Perforated brick type filling support type reactor used in artificial liver

Abstract

The invention relates to a perforated brick type filling support type reactor used in artificial liver, belongs to the medical equipment field. The reactor comprises a reactor housing; the inside of the reactor is divided into three cabins by two isolation plates densely covered by grids: an oxygenation cabin, a filling support cabin and a immunization obstructing cabin disposed from up down. The invention adopts unique perforated brick type fixing bed as the inner main body of the reactor; divides the inside of the reactor into minisized independent units by unconnected elongated hole columns in the fixing bed; divides up the inner cavity of the reactor, reduces unavailability cavity, dead cavity and liquid flow resistance to cause the inner liquid flow of the reactor to be uniform; not only solves the problems of immunization isolation lack and insufficient oxygen supply, but also compensates the defects of cell growth space deficiency, poor cell adhesion, no three dimensional growth environment and easily semipermeable membrane obstruction in hollow fiber type reactor; combines the functions of oxygenation, immunization obstruction and three dimensional cultivation; achieves strong properties, simple manufacturing technology and low cost, and is easily to be amplified.

Description

technical field [0001] The invention relates to a medical device, which is a core device for biological or hybrid artificial liver treatment-a porous brick-type filled-stent type reactor for artificial liver. Background technique [0002] As one of the effective treatment methods for patients with severe hepatitis and liver failure, artificial liver support therapy has been recognized all over the world. It includes three categories of non-biological, biological and hybrid artificial livers, of which the latter two are the main international development directions. Bioreactor (i.e., reactor) is the core device of biological and hybrid artificial liver treatment, which not only provides a place for material exchange between exogenous liver cells and patient blood or plasma, but also provides a suitable growth environment for liver cells. The application prospect is broad. An ideal artificial liver bioreactor should meet the following basic requirements: 1. Sufficient space ...

AI Technical Summary

Problems solved by technology

At present, the most clinical application is the hollow fiber reactor, which has the functions of immune isolation and oxygenation, and the cells are less sheared, but has the following disadvantages: 1. The traditional hollow fiber reactor has insufficient space for cell growth and uneven distribution. 2. It can only provide two-dimensional culture, but not three-dimensional culture; 3. The semi-permeable membrane barrier or collagen layer will affect the material exchange efficiency; 4. Cells grow on the surface of the fiber, so it is easy to block the fiber hole

But it has the following disadvantages: 1. There is a potential safety hazard of lack of immune isolation; 2. The oxygen supply of cells is insufficient; 3. The center and edge of the entire reactor support are prone to produce dead space and dead space; 4. Through a large number of supports The resistance is large, and the required perfusion intensity is high, which causes the cells to be subjected to a large shear force and is difficult to amplify

The existing reactors with good comprehensive performance in the world often have complex structures, high manufacturing process requirements, and high costs.

Images