175results about How to "Reduce onset time" patented technology

A formulation to treat ocular conditions such as dry eye disease, as well as other conditions, is disclosed. Rapamycin and / or ascomycin is administered intraocularly, such as by topical application, injection into the eye, or implantation in or on the eye. For example, a topical administration may contain between about 50 pg / ml drug to about 50 μg / ml drug in a formulation which may be applied at bedtime or throughout the day. For injection, a dose of about 50 pg / mi to about 200 μg / ml may be used. Rapamycin and / or ascomycin may also be administered in milligram quantities as a surgical implant, for example, in a diffusible walled reservoir sutured to the wall of the sclera, or may be contained within an inert carrier such as microspheres or liposomes to provide a slow-release drug delivery system.

A formulation to treat ocular conditions such as dry eye disease, as well as other conditions, is disclosed. Rapamycin and / or ascomycin is administered intraocularly, such as by topical application, injection into the eye, or implantation in or on the eye. For example, a topical administration may contain between about 50 pg / ml drug to about 50 μg / ml drug in a formulation which may be applied at bedtime or throughout the day. For injection, a dose of about 50 pg / ml to about 200 μg / ml may be used. Rapamycin and / or ascomycin may also be administered in milligram quantities as a surgical implant, for example, in a diffusible walled reservoir sutured to the wall of the sclera, or may be contained within an inert carrier such as microspheres or liposomes to provide a slow-release drug delivery system.

The invention discloses a feed additive for improving the reproductive capacity of a boar. The feed additive comprises the following raw materials in percentage by weight: 40 to 50 percent of epimedium, 8 to 10 percent of cynomorium songaricum, 8 to 10 percent of codonopsis pilosula, 8 to 10 percent of angelica sinensis, 8 to 10 percent of medlar, 0.5 to 1 percent of vitamin A, 0.1 to 0.2 percent of vitamin D3, 1 to 4 percent of vitamin E, 0.1 to 0.3 percent of vitamin B2 and the balance of zeolite powder. A preparation method for the feed additive comprises the following steps of: mixing the epimedium, the cynomorium songaricum, the codonopsis pilosula, the angelica sinensis and the medlar; smashing a mixture to a particle size of between 25 and 40 microns; adding the vitamin A, the vitamin D3, the vitamin E, the vitamin B2 and the zeolite powder; and mixing uniformly. The feed additive prepared by the method has the characteristics of remarkable improvement on boar sexual desire, ejaculatory amount, sperm concentration, survival time and oestrum conception rate without any adverse effect, less additive amount, low cost and obvious effect.

A multilayered solid oral pharmaceutical formulation of trimetazidine or a pharmaceutically acceptable salt or polymorph of trimetazidine wherein one layer of said formulation provides controlled release, while the other layer provides immediate release.

The invention relates to a triad integration freckle-removing functional nano cream for skin external use and a method for preparing the same. The three types (night use type, daytime use type and auxiliary type) freckle-removing nano creams improve and optimize a novel international passive target transdermal drug delivery system (TDDS) as a carrier, and organically combine and solubilize freckle-removing functional components with different biological efficacies, action ways and physical and chemical properties to form a good mutual aid synergic function system which has remarkable effect of controlling and relieving colored patches (such as chloasma, inflammatory pigmentation, sunburn, and the like) caused by abnormal facial metabolism of pigment. The product has the advantages of tiny particle sizes of spherical particles, obvious passive target function, excellent adaptability, homodromous property, fluidity and dispersion, strong penetrability, even texture, subtleness, lubricity and luster, is simple and convenient to use, and is comfortable without pungency and side effects; besides, the appearance is light yellow with slight opalescence, is glittering and translucent, clear and transparent, sticky but not viscous, thick but not dense, and oily but not greasy, has good stability, excellent curative effect, short industrialization cycle and high production efficiency, saves time, materials and energy sources, dose not need special devices and heat energy, and is easy for popularization and application.

