Sunflower disc extract, medicine containing sunflower disc extract, preparation method and application of medicine

A technology of extracts and sunflower discs, applied to medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc.

Inactive Publication Date: 2021-04-30
JILIN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no records and reports about the sunflower disc extract being used to repair liver damage caused by alcohol

Method used

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  • Sunflower disc extract, medicine containing sunflower disc extract, preparation method and application of medicine
  • Sunflower disc extract, medicine containing sunflower disc extract, preparation method and application of medicine
  • Sunflower disc extract, medicine containing sunflower disc extract, preparation method and application of medicine

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preparation example Construction

[0021] The invention provides a kind of preparation method of sunflower dish extract, comprises the following steps:

[0022] 1) Carry out water extraction to sunflower dish powder, obtain water extract;

[0023] 2) The water extract is mixed with cellulase for hydrolysis, and the obtained hydrolyzate is sunflower disc extract.

[0024] In the invention, firstly, the sunflower dish powder is subjected to water extraction to obtain a water extract. In the present invention, the sunflower dish powder is prepared by crushing the sunflower dish; the sunflower dish preferably comes from the oil sunflower produced in Baicheng, which contains unique alkaloids, flavonoids and small molecules Biologically active substances such as peptides; the particle size of the sunflower powder is preferably 100-200 mesh, more preferably 150 mesh. In the present invention, the water extraction is preferably water extraction, and the temperature of the water extraction is preferably 45-50° C.; the...

Embodiment 1

[0035] 1) Crush the sunflower disc to 100 mesh, add 6 times the mass of deionized water, and fully stir at 45°C for 120 minutes to obtain a water extract;

[0036] 2) Heat the water extract of the sunflower dish to 85°C, stir for 1 hour, cool to 45°C, add 0.1% cellulase of the total mass of the water extract of the sunflower dish, and hydrolyze for 3 hours to obtain a hydrolyzate;

[0037] 3) Centrifuge the hydrolyzate in step 2) at a speed of 7000rpm for 20min, collect the supernatant, and obtain the crude extract of sunflower disc;

[0038] 4) Concentrate the crude sunflower pan extract in step 3) to one-fifth of its original volume by suspension distillation, and spray dry to obtain sunflower pan powder. Rotary evaporation concentration parameters: decompression to 400-600 mm Hg, speed 100 rpm, electric heating. Spray drying parameters: the inlet temperature reaches 180°C, the outlet temperature reaches 75°C, the feed starts when the surface temperature of the heater reach...

Embodiment 2

[0040] 1) Crush the sunflower disc to 200 mesh, add 10 times the mass of deionized water, and fully stir at 50°C for 240 minutes to obtain a water extract;

[0041] 2) heating the water extract of the sunflower dish to 90°C, stirring for 1 hour, cooling to 55°C, adding 0.1% cellulase of the total volume of the water extract of the sunflower dish, and hydrolyzing for 3 hours to obtain a hydrolyzate;

[0042] 3) Centrifuge the hydrolyzate in step 2) at a speed of 7000rpm for 20min, collect the supernatant, and obtain the crude extract of sunflower disc;

[0043]4) Concentrate the crude sunflower pan extract in step 3) to one-fifth of its original volume by suspension distillation, and spray dry to obtain sunflower pan powder. Rotary evaporation concentration parameters: decompression to 400-600 mm Hg, speed 100 rpm, electric heating. Spray drying parameters: the inlet temperature reaches 180°C, the outlet temperature reaches 75°C, the feed starts when the surface temperature of...

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Abstract

The invention provides a sunflower disc extract, a medicine containing the sunflower disc extract as well as a preparation method and application of the medicine, and belongs to the technical field of biological medicines. The preparation method of the sunflower disc extract comprises the following steps: mixing crushed sunflower discs with water, carrying out extracting, adding cellulase into the obtained water extract, carrying out hydrolyzing to obtain hydrolysate, carrying out solid-liquid separation on the hydrolysate, and collecting liquid components to obtain the sunflower disc extract. The sunflower disc extract prepared by the invention can significantly inhibit the increase of MDA content, liver index, ALT and AST activity caused by alcohol acute liver injury, effectively inhibit the reduction of SOD activity in the liver, and reduce the liver tissue injury degree of mice, and HE staining shows that the sunflower disc extract can alleviate the inflammatory infiltration phenomenon of liver cells. The sunflower disc extract has an obvious repairing effect on alcohol-induced acute liver injury of mice.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a sunflower disc extract, a medicine containing the sunflower disc extract, a preparation method and an application. Background technique [0002] The sunflower disc is the flower disc of the Compositae plant sunflower (Helianthus annuuss L.), also known as sunflower receptacle, sunflower cake and sunflower house. It is flat in nature, sweet in taste, non-toxic, and returns to the liver meridian. , hemostasis, for the treatment of arthritis, mastitis, dizziness, tinnitus, abdominal pain and so on. The water decoction of sunflower disc has the effect of treating tumors, and the ethanol extract of sunflower disc has a certain antihypertensive effect. It is also used as a medicinal diet for regulating atrophic gastritis. CN 108354956 A discloses the use of sunflower powder and its active ingredients in the preparation of drugs for repairing damaged liver cells, specifically for...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P1/16
CPCA61K36/28A61K2236/19A61K2236/331A61K2236/51A61K2236/53A61P1/16
Inventor 李婉南赵国安康明葛振龙韩葳葳韩璐高波常浩周喜鹏
Owner JILIN UNIV
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