Chinese medicine film as well as preparation method and application thereof

A technology of film preparation and traditional Chinese medicine, which is applied in the direction of medical formula, medical preparations of non-active ingredients, sheet-like transportation, etc. It can solve problems such as poor taste, easy aging during production or storage, and large differences in pill weight.

Active Publication Date: 2013-10-09
KANGMEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the application of oral instant film preparations in the field of Chinese patent medicines is still blank. For Chinese medicine dripping pills that are also administered orally, there are large differences in pill weight, low pass rate, easy aging during production or storage, and poor taste. Poor disadvantages such as poor, because the drug loading of oral instant film and drop pills is similar, if traditional Chinese medicine drop pills are converted into oral instant film, not only can carry the advantages of traditional drop pills, but also can overcome the shortcomings of drop pills, it must have Broad application prospects

Method used

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  • Chinese medicine film as well as preparation method and application thereof
  • Chinese medicine film as well as preparation method and application thereof
  • Chinese medicine film as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1 Extraction of Active Components of Ginseng

[0051] Extraction of ginsenosides: Weigh 50g of ginseng fibrous root coarse powder, soak in water overnight (add CaO to adjust the pH value to 11), ultrasonically extract 3 times (solvent volumes are: 500ml, 400ml, 300ml in turn, ultrasonic time is 30min each time, and keep The extract is alkaline), filter with suction, combine the filtrates, put them on a macroporous adsorption resin column, wash with water until the eluate is colorless and the solution is neutral, then elute with 80% ethanol until TLC checks that the effluent has no saponin reaction So far, the ethanol eluent was recovered to dryness under reduced pressure, and the residue was crude ginsenoside. It is refined with 95% ethanol (the crude product is dissolved in 20 times the amount of 95% ethanol and ultrasonically dissolved, filtered with suction, and the filtrate is recovered to dryness under reduced pressure), and the residue is the refined gin...

Embodiment 2

[0052] Example 2 Extraction of active components from Cordyceps sinensis

[0053] (1) Extraction of cordyceps sterol: Add organic solvent to the dried and crushed Cordyceps sinensis mycelium, add 40 ml of organic solvent per 1 gram of mycelium, extract at 30°C for 0.1 hour, filter, and repeat the extraction 4 times , mixing the filtrate obtained each time, and the residue for later use; wherein the organic solvent is cyclohexane; concentration: the filtrate is concentrated at a temperature of 30°C under normal pressure or reduced pressure until there is no organic solvent smell, and the organic solvent is recovered. Obtain a concentrate; saponification: add 5 milliliters of alkaline solution to every 1 gram of concentrate at normal temperature, mix well, let stand for 0.5 hour, remove the saponifiable matter in the lower layer, obtain unsaponifiable liquid, repeat saponification 3 times, wherein the alkali The neutral solution is a sodium hydroxide solution with a concentrat...

Embodiment 3

[0054] Example 3 Extraction of active ingredients from rhino horn

[0055] The rhinoceros horn is pounded into slices and ultrafinely pulverized, and the fine powder is sieved to 400 mesh. Add 10 times of water to the superfine powder and cold soak twice, each time for 12 hours, add 20 times of water to decoct the medicinal residues 4 times, each time for 4 hours. The cold extract and the water decoction are concentrated under reduced pressure and vacuum respectively, and then combined to obtain the active ingredient of rhino horn.

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PUM

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Abstract

The invention provides a Chinese medicine oral instant film as well as a preparation method and application thereof. The film comprises Chinese medicine active ingredients and auxiliary materials and is a light and thin film which is placed on a tongue and instantly released. The Chinese medicine oral instant film preparation has the advantages that the onset time of the traditional Chinese medicine can be shortened; the bioavailability of the traditional Chinese medicine is increased; the taste of the traditional Chinese medicine is improved; the irritation of the traditional Chinese medicine to stomach and intestine is reduced; and accordingly, the application range of the traditional Chinese medicine in specific crowd is widened.

Description

technical field [0001] The invention relates to a traditional Chinese medicine film, belonging to the field of pharmaceutical preparations. Background technique [0002] Oral instant film (lingual film) is a new pharmaceutical preparation abroad, and it is a brand-new and advanced drug delivery system, which is highly recognized by experts in the industry. Its dosage form is a light film, which can be placed directly on the tongue On the other hand, with the dissolution of the diaphragm, the drug is released rapidly and absorbed through the oral cavity. Compared with traditional drug dosage forms, it has the advantages of rapid drug release (3-5 seconds), long action time, high availability, accurate content, uniform dispersion and stability. Good sex, light weight, small size and other advantages, because of its good taste, convenient application and cute appearance, it is very popular among children and patients. In 2005, the product "Thin Strips" of Novartis Pharmaceutic...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/36A61K47/26A61K47/38
Inventor 向飞军马兴田许冬瑾
Owner KANGMEI PHARMA
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