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Mouthwash for preventing and treating gingivitis and preparation method thereof

A technology for mouthwash and gingivitis, which is applied in the field of mouthwash for prevention and treatment of gingivitis and its preparation, can solve the problems of unsuitable for long-term use, frequent use, complex components, etc. simple effect

Pending Publication Date: 2021-11-12
合肥赛为智慧医疗有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the commonly used antibacterial mouthwash active ingredients are broad-spectrum anti-inflammatory drugs such as chlorhexidine, which are not suitable for long-term use; while mouthwashes with Chinese herbal medicines and essential oils as the main components often have complex ingredients, or high costs, or Poor curative effect, or frequent use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A mouthwash for preventing and treating gingivitis, comprising the following raw materials in mass percentage: enzymatically hydrolyzed bee pollen 2%, glycerin 5%, vitamin C 0.5%, hydrolyzed fish skin collagen 0.5%, menthol 1%, Tween -80 2.5%, sodium carboxymethylcellulose 0.5%, ethylparaben 0.1%, sorbitol 1%, and the balance is water.

[0022] Wherein, the preparation method of enzymolysis bee pollen is: add 0.5g cellulase to the buffer solution to prepare the cellulase solution with a mass concentration of 0.05%, then add 100g camellia bee pollen and mix evenly, at a temperature of 50°C and a pH Enzymolysis treatment for 120 minutes under the condition of 6, to obtain.

[0023] Wherein, the hydrolyzed fish skin collagen is a hydrolyzed product of tilapia fish skin, and its molecular weight is 3000 Da.

[0024] To prepare a mouthwash for gingivitis:

[0025] Add glycerol, Tween-80, sodium carboxymethylcellulose and hydrolyzed fish skin collagen to the water, stir to ...

Embodiment 2

[0027] A mouthwash for preventing and treating gingivitis, comprising the following raw materials in mass percentage: enzymatically hydrolyzed bee pollen 5%, glycerin 2%, vitamin C 1%, hydrolyzed fish skin collagen 0.3%, menthol 0.5%, poloxa Mulberry 1881.5%, sodium carboxymethylcellulose 0.1%, ethylparaben 0.01%, and the balance is water.

[0028] Wherein, the preparation method of enzymolysis bee pollen is: add 0.8g alkaline protease in the buffer solution and prepare the cellulase solution that the mass concentration is 0.05%, then add 100g rapeseed bee pollen and mix evenly, at a temperature of 60°C, Under the condition of pH 10, it is obtained by enzymolysis treatment for 90 minutes.

[0029] Wherein, the hydrolyzed fish skin collagen is a hydrolyzed product of tilapia fish skin, and its molecular weight is 3000 Da.

[0030] To prepare a mouthwash for gingivitis:

[0031] Add glycerol, poloxamer 188, sodium carboxymethylcellulose and hydrolyzed fish skin collagen to the...

Embodiment 3

[0033] A mouthwash for preventing and treating gingivitis, comprising the following raw materials in mass percentage: enzymatically hydrolyzed bee pollen 4%, glycerol 3%, vitamin C 0.8%, hydrolyzed fish skin collagen 0.4%, menthol 0.8%, Tween -20 2%, sodium carboxymethylcellulose 0.4%, ethylparaben 0.05%, xylitol 0.5%, and the balance is water.

[0034] Wherein, the preparation method of enzymolysis bee pollen is: add 1g xylanase to the buffer solution to prepare cellulase solution with a mass concentration of 0.05%, then add 100g lotus flower bee pollen and mix evenly. Enzymolysis treatment for 150 minutes under the condition of 5, to obtain.

[0035] Wherein, the hydrolyzed fish skin collagen is a hydrolyzed product of tilapia fish skin, and its molecular weight is 3000 Da.

[0036] To prepare a mouthwash for gingivitis:

[0037] Add glycerol, Tween-20, sodium carboxymethylcellulose and hydrolyzed fish skin collagen to the water, stir to dissolve completely, then add xylit...

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Abstract

The invention discloses mouthwash for preventing and treating gingivitis. The mouthwash is prepared from the following raw materials in percentage by mass of 2 to 5 percent of enzymolysis bee pollen, 2 to 5 percent of glycerol, 0.5 to 1 percent of vitamin C, 0.3 to 0.5 percent of hydrolyzed fish skin collagen, 0.5 to 1 percent of menthol, 1.5 to 2.5 percent of a surfactant, 0.1 to 0.5 percent of sodium carboxymethyl cellulose, 0.01 to 0.1 percent of a preservative, 0 to 1 percent of a sweetening agent and the balance of water. The invention also discloses a preparation method of the mouthwash for preventing and treating gingivitis. The mouthwash provided by the invention has good prevention and treatment effects on gingivitis, the components are safe and harmless, the processing method is simple, and the use frequency is low.

Description

technical field [0001] The invention relates to the technical field of oral cavity cleaning and care, in particular to a mouthwash for preventing and treating gingivitis and a preparation method thereof. Background technique [0002] Gingivitis refers to an inflammatory disease that occurs in the gum tissue without invading other deep periodontal tissues, and is a common oral disease. The direct cause of gingivitis is the accumulation and infection of pathogenic microorganisms in the oral environment. Pathogenic microorganisms continue to accumulate on the teeth and gums to form a sticky bacterial film, namely plaque, and damage the gums through toxic products . Gingivitis will not only cause swollen, hyperemic, and painful gums, but may also lead to periodontal disease and loose teeth. Therefore, prevention and treatment of gingivitis is very important for oral cleaning and protection. Among them, the main measure of prevention and treatment of gingivitis is exactly to co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/37A61K8/65A61K8/67A61K8/73A61K8/34A61K38/01A61K9/00A61K47/10A61Q11/00A61P1/02A61P29/00A61P31/02A61P31/04A61P39/06
CPCA61K8/987A61K8/65A61K8/676A61K8/34A61K8/345A61K8/37A61K8/731A61Q11/00A61P1/02A61P29/00A61P31/04A61P31/02A61P39/06A61K35/64A61K36/00A61K38/014A61K31/375A61K31/045A61K9/006A61K47/10A61K2300/00
Inventor 宋海威王晗陈洋
Owner 合肥赛为智慧医疗有限公司
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