148 results about "Tumor resection" patented technology

Described herein is a device and method used to effectively remove volume inside a patient in various types of surgeries, such as spinal surgeries (e.g. laminotomy), neurosurgeries (various types of craniotomy), ENT surgeries (e.g. tumor removal), and orthopedic surgeries (bone removal). Robotic assistance linked with a navigation system and medical imaging it can shorten surgery time, make the surgery safer and free surgeon from doing repetitive and laborious tasks. In certain embodiments, the disclosed technology includes a surgical instrument holder for use with a robotic surgical system. In certain embodiments, the surgical instrument holder is attached to or is part of an end effector of a robotic arm, and provides a rigid structure that allows for precise removal of a target volume in a patient.

A method is described for preventing breast cancer recurrence after surgical removal of a breast cancer mass. Specifically, the method is thermal treatment of breast tissue surrounding a cavity after lumpectomy for breast cancer. Delivery of a heated fluid is through a balloon catheter to the cavity generated after lumpectomy with the goal of ablating the surrounding tissue, including transformed cells that were not removed through surgery. A balloon and controller were designed for this application.

The present invention relates to resector balloons (1) employed in treating endoluminal-endobronchial tumoral lesions and endovascular occlusions encountered in blood vessels and in other hollow tube-like organs (7), such as trachea, windpipe, food pipe, urinary tract, bile ducts. Said resector balloon (1) is composed of a resection tip (2); a resection part (3) that is swollen or inflated in such tube-like organs (7) and is displaced or moved back and forth therein to provide tumor resection; a hardening surface (4) provided on the outer surface of said resection part (3) to shave and destroy such tumoral tissues; a catheter section (5) providing access to an endoluminal site; and an injection terminal (6) capable to inflate said resection part (3) by injecting air or fluid.

The invention provides devices and methods for use in removing tissue samples from within a patient's body. The devices include instruments having shafts for cutting a path to a tissue mass, and an inflatable balloon or balloons attached to the shaft effective to dilate the path upon inflation in order to aid in the removal of tissue masses from within the body of a patient. The devices also include instruments having dilation plates that may be inserted into a path leading to a tissue mass to be removed, and the plates separated effective to dilate the path to aid in the removal of tissue masses. Methods include inserting a device into a path leading to a tissue mass, and inflating a balloon or separating plates, thereby widening the path, and removing the tissue mass. Such devices and methods find use, for example, in biopsy and in lumpectomy procedures.

The invention provides devices and methods for use in removing tissue samples from within a patient's body. The devices include instruments having shafts for cutting a path to a tissue mass, and an inflatable balloon or balloons attached to the shaft effective to dilate the path upon inflation in order to aid in the removal of tissue masses from within the body of a patient. The devices also include instruments having dilation plates that may be inserted into a path leading to a tissue mass to be removed, and the plates separated effective to dilate the path to aid in the removal of tissue masses. Methods include inserting a device into a path leading to a tissue mass, and inflating a balloon or separating plates, thereby widening the path, and removing the tissue mass. Such devices and methods find use, for example, in biopsy and in lumpectomy procedures.

The present disclosure provides a brachytherapy apparatus that delivers a low dose, partial breast irradiation treatment for post-lumpectomy patients via introduction of a catheter-like device through a cannula. The apparatus may be introduced post-surgically with local anesthesia under image guidance into the previous excision site and into a cavity by a surgeon. The brachytherapy apparatus includes a seed containment device configured to contain a plurality of low-dose radioactive seeds therein. The seed containment device may be one or more thin-walled tubes. The apparatus is further configured to expand so that at least a portion of the seed containment device is positioned against the remaining tissue and the plurality of radioactive seeds are disposed at the perimeter of the seed containment device. Also described are various clamps for the apparatus, and sleeves for adjusting the size of the device to fit a cavity when the apparatus is in use.

