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Application of dendrobium candidum polysaccharide in preparing drug for promoting hair growth

A Dendrobium candidum polysaccharide and hair growth technology, which can be used in drug combination, skin diseases, etc., can solve problems such as hair loss, unclear mechanism, and nephrotoxicity

Inactive Publication Date: 2013-07-31
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above drugs (or active ingredients) all have certain defects, such as minoxidil takes a long time to take effect (12 weeks), new hairs gradually fall off after oral administration, and the mechanism is still unclear; finasteride, RU58841 , CyA will continue to lose hair after stopping the drug, CyA should monitor the liver and kidney function during the medication; FK506 has obvious nephrotoxicity when taken orally

Method used

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  • Application of dendrobium candidum polysaccharide in preparing drug for promoting hair growth
  • Application of dendrobium candidum polysaccharide in preparing drug for promoting hair growth
  • Application of dendrobium candidum polysaccharide in preparing drug for promoting hair growth

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0015] Example 1 (Preparation of Dendrobium officinale polysaccharide)

[0016] 1.1 Extraction of Dendrobium officinale polysaccharides

[0017] Sample 1:

[0018] The dried stem of Dendrobium candidum is crushed and passed through 50 meshes to obtain Dendrobium candidum powder; water 50 times the powder mass is added to the Dendrobium candidum powder, decocted and extracted twice, each time for 2 hours; the two extracts are combined and concentrated to the original One-tenth of the volume, add 4 times the volume of ethanol with a volume concentration of 95% to the concentrated solution, let it stand overnight, centrifuge, remove the lower layer of sediment, freeze-dry and fully dissolve it with an appropriate amount of water, add Sevage reagent (positive Butanol and chloroform mixed solution, the volume ratio is n-butanol: chloroform = 1:5) to remove protein 6 times, add half volume of Sevage reagent each time, shake well, let stand for 30min to separate layers, collect the ...

example 2

[0024] Example 2 (preparation of dendrobium cream containing 0.1% dendrobium officinale polysaccharide)

[0025] (1) Formulation:

[0026] Dendrobium officinale polysaccharide: 10.1 g of the sample obtained in Example 1;

[0027] Oil phase: simethicone 2.5g, liquid paraffin 3.5g, white oil 4g;

[0028] Water phase: Carbomer ultra-1019.6g, glycerin 2g, PEG-4002g;

[0029] Antibacterial agent: clove oil 0.2g;

[0030] Emulsifier: Lecithin 2g.

[0031] (2) Preparation method: After the Dendrobium officinale polysaccharide is added to the water phase, the water phase and the oil phase are heated in a water bath at 60°C respectively, and after mixing well, the water phase is slowly poured into the oil phase, and after stirring evenly, Use 18% NaOH to adjust the pH to 6.5-7.5, add water to 100g to constant volume. Stir and cool to 25°C. Stop stirring, and make 0.1% dendrobium cream after leaving standstill 30min.

[0032] (3) Usage and dosage: topical application, when the ha...

example 3

[0033] Example 3 (preparation of dendrobium cream containing 0.5% dendrobium officinale polysaccharide)

[0034] (1) Formulation:

[0035] Dendrobium officinale polysaccharide: 10.5 g of the sample obtained in Example 1;

[0036] Oil phase: simethicone 2.5g, liquid paraffin 3.5g, white oil 4.5g;

[0037] Water phase: Carbomer ultra-1018.6g, glycerol 1.9g, PEG-4001.8g;

[0038] Antibacterial agent: clove oil 0.2g;

[0039] Emulsifier: Lecithin 2g.

[0040] (2) Preparation method: After the Dendrobium officinale polysaccharide is added to the water phase, the water phase and the oil phase are heated in a water bath at 60°C respectively, and after mixing well, the water phase is slowly poured into the oil phase, and after stirring evenly, Use 18% NaOH to adjust the pH to 6.5-7.5, add water to 100g to constant volume. Stir and cool to 25°C. Stop stirring, make 0.5% dendrobium cream after standing 30min.

[0041] (3) Usage and dosage: topical application, when the hair and s...

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Abstract

The invention relates to application of dendrobium candidum polysaccharide in preparing a drug for promoting hair growth, wherein the dendrobium candidum polysaccharide in the drug is 0.1%-5% by weight. The dendrobium candidum polysaccharide in the drug disclosed by the invention can be used for regulating up expression of a vascular endothelial growth factor (VEGF) gene in a keratoderma forming cell (HaCaT cell) blood vessel, so that the effect of prompting the hair growth is achieved.

Description

technical field [0001] The invention relates to a pharmaceutical preparation containing organic active ingredients, in particular to the application of dendrobium officinale polysaccharide in pharmacy. technical background [0002] With the acceleration of the pace of life and the increase of work pressure, the number of people with hair loss is increasing, which has a great impact on the patient's spirit, mental health and social interaction. At present, the methods of preventing and treating hair loss mainly contain surgical treatment and drug treatment. Surgical treatment has the disadvantages of high cost and possible complications such as infection and transplanted hair necrosis. Drug treatment (or active ingredient) includes antihypertensive drug minoxidil, steroidal drug finasteride, non-steroidal drug RU58841, cellular immunosuppressant cyclosporine A (CyA), T cell inhibitor FK506 Wait. However, the above drugs (or active ingredients) all have certain defects, suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P17/14
Inventor 魏小勇陈健
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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