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Preparation method of periplaneta americana active peptide

A technology of Periplaneta americana and active peptides, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, allergic diseases, etc., can solve the problems of waste of raw materials and human absorption and utilization, and achieve nutritional value and absorption and utilization as well as edible Improved safety, rigorous and reasonable process, enhanced immune effect

Inactive Publication Date: 2017-04-26
赵德润
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the waste of raw materials in the extraction process of the active substance of the American cockroach in the prior art and the shortcomings of the low absorption and utilization rate of the human body, the invention provides a preparation method of the active peptide of the American cockroach, which is rich in the active peptide of the American cockroach Bioactive peptides have pharmacological activities such as anti-tumor, immune enhancement, tissue repair, antibacterial, antiviral, cardiac boost, and microcirculation improvement, and are easy to digest and absorb, rich in nutrients and high in body utilization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0015] Example 1. 1. Preparation of Periplaneta americana Active Peptide Liquid: Select 15 kg of Periplaneta americana that was dried and pulverized, put it into a cooking pot, add water 10 times its weight and boil for 40 minutes, let it cool and remove the fat from the upper layer. Collect and discard, then crush the cooked Periplaneta americana pulp through a tissue crusher to obtain a dry product homogenate of Periplaneta americana; select 30 kg of clean and fresh Periplaneta americana adults and scald them to death with boiling water, add 5 times its weight in water and pass through the tissue Break the homogenate with a crusher, then put it into a cooking pot and cook for 30 minutes, let it cool, collect and discard the fat in the upper layer, and obtain the fresh product homogenate of Periplaneta americana;

[0016] 2. Adjust the homogenate of Periplaneta americana treated in step 1 to PH7, add trypsin, papain, and flavor protease for multi-enzyme hydrolysis, the enzyme ...

Embodiment 2

[0021] Example 2. 1. Preparation of Periplaneta americana Active Peptide Liquid: Select 20 kg of Periplaneta americana that was dried and pulverized, put into a cooking pot, add 12 times its weight in water and boil for 50 minutes, let it cool and remove the fat from the upper layer Collect and discard, then crush the cooked Periplaneta americana slurry through a tissue crusher to obtain a dry product homogenate of Periplaneta americana; select 25 kg of clean and fresh Periplaneta americana adults and scald them to death with boiling water, add 6 times its weight in water and pass through the tissue Break the homogenate with a crusher, then put it into a cooking pot and cook for 40 minutes, let it stand to cool, collect and discard the fat in the upper layer, and obtain the fresh product homogenate of Periplaneta americana;

[0022] 2. Adjust the homogenate of Periplaneta americana treated in step 1 to pH 6.5, add trypsin, compound protease, and papain for multi-enzyme hydrolys...

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Abstract

The invention relates to the technical field of traditional Chinese medicine and biology, in particular to a method for preparation of periplaneta americana active peptide from periplaneta Americana. The method includes: selecting dried and fresh imagoes of periplaneta americana as the raw materials, conducting crushing homogenizing, enzymolysis, fishy smell removal, enzyme inactivation, centrifugation, sterilization and ultrafiltration, then according to oral solution production practices, performing filling to obtain oral solution dosage forms; making dry powder according to spray drying or freeze drying production process practices, and performing filling to obtain capsule dosage form and bottled freeze-dried powder dosage form. The nutritional value, the absorption and utilization rate and food safety are greatly improved. Also the periplaneta americana active peptide has anti-tumor, immunity enhancing, tissue repair, antibacterial, antiviral, heart strengthening and pressure boosting, microcirculation improving and other pharmacological activities. The preparation method of the periplaneta americana active peptide has the characteristics of rigorous and reasonable process and strong operability, and is easy for realizing industrial production.

Description

technical field [0001] The invention relates to the fields of traditional Chinese medicine and biotechnology. In particular, it is a method for preparing active peptides of Periplaneta americana by using Periplaneta americana. Background technique [0002] The American cockroach is the most widely distributed and the oldest, most primitive and most adaptable winged insect in the world. Traditional Chinese medicine believes that it has the effects of promoting blood circulation and dispelling blood stasis, detoxifying and eliminating malnutrition, diuresis and reducing swelling; modern pharmacological research is also more in-depth. It has been reported that the extract of Periplaneta americana has the effect of alleviating malignant tumors, and it has also been proved to have a strong anti-inflammatory effect. Repair ability, can be used to treat burns, ulcers, etc. In addition, the study of Periplaneta americana extract in anti-cardiovascular and cerebrovascular sclerosis...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K9/08A61K9/48A61P35/00A61P37/04A61P17/02A61P43/00A61P31/04A61P31/12A61P9/12A61P9/14A61K9/19A61K35/64
CPCA61K38/012A61K9/0095A61K9/19A61K9/4808A61K35/63
Inventor 赵德润
Owner 赵德润
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