The invention discloses a compound bifonazole nano-emulsion spray preparation. The nano-emulsion spray preparation has the grain size of 1 nm to 100 nm and is formed by the following raw materials in mass percent: 30%-40% of surfactant, 3%-14% of cosurfactant, 5%-10% of oil phase, 0.8%-2% of bifonazole, 0.02%-0.1% of clobetasol propionate, 0.01%-0.2% of cinnamyl aldehyde and the balance of deionized water, wherein the sum of the mass percents of the raw materials is 100%. The compound bifonazole nano-emulsion spray preparation has multiple actions, such as fungicide, bactericide, anti-bacterial, anti-fungal, antiinflammation, itching relieving and the like, treats superficial skin fungous infection, fungous paronychia and candidal vulvovaginitis, and is also effective to external otitis and bacterial skin infection. The compound bifonazole nano-emulsion spray preparation prepared by a preparation method of the compound bifonazole nano-emulsion spray preparation has the advantages that: the activity of the three drugs is remarkably improved, the effect of sterilization and itching relieving is rapid, the recurrence is difficult, and the preparation method is simple, so that the compound bifonazole nano-emulsion spray preparation and the preparation method thereof have broad market prospects in the medicine field.

The invention discloses a feed additive for improving the lactation performance of lactating sows and a preparation method thereof. The feed additive consists of the following components in part by weight: 0 to 60 parts of cowherb seed, 5 to 8 parts of dandelion, 8 to 10 parts of atractylis, 5 to 8 parts of akebia stem, 5 parts of astragalus, 5 pars of liquoric root, and the balance of zeolite powder. The feed additive for improving the lactation performance of the lactating sows has the advantages of obvious improvement on the lactation performance of the lactating sows (lactation yield and lactic quality), low addition volume, good effect, no residue, and no toxic or side effects.

The present invention generally relates to use of a stable solid pharmaceutical compositions that includes a clavulanate as the pharmaceutically active ingredients in an immediate-release or an extended-release solid dosage form. The composition can be used in a method of treating a neurodegenerative disease, providing neuroprotection, or preventing neuronal cell loss or death. Exemplary neurodegenerative diseases include Parkinson's disease, Alzheimer's disease and multiple sclerosis.

The invention relates to a preparation method and application of q beauveria-spinosad suspending agent. Beauveryia bassiana and spinosad are the active ingredients of the suspending agent which is used for preventing and treating agriculture and forestry injurious insects, such as leptinotarsa decemlineata and acridid and the like. The invention is characterized in that (1) the suspending agent comprises active ingredients, namely the beauveryia bassiana and the spinosad; and (2) the mass ratio of the beauveryia bassiana and the spinosad is (30:1)-(30:2), and the mass percent of the effective components in the preparation is 3.1-10%. The preparation method has the advantages that the product can be dissolved with oil or water; the effective duration of the beauveria vuillemin and the relative quick action of spinosad have complementary advantages, and injurious insects of various crops are treated; and the suspending agent prepared by the method has the advantages of good synergism and permeability, strong adhesivity and evaporation resistance and the like.

The invention relates to hydrotalcite preparation with rapid efficiency and a preparation process thereof, which belong to the biopharmaceuticals field. Every 1000 hydrotalcite units of the invention comprise the following constituents: 0.45-0.55kg of hydrotalcite, 0.18-0.25kg of mannitol, 12-18g of carboxymethyl starch sodium, 8.0-15.0g of magnesium stearate, 0.5-1.0g of sodium cyclamate, 0.3-0.9ml of peppermint flavor, 0.378kg-0.462kg of pre-gelatinized starch paste (12 percent by mass specific concentration) and 0.504kg-0.616kg of pre-gelatinized starch paste (5 percent by mass specific concentration). The preparation process of the invention comprises the following steps: hydrotalcite and mannitol are prepared into super-fine powder with grain diameter of 5-15um, which are blended with carboxymethyl starch sodium, sodium cyclamate and pre-gelatinized starch paste, wet granulated, sieved by a sieve with 12-16 meshes, totally mixed, packaged or tabletted to prepare finished product of hydrotalcite preparation; the hydrotalcite preparation prepared by adopting the method of the invention has fast effectiveness, good effect with low toxicity, small side-effects, pleasant taste and high suffer compliance, which is an ideal clinical antiacid.

The invention provides a Chinese medicine oral instant film as well as a preparation method and application thereof. The film comprises Chinese medicine active ingredients and auxiliary materials and is a light and thin film which is placed on a tongue and instantly released. The Chinese medicine oral instant film preparation has the advantages that the onset time of the traditional Chinese medicine can be shortened; the bioavailability of the traditional Chinese medicine is increased; the taste of the traditional Chinese medicine is improved; the irritation of the traditional Chinese medicine to stomach and intestine is reduced; and accordingly, the application range of the traditional Chinese medicine in specific crowd is widened.

