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Composition for reducing irritation of surfactant to skin and application of composition

The technology of a surfactant and a composition is applied in the field of compositions that reduce the irritation of the surfactant to the skin, which can solve the problems of high skin irritation in infants and children, and achieve the effects of low toxicity and reduced cytotoxicity

Active Publication Date: 2021-01-26
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still problems such as surfactants being more irritating to the skin of infants and children in the current products.

Method used

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  • Composition for reducing irritation of surfactant to skin and application of composition
  • Composition for reducing irritation of surfactant to skin and application of composition
  • Composition for reducing irritation of surfactant to skin and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0036] Embodiment 1-6 and comparative example:

[0037] According to the following Table 1, the comparative examples and the examples were manufactured respectively, so as to implement the cytotoxicity experiment to verify that vitamin E, dipotassium glycyrrhizinate, and panthenol can reduce the toxicity of surfactants to HacaT cells.

[0038] Table 1

[0039]

[0040]

Embodiment 7

[0041] Embodiment 7: baby shampoo and baby shower gel products

[0042] The composition of the present invention adopted in the infant and child care products in this embodiment is the formula ratio of Example 1 in Table 1, and the specific formula is shown in Table 2. The difference between the baby shampoo and the body wash is that the amount of the care agent is 1.5%. One is 1.0%. .

[0043] Table 2 Formula of baby shampoo

[0044]

[0045]

Embodiment 8

[0046] Example 8: Cytotoxicity Test and Eye Irritation Test

[0047] 1. Grouping

[0048] Each group in Table 1 and the baby shampoo and shower gel of Examples 7 and 8 in Example 7, and comparative example 9 Innisfree baby soft foam shampoo and shower gel, comparative example 10 Amria honey shampoo and shower gel, Comparative Example 11 Shiba Baby Bubble Shower Gel;

[0049] 2. Cytotoxicity test to evaluate irritation

[0050] The cytotoxicity evaluation model of HacaT cells (MTT experiment) was used to compare the effects of different compositions on cytotoxicity, so as to screen out the compositions with lower cytotoxicity. Samples with five concentrations of 1000, 500, 250, 125, and 62.5 μg / mL were applied to HacaT cells for 24 hours, and MTT was added to incubate to test cell viability. The detection principle is that succinate dehydrogenase in the mitochondria of living cells can reduce exogenous MTT to water-insoluble blue-purple crystalline formazan and deposit in th...

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PUM

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Abstract

The invention relates to the technical field of baby washing and caring, and discloses a composition for reducing irritation of a surfactant to skin and application of the composition. The compositiondisclosed by the invention is prepared from vitamin E, dipotassium glycyrrhizinate and D-panthenol. According to the composition, vitamin E, dipotassium glycyrrhizinate and panthenol are used as theirritation-reducing composition adapted to disodium coco-glucoside citrate, so that the toxicity to HacaT cells and the irritation to eyes can be remarkably reduced; and in comparison with other surfactants for irritation reduction, the composition has high concentration adaptability to disodium coco-glucoside citrate, and can be applied to washing and caring products using disodium coco-glucosidecitrate, particularly to washing and caring products for infants and children.

Description

technical field [0001] The invention relates to the technical field of baby care and care, in particular to a composition for reducing the skin irritation of surfactants and an application thereof. Background technique [0002] With the maturity of the daily chemical product market, the variety of products and the target groups are becoming more and more perfect and comprehensive. Under the trend of market demand, baby and child care products have more and more product varieties. [0003] In addition, with the change of the national family planning policy, the number of infants and children will increase year by year in the future, and the number and variety of infant and child care products will also increase. The stimulation sources of the external environment are also constantly diversifying. And the irritants such as detergents, emulsifiers, essences, pigments, and preservatives in cosmetics are the most common. [0004] The skin of infants is delicate, the epidermis is...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/63A61K8/42A61K8/60A61Q19/00A61Q19/10A61Q5/02
CPCA61K8/678A61K8/63A61K8/42A61K8/602A61Q19/005A61Q19/10A61Q5/02Y02A50/30
Inventor 李莉楠刘光荣杨凯业杜志云刘冠廷林丽刘晓英苏玉婷
Owner INFINITUS (CHINA) CO LTD
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