Compound bifonazole nano-emulsion spray preparation and preparation method thereof

Abstract

The invention discloses a compound bifonazole nano-emulsion spray preparation. The nano-emulsion spray preparation has the grain size of 1 nm to 100 nm and is formed by the following raw materials in mass percent: 30%-40% of surfactant, 3%-14% of cosurfactant, 5%-10% of oil phase, 0.8%-2% of bifonazole, 0.02%-0.1% of clobetasol propionate, 0.01%-0.2% of cinnamyl aldehyde and the balance of deionized water, wherein the sum of the mass percents of the raw materials is 100%. The compound bifonazole nano-emulsion spray preparation has multiple actions, such as fungicide, bactericide, anti-bacterial, anti-fungal, antiinflammation, itching relieving and the like, treats superficial skin fungous infection, fungous paronychia and candidal vulvovaginitis, and is also effective to external otitis and bacterial skin infection. The compound bifonazole nano-emulsion spray preparation prepared by a preparation method of the compound bifonazole nano-emulsion spray preparation has the advantages that: the activity of the three drugs is remarkably improved, the effect of sterilization and itching relieving is rapid, the recurrence is difficult, and the preparation method is simple, so that the compound bifonazole nano-emulsion spray preparation and the preparation method thereof have broad market prospects in the medicine field.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a compound formula of an antifungal drug bifonazole for external use, and a method for preparing the compound into a new dosage form, specifically a transparent and stable oil-in-water compound bifonazole An azole nanoemulsion spray and a preparation method thereof. Background technique [0002] Bifonazole (Bifonazole) is an imidazole antifungal drug, its antibacterial mechanism is dual inhibition of fungal cell membrane ergosterol synthesis, in addition to acting on P450-14a demethylation like other imidazole drugs, it also acts on hydroxymethyl Glutamate-CoA reductase has a broad-spectrum antifungal effect and can inhibit 90% of pathogenic fungi. Against dermatophytes (e.g. Trichophyton, Microsporum), yeasts (e.g. Candida, Saccharomyces, Torulopsis), molds (e.g. Aspergillus), filamentous fungi, Phytophthora phyllosa, Corynebacterium tiny, etc. are effective, and are suitable for superf...

AI Technical Summary

Problems solved by technology

At present, there are few reports of adding cinnamaldehyde to external antifungal infection drugs. Cinnamaldehyde is insoluble in water, which limits the transdermal absorption rate of external drugs.

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