New uses of Ajuga ciliata Bunge extract

The technology of a sinensis grass and its extract is applied in the new use field of the sinensis grass extract, which can solve the problems such as the reports of the sinensis grass extract that have not been seen yet.

Inactive Publication Date: 2015-05-13
BEIJING KONRUNS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the treatment of pelvic inflammatory disease

Method used

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  • New uses of Ajuga ciliata Bunge extract
  • New uses of Ajuga ciliata Bunge extract
  • New uses of Ajuga ciliata Bunge extract

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0059] Experimental example 1: Inhibitory effect on rat chronic pelvic inflammatory disease model induced by Escherichia coli infection

[0060] 1. Experimental grouping: Animals except the sham operation group were randomly divided into model group, positive drug group 1 and positive drug group 2, large, medium and low dose groups of Herba sinensis extract, 10 animals in each group.

[0061] 2. Strain preparation: Add the Escherichia coli subcultured by mice to the broth medium (0.3 grams of beef extract, 1.0 grams of peptone, 0.5 grams of NaCl, 100 ml of water, pH7.0-7.2, add water to the beaker , weigh beef extract, peptone and NaCl, heat and dissolve, adjust the pH value to 7.0-7.2. Subpackage, add cotton plugs, high-pressure steam sterilization Serve), incubator at 37°C for 7 hours, take 0.1ml Add the bacterial solution to 10ml nutrient broth medium, continue to cultivate for 17 hours, count with sterile saline before use, and dilute to 1×10 7 / ml, spare.

[0062] 3. Pr...

experiment example 2

[0081] Experimental example 2: Inhibitory effect on the inflammatory adhesion model of rat pelvic inflammatory disease induced by phenol paste

[0082] 1. Influence on inflammatory factors

[0083] 1.1 Experimental method: Take rats, randomly select 10 rats according to body weight as the sham operation control group, and the rest rats are anesthetized by intraperitoneal injection of pentobarbital sodium, fixed animals, routine disinfection, laparotomy, exposed uterus, from both uteri At the cross-linking point, the needle was carefully inserted into the left uterine cavity, and 0.04ml of phenol paste was slowly injected. The rats in the sham operation group were the same as before except that the uterus was not injected with phenol paste.

[0084] 1.2 Experimental grouping and administration: 15 days after modeling, the animals except the sham operation group were randomly divided into model group, positive drug ofloxacin group, positive drug Huahong tablet group, large and ...

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Abstract

The present invention relates to new uses of an Ajuga ciliata Bunge extract, particularly to applications of the Ajuga ciliata Bunge extract in preparation of drugs for prevention and treatment of gynecological inflammatory diseases. According to the present invention, experimental results show that the gynecological inflammation treatment effects of the Ajuga ciliata Bunge extract on the two chronic pelvic inflammatory disease rat models caused by escherichia coli and phenol paste are verified, wherein the change of the blood rheology, the inflammatory factors and other indicators of the chronic pelvic inflammatory disease rat model caused by the phenol paste are observed after using the Ajuga ciliata Bunge extract, the change of the immunology indicator of the chronic pelvic inflammatory disease rat model caused by the escherichia coli is observed after using the Ajuga ciliata Bunge extract, and the intervention effects of the Ajuga ciliata Bunge extract on the uterus tissue inflammatory infiltration caused by chronic inflammations, tissue adhesion, and inflammatory mass caused by attachment hyperblastosis and the like are observed, such that the Ajuga ciliata Bunge extract provides the treatment effects on the long-term chronic inflammations and the attachment hyperblastosis caused by the long-term chronic inflammations.

Description

technical field [0001] The present invention relates to a new application of the extract of the herba sinensis, in particular to the application of the extract of the herb sinensis in the preparation of medicine for treating pelvic inflammatory disease. Background technique [0002] Extract of Grass sinensis, see CN200510085017.2 (publication number is CN1899367A), this patent application discloses an extract of Grass sinensis, preparation method and use, wherein: [0003] The extract of Herba sinensis is prepared by the following method: take Herba sinensis coarse powder as raw material, heat extraction with water or ethanol with a concentration lower than 80% at 30-90°C, or perform percolation, and concentrate the extract to a specific gravity of 1.0 -1.3, filter, treat with macroporous adsorption resin, wash with water to remove impurities, elute the resin with 30-95% ethanol solution until the active ingredients are completely washed out, recover the solvent, and dry to ...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/48A61K9/20A61K9/14A61K9/10A61K9/02A61P15/00A61P15/08
CPCY02A50/30
Inventor 李建荣温彬宇
Owner BEIJING KONRUNS PHARM CO LTD
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