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Application of glaucocalyxin in preparing anti-inflammation and anti-light-aging products

A blue calyxine, anti-photoaging technology, applied in the fields of medical technology and cosmetics, to achieve good application prospects, good anti-photoaging, good skin cell protection effects

Active Publication Date: 2019-04-02
广州茱颜化妆品有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0006] However, there is no report on the anti-inflammatory and anti-photoaging aspects of cyanine A and compounds with similar structures

Method used

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  • Application of glaucocalyxin in preparing anti-inflammation and anti-light-aging products
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  • Application of glaucocalyxin in preparing anti-inflammation and anti-light-aging products

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Embodiment Construction

[0038] The technical solution of the present patent will be described in further detail below in conjunction with specific embodiments.

[0039] Lipopolysaccharide (LPS)-induced inflammation in mouse macrophages RAW264.7 is a commonly used cellular model for inflammation research. LPS can activate inflammatory signaling pathways such as NF-κb and MAPK by binding to the macrophage membrane receptor TLR4, thereby inducing the expression of downstream inflammatory genes and secreting a series of inflammatory factors such as nitric oxide (NO) and interleukin-6 (interleukin 6). )Wait. The present invention takes LPS-induced RAW264.7 cells to release NO and IL-6 as the target, and investigates the anti-inflammatory effect of bluecalyxine and its similar structural compounds.

[0040] Skin aging includes natural aging and photoaging, in which photoaging not only causes changes in skin color, texture, elasticity, thickness, etc., but may even cause various benign or malignant tumors ...

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Abstract

The invention discloses an application of glaucocalyxin and a compound with a similar structure to glaucocalyxin in preparing anti-inflammation and anti-light-aging products, and relates to the technical field of medicines and cosmetics in order to solve the problem that a study of glaucocalyxin and the compound with the similar structure to glaucocalyxin in terms of inflammation resistance and light aging resistance is unavailable. A good anti-inflammatory effect of glaucocalyxin and the compound with the similar structure is verified by taking LPS (lipopolysaccharide) induced release of NO and IL-6 (interleukin 6) from RAW264.7 cells as a target; glaucocalyxin and the compound with the similar structure are proven to have good application prospects in preparing the anti-inflammation products; a good anti-light-aging effect of glaucocalyxin and the compound with the similar structure is verified by taking UVB induced HaCaT cell damage and IL-6 secretion as a target; and glaucocalyxinand the compound with the similar structure are proven to have good application prospects in preparing the anti-light-aging products.

Description

technical field [0001] The invention relates to the technical fields of medical technology and cosmetics, in particular to the application of blue calyxine in the preparation of anti-inflammatory and anti-photoaging products. Background technique [0002] Blue calyx incense tea, also known as mountain suzi and cauliflower, is the dry ground whole grass of the Lamiaceae plant blue calyx incense tea. It is cool in nature, bitter and sweet in taste, and has the functions of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis. In clinical practice, blue calyx incense tea is used to treat colds, sore throat, tonsillitis, and snake and insect bites. [0003] Modern research has found that the blue calyx tea has a variety of biological activities, including anti-tumor, anti-viral and cardiovascular improvement, and most of these activities are based on the kaurane-type diterpenoids such as blue calyxine. , B, C, D, Pen, G, etc. Among these c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K8/35A61Q19/08A61P29/00A61Q19/00A61P17/16
CPCA61K8/35A61K31/122A61Q19/004A61Q19/08A61P17/16A61P29/00
Inventor 周鲁先李宁王惠琇
Owner 广州茱颜化妆品有限公司
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