A breast brachytherapy applicator providing a stable semi permanent / permanent in dwelling platform that is configured to replicate anatomically the excised cancer bed and allows for a more precise anatomically correct delivery of limited field radiation treatment. This device may be used to reconstitute a resected tissue space to its pre-operative size and shape to 1) facilitate the accurate and precise delivery of adjunctive breast brachytherapy following breast cancer surgery and 2) prevent / decrease post-operative deformity as a result of surgical resection, whether for benign or malignant disease, and in particular after radiation treatment of malignant disease in the post lumpectomy patient.

The invention discloses a method for designing and forming a stiffness-controllable bone tumor defect repair implant. The method comprises the following steps of acquiring and preprocessing image data; performing reverse image fusion and registration, and constructing an accurate curve surface materialized repair body model; carrying out parallel finite element analysis and optimization on a porous design scheme by a microscopic porous scheme design; and importing the model into a 3D printing system for printing forming. According to the method, a personalized porous structure, mechanical optimization design and 3D printing forming of a post-bone tumor excision defect area reconstruction repair body are realized in combination with digital modeling, finite element analysis and medical 3D printing technologies according to a symmetric characteristic of a human body structure morphology, so that the reconstruction effect of an individualized anatomic morphology and the design forming efficiency of the repair body are improved, the time and material costs are reduced, the mechanical properties and the bone integration microenvironment after reconstruction are better optimized, and the bone growth repair of a bone defect area is facilitated.

The invention relates to the field of radiation oncology, specifically the use of novel radio-opaque fiduciary markers which resist migration within tissues, which may be implanted in the body and imaged during radio-therapy to insure accurate treatment of target regions while avoiding irradiation of non-target regions. In one embodiment, the markers comprise oblong bodies from which a plurality of short tines protrude. Also provided are novel devices for implanting such markers. Additionally, the invention provides methods of delineating tumor resection beds and whole-bladder contours in the radiotherapeutic treatment of bladder cancer. Lastly, the invention encompasses novel methods of delivering fiduciary markers and other implants and materials by needle with sealing aids that increase the retention rate of the delivered markers, implants, or materials.

The invention relates to an anti-hematocele tumor resection device, and belongs to the technical field of medical apparatuses. The anti-hematocele tumor resection device comprises a resection device charging disinfection box, a resection device storage layer, a resection device disinfection layer, a resection device hematocele recovery device and an electric operation panel, wherein a push-pull rod nested catheter is arranged at the upper side of the resection device charging disinfection box, a conveying push-pull rod is arranged at the upper side of the push-pull rod nested catheter, an instrument charging box is arranged at the lower side of the resection device charging disinfection box, and a charging battery is arranged in the instrument charging box. The anti-hematocele tumor resection device has the advantages that the functions are complete, and the convenience in use is realized; when a tumor is resected by a medical staff, the operation is simple and convenient, the time and labor are saved, and the working difficulty of the medical staff is decreased.

The invention discloses a method for processing scalp positioning images of brain tumors, which comprises the following steps of: (1) preliminarily estimating a scalp projected area of a brain tumor of a patient, adhering two mark points which can be identified by an imaging device in the area, obtaining a two-dimensional medical image slice set from the imaging device, and reconstructing a three-dimensional profile of a scalp layer; (2) manually drawing a profile line of the tumor on a two-dimensional image, and reconstructing the surface of the tumor; (3) determining the positions of the two mark points on the two-dimensional image, and reconstructing the mark points; and (4) rotating a profile image of the reconstructed three-dimensional profile image to an appropriate position, and then printing the image in an equal proportion. Compared with the prior art, the method disclosed by the invention is implemented simply; and when the method is applied to the positioning of a brain tumor, the positioning precision meets the demands of tumor resection through a craniotomy, the shortening of operation time and the reduction of surgical traumas are facilitated, and the incision length can be minimized under the premise of guaranteeing good exposures.

