A laser sputtering ionization cold focusing orthogonal time-of-flight mass spectrometer relates to a mass spectrometer. Provided is a laser sputtering ionization cold-focus orthogonal time-of-flight mass spectrometer that matches a laser ionization source with a mass spectrometer, removes interference peaks, provides clear spectrograms, and analyzes solid samples without a standard sample. A laser, a focusing lens group, a sampling probe rod, a two-dimensional mobile platform, an ion source cavity, a main cavity, a sampling cone, a radio frequency multipole rod, a skimmer cone, an ion lens group and a time-of-flight mass analyzer are provided. The laser and focusing lens are set outside the ion source cavity, and the sample injection probe, two-dimensional mobile platform and sampling cone are set inside the ion source cavity; the wall of the ion source cavity is equipped with quartz windows, vacuum ports and valves; the main cavity A vacuum port is set on the wall of the body cavity, and the skimmer, radio frequency multi-stage rod and ion lens group are arranged in the main cavity; the sampling probe rod, two-dimensional mobile platform and sampling cone are the same as the skimmer cone, radio frequency multi-stage rod and ion lens group. axis.