The invention relates to a Chinese medicinal compound for improving lactation amount of a sow and growth performance of a piglet. The Chinese medicinal compound comprises the following components: 12-18 parts by weight of radix astragali, 8-10 parts by weight of radix codonopsis, 8-10 parts by weight of Chinese angelica, 10-15 parts by weight of Chinese yam, 12-15 parts by weight of semen cuscutae, 8-10 parts by weight of wolfberry, 5-8 parts by weight of liriope. The Chinese medicinal compound is used to enhance anti-infection ability of a postpartum sow (reduce postpartum dysgalactia syndrome), improve lactation amount of the sow and improve the growth performance of the piglet; and the Chinese medicinal compound without residual and toxic side effect is small in required addition amount and good in effect.

The invention provides a glyphosate weeding composition containing a brassinolide compound. Effective ingredients of the glyphosate weeding composition include a glyphosate compound and a brassinolide compound. In the glyphosate weeding composition, the glyphosate compound is glyphosate acid or a herbicidal active derivative thereof, and the brassinolide compound is one or more of 24-hybrid epibrassinolide, 24-epibrassinolide, 28-epihomobrassinolide, 28-homobrassinolide and other brassinolide compounds. The mass ratio of glyphosate to brassinolide is 100:(0.01*10<-3>-10*10<-3>). The glyphosate weeding composition containing the brassinolide compound has the advantages that brassinolide and a glyphosate product are compounded, and the uptake and translocation effects of glyphosate in stems and leaves and the growth regulation effect of brassinolide are utilized and combined, so that the weeding composition has obvious synergistic effects, the initial weeding effect time is shortened for 2-4 days, the usage amount of a herbicide is reduced by 20-50%, and control effects on some noxious weeds are better. The weeding composition provided by the invention has the advantages of broad spectrum, high efficiency, low toxicity, little pollution, high effect taking speed, low cost and convenience in application.

Methods, devices and systems for improving sleep (including reducing sleep onset and maintenance of sleep duration), enhancing, or increasing sleep, including (but not limited to) treating sleeping disorders such as insomnia.

A sobering-up composition in the form of instant powder is prepared from 6 Chinese-medicinal materials including pueraria root, bitter pattra fruit, tuckahoe, schisandra fruit, green tea and cloves through proportional mixing, breaking, pulverizing, adding excipient and suspending agent, granulating, and baking. Its advantage is high effect.

The invention discloses traditional Chinese medicine superfine powder composition resistant to chicken colibacillosis and a preparation method thereof. The traditional Chinese medicine superfine powder composition is prepared from dark plum, scutellaria baicalensis, chinese rhubarb, sophora flavescens, folium isatidis, pomegranate bark and liquorice in a certain ratio. The preparation method of the traditional Chinese medicine superfine powder composition comprises the following steps of: selecting the traditional Chinese medicines, and respectively grinding, sieving by adopting a 65-mesh sieve and preparing single Chinese drug common powder; and carrying out superfine grinding on compound traditional Chinese medicine common powder obtained by uniformly mixing single Chinese drug common powder, so that all the compound traditional Chinese medicine common powder can pass through a 400-mesh sieve, subpackaging, and then sealing and storing. The traditional Chinese medicine superfine powder composition preparation prepared by adopting the preparation method has the advantages that pharmaceutical particle size is obviously reduced, cell-wall breaking ratio and release speed of active ingredients are obviously increased, bioavailability of the traditional Chinese medicine superfine powder composition is improved, and pharmacodynamic study results show that a preparation prepared by adopting a superfine grinding process has a more obvious effect when being used for treating chicken colibacillosis compared with a preparation prepared by adopting the traditional process; the traditional Chinese medicine superfine powder composition can be directly used as drinking water, and a method that traditional Chinese medicine powder can be stirred only and can not be drunk is changed.

The invention belongs to the field of biomedical polymer materials, and discloses a micro-needle array patch capable of generating gas to take effect quickly and preparation and application thereof. The micro-needle array patch comprises a substrate and a needle tip located on the substrate, the substrate is composed of a biocompatible matrix, the needle tip is mainly composed of the biocompatible matrix and inorganic particles capable of generating gas, and the inorganic particles capable of generating gas are formed on the surface and / or in the biocompatible matrix of the needle tip; the needle tip part of the micro-needle array patch can interact with skin tissue fluid to generate gas during application, rapid dissolution of micro-needles and diffusion of drugs to a corium layer are promoted, and the drugs can be efficiently and rapidly delivered to subcutaneous parts and take effect without the help of external equipment.

