The invention belongs to the technical field of medicaments for
skin diseases, and discloses a
medicine for improving symptoms of
acne rosacea, an
animal model of the
medicine and a construction method of the
animal model. A BALB / C mouse of 7 weeks old is used,
subcutaneous injection of LL37 polypeptide is performed twice each day, injection is performed for 2 days, and
acne rosacea skin injury isinduced to make a model of the
acne rosacea. As for the
animal model, the mouse is subjected to
intragastric administration of
tranexamic acid 5 days in advance, a
medicine control group is subjectedto
intragastric administration of a PBS
buffer solution, and 6-7 days after the
intragastric administration, acne rosacea
skin injury is induced. Through the adoption of an LL37 induced mouse model and a
HaCaT cell model, the influence of TXA on the acne rosacea and the
molecular mechanism of the TXA are assessed; through TXA treatment, the acne rosacea symptoms are obviously improved; and in addition, the TXA reduces the expression level of congenital
immunity genes (TLR2, KLK5 and Camp) and neutral
granulocyte related genes in acne rosacea sample
lesion.