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Preparation method and application of chitosan and/or metal composite of chitosan derivative

A technology of chitosan derivatives and metal complexes, which is applied in the direction of drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems that have not been reported in the application, and achieve low metal content , reduce the effect of toxic and side effects

Inactive Publication Date: 2010-02-24
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method and application of chitosan / its derivative zinc, silver, bismuth and rare earth metal complexes using chitosan and its derivatives as carrier, dispersant and protective agent have not been reported

Method used

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  • Preparation method and application of chitosan and/or metal composite of chitosan derivative
  • Preparation method and application of chitosan and/or metal composite of chitosan derivative
  • Preparation method and application of chitosan and/or metal composite of chitosan derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A chitosan zinc, silver, bismuth and rare earth metal cerium complex, the preparation method steps are as follows:

[0044] (1) 10g chitosan is ground into fine powder;

[0045] (2) 0.005g zinc nitrate, 0.005g bismuth nitrate, 0.005g silver nitrate, 0.005g cerium nitrate are ground into fine powder;

[0046] (3) Mix the chitosan fine powder with the fine powder obtained in step (2), and thoroughly grind for 3 hours to obtain the chitosan zinc, silver, bismuth and rare earth metal cerium complex (sample 1).

Embodiment 2

[0048] A chitosan silver, bismuth and rare earth metal cerium, lanthanum complex, the preparation method steps are as follows:

[0049] (1) 10g chitosan is ground into fine powder;

[0050] (2) 0.005g zinc nitrate, 0.005g bismuth nitrate, 0.005g silver nitrate, 0.005g cerium nitrate, 0.005g lanthanum nitrate are ground into fine powder;

[0051] (3) Mix the fine powder of chitosan with the fine powder obtained in step (2), and thoroughly grind for 4.5 hours to obtain the complex of chitosan zinc, silver, bismuth and rare earth metal cerium and lanthanum (sample 2).

Embodiment 3

[0053] A chitosan zinc, silver, bismuth and rare earth metal cerium, lanthanum, rubidium, samarium complex, the preparation method steps are as follows:

[0054] (1) Grinding 5g of succinyl chitin into fine powder;

[0055] (2) Grinding each 0.01 g of zinc nitrate, bismuth nitrate, silver nitrate, cerium nitrate, lanthanum nitrate, rubidium nitrate, rubidium oxide, samarium nitrate, and samarium oxide into fine powder;

[0056] (3) Mix the succinyl chitin fine powder with the fine powder obtained in step (2), and fully grind for 6 hours;

[0057] That is, succinyl chitin zinc, silver, bismuth and rare earth metals cerium, lanthanum, rubidium, samarium complex (sample 3).

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Abstract

The invention discloses a solid phase synthesis method and a liquid phase synthesis method of chitosan and / or zinc, silver, bismuth and rare earth metal composite of chitosan derivative. The solid phase synthesis comprises the following steps: (1) grinding chitosan and / or chitosan derivative to fine powder; (2) grinding the oxides of zinc and / or silver and / or bismuth and rare earth metal to fine powder of which content is 0.0005-2wt% of the weight of chitosan and / or chitosan derivative; (3) mixing the fine powders obtained in step (1) and step (2) and fully grinding for 1-6h to obtain the chitosan and / or metal composite of chitosan derivative. The product of the preparation method can be used to cure diseases such as female vaginitis, cervicitis, cervical erosion, bedsore, skin ulcer, fireburn, empyrosis, trauma, other dermatitis disease, tinea of feet and hands and the like and can be used to prepare various surgical dressings such as film, sponge, gynecological suppository, adhesivefilm and the like.

Description

technical field [0001] The invention relates to the technical fields of chemical industry and medicine, in particular to a preparation method of chitosan and / or chitosan derivative zinc, silver, bismuth and rare earth metal complex powder and its application in the treatment of female vaginitis, cervicitis, cervical Erosion, bed sores, skin ulcers, burns, scalds, wounds, and other skin inflammations, tinea pedis and other pharmaceutical applications, can also be used to prepare various trauma dressings such as films, sponges, gynecological suppositories, films, etc. Background technique [0002] Since the late nineteenth century, foreign countries have carried out extensive and in-depth research on rare earths in medicine. In 1949, the United Kingdom, Australia, Japan and other countries successively included cerium oxalate into the pharmacopoeia for the treatment of motion sickness and vomiting of pregnancy. After the 1960s, it was discovered that rare earth compounds have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08K3/24C08K5/098C08K3/22C08K3/26C08J3/20A61K31/722A61K47/36A61K9/70A61K9/02A61K9/00A61P15/02A61P15/00A61P17/02A61P17/00A61P31/10A61L15/28A61L15/44
Inventor 桑青秦东风牛梅菊
Owner LIAOCHENG UNIV
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