The invention relates to a repaglinide crystal, a preparation method thereof, and a solid oral preparation containing the same. The particle size of the crystal is 1 to 5 mu m. The solid oral preparation is a tablet prepared from repaglinide, compressible starch, microcrystalline cellulose calcium hydrogen phosphate, polyvinylpyrrolidone, cross-linked sodium carboxymethyl cellulose, glycerin, poloxamer, meglumine, iron oxide and magnesium stearate. Raw materials and accessories for the tablet are safe and easily available; the prepared tablet has good dissolvability and a good dissolution rate and enables stable plasma concentration; prepared repaglinide tablets have the function characteristics of rapid absorption, fast action, a fast clearance speed in vivo and a short half life and canbe used for treating 2 type diabetes. Prescription for the repaglinide cystals is reasonable; the repaglinide cystals have stable and reliable quality and good disintegration time and dissolution rates; repaglinide tablets are prepared through a direct compression process, which enables a simple process, a short production period and low production cost; therefore, industrial production of the repaglinide tablets is easy to realize.

The onset of activity of a first analgesic / antipyretic composition containing an analgesic / antipyretic effective amount of acetaminophen, caffeine and, optionally, aspirin is shortened by incorporating in the first composition an onset of analgesic / antipyretic activity shortening amount of at least one alkaline agent whereby a second composition is produced. The second composition being bioequivalent to the first composition but having a shorter onset of analgesic / antipyretic activity than the first composition.

The invention discloses a medicament for preventing and curing avian infectious laryngotracheitis and a preparation method thereof. The medicament is prepared by the following traditional Chinese herbs by weight: 12 parts of subprostrate sophora, 10 parts of scutellaria baicalensis, 12 parts of blackberry lilies, 10 parts of isatis roots, 8 parts of platycodon grandiflorum and 6 parts of liquorice. The preparation method of the medicament comprises the following steps: first extracting the herbs with ethanol to obtain extract; adding water to dregs of the decoction after ethanol extraction and extracting, and then concentrating and drying to obtain water extract powder; mixing with the extract and obtaining the needed medicament, or adding microcrystalline cellulose to serve as a filler and a joint disintegrating agent and making into dispersible tablets. The medicament for preventing and curing the avian infectious laryngotracheitis gives full consideration to anti-inflammation, resistance to secondary infection, medicament guidance to lung channels and other aspects, has considerably good curative effects, and also can improve absorption of the insoluble medicament, shorten the time of the medicament for taking effect and improve bioavailability of the insoluble medicament.

Methods, devices and systems for improving sleep (including reducing sleep onset and maintenance of sleep duration), enhancing, or increasing sleep, including (but not limited to) treating sleeping disorders such as insomnia.

The compound pesticide of the present invention consists of re-compounded bacillus thringiensis as biological produces and pyridaben as chemical pesticide, as well as proper amount of assistant and carrier. It has the weight ratio between parasporal crystal protein as the effective component of bacillus thringiensis and pure pyridaben is 0.143-7, and its optimal ratio results in one CTC to beet noctuid up to 214.2, one CTC to cotton bollworm up to 198.9 and obvious synergistic pesticidal effect. It has fast effect, spread pesticidal spectrum, less residue and low cost.

The invention discloses a preparation method of a lidocaine carbonate injection. The preparation method comprises the following processes of solution preparation, pH adjustment, filtration and disinfection. The preparation method is characterized in that the filtration process comprises filtering a solution subjected to pH adjustment by a cellulose acetate microfiltration membrane having an aperture size of 0.22 micrometers, filtering the solution by a PVDF microfiltration membrane having an aperture size of 0.22 micrometers until clarification, filling the filtered solution in an ampoule, and carrying out sealing. The solution subjected to pH adjustment is filtered by the cellulose acetate microfiltration membrane having an aperture size of 0.22 micrometers, then is filtered by the PVDF microfiltration membrane, and is subjected to high-pressure steam sterilization at a high temperature of 121 DEG C so that impurities and bacteria in the solution are removed thoroughly and preparation bioavailability and absorption effects are improved. The preparation method has simple processes and is convenient for operation. The lidocaine carbonate injection obtained by the preparation method is safe and effective in clinical use and has small side-effects. Compared with the existing lidocaine carbonate injection, the lidocaine carbonate injection obtained by the preparation method obviously shortens onset time and pain sensation disappearance time and prolongs anaesthesia duration time.

