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Esophageal heat transfer devices and methods for cardiac tissue ablation

A technology for heart tissue and esophagus, applied in the field of esophageal heat transfer device, temperature management system, and esophageal tissue temperature, can solve the problems of not reducing the incidence of esophageal damage

Pending Publication Date: 2021-01-15
ADVANCED COOLING THERAPY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Kuwahara reports that its method did not reduce the incidence of esophageal damage due to radiofrequency ablation

Method used

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  • Esophageal heat transfer devices and methods for cardiac tissue ablation
  • Esophageal heat transfer devices and methods for cardiac tissue ablation
  • Esophageal heat transfer devices and methods for cardiac tissue ablation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0249] Example 1. Pig model

[0250] method

[0251] design. This prospective interventional study was conducted by an experienced team that included a practicing electrophysiologist and assistant professor of cardiology, and according to the U.S. Department of Preclinical Services, Minneapolis, Minnesota ( American Preclinical Services' Institutional Animal Care and Use Committee-approved protocol, with input and contributions from two other practicing electrophysiologists with university backgrounds. The methods used in this study are consistent with current veterinary and United States Department of Agriculture (USDA) standards and employ state-of-the-art animal care internationally recognized by the Association for Assessment and Accreditation of Laboratory Animal Care room. Animals were cared for and handled in accordance with Office of Laboratory Animal Welfare guidelines for the human care and use of animals and in compliance with the USDA Animal Welfare Act, 9CFR Pa...

Embodiment 2

[0272] A robust mathematical model was derived to describe the effects seen in the above experiments to establish a framework from which to guide further analysis and development of this novel esophageal protection strategy.

[0273] A two-dimensional model of the esophageal injury was established using mathematical modeling software. The model was compared with experimentally derived data from the animal model described above by applying RF energy directly to the exposed esophagus.

[0274] The modeling governing equations utilize mass, momentum, and energy balances under boundary conditions defined by experimental values ​​for the temperature of the ablation catheter tip, cooling water, and animal patient. Other inputs are the heat capacity, density and thermal conductivity of the esophagus and cooling device walls, and the dynamic viscosity and specific heat ratio of the water domain.

[0275] RF ablation is applied using two electrodes: one electrode corresponds to a cath...

Embodiment 3

[0324] Example 3. Esophageal protection during radiofrequency ablation

[0325] The results presented below demonstrate that cooling fluid temperature can be adjusted for specific RF ablation parameters to ensure desired ablation of myocardial tissue while protecting esophageal tissue from thermal injury.

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Abstract

Method and apparatus are disclosed for esophageal heat transfer devices and methods for cardiac tissue ablation procedures. An exemplary method includes collecting esophageal data via one or more sensing elements of an esophageal heat transfer device positioned within an esophagus of the patient. The exemplary method includes determining, based on the esophageal data and / or operator selected powersetting, a temperature setting and / or a flow rate setting for fluid flowing through the esophageal heat transfer device to maintain a target temperature of esophageal tissue adjacent to the ablationsite via a heat transfer region. The exemplary method includes adjusting, via the controller, a fluid source to provide the fluid to the esophageal heat transfer device at the temperature setting and / or a flow rate setting.

Description

[0001] Cross References to Related Applications [0002] This application claims U.S. Provisional Patent Application No. 62 / 652,641, filed April 4, 2018, U.S. Provisional Patent Application No. 62 / 739,595, filed October 1, 2018, filed January 18, 2019 Priority to U.S. Provisional Patent Application No. 62 / 793,998 and U.S. Provisional Patent Application No. 62 / 795,916, filed January 23, 2019, the entire contents of each of which are incorporated herein by reference. technical field [0003] The present technology relates to devices, systems and methods for protecting a patient's esophageal tissue by managing the temperature of the esophageal tissue adjacent to the ablation site while the patient is undergoing cardiac tissue ablation. In one aspect, the present technology relates to an esophageal heat transfer device for managing the temperature of esophageal tissue adjacent to an ablation site during cardiac tissue ablation. In another aspect, the technology relates to a temp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F7/12
CPCA61B2018/00577A61B2018/00351A61B2018/00023A61B18/1492A61B2018/0212A61B2018/00982A61B2034/2051A61B2034/2063A61B2090/065A61B2018/00744A61B2018/00714A61B2018/00285A61B2018/00791A61B2018/00357A61F7/123A61B2090/376A61B90/04A61B2090/0418A61B2090/0463A61B2090/0481A61B34/20A61B2018/0022A61B2018/00488
Inventor E·库尔斯塔德J·D·希伯
Owner ADVANCED COOLING THERAPY INC
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