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84results about How to "Timely genetic diagnosis" patented technology

Application of CFAP20 gene in diagnosis of osteoporosis

The invention discloses an application of a CFAP20 gene as a molecular marker in early diagnosis of osteoporosis. The invention researches the differential expression genes in patients with osteoporosis by using high flux sequencing and QPCR experiments. The research findings of the invention show that whether a subject suffers from osteoporosis can be judged through detecting the condition of CFAP20 gene expression in blood, and the detection method can be used for early diagnosis of osteoporosis and has the characteristics of timeliness and accuracy.
Owner:TAISHAN MEDICAL UNIV

Acute myocardial infarction early diagnosis marker

The invention discloses a DSG3 gene as a molecular marker for early diagnosis of acute myocardial infarction. By utilization of a gene chip and a QPCR method, the situation is discovered that expressions of the DSG3 gene in blood of normal persons and patients with acute myocardial infarction show significant difference, and whether a subject suffers from acute myocardial infarction can be determined through detection of the expression situation of the DSG3 gene in blood. A kit for diagnosis of acute myocardial infarction is developed according to correlation. Diagnosis of acute myocardial infarction is carried out through detection of expression of the DSG3 by utilization of the kit. The diagnostic kit can be used for early diagnosis of diseases, and has wide application prospects in clinic.
Owner:TIANJIN PEOPLE HOSPITAL

Novel application of BPIFB1 to preparing tongue squamous cell carcinoma diagnosis and treatment preparations

The invention discloses a gene BPIFB1 and an expression product thereof. The gene BPIFB1 is a molecular marker for tongue squamous cell carcinoma early diagnosis. The gene BPIFB1 and the expression product have the advantages that as proved by QPCR (quantitative polymerase chain reaction), the gene BPIFB1 can be differently expressed in tongue squamous cell carcinoma tissues and para-carcinoma tissues and can be used as an indicator for tongue squamous cell carcinoma early diagnosis; the gene BPIFB1 and the expression product can be used as targets for treating tongue squamous cell carcinoma and can be used for guiding research and development of new medicines.
Owner:XIANGYA STOMATOLOGICAL HOSPITAL CENT SOUTH UNIV

Molecular marker for osteoporosis and application of marker

The invention discloses an LYPD3 gene and an expression product thereof both of which can serve as molecular markers for diagnosing osteoporosis. According to the LYPD3 and the expression product disclosed by the invention, a QPCR (quantitative polymerase chain reaction) experiment and a Western blot experiment provide that the LYPD3 gene has expression difference in blood or bone tissues of a normal person and an osteoporosis patient and can be used as an index for early diagnosis of the osteoporosis. In addition, the invention also discloses the LYPD3 gene and the expression product thereof both of which can serve as targets for diagnosing the osteoporosis and be used for guiding the research and development of novel medicaments.
Owner:GUAN BOJIAN BIOTECH CO LTD

PLAC1 (placenta-specific 1) genes serving as diagnosis target of osteoarthritis

The invention discloses PLAC1 (placenta-specific 1) genes which can serve as a molecular marker for early diagnosis of osteoarthritis. Expressions of the PLAC1 genes in synovial tissue of a normal person and a patient suffering from osteoarthritis prove to be different in terms of the transcriptional level and the protein level, and accordingly, the disease risk and the disease state of a subject can be judged according to the identified expression level of the PLAC1 genes. Additionally, experiments prove that interference to expression of the PLAC1 genes or inhibition on the function of PLAC protein can inhibit proliferation of synovial cells, and a new target is provided for development of medicines for treating osteoarthritis clinically.
Owner:BEIJING MEDINTELL BIOMED CO LTD

MTUSI gene serving as osterarthritis diagnosis target

The invention discloses an osterarthritis diagnosis marker which refers to MTUSI gene and expression products thereof. According to gene chip and protein immunization tests, expressions of the MTUSI gene and expression products thereof are lowered in blood and bone tissue of osterarthritis patients as compared with those of the normal; thus, products for diagnosis of osterarthritis can be developed and can be applied to testing expression level of the MTUSI gene or expression products thereof. According to experiment in vitro, bone cell proliferation can be improved by over-expression of the MTUSI gene, and accordingly the MTUSI gene and the expression products thereof can be applied to development of medicines for treating osterarthritis.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Application of EPB41L4B gene in diagnosis and treatment of Parkinson disease

