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Lansoprazole liposome and its preparation

A technology of lansoprazole fat and lansoprazole, which is applied in the field of medicine to achieve the effect of improving curative effect and poor oral absorption

Inactive Publication Date: 2006-03-15
胡才忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, only ordinary tablets and capsules are reported and under research; injections have just been launched abroad in June this year; there is no recommendation for making lansoprazole into liposomes and proliposomes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Preparation of lansoprazole liposomes by ethanol injection method: take soybean phospholipids, cholesterol, VE and dissolve them with absolute ethanol and inject them into lansoprazole aqueous solution, stir at constant temperature and high speed, evaporate under reduced pressure to remove ethanol, pass through a microporous membrane for sizing , that is, lansoprazole liposome, the encapsulation efficiency can reach 63.8%.

Embodiment 2

[0013] Film dispersion method prepares lansoprazole liposome: get soybean lecithin, cholesterol, VE is dissolved in 150ml eggplant-shaped bottle with 15ml chloroform, forms film under reduced pressure on rotary film evaporator and removes organic solvent completely, adds 10ml lansoprazole The prazole aqueous solution is hydrated, passed through a microporous membrane for granulation, and the lansoprazole liposome is obtained, and the encapsulation efficiency can reach 60.7%.

Embodiment 3

[0015] Reversed-phase evaporation method prepares lansoprazole liposome: take soybean lecithin, cholesterol, VE and add 5ml chloroform to make dissolving, then add 10ml ether, then add in the phosphate buffered saline solution of 15ml lansoprazole, bath type ultrasonic makes A homogeneous single-phase system was formed, and the chloroform ether was evaporated under reduced pressure to form a gel. Continue to evaporate under reduced pressure for 5 to 10 minutes, and vortex until the aqueous suspension, that is, liposome, was formed. The encapsulation efficiency can reach 27.8%.

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Abstract

A liposome of lansoprazole is prepared from lansoprazole, phosphatide, cholesterol and the supporting agent chosen from sorbitol, mannitol, cane sugar, sodium chloride, water-soluble starch, etc. It is used for treating gastric ulcer, duodenal ulcer, reflux esophagitis, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a lansoprazole liposome (including proliposome) and a preparation method thereof. Background technique [0002] Lansoprazole Alias: Dakopron, TAKEPRON, O-GAST Listed by Takeda Pharmaceutical Company in Japan in 1992; traits: slightly brownish white crystalline powder. Melting point (decomposition) 166°C; easily soluble in dimethylformamide, soluble in methanol, insoluble in absolute ethanol, extremely insoluble in ether, almost insoluble in water. Lansoprazole is a new proton pump inhibitor. After entering the parietal cells from the blood, it is activated under acidic conditions and combines with the (H+ / K+)-ATPase base of the proton pump to inhibit the activity of the enzyme and thereby inhibit acid secretion. In vitro, when histamine, carbamylcholine, and cAMP were added to isolated parietal cells of dogs, the acid production was significantly increased. After administratio...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61K9/127A61P1/04
Inventor 胡才忠
Owner 胡才忠
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