The invention provides a healthcare product for conditioning gastrointestinal functions. The healthcare product consists of a component A and a component B, wherein the component A is fermentation broth of probiotic flora, natural mineral water, rice bran, spiral seaweed, momordica grosvenori, radix puerariae and brown sugar; the component B is a fructo-oligose solution. The component A and the component B are uniformly mixed before drinking. The healthcare product provided by the invention is easy to be absorbed by human bodies after being taken, is safe and free of side effects, is not limited by the age, gender or physiological conditions, is applicable to people (including the old and the weak, patients after operation, puerperae, children and the like) with constipation caused by various factors, and particularly has a function of preventing accidents of heart and cerebral vessels of patients with severe hypertension and heart and cerebral vessel diseases; and in addition, the healthcare product has remarkable effects on removing waste and toxicity in intestinal canals as well as beautifying and maintaining beauty.

The invention discloses new compounds and application thereof. The compounds are L-ascorbic acid-6-(E-2-caproleic acid)ester or derivatives thereof, or acceptable salts or solvates thereof in food, pharmacy, veterinary medicine, animal feed, daily chemicals, relating to the technical field of heterocyclic compounds. The chemical general formula of the L-ascorbic acid-6-(E-2-caproleic acid)ester or derivatives thereof is disclosed in the specification, wherein R1-3 are H or C2-20 aliphatic acyl groups. The compounds are applicable to the fields of pharmacy, food, health food, daily chemicals, veterinary medicine, animal feed and the like. The compounds have the advantages of simple preparation method, low cost, stable structure and obvious effect, and have favorable application prospects.

The invention discloses dihydroartemisinin piperaquine phosphate tablets and a preparation method thereof. The tablets are prepared from dihydroartemisinin, piperaquine phosphate, hydroxypropyl methyl cellulose E5, hydrophilic accessory and lubricating agent, wherein the weight ratio of the dihydroartemisinin to the hydroxypropyl methyl cellulose E5 is 1:(1-5). Solid dispersion of the dihydroartemisinin and pulverized piperaquine phosphate can be obtained by adopting one-step operation, so that the production efficiency is improved; and the tablets are dissolved quickly.

The invention provides a pharmaceutical composition containing (S)-2-(4-(((1R,2S)-2-hydroxycyclopentyl)methyl)phenyl)propionic acid represented by a formula I, wherein the pharmaceutical composition can be in various preparation forms including injections, oral solid preparations, external semisolid preparations and the like. The invention also provides a preparation method of the pharmaceutical composition, and application of the pharmaceutical composition in preparation of antipyretic, analgesic and anti-inflammatory drugs. The pharmaceutical composition disclosed by the invention has the advantages of relatively small dosage, relatively fast drug effect and relatively small toxic and side effects, and has a wide prospect in the clinical treatment fields of analgesia, antipyretic treatment and inflammation diminishing.

The invention discloses a nasal gel agent containing risperidone and a preparation method of the nasal gel agent, and belongs to the field of pharmaceutical preparations. The nasal gel agent comprises risperidone, a matrix material, pharmaceutically acceptable water and other pharmaceutically effective auxiliary materials such as an osmotic pressure regulator, an absorption enhancer, a preservative, a humectant and a pH regulator. The preparation method comprises the following steps: dissolving risperidone and the other pharmaceutically effective auxiliary materials in the water in sequence, adding into a blank gel matrix in sequence, and fully and uniformly grinding. The nasal gel agent is simple in preparation process and has the characteristics of remarkable brain-targeting characteristic, high absorption and action speed, high bioavailability, good clinical curative effect and high convenience and safety in use.

The present invention provides a glyphosate herbicidal composition containing a gibberellin like compound, and effective components of the glyphosate herbicidal composition are a glyphosate compound and the gibberellin compound. The glyphosate herbicidal composition is glyphosate acid or a herbicidal-activity derivative thereof, and the gibberellins is any one or more of GA1, GA2, GA3, GA4, GA5, GA6, GA7 and other gibberellins matter The ratio of glyphosate: gibberellin is 100:0.01-100:10. The glyphosate and the gibberellin product are compounded, by combination of glyphosate stem leaf uptake and translocation effect and gibberellin growth regulating mechanism, the herbicide has obvious synergy, the herbicidal-effect-taking time is shorten by 2-5 days, the herbicide use amount is reduced by 20%-50%, and the glyphosate herbicidal composition has better effect on for some malignant weeds, and has the advantages of broad spectrum, high efficiency, low toxicity, low pollution, quick effect, low cost and convenient use.