116 results about "Dimethyl fumarate" patented technology

The invention provides compositions and methods for treating autoimmune diseases such as multiple sclerosis. The compositions include a combination of an NMDA Receptor antagonist, such as memantine or rimantadine, and a fumarate agent, such as dimethyl fumarate.

Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain NF-kappaB inhibitors, particularly certain dialkyl fumarates, are disclosed. Dimethyl fumarate is a particularly preferred dialkyl fumarate. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the dialkyl fumarate with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-dialkyl fumarate blends are disclosed. Additionally, medical devices having a coating comprising at least one dialkyl fumarate in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.

Provided herein are compositions containing compounds, or pharmaceutically acceptable salts, that metabolize to monomethyl fumarate with certain pharmacokinetic parameters and methods for treating, prophylaxis, or amelioration of neurodegenerative diseases including multiple sclerosis using such compositions in a subject, wherein if the compositions contain dimethyl fumarate, the total amount of dimethyl fumarate in the compositions ranges from about 43% w/w to about 95% w/w.

The invention discloses a continuous production process for dimethyl fumarate. The process comprises the following steps of: uniformly filling a strong acid cation exchange resin catalyst into a reaction cylinder, and heating at the temperature of between 60 and 100 DEG C; adding fumaric acid and a methanol solution which serve as reaction raw materials into the reaction cylinder from an inlet of the fixed reaction cylinder, regulating the flow velocity of a flow pump to ensure that the raw materials are kept in the reaction cylinder for 4 to 8 hours, and collecting a reaction product at an outlet; introducing the reaction product into cold water, stirring, and crystallizing a large number of white crystals; filtering, and washing a filter cake by using 8 to 10 percent Na2CO3; and filtering again, washing the filter cake to be neutral by using distilled water, drying at room temperature, and thus obtaining the dimethyl fumarate. In the process, strong acid cation exchange resin is utilized, does not corrode reaction equipment and pollute the environment, can be repeatedly used and is a good environment-friendly catalyst. The catalyst is fixed in the reaction cylinder; the materials are continuously fed and discharged, so that the continuous operation of the reaction can be realized; and the process has simple reaction conditions and makes the operation convenient.

The invention discloses a method for preparing fumaric dimethyl ester (DMF). The method comprises the steps of taking maleic anhydride as raw material and subjecting the raw material and methanol to catalytic reaction in the presence of a solid-acid SO4/Al2O3 catalyst so as to obtain the fumaric dimethyl ester, namely a target product of the invention. The purity of the fumaric dimethyl ester obtained by the preparation method is up to over 98.5 percent, and the yield of the fumaric dimethyl ester is between 85 and 95 percent. Compared with the prior art, the method has the advantages that the method adopts the solid-acid SO4/Al2O3 catalyst, is safe and convenient in operation, improves environment, reduces corrosion on equipment, can cyclically recycle reaction solvent and the solid-acid catalyst, reduces the three wastes, ensures stable product quality, and is suitable for industrial production.

The invention discloses high-density dimethyl fumarate enteric-coated granules and a preparation method thereof. The density of the high-density dimethyl fumarate enteric-coated granules is 1.0g/mL or higher, or is 1.3g/mL or higher, or is 1.6g/mL or higher. Preparation size of the high-density dimethyl fumarate enteric-coated granules is small; the high-density dimethyl fumarate enteric-coated granules are convenient for administration, and are especially suitable for patients, elders, and children with swallowing difficulty, and are capable of increasing patient compliance; preparation content uniformity is high; rapid release is realized; stability is high; and the preparation method is simple, and is suitable for industrialized production.

The present invention discloses a special cherry preservative which is composed of the following components (parts by weight): 22 parts of tea leaves, 23 parts of propolis, 22 parts of dried tangerine peels, 9 parts of chitosans, 20 parts of lotus leaves, 4 parts of butylated hydroxy anisole, 6 parts of benzoic acids, 7 parts of propyl gallate, 7 parts of vitamin E, 8 parts of vanilla amide, 11 parts of rosemary, 10 parts of salvia japonica, 9 parts of sorbitols, 10 parts of maltitols, 4 parts of xylitols, 18 parts of sesame oil, 20 parts of rice bran oil, 3 parts of cephalins, 3 parts of polylysines, 3 parts of cinnamic acids, 3 parts of beta-cyclodextrins, 2 parts of sodium diacetate, 2 parts of sorbic acid, 6 parts of glycerol monocaprylate and 5 parts of dimethyl fumarate. The special cherry preservative can effectively reduce adhesive rate of the preservative to achieve lower residues, at the same time the toxicity of the preservative is much lower than the existing commercial products, and thus the preservative is suitable for the need of a large-scale industrial production.

The present invention discloses a special onion preservative which is composed of the following materials (parts by weight): 22 parts of tea leaves, 23 parts of propolis, 22 parts of dried tangerine peels, 19 parts of konjac, 19 parts of forsythia suspensa, 9 parts of chitosans, 20 parts of lotus leaves, 4 parts of butylated hydroxy anisole, 7 parts of vitamin E, 8 parts of vanilla amide, 11 parts of rosemary, 10 parts of salvia japonica, 9 parts of sorbitols, 10 parts of maltitols, 4 parts of xylitols, 18 parts of sesame oil, 20 parts of rice bran oil, 3 parts of cephalins, 3 parts of polylysines, 3 parts of cinnamic acids, 3 parts of beta-cyclodextrins, 2 parts of sodium diacetate, 2 parts of sorbic acid, 6 parts of glycerol monocaprylate and 5 parts of dimethyl fumarate. The special onion preservative can effectively reduce adhesive rate of the preservative to achieve lower residues, at the same time the toxicity of the preservative is much lower than the existing commercial products, and thus the preservative is suitable for the need of a large-scale industrial production.

The invention discloses a special antistaling agent for litchi. The special antistaling agent comprises the following components by weight: 22 parts of tea leaf, 23 parts of propolis, 19 parts of fructus forsythia, 9 parts of chitosan, 20 parts of lotus leaf, 4 parts of butylated hydroxyanisole, 6 parts of benzoic acid, 7 parts of propyl gallate, 7 parts of vitamin E, 8 parts of vanilla amide, 11 parts of rosemary, 10 parts of sage, 9 parts of sorbitol, 10 parts of maltitol, 4 parts of xylitol, 18 parts of sesame oil, 20 parts of rice bran oil, 3 parts of cephalin, 3 parts of polylysine, 3 parts of cinnamic acid, 3 parts of beta-cyclodextrin, 2 parts of sodium diacetate, 2 parts of sorbic acid, 6 parts of mono-caprylin glycerate and 5 parts of dimethyl fumarate. The special antistaling agent for litchi provided by the invention has the beneficial effects of capability of effectively reducing the adhesive rate of the antistaling agent, low residue, much lower toxicity compared with conventional commercial products and capacity of meeting the need of large-scale industrial production.

The invention provides cinnabar coloring paint which is good in adhesion. After a cinnabar painting is colored, the paint can be well attached to the surface of the cinnabar painting and not prone to peeling off. Meanwhile, cured high-aluminum powder, modified nanowhisker materials, dimethyl fumarate, polyurethane resin, polytetrafluoroethylene, zinc stearate, dibutyl phthalate, silicone macromonomer and a white oil component are added. Adhesion of the cinnabar coloring paint is guaranteed, meanwhile, gaps between all colored substances of the cinnabar coloring paint are small, the outer surface of the colored part of the cinnabar painting forms a smooth curved face, and the cinnabar painting looks natural.

The present invention relates to pharmaceutical compositions containing dimethyl fumarate (DMF), More specifically, the present invention relates to a pharmaceutical composition for oral use in treating hyperproliferative, inflammatory or autoimmune disorders by administering a low daily dosage in the range of 410 mg±5% or 400 mg±5% dimethyl fumarate, wherein the pharmaceutical formulation is in the form of an erosion matrix tablet.

A compound specified by formula (I), in particular dimethylfumarate (trans-1,2-ethylenedicarboxylic acid dimethyl ester) is provided for use in prevention or therapy of gout, acne, pyoderma gangrenosum, Vitiligo, cardiovascular disease, metabolic syndrome, diabetes and/or complications of diabetes. Also provided are a dosage form comprising said compound and a method of treatment comprising administration of said compound to a patient in need thereof.