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87results about How to "Inhibit hyperproliferation" patented technology
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Dressing composition used for inhibiting scars and accelerating wound healing and application thereof
InactiveCN101897990APromote healingShorten healing timeAbsorbent padsBandagesCarboxymethyl-chitosanSodium hyaluronate
The invention discloses a dressing composition used for inhibiting scars and accelerating wound healing and application thereof. The dressing composition consists of chitosan, acidic polysaccharide and panax notoginseng saponins in a weight proportion of 100:10-50:10-100, wherein the chitosan is selected from chitosan, chitosan lactate, acetate and hydrochloride; the acidic polysaccharide is selected from sodium carboxymethyl chitosan, sodium hyaluronate, zinc hyaluronate, sodium alginate and sodium carboxymethyl cellulose; and the panax notoginseng saponins accounts for no less than 40.0 percent of the total weight of ginsenosides Rg1 and Rb1. The formulations of the dressing composition are xerogel powder, capsules, gel membranes, hydrogels and fiber coatings. The dressing composition is used for wounds, burns, scalds, crush injuries, skin ulcers, gastroenteric ulcers and no healing of the wounds, has the advantages of rapid hemostasis, exudate reduction, moisturizing, air permeability, bacteriostasis, inflammation diminishing, itch relieving, no adhesion, effective inhibition of scarring, remarkable reduction of wound healing time and no need of replacing dressings, so that thedressing composition basically meets requirements of perfect functional external dressings.
Owner:DALIAN UNIV OF TECH
Composite coating cardiovascular medicaments elution stent and preparation thereof
ActiveCN101264351AInhibit hyperproliferationPrevention of acute thrombosisStentsSurgeryDrug coatingPercent Diameter Stenosis
The invention provides a blood vessel drug elution bracket with coating layers and the preparation method. The blood vessel drug elution bracket with coating layers comprises: a: a bare stents with supporting role; b: a non-degradation bioactive coating coated on the surface of the bare stents; and c: a degradation bioactive drug coating coated on the surface of the bioactive coating. The blood vessel drug elution bracket with coating layers has the advantages of not only obvious anti-restenosis properties, but also ability to decrease the occurrence of thrombus for the stable bioactive coating; simultaneously, the bioactive coating can intensify the adsorption force of the drug coating on the bracket surface, reduce the crack, upwrap and shedding during the using process of the drug coating, thus improving the effectiveness and safety of the drug bracket.
Owner:ESSEN TECH (BEIJING) CO LTD
Medical degradable Zn-Cu-X alloy material and preparation method thereof
The invention discloses a medical degradable Zn-Cu-X alloy material and a preparation method thereof. The alloy material includes the following components in percentage by weight: 1-10% of Cu, 0-4% of X and the balance Zn, wherein the element X is one of Mg, Ca, Sr, Si, Fe, Mn, Ag, Y, Nd, Gd, Er, Ho and Dy or is a mixture of more of Mg, Ca, Sr, Si, Fe, Mn, Ag, Y, Nd, Gd, Er, Ho and Dy. The invention further relates to the preparation method of the alloy material. The alloy material provided by the invention is a multi-element degradable Zn-based alloy material composed of the human nutrient elements Zn, Cu and X, which completely have biosecurity, has favorable biocompatibility, excellent mechanical properties and an adjustable and controllable corrosion rate, and has a favorable application prospect in the field of medical degradable inner implantation material.
Owner:SHANGHAI JIAO TONG UNIV
Organization engineering skin containing peripheral hematopoietic stem cells and method of preparing the same
InactiveCN101138654APromote proliferationPromote differentiationProsthesisMechanical wearTissue engineered skin
The present invention is a tissue engineering skin containing the peripheral blood stem cell and the preparation method. The present invention puts the peripheral blood stem cell and the skin fibroblast cell inside the biological frame. The active tissue engineering skin containing the peripheral blood stem cell is built by planting the epidermal cell on the surface. The tissue engineering skin is similar to the natural skin tissue in structure. Compared with the present skin replacing product, the present invention has properties of improving the blood supply in the wound and promoting the wound healing. The present invention can improve the elastic and toughness properties of the skin as well as the mechanical wear tolerance. The present invention can also reduce the scar proliferation and improve the healing quality. The present invention can improve the success rate of the artificial skin planting and can be effectively applied in repairing the skin defect, which is hard to heal.
Owner:陕西艾尔肤组织工程有限公司
Arginyl-glutamine dipeptide for treatment of pathological vascular proliferation
ActiveUS20050070484A1Extend your lifeImprove survival rateDipeptide ingredientsDepsipeptidesVascular proliferationAqueous solution
The subject invention provides dipeptides useful in preventing pathological proliferation of blood vessels. The dipeptides of the subject invention are particularly advantageous because they are stable, bioavailable, and can be formulated in an aqueous solution.
Owner:UNIV OF FLORIDA RES FOUNDATION INC
Method for planting esoderma/endothelial cell on inner surface of artificial blood vessel
InactiveCN1559360AImprove adhesionInhibit hyperproliferationMicroorganismsGenetic material ingredientsBlood vessel featureFluid shear
A method for implanting the endothelial cells on the inner surface of artificial blood vessel features that a biomechanical method is used, that is, an external pulsive fluid shearing force increased step by step acts on the planted endothelial cells to make them be attached well on the inner surface of artificial blood vessel in advance.
Owner:CHONGQING UNIV
Inductive uterine slow release system
The invention discloses an inductive uterine slow release system. The incidence of uterine adhesion after an induced abortion operation is high, the re-adhesion is serious after a uterine adhesion operation, and no good solution is available at present. The system comprises a uterus-shaped elastic balloon stent, a slow release drug film, a catheter and a one-way inflation valve, wherein the uterus-shaped elastic balloon stent is a hollow isosceles triangle structural body; waists of the isosceles triangle are 3.5cm; the bottom edge of the isosceles triangle is 3cm; one end of the catheter is connected and communicated with the vertex angle end of the uterus-shaped elastic balloon stent; the other end of the catheter is connected with the one-way inflation valve; a plurality of annular scales are arranged on the outer side face of one end, close to the uterus-shaped elastic balloon stent, of the catheter; and the one-way inflation valve comprises an inflation valve and a pressure sensor. The uterus-shaped elastic balloon stent is coated with the slow release drug film, and the slow release drug film is made of fibrin glue and contains a slow release drug. The system is simple in structure and easy to operate, does not injure a uterine cavity easily, and can effectively avoid the uterine adhesion.
Owner:杭州安体科技有限公司
Materials and Methods for Treatment of Pathological Ocular Vascular Proliferation
InactiveUS20090192226A1High survival rateInhibit hyperproliferationBiocideSenses disorderDocosahexaenoic acidVascular proliferation
The subject invention provides for the administration of docosahexaenoic acid in preventing pathological proliferation of blood vessels. The compositions of the subject invention are particularly advantageous because they are stable, bioavailable, and can be formulated in an aqueous solution.
Owner:UNIV OF FLORIDA RES FOUNDATION INC +1
Breakthrough to cure psoriasis, psoriatic arthritis and treatment of other unrelated skin disorders, and external rectal and genital itching
InactiveUS20070031509A1Efficient and economical treatmentInhibit hyