463 results about "Near infrared fluorescence" patented technology

An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.

According to one embodiment of the invention, a method for biomedical imaging includes directing time-varying excitation light at a surface area of a light scattering material, the material comprising a fluorescent target. Time-varying emission light from the fluorescent target is detected, substantially at a two-dimensional sensor surface, in response to the time-varying excitation light stimulating the fluorescent target. The time-varying emission light is filtered to reject excitation light re-emitted from the material. A three-dimensional image of the fluorescent target is generated based on the detection substantially at the sensor surface.

The invention relates to a mitochondrion-targeted heptamethine indocyanine dye, a preparation method and application. The mitochondrion-targeted heptamethine indocyanine dye is composed of a mitochondrion-targeted indoheptamethine chain and N-alkyl side chains of different lengths. The mitochondrion-targeted heptamethine indocyanine dye is multifunctional small organic molecules which are guided by near infrared fluorescence imaging to synchronously achieve the precise and efficient photothermal and photodynamic anti-tumor effect by taking a tumor mitochondrion as a target. The mitochondrion-targeted heptamethine indocyanine dye provides feasibility for thorough inhibition on tumor growth and prevention on drug resistance and relapse. A photosensitizer prepared from the mitochondrion-targeted heptamethine indocyanine dye better has the application and conversion prospect compared with an existing relying nanomaterail photosensitizer which is expensive and complex in preparation.

The invention belongs to the technical field of near infrared fluorescent nano materials, and particularly relates to a method for preparing Ag2S nanocrystalline with near infrared fluorescence using one-step aqueous phase process. The method includes: adding water-soluble sulfur source into silver ion solution, and using water-soluble sulfhydryl compound as stabilizer to prepare the water-soluble Ag2S nanocrystalline at one step under room temperature. The nanocrystalline prepared by the method has the advantages that size of the nanocrystalline can be controllably synthesized in a range of 0.5nm-10nm, particle size is uniform, controllable fluorescence emission of the nanocrystalline is fine, and emission peak positions can be controlled from a red region to a near infrared region (from 650nm to 900nm). Due to the fact that the water-soluble sulfhydryl compound is used as the stabilizer, environmental pollution is low, product purity is high, and fine optical property and water solubility are revealed. In addition, the method for preparing silver sulfide nanocrystalline with near infrared fluorescence is simple, mild in conditions, easy to operate, fine in repeatability and suitable for mass production.

This invention provides a novel bioimaging technique that can achieve a deep observation depth and a novel method for marking a lesion that allows clear recognition of the lesion from outside a living body. This invention also provides a bioimaging marker comprising a fluorescent material obtained by doping a ceramic with rare earths and the like and a bioimaging technique comprising detecting near-infrared fluorescence that can sufficiently penetrate a living body generated upon excitation of the marker with near-infrared excitation light.

The invention relates to a synthesis method and application of a novel high-selectivity and high-sensitivity near infrared fluorescence probe for visually detecting hydrogen polysulfide. The method comprises the steps of making benzopyran carbonitrile and p-hydroxy benzaldehyde react to obtain a precursor, and then conducting an esterification reaction with 2-fluoro-5-nitrobenzoic acid to obtain the fluorescence probe. The probe reacts with sodium polysulfide to generate a strengthened fluorescence change, which is that the fluorescence at the 682 nm is strengthened remarkably. Besides, a dynamic experiment result shows that the reaction time of the compound and hydrogen polysulfide is shorter than 5 min, and the interference rejection is strong. Thus, the pyran carbonitrile compound can serve as the application of the near infrared fluorescence probe for detecting hydrogen polysulfide.