The invention relates to a radionuclide-labelled biodegradable bioabsorbable biopolymer nano fibrous membrane, a preparation process and application thereof. The preparation process includes steps of firstly adopting the electrostatic spinning technique to prepare a biopolymer nano fibrous membrane consisting of biopolymer nano fibers with diameters ranging from 50nm to 5000nm, performing chemical modification on the surface of the biopolymer nano fibrous membrane, enabling the surface of the biopolymer nano fibrous membrane to be in coupling reaction with double-functional-group coupling agent, chelating the surface of the biopolymer nano fibrous membrane after coupling reaction in buffer solution of acetic acid-sodium acetate anhydrous containing radionuclide compounds, and finally obtaining the radionuclide-labelled biodegradable bioabsorbable biopolymer nano fibrous membrane, wherein the double-functional-group coupling agent which is combined with amino in biopolymer nano fibers via chemical bonds on the surface of the biopolymer nano fibrous membrane, the radionuclide is chelated and fixed on the surface of the biopolymer nano fibrous surface via the double-functional-group coupling agent. The radionuclide-labelled biodegradable bioabsorbable biopolymer nano fibrous membrane can be used as an oncotherapy material or a material for focal tissue portions after tumor resection operation.

The invention discloses an operation robot system for performing laser resection and refrigeration on tumor tissues. The operation robot system comprises a computer system, a cryogenic system and an operation robot system, wherein an operation mechanical arm of the operation robot system is controlled by a computer mainframe to move freely; a cryogenic transmission tube of the cryogenic generator, laser fibers of a laser and a tail end image detector electrically connected with the computer mainframe extend into multiple arm sections sequentially and respectively to reach the tail end of the operation mechanical arm; cryogenic fluid is communicated with the cryogenic generator by virtue of a cryogenic solenoid valve; the tail end image detector is used for receiving relevant images and transmitting the relevant images to the computer mainframe by virtue of a data transmission line, and simultaneously, the relevant images are displayed on a display screen; the computer mainframe controls an operation robot mainframe and orders the movement, refrigeration and resection work in different directions of the operation mechanical arm; and as a doctor controls the mechanical arm to implement a whole operation in a non contact way, the tumor tissues are subjected to refrigeration and resection simultaneously, and the whole process is visualized, the precision and digitalization of the tumor resection are ensured, the risk of tumor spread is low, and the mechanical trauma is small.

The present invention provides a tumor-targeted nuclear magnetic resonance / fluorescence dual-mode imaging contrast agent, preparation and applications thereof. According to the present invention, the contrast agent is nanometer micro-particles formed by self-assembling a nuclear magnetic resonance amphiphilic molecule, a near-infrared fluorescent dye amphiphilic molecule and a tumor targeting amphiphilic molecule in a solution, can stably exists under a physiological pH value condition, can be specifically accumulated at a tumor site in a targeting manner, can significantly enhance the intensity of the MRI signal and the near-infrared fluorescence signal at a tumor lesion site, can improve the specificity and the sensitivity of nuclear magnetic resonance imaging and near infrared fluorescence imaging scanning, and is expected to be adopted as the contrast agent for fluorescence guidance during tumor resection surgeries and postoperative nuclear magnetic resonance monitoring.

The present invention discloses that an intratumoral injection of: i) glycolipids with α-gal epitope; ii) gene vectors comprising an α1,3galactosyltransferase gene; or iii) a mixture of α1,3galactosyltransferase, neuraminidase, and uridine diphosphate galactose results in tumor regression and / or destruction. Binding of the natural anti-Gal antibody to de novo expressed tumoral α-gal epitopes induces inflammation resulting in an anti-Gal antibody mediated opsonization of tumor cells and their uptake by antigen presenting cells. These antigen presenting cells migrate to draining lymph nodes and activate tumor specific T cells thereby converting the treated tumor lesions into in situ autologous tumor vaccines. This therapy can be applied to patients with multiple lesions and in neo-adjuvant therapy to patients before tumor resection. In addition to the regression and / or destruction of the treated tumor, such a vaccine will help in the immune mediated destruction of micrometastases that are not detectable during the removal of the treated tumor.