The invention discloses application of an EPB41L4B gene in diagnosis and treatment of a Parkinson disease. It is proved by experiments that compared with a normal person, expression of the EPB41L4B gene in the blood of a Parkinson disease patient is up-regulated, and it is shown that whether a subject suffers from the Parkinson disease or not can be diagnosed according to the expression level of EPB41L4B in the blood. According to the research results of the application of the EPB41L4B gene in the diagnosis and treatment of the Parkinson disease, the EPB41L4B can further be used for preparing a drug for treating the Parkinson disease. According to the application of the EPB41L4B gene in the diagnosis and treatment of the Parkinson disease, the sensibility and the specificity of Parkinson disease diagnosis are greatly improved, and meanwhile a new target is provided for gene treatment of the Parkinson disease.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

CERS2 (ceramide synthase 2) gene and its expression product serving as treatment target of osteoporosis

The invention discloses a CERS2 (ceramide synthase 2) gene and its expression product serving as a molecular marker for treating osteoporosis. Judgment may be given to whether a patient with osteoporosis or a treatment subject has the risk of suffering from osteoporosis, by detecting CERS2 gene and its expression product contents of bone tissues. The study on proliferation of osteoblasts cultured in vitro discovers that the expression inhibition of the CERS2 gene may promote the proliferation of the osteoblasts and that the proliferation of the osteoblasts may also be promoted by inhibiting the function of CERS2 proteins, and results of the study show that the CERS2 gene and its expression product are potential drug targets for treating osteoporosis.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Molecular marker for diagnosis and treatment of osteoporosis

The invention discloses a molecular marker for diagnosis and treatment of osteoporosis, wherein the marker for diagnosis and treatment of osteoporosis is KPNA3 gene and expression products thereof. The high-throughput sequencing and QPCR method show that the KPNA3 gene and expression products thereof have differences in expression in bone tissues between normal people and patients with osteoporosis, and according to the correlation between the expression differences, the KPNA3 gene and expression products thereof can be used for serving as the molecular marker for diagnosis and treatment of osteoporosis. In addition, in vivo experiments show that over-expression of the KPNA3 gene can promote the proliferation of bone cells, therefore the KPNA3 gene and the expression products thereof can also be used for development of drugs for treating osteoporosis.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Molecular marker for nasopharynx cancer diagnosis and treatment

The invention discloses a molecular marker, namely an SMPD3 gene and an expression product thereof which are used for early diagnosis of nasopharynx cancer. QPCR and Western blot methods prove that the expressions of the SMPD3 gene in a nasopharynx cancer patient and a normal person are different, which can be used as an index for early diagnosis of nasopharynx cancer. In addition, the invention further discloses the expression product of the SMPD3 gene, and the expression product can be used as a therapeutic target of nasopharynx cancer for guiding the development of new medicines.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Alzheimer disease diagnosis and treatment marker and application thereof

The invention discloses an application of COPG1 gene in early diagnosis and treatment of Alzheimer disease, belonging to the technical field of new application of genes. Experiments prove that the expression of COPG1 gene in the blood of Alzheimer disease patients is reduced in comparison with normal people, indicating that the expression level of COPG1 gene in the blood of a subject can be measured to judge whether the subject suffers the Alzheimer disease. In the invention, A beta neurotoxicity experiments indicate that overexpression of COPG1 gene can effectively inhibit the neurotoxicity of A beta mediation. Therefore, the COPG1 gene can be used for preparing a medicine for treating or preventing Alzheimer disease and has a good prospect in development and application.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Application of ALKBH2 gene to diagnosis of cerebral ischemic stroke

The invention discloses application of ALKBH2 gene to diagnosis of cerebral ischemic stroke. The ALKBH2 gene has low expression in cerebral ischemic stroke, and whether a patient has cerebral ischemic stroke or has a possibility of suffering from cerebral ischemic stroke or not can be judged by detecting the expression level of the ALKBH2 gene. According to the application of ALKBH2 gene to diagnosis of cerebral ischemic stroke, provided by the invention, the diagnostic sensitivity and specificity of cerebral ischemic stroke can be greatly improved, and an early diagnosis means of cerebral ischemic stroke is further provided.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Diagnosis and treatment target of degenerative disc disease

