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Application of icariin in preparation of medicine for treating dermatitis

A technology for the use of icariin, which is applied in the field of icariin in the preparation of medicines for treating dermatitis, and can solve the problems that the use of icariin has not been reported.

Inactive Publication Date: 2016-11-23
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the use of icariin in anti-dermatitis

Method used

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  • Application of icariin in preparation of medicine for treating dermatitis
  • Application of icariin in preparation of medicine for treating dermatitis
  • Application of icariin in preparation of medicine for treating dermatitis

Examples

Experimental program
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Effect test

Embodiment 1

[0014] Embodiment 1: In vitro test of icariin against dermatitis

[0015] 1. Materials and methods

[0016] 1. Cell line: Human keratinocyte line (HacaT) was incubated at 37°C with a volume fraction of 5% CO in DMEM medium containing 10% fetal calf serum. 2 , Routine culture under fully saturated humidity conditions, replace the medium for 48 hours, when the cell growth reaches saturation, digest with 0.25% trypsin + 0.02% EDTA for passage, once every 2-3 days, the experiment uses logarithmic growth phase cells.

[0017] 2. Detection of Cytotoxicity of Icariin:

[0018] Adjust the concentration of HacaT cell line cell suspension to 1×10 5 / mL, added to 96-well culture plate, 100 μL per well, placed at 37°C 5% CO 2 Incubator for 24h. The old medium was sucked off, and DMEM medium containing icariin (drug concentration: 5 μM, 10 μM, 30 μM, 50 μM, 70 μM, 100 μM, 150 μM) was added respectively, and a blank control group and a zero adjustment group were set up. 3 duplicate wel...

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Abstract

The invention discloses novel medicinal application of icariin, and particularly relates to application of icariin in preparation of medicine for treating dermatitis. TNF-alpha / IFN-gamma-irritated skin keratinocytes (HaCaT cells) are adopted as an in-vitro dermatitis model and subjected to icariin intervention. A result shows that icariin can effectively inhibit rising of the level of HaCaT cell inflammatory factors (IL-6, IL-1beta and IL-8) which are induced by TNF-alpha / IFN-gamma; the skin inflammatory resisting effect of icarriin is related to inhibition on expression of phosphorylation p38 and phosphorylation ERK; the skin inflammatory resisting effect of icarriin is related to improvement of cortisol secretion of the skin keratinocytes. Icariin can be used for preparing the medicine for treating the dermatitis.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a new medicinal application of icariin, an effective component of traditional Chinese medicine, and specifically relates to the application of icariin in preparing a medicine for treating dermatitis. Background technique [0002] The prior art discloses that dermatitis is a common skin disease, including summer dermatitis, seborrheic dermatitis, solar dermatitis, drug-induced dermatitis, contact dermatitis, hormone-dependent dermatitis, neurodermatitis, etc., and its clinical manifestations can be Redness, swelling, itching, peeling, and thickening of the skin occur. [0003] Screening active ingredients from natural medicines has always been a hot spot in the research and development of anti-dermatitis drugs. [0004] Icariin exists in Epimedium medicinal material, and its chemical structure formula is as follows: [0005] [0006] Studies have found that icariin can inhibit skin m...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P17/00
Inventor 董竞成孔令雯
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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