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Esophageal tissue and/or organoid compositions and methods of making same

A technology of esophagus and organs, applied in biochemical equipment and methods, drug combination, tissue culture, etc., can solve difficult mouse modeling problems

Pending Publication Date: 2020-08-21
CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tracheal and esophageal disorders are prevalent in humans and difficult to accurately model in mice

Method used

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  • Esophageal tissue and/or organoid compositions and methods of making same
  • Esophageal tissue and/or organoid compositions and methods of making same
  • Esophageal tissue and/or organoid compositions and methods of making same

Examples

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Embodiment

[0086] The following non-limiting examples are provided to further illustrate embodiments of the invention disclosed herein. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent approaches that have been found to function well in the practice of the invention, and thus can be considered to constitute examples of modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.

[0087] Wnt and retinoic acid signaling control anterior versus posterior foregut fate

[0088] To generate foregut derivatives, hPSCs were first induced into DE as previously described (Fig. 1), followed by three-dimensional (3D) SOX2-expressing foregut spheroids (D'Amour et al., 2005; Dye et al., 2016); M...

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Abstract

The instant disclosure relates to methods for converting mammalian definitive endoderm (DE) cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the disclosure relates to formation of esophageal tissue and / or organoids formed from differentiated definitive endoderm.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to and benefit of US Provisional Application 62 / 570,182 to James Wells, filed October 10, 2017, the contents of which are incorporated in their entirety for all purposes. [0003] Statement Regarding Federally Funded Research [0004] This invention was made with US Government support under NIH Grant No. P01HD093363. The US Government has certain rights in this invention. Background technique [0005] The esophagus actively facilitates the passage of food from the mouth and pharynx to the stomach. It consists of stratified squamous epithelium, a muscular layer, and the enteric nervous system that senses stretch and controls peristalsis. Congenital disorders such as esophageal atresia are caused by genetic mutations that result in narrowing or discontinuity of the lumen. Other diseases affect the esophagus later in life, such as esophageal cancer, eosinophilic esophagitis, achalasia...

Claims

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Application Information

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IPC IPC(8): A61P1/00C07K14/475C07K14/485C07K14/50C07K14/51C07K14/52
CPCA61P1/00C12N5/0679C12N2501/415C12N2506/02C12N2506/45C12N2501/155C12N2501/115C12N2501/385C12N2501/11A61P1/04A01K67/0271A01K2207/30A01K2227/105A01K2267/0306A61K35/37C12N5/0062C12N2500/38C12N2501/119C12N2501/41C12N2513/00C12N2533/54G01N33/5044
Inventor J·M·威尔斯S·特里斯诺
Owner CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
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