The invention discloses a diagnosis and treatment target TULP2 gene of a degenerative disc disease. Whether a subject has the degenerative disc disease or not can be judged or whether the subject has the risk of the degenerative disc disease or not can be diagnosed by detecting the content of TULP 2 gene and an expression product thereof in intervertebral disc tissues of the subject. In addition, the TULP2 gene is proved to be used as a drug target for treating the degenerative disc disease by researching growth, senility and apoptosis indexes of the in-vitro cultured nucleus pulposus cells.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Intervertebral disc degenerative change diagnosis and treatment marker

The invention discloses a gene TMED2 which can serve as a molecular marker for diagnosing the intervertebral disc degenerative change. Experiments prove that in comparison with a normal person, the expression quantity of the gene TMED2 in intervertebral disc degenerative change patients is large. The invention further discloses the gene TMED2 which can be used for preparing a drug for treating the intervertebral disc degenerative change. Apoptosis experiments prove that overexpression of the gene TMED2 can promote nucleus pulposus cell apoptosis. The research result provides a new intervertebral disc degenerative change clinic diagnosis method and provides a drug new target for treating the intervertebral disc degenerative change.
Owner:GUAN BOJIAN BIOTECH CO LTD

Esophageal cancer markers

The invention discloses a molecular marker for diagnosis and treatment of esophagus cancer. A PCP4L1 gene can serve as the molecular marker. Whether a subject suffers from the esophagus cancer or has the esophagus cancer risks or not can be judged through detection of content of the PCP4L1 gene in esophagus tissues. Overexpressed PCP4L1 gene expression capable of inhibiting esophagus cancer cell proliferation is discovered through studies on proliferation conditions of esophagus cancer cells cultured in vitro, and study results show that the PCP4L1 gene is a potential drug target for treating the esophagus cancer.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

NUDT11 genes and expression products thereof serving as diagnosis targets of UL (uterine leiomyoma)

The invention discloses NUDT11 genes and expression products thereof serving as molecular markers for diagnosis of UL (uterine leiomyoma). Whether a subject suffers from UL can be judged and whether the subject has the risk of suffering from UL can be diagnosed by detecting the content of the NUDT11 genes and the expression products thereof in tissue. Researches on proliferation conditions of UL cells cultured in vitro show that expression inhibition of the NUDT11 genes can inhibit UL cell proliferation, proliferation of the UL cells can be inhibited by inhibiting the function of NUDT11 protein, and research results show that the NUDT11 genes and the expression products thereof are potential medicine targets for treatment of UL.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Gene combination for distinguishing non-invasive and invasive non-functional pituitary adenomas

The invention discloses a gene combination for distinguishing non-invasive and invasive non-functional pituitary adenomas. The gene combination consists of the following genes of INSM1, Jun, JunB, RHOU, RHOB, EZR, LLGL2, SNX33, SPIRE2, MLF1, HSPA2, CDKN1A, ERN1, NR2F2, GAS2, CDK6, SFRP1, EMILIN2, CD9 and SEMA7A. By detecting the expression level of the gene combination, the non-invasive and invasive non-functional pituitary adenomas can be distinguished.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI +1

Application of ARHGAP26 gene to preparation of Parkinson diagnostic tool

The invention discloses an ARHGAP26 gene capable of being taken as a molecular marker for early diagnosis of a Parkinson's disease. The invention discovers that significant differences exist in the expressions of the ARHGAP26 gene in blood of an average person and a patient with the Parkinson's disease by utilizing a gene chip and a QPCR method, that is, whether a subject suffers from the Parkinson's disease or not can be judged by detecting the expression situation of the ARHGAP26 gene in the blood. According to the correlation between the both, the invention develops a kit for diagnosing theParkinson's disease, the kit is used for the diagnosis of the Parkinson's disease by detecting the expression of the ARHGAP26 gene. The diagnostic kit developed by the invention can be used for earlydiagnosis on diseases and has a wide application prospect clinically.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Application of CLEC1B (C-type lectin domain family 1 member B) genes on diagnosis and treatment of bile duct carcinoma

