The invention relates to a perforated brick type filling support type reactor used in artificial liver, belongs to the medical equipment field. The reactor comprises a reactor housing; the inside of the reactor is divided into three cabins by two isolation plates densely covered by grids: an oxygenation cabin, a filling support cabin and a immunization obstructing cabin disposed from up down. The invention adopts unique perforated brick type fixing bed as the inner main body of the reactor; divides the inside of the reactor into minisized independent units by unconnected elongated hole columns in the fixing bed; divides up the inner cavity of the reactor, reduces unavailability cavity, dead cavity and liquid flow resistance to cause the inner liquid flow of the reactor to be uniform; not only solves the problems of immunization isolation lack and insufficient oxygen supply, but also compensates the defects of cell growth space deficiency, poor cell adhesion, no three dimensional growth environment and easily semipermeable membrane obstruction in hollow fiber type reactor; combines the functions of oxygenation, immunization obstruction and three dimensional cultivation; achieves strong properties, simple manufacturing technology and low cost, and is easily to be amplified.