The invention discloses a near-infrared window fluorescent imaging agent containing diazosulfide and a fluorene ring and a preparation method thereof. A modifiable group is introduced into the fluorene ring of the fluorescent compound, increased modifiable sites can be used for connection of different bioactive substances, water solubility and biological compatibility can be improved, and the application range in the biomedical field can be expanded. The fluorescent imaging agent has the advantages of high fluorescence intensity, no toxicity, good biocompatibility, and the like, and has excellent application prospects. The invention also discloses the application of the fluorescent imaging agent in the field of brain glioma, systemic angiography and sentinel lymph node dissection. In addition, the imaging agent has good modificability, and also can be used for in-vitro detection of various disease markers, in-vivo diagnosis and surgical navigation treatment of breast cancer, prostate cancer and colon cancer and other cancer, evaluation of curative effect after tumorectomy, and the like.

The invention discloses a photo-thermal chemotherapy bone repair material and a preparation method of a tissue engineering scaffold. The bone repair material includes an oil-soluble high-molecular material, bio-ceramic powder, an oily solvent, a water-soluble bioactive material, water, an emulsifier, a chemotherapy medicine, and a photo-thermal agent. The preparation method includes: according tothe bone repair material, preparing a W / O emulsion, and sending the W / O emulsion to an ink cartridge of a printer as printing ink; establishing a tissue engineering scaffold three-dimensional model onCAD software, setting printing parameters, regulating the temperature of a shaping chamber in the printer, and printing a tissue engineering scaffold prefabricated member, so that when solvent in theprefabricated member is volatilized naturally, a finish product of the tissue engineering scaffold is formed. The tissue engineering scaffold has good mechanical character, can simulate bone tissue structure, has excellent bone guidance and bone conduction and excellent photo-thermal effect and is toxic-free, and can promote recovery of massive bone defects caused by bone tumor resection.

The invention provides an additive-manufactured guiding positioning assembly for jawbone tumor resection and reconstruction. The additive-manufactured guiding positioning assembly sequentially comprises a first guiding positioner, a second guiding positioner and a third guiding positioner according to the jawbone tumor resection and reconstruction operation process; the first guiding positioner is fixed to the fibula and assists in fibular osteotomy shaping; the second guiding positioner is fixed to the sclerotin parts of the front side and the back side of a jawbone tumor and assists in jawbone tumor resection; the third guiding positioner is connected with the osteotomy part of the fibula and connected between the sclerotin parts of the front side and the back side of the position where the jawbone tumor is resected and assists in jawbone reconstruction by taking the osteotomy part of the fibula as grafted bone. By means of the additive-manufactured guiding positioning assembly, operations such as fibular osteotomy, jawbone tumor resection and jawbone reconstruction can be guided to be accurately implemented, operation is easy and convenient, the experience requirements for an operator are low, and the problem of surgical operation errors caused due to the fact that the operator operates by feel can be completely eradicated.

The invention belongs to the technical field of medical image three-dimensional reconstruction, in particular to a brain tumor medical image three-dimensional reconstruction display interaction methodand a system, comprising the following steps: acquiring a plurality of medical diacom images, preprocessing each medical diacom image to obtain a preprocessed image; According to the pre-processed images, the three-dimensional model of brain can be obtained by three-dimensional modeling. The brain tumor information was obtained by analyzing the three-dimensional brain model, and the brain tumor resection scheme was recommended according to the brain tumor information. According to the operation instruction, the tumor resection was simulated on the three-dimensional brain model, and the wholeoperation process was simulated by the doctor through the naked eye 3D display, and the operation was reminded according to the doctor's intraoperative operation. The invention constructs a three-dimensional model of the brain through the medical image of the brain tumor and simulates the operation, the human-computer interaction process is displayed through the naked eye 3D display, the sense ofvirtual reality is enhanced, and the analysis of the brain tumor is a scheme for the doctor to remove the tumor, thereby improving the diagnosis efficiency of the doctor.