The invention discloses application of CLEC1B (C-type lectin domain family 1 member B) genes on diagnosis and treatment of bile duct carcinoma. RNA (ribonucleic acid)-sep screening is carried out, and a large sample RT-PCR (reverse transcription-polymerase chain reaction) proves that CLEC1B gene expression abnormality is related to initiation and development of the bile duct carcinoma. According to a research result, CLEC1B can also be used for preparing medicines for treating the bile duct carcinoma. By the application of the CLEC1B genes on diagnosis and treatment of the bile duct carcinoma, sensitivity and specificity of diagnosis of the bile duct carcinoma are greatly improved, and a new target spot is provided for gene therapy of the bile duct carcinoma.
Owner:BEIJING MEDINTELL BIOMED CO LTD

Diagnosis and treatment markers for hysteromyoma

The invention discloses GPSM2 genes which can be used as the molecular markers of the early diagnosis of hysteromyoma. Experiments prove that the GPSM2 gene expression in hysteromyoma tissue is increased evidently as compared with that of normal muscular layer tissue. RNA interference experiments prove that the GPSM2 can affect the proliferation of hysteromyoma cells. Medicine capable of inhibiting the GPSM2 gene expression can be developed, and clinical prevention and treatment of the hysteromyoma can be achieved.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Application of DACT2 gene in preparation of product for diagnosis and treatment of atrial fibrillation

ActiveCN110305950AAchieve early diagnosisReduce the probability of cardiovascular and cerebrovascular eventsMicrobiological testing/measurementDisease diagnosisMortality rateCardiac muscle
The invention discloses an application of DACT2 gene in preparation of a product for diagnosis and treatment of atrial fibrillation. The application finds for the first time that DACT2 gene expressionis associated with atrial fibrillation, by detecting the expression of DACT2 in the myocardial tissue of a subject, the subject can be judged whether the subject has atrial fibrillation or not, or whether the subject is at risk of having atrial fibrillation or not, so that a clinician can be instructed to provide the subject with a prophylactic scheme or a treatment scheme. The invention discovers a new molecular marker of atrial fibrillation-DACT2 gene, which is more timely, more specific and more sensitive than traditional detection methods, early diagnosis of atrial fibrillation can be achieved, and the mortality of atrial fibrillation is reduced.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV

Application of PZP gene in diagnosis and treatment of biliary duct cancer

The invention discloses application of a PZP gene in diagnosis and treatment of a biliary duct cancer. The PZP gene is low-expressed in tissue of a biliary duct cancer patient, and growth and invasion of biliary duct cancer cells can be restrained by increasing expression of PZP. According to the application of the PZP gene in the diagnosis and treatment of the biliary duct cancer, the sensibility and the specificity of biliary duct cancer diagnosis are greatly improved, and meanwhile a new target site is provided for gene treatment of the biliary duct cancer.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Application of C21orf62 gene in liver cancer diagnosis

The invention discloses application of a C21orf62 gene in liver cancer diagnosis. The C21orf62 gene is in low expression in tissues of a liver cancer patient, through detecting the expression level of the C21orf62 gene, whether a patient suffers from liver cancer can be diagnosed, and through the application of the C21orf62 gene in liver cancer diagnosis, sensitivity and specificity of liver cancer diagnosis are greatly improved.
Owner:陈娟 +1

Application of KHDC1L gene serving as disease diagnosis marker

The invention discloses that a KHDC1L gene and KHDC1L protein can be served as molecular markers of osteoarthritis diagnosis. The invention uses tests to prove that: compared with a normal person, the expression quantity of the KHDC1L gene and the KHDC1L protein in the synovial tissues of a patient with osteoarthritis is high, and the difference has statistical significance. The invention also discloses that the KHDC1L gene and the KHDC1L protein can be used for preparing the medicine for curing osteoarthritis, and a cell proliferation test proves that by disturbing the KHDC1L gene or inhibiting the activity of the KHDC1L protein, synoviocyte proliferation can be inhibited. The research result of the invention provides a new bone and arthrosis clinical diagnosis method, and simultaneously provides a medicine new target for curing bone and arthrosis.
Owner:GUAN BOJIAN BIOTECH CO LTD

