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Infusion bag with rabeprazole sodium injection and infusion liquor in isolated two chambers and preparation method thereof

A technology for rabeprazole sodium and injection, which is applied in the field of solid-liquid double-chamber bag infusion of rabeprazole sodium for injection and its preparation, and can solve the problems of inconvenient clinical use of medical staff and cross-contamination of rabeprazole sodium.

Inactive Publication Date: 2006-09-06
肖广常 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, this drug is mainly used for intravenous infusion. When using it, first dissolve it with 5ml sterile water for injection, and then add glucose injection or glucose sodium chloride injection to dilute. Within 15 to 30 minutes, the drip is finished and given to the medical staff. It brings inconvenience to the clinical use, and also makes it easy to cause cross-contamination during the compatible use of rabeprazole sodium for injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 sterile injection rabeprazole sodium raw material

[0019] In a sterile room, take 1000 g of rabeprazole sodium, add 10 L of ethyl acetate solution and stir, heat to reflux to dissolve it completely, cool down, add 50 g of activated carbon to absorb after cooling, heat to reflux for 30 minutes, filter while hot and cool to room temperature , crystallized, filtered, and the filter cake was collected, dried and pulverized to obtain 830 g of sterile rabeprazole sodium raw material.

Embodiment 2

[0020] The preparation of embodiment 2 sterile injection rabeprazole sodium raw materials

[0021] Weigh 1000g of rabeprazole sodium, 200g of sodium sulfite, add 100L of water for injection to dissolve, adjust the pH to above 10, add 200g of activated carbon for adsorption for 30 minutes, filter in a sterile room, and freeze-dry the filtrate to obtain the raw material of sterile rabeprazole sodium 995g.

Embodiment 3

[0022] Embodiment 3 Rabeprazole sodium solid-liquid double-chamber bag infusion for injection, the drug composition is as follows:

[0023] Small chamber: Rabeprazole Sodium Raw Material for Sterile Injection 20g

[0024] big room:

[0025] Sodium chloride 900g

[0026] Sodium sulfite 400g

[0027] Add water for injection to 100L

[0028] Makes 1000 applied units.

[0029] Preparation method: the co-extrusion film is printed, heat-sealed to make bags, cut, and heat-sealed to prepare an infusion bag for standby. The raw materials are removed from the outer packaging, sterilized on the surface, and introduced into the first-class clean area. Weigh 900g of sodium chloride and 400g of sodium sulfite into 50L of water for injection, stir to dissolve, adjust the pH value to 5.5, add 50g of activated carbon for adsorption, decarbonize and filter, add water for injection to the full amount, and sterilize and filter , the clarity and content of the filtrate are qualified, filled ...

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PUM

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Abstract

This invention is a solid-liquid double chambers transfusion of injection bemegridethiazole, and it contains a bigger chamber and a smaller one. The smaller chamber is used to fill injection bemegridethiazole, while the bigger one is used to fill transfusion liquid. In the smaller chamber, each application unit contains 5mg-800mg sterile bemegridethiazole; In the bigger chamber, each application unit contains 100mg-50000mg isotonic conditioning agent, 0mg-4000mg sodium sulfite and 50mL-1000mL water for injection. The solid-liquid double chamber transfusion of injection bemegridethiazole is mainly used to short-term treat duodenum ulcer, gastric ulcer, pathological hyper stomach-acid secretion and reflux esophagitis. Closely before using this product, press the bigger chamber with hand and the two chambers will be dredged, rock back and forth to mix the medicine liquid even and intravenous drip. This production brings convenience to rescue personnel in clinical usage.

Description

(1) Technical field [0001] The invention relates to a solid-liquid double-chamber bag transfusion of rabeprazole sodium for injection and a preparation method thereof, belonging to the technical field of medicine. (2) Background technology [0002] Rabeprazole sodium is a new type of proton pump inhibitor. Receptor antagonists and proton pump inhibitors are the two most commonly used drugs for the treatment of acid-related digestive diseases. They both increase gastric pH, but proton pump inhibitors It acts on H / K ATPase, strongly inhibits gastric acid secretion, and causes a large and lasting increase in gastric pU. Rabeprazole sodium is the latest proton pump inhibitor, and its anti-gastric acid secretion activity is greater than that of the original proton pump inhibitor Omeprazole. Compared with omeprazole, rabeprazole sodium has a stronger inhibitory effect on H / K-ATPase, and the inhibition can be restored; it has less effect on plasma gastrin levels; it has selective ...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61K9/08A61K9/19
Inventor 肖广常张颖
Owner 肖广常
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