The invention provides application of miR-1246 and / or TERF2IP in diagnosis and treatment of glioma. The fact that that microRNA-1246 (miR-1246) is the most abundant microRNA expressed in glioma-derived exosomes (GDEs) and is significantly up-regulated in anoxic glioma-derived exosomes (H-GDEs) is disclosed for the first time. In addition, the miR-1246 is also enriched with exosomes isolated from cerebrospinal fluid (CSF) of a patient with preoperative glioblastoma (GBM), and the exosomes miR-1246 in cerebrospinal fluid of the patient with GBM after tumor resection are significantly reduced. The MicroRNA-1246 is shown to have the strongest capability to induce polarization of M2 macrophages. In addition, studies find that H-GDEs-induced M2 macrophage polarization is mediated by the miR-1246 / TERF2IP / STAT3 and miR-1246 / TERF2IP / NF-kappa B pathways.

A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents mixed with Avastin at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, the medicating agent Avastin is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. In cases where a tumor resection is not performed, an intratumoral catheter will be implanted. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

The present invention discloses that an intratumoral injection of: i) glycolipids with α-gal epitope; ii) gene vectors comprising an α1,3galactosyltransferase gene; or iii) a mixture of α1,3galactosyltransferase, neuraminidase, and uridine diphosphate galactose results in tumor regression and / or destruction. Binding of the natural anti-Gal antibody to de novo expressed tumoral α-gal epitopes induces inflammation resulting in an anti-Gal antibody mediated opsonization of tumor cells and their uptake by antigen presenting cells. These antigen presenting cells migrate to draining lymph nodes and activate tumor specific T cells thereby converting the treated tumor lesions into in situ autologous tumor vaccines. This therapy can be applied to patients with multiple lesions and in neo-adjuvant therapy to patients before tumor resection. In addition to the regression and / or destruction of the treated tumor, such a vaccine will help in the immune mediated destruction of micrometastases that are not detectable during the removal of the treated tumor.

The invention discloses application of histatin 1 (Hst1) polypeptide in preparation of composite materials for promoting repair of large-area skin defects. The Hst1 polypeptide is found to have the characteristics of promoting cell adhesion and vascularization and inhibiting inflammatory response. The Hst1 polypeptide can be loaded on a variety of biological materials, and can be prepared into dressing, injection, ointment, powder, hydrogel, membranes, sponges, fiber scaffold materials and the like, which can effectively promote the healing of the large-area skin defects, by being compounded with bioactive composite materials, wherein large-area skin defects include traumas, burns, skin ulcer caused by tumor resection or diabetes, and the like. The Hst1 polypeptide provided by the invention is human-derived polypeptide, and has good biocompatibility and biosafety. When being used for the preparation of the composite materials for promoting the repair of the large-area skin defects, theHst1 polypeptide has an important medical value and a good industrialization prospect.

The present invention relates to an auxiliary evaluation system and method for prognosis and chemotherapy benefit of gastric cancer based on enhanced CT imaging omics. A system and method of that present invention include extracting 19 image texture and morphological characteristic data of gastric cancer focus areas on enhanced CT portal vein phase images of gastric cancer objects, calculating gastric cancer imaging omics score GC Rad-score of each object, and extracting the image texture and morphological characteristic data of the gastric cancer focus areas on the enhanced CT portal vein phase images of the gastric cancer objects. Score, according to the score, predicts the prognosis and chemotherapy benefit after tumor resection and provides credible predictive and analytical results for specific individuals. The system and method of the invention are based on GC Rad-score score can be used to evaluate the prognosis and chemotherapy benefit after gastric cancer surgery. The procedure is simple, intuitive and easy to repeat. The system and method of the invention can evaluate the postoperative prognosis and chemotherapy benefit of gastric cancer, and better assist doctors to formulate treatment and follow-up plan.