Application of gene SHISA4 as intervertebral disc degenerative change diagnosis and treatment marker

The invention discloses a gene SHISA4 and an expression product thereof. The gene SHISA4 can serve as a molecular marker for diagnosing and treating the intervertebral disc degenerative change. By detecting the gene SHISA4 and the expression product thereof in intervertebral disc tissue of a subject, whether the subject gets the intervertebral disc degenerative change or not is judged or whether the risk of getting the intervertebral disc degenerative change exists or not in the subject is diagnosed. By studying growth, senium and apoptosis indexes of nucleus pulposus cells cultured in vitro, it is proved that the gene SHISA4 serves as a drug target for treating the intervertebral disc degenerative change.
Owner:BEIJING MEDINTELL BIOMED CO LTD

SENP3 gene and use of its expression product as diagnosis and treatment target for esophageal cancer

The invention discloses SENP3 gene and use of its expression product as diagnosis and treatment target for esophageal cancer. Whether a subject has esophageal cancer can be determined or whether a subject is under risk of having esophageal cancer can be diagnosed by detecting the contents of SENP3 gene and its expression product in tissues. By studying proliferation of esophageal cancer cells cultured in vitro, it is discovered that expression inhibition for SENP3 gene may inhibit the proliferation of esophageal cancer cells, and by inhibiting functionality of SENP3 protein, it is also possible to inhibit the proliferation of esophageal cancer cells; results of this study show that SENP3 and its expression product are a potential drug target to treat esophageal cancer.
Owner:FOURTH HOSPITAL OF HEBEI MEDICAL UNIV

Application of product for detecting CALN1 gene expression in diagnosis of cholangiocarcinoma

The invention discloses CALN1 genes and an expression product thereof used as a molecular marker for the early diagnosis of cholangiocarcinoma. By utilizing RNA-sep screening and by virtue of large-sample RT-PCR verification, the abnormality of the CALN1 gene is associated to the occurrence and development of cholangiocarcinoma. According to a research result of the invention, a drug capable of improving the CALN1 gene expression level in cholangiocarcinoma tissues can be researched and developed, so that the cholangiocarcinoma can be clinically prevented and treated.
Owner:QINGDAO MEDINTELL BIOMEDICAL CO LTD

Application of TEX19 gene in diagnosis and treatment of biliary duct cancer

The invention discloses a TEX19 gene and an expression product of the TEX19 gene serving as a molecular marker in early diagnosis of biliary duct cancer. In the invention, RNA-sep is used for screening, large-sample RT-PCR is used for verification, and TEX19 gene expression abnormity is related to generation and development of biliary duct cancer. According to the search achievements, a drug capable of inhibiting TEX19 gene expression in biliary duct tissue or inhibiting TEX19 gene from expressing product functions can be searched, thus realizing prevention and treatment of biliary duct cancer on clinic.
Owner:BEIJING MEDINTELL BIOMED CO LTD

Gene marker RGL4 of sepsis

The invention discloses a gene marker RGL4 of sepsis. The expression of the RGL4 gene in sepsis is up-regulated, so that early diagnosis can be provided for a patient with sepsis by detecting the expression level of the RGL4 gene, and early treatment and reduction of the case-fatality rate of the patient with sepsis are expected to be realized.
Owner:BEIJING MEDINTELL BIOMED CO LTD

Early diagnosis marker for hypertensive intracerebral hemorrhage

The invention discloses application of a SETD6 gene for diagnosing hypertensive intracerebral hemorrhage. The SETD6 gene transcription level in blood of a patient suffering from hypertensive intracerebral hemorrhage has remarkable difference with that of a normal person, and according to the difference, the patient suffering from hypertensive intracerebral hemorrhage and the normal person can be distinguished. The invention further discloses a diagnosis product for hypertensive intracerebral hemorrhage. The diagnosis product can achieve diagnosis of hypertensive intracerebral hemorrhage by detecting the SETD6 gene in blood.
Owner:中国人民解放军联勤保障部队第九八0医院
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