The invention discloses dendrobium nobile skin regeneration promotion combination essence which is prepared from, by weight parts, 15-25 parts of dendrobium candidum extract, 10-20 parts of spiral snail secretion, 3-6 parts of glycosylglycerol, 5-10 parts of centella asiatica extract, 3-5 parts of gingko extract, 3-6 parts of persimmon leaf extract, 10-15 parts of placenta extract, 3-7 parts of salmon ovarian peptide, 5-10 parts of nostoc sphaeroids kutz ferment powder, 2-3 parts of glycerin, 0.05-0.1 part of hyaluronic acid, 1.5-2.5 parts of water soluble chitosan, 30-40 parts of deionized water, 5-10 parts of ginseng and 5-10 parts of astragalus. Through synergistic effects of the spiral snail secretion, the placenta extract, the salmon ovarian peptide and the home-made dendrobium candidum extract, the essence has remarkable functions of promoting rebirth of cells and restoring and reconstructing tissues; and due to the reasonable adding of the nostoc sphaeroids kutz ferment powder and the like, the dendrobium nobile skin regeneration promotion combination essence has good functions of moisture preservation, anti-aging and restoration.