided by the invention have novel applications for ameliorating diabetes and complications thereof.

The invention relates to a medicine recommending method and device, computer equipment and a storage medium. The method comprises that a to-diagnose label and patient information are obtained; a medicine record matching the to-diagnose label is searched for; initial medicine use combinations are generated according to the found medicine record; medicine conflict verification is carried out on theinitial medicine use combinations, and the initial medicine use combinations which fail in medicine conflict verification are deleted to obtain a first screening medicine use combinations; informationconflict verification is carried out on medicines in the first screening medicine use combination according to the patient information, and medicines which fail in information conflict verification are deleted to obtain a second screening medicine use combination; and a medicine recommendation result is generated according to the second screening medicine use combination. Thus, medicines can be recommended intelligently.

The invention discloses a real-time blood pressure monitoring device based on a one-channel PPG signal. A signal acquisition module illuminates human body tissues and detects the intensity of the reflected light, and outputs a photocurrent signal; a signal modulation module modulates the photocurrent signal and feeds back and controls a light source emitter to obtain PPG voltage signals; a signalsending module samples the PPG voltage signals and sends the PPG voltage signals to a blood pressure calculation module; and the blood pressure calculation module performs filter pre-processing on thePPG voltage signals, and extracts characteristic values into a blood pressure calculation model for calculation to obtain real-time blood pressure and heart rate values. The real-time blood pressuremonitoring device is based on the real-time and continuity of the PPG signals, carries out all-weather blood pressure monitoring, reflects the diurnal variation of blood pressure, diagnoses early hypertension, assists in the identification of primary, secondary and complex hypertension, and has important significance in guiding rational medicine use. The real-time blood pressure monitoring devicehas obvious advantages in device power consumption, monitoring real-time performance and measurement accuracy.

The invention discloses a total lignans from caulis trachelospermi and extracting method, which is characterized by the following: possessing 30-90% lignans in the total lignans; fitting for preparing medicine to treat inflammation and or pain; making the lignan as inhibitor of epoxidised enzyme.

Indirubin is the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia (CML). Indirubin derivatives (IRDs) potently reduce the viabilities of various cancer cells and affect kinase activities. IRDs disclosed herein provide new therapeutics for cancer and conditions regulated by the kinase activities.

The invention provides a polypeptide used for preventing and treating diabetes and lipid metabolic disturbance. The polypeptide has obvious curative effect to type II diabetes, the blood sugar reducing function is realized on the basis of hyperglycemia, and the blood sugar concentration is reduced by virtue of glucose, thus being capable of not causing hypoglycaemia, having good safety and protecting pancreas beta cells. The polypeptide also has the function of obviously reducing triacylglyceride in blood and can be taken as a medicine used for preventing and treating diabetes and lipid metabolic disturbance. The polypeptide is resistant to enzymolysis, thus being applicable to being developed into oral preparations.

A high-molecular mPEG-PLGA-mPEG (PELGE) used as the axcessory of injection, oral-applied medicine, and the water-soluble medicine or the medicine difficult to dissolve in water is an amphipathic three-block copolymer, which is prepared from stannous octoate as catalyst, diisocyanate as coupling agent, polyethene glycol with single terminated end, glycollide, and lactide or polylactic acid-glycollic acid copolymer.

The invention discloses an Internet-based method for monitoring and personalized self-adaption nursing of a blood sugar patient. The method is characterized in that a personalized and self-adaption nursing analysis model for the blood sugar patient based on the real-time continuous monitoring of the patient's physiological data such as a blood sugar level and a blood pressure level as well as assistant data such as catering, medicine use, sports and weight is established according to technologies of cloud computing, Internet of Things, medical monitoring, intelligent terminals and the like as well as mathematical statistics principles. The method disclosed by the invention has the advantages that the blood sugar patient can master whether the blood sugar level is normal and master overall changing trends of the blood sugar level at any time and any place; the patient can know factors such as the catering, the sports or the medicine use which cause the abnormal blood sugar level at any time; and the patient can be reminded to adjust relevant life modes in time so as to control a blood sugar index to return to a normal scope. The method disclosed by the invention solves the problems that physical health gets worse because an existing patient does not know blood sugar index changes, or the changes are known by the patient and can only be found after the patient monitors scattered data or even after a medical worker makes a visit to monitor the scattered data, and overall changing trends cannot be mastered in real time.