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Application of rosa roxburghii aqueous extracts

A technology of water extract and Rosa roxburghii, which is applied in the field of medicine, can solve problems such as the research on the role of Rosa roxburghii, the research on efficacy parameters and physiological indicators is not complete, the types of medicinal materials and complex chemical components, etc., to achieve good curative effect, vacuoles Reduced degree of lesions and inflammatory infiltration, no obvious side effects

Inactive Publication Date: 2019-04-16
阎永平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned invention only uses Rosa roxburghii as one of the components, and the types and chemical components of medicinal materials are very complicated; there is no targeted discussion on the role of Rosa roxburghii itself or its water extract
Discussion of efficacy parameters and physiological indicators is somewhat incomplete

Method used

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  • Application of rosa roxburghii aqueous extracts
  • Application of rosa roxburghii aqueous extracts
  • Application of rosa roxburghii aqueous extracts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1 Rosa roxburghii aqueous extract is used for the prevention and treatment of alcoholic liver disease caused by NIAAA model

[0053] 1. Instruments and materials

[0054] Main instruments: electronic balance (Shanghai METTLER TOLEDO); Buchi rotary evaporator (Switzerland Buchi); electric heating mantle (Tianjin Tioste Instrument Co., Ltd.); traditional Chinese medicine pulverizer (Shanghai Dianjiu Traditional Chinese Medicine Machinery Manufacturing Co., Ltd.); Full-wavelength microplate reader (Thermo Company, USA); centrifuge (Eppendorf Company, Germany); low-speed desktop centrifuge (Keda Zhongjia); DZF-6020 vacuum drying oven (Shanghai Jinghong).

[0055] Drugs and reagents: Rosa roxburghii water extract (solid-liquid ratio 1:10, Xi'an Senran Biotechnology Co., Ltd.); liquid feed (Lieber-DeCarli diet ad libitum) and liquid alcohol feed (Nantong Trophy Feed Technology Co., Ltd.) ; Ethanol (Burdick&Jackson); Rosa roxburghii Dried Fruit (Guang Ren Tang Medicin...

Embodiment 2

[0084] Embodiment 2: preparation comprises the tablet and / or capsule of 80-99% Rosa roxburghii aqueous extract:

[0085] Get the dried powder of Rosa roxburghii water extract, pass through a 60-100 mesh sieve for later use. (1) Add one or several kinds of excipients commonly used in tablets; compress into tablets by a tablet machine. Each tablet contains 825-1000 mg of Rosa roxburghii aqueous extract, and the weight of the tablet is 0.75-1 g. (2) Add one or several kinds of auxiliary materials commonly used in capsules, granulate, granulate, and pack into capsules. Each capsule contains 825-1000mg of Rosa roxburghii aqueous extract, and the weight of the capsule is 0.75-1g. See Table 5. Suggested dosage: take 6 capsules per day, 2 capsules per meal, and the daily intake is 4950-6000mg.

[0086] Table 5 - Taking Tablets and Capsules as Examples

[0087]

[0088] According to calculations: the content range of Rosa roxburghii water extract in tablets and capsules is 82.5...

Embodiment 3

[0102] Embodiment 3: preparation comprises the granule and the suspension of 20-99% Rosa roxburghii aqueous extract:

[0103]Get the dried powder of Rosa roxburghii water extract, pass through a 60-100 mesh sieve for later use. Take 2475-9900g of dry powder of the above-mentioned Rosa roxburghii water extract, and adjuvant materials in an arbitrary proportion of 100-7525g; make the total weight 10000g. Add a small amount of solvent and mix well to make granules, dry, pack one bag per 10g; 1000 bags in total. The excipients include, but are not limited to: sweeteners, powdered sugar, dextrin, β-cyclodextrin, and effervescent disintegrants. The prepared Rosa roxburghii water extract granule / suspension contains 24.7-99% of Rosa roxburghii water extract in each bag; recommended dosage: take 2 bags per day, and the daily intake is 4950-9900mg. See Table 6.

[0104] Table 6-Taking Granules and Suspensions as Examples

[0105]

[0106] According to calculations: the content ra...

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Abstract

The invention discloses an application of various rosa roxburghii aqueous extracts in preparation of drugs, health-care products and health-care food for preventing and / or treating alcoholic liver disease. Provided are drugs and health-care products for preventing and treating alcoholic liver disease, wherein the drugs and health-care products comprise 20-99% of the rosa roxburghii aqueous extracts. The invention also provides health-care drinks suitable for patients with alcoholic liver disease, wherein the health-care drinks comprise 0.5-33% of the rosa roxburghii aqueous extracts; the invention also provides a blended alcoholic drinks comprising 0.5-7% of the rosa roxburghii aqueous extracts; the invention also provides fruit-flavored beer drinks comprising 0.5-4% of the rosa roxburghiiaqueous extracts; the invention also provides additive grape wine comprising 0.5-2% of the rosa roxburghii aqueous extracts; the invention also provides blended grape wine drinks comprising 0.5-2% ofthe rosa roxburghii aqueous extracts. Through implementation of the most recognized model of alcoholic liver disease in mice, the rosa roxburghii aqueous extracts with various concentrations are found out to alleviate the liver pathological changes induced by alcohol in different extents; liver enlargement, weight gain, fat accumulation and inflammatory infiltration degree are significantly improved; biochemical and pathological indicators are significantly reduced. The rosa roxburghii aqueous extracts can prevent and treat alcoholic liver disease, can be used as drugs separately or in combination, and is used for developing corresponding drugs, health-care products or health-care food.

Description

technical field [0001] The invention belongs to the field of medicine. It relates to the water extract of roxburghii and its application. More specifically, it relates to the water extract of Rosa roxburghii and its application in the preparation of drugs and / or health products for the prevention and / or treatment of alcoholic liver disease. Rosa roxburghii water extract can be obtained by different processes. Background technique [0002] Alcoholic liver disease (ALD) is liver damage caused by long-term heavy drinking, including alcoholic fatty liver (Alcoholic fatty liver, AFL), alcoholic hepatitis (Alcoholichepatitis, AH) and alcoholic cirrhosis (Alcoholic cirrhosis) , AC); these three often exist in a mixture. Clinical data confirm that 80% to 90% of liver cirrhosis is caused by excessive drinking. In recent years, the incidence of liver disease caused by excessive alcohol intake has been increasing year by year; it has become the second leading cause of liver damage ...

Claims

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Application Information

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IPC IPC(8): A23L33/105A23L2/02C12C12/00A61K36/738A61P1/16
CPCA23L2/02A23L33/105A61K36/738C12C12/00A23V2002/00A23V2200/32A23V2250/21A23V2300/14A23V2250/5118A23V2250/5112A23V2250/608A23V2250/606A23V2250/628A23V2250/70A23V2250/51A23V2250/161
Inventor 胡冰芳
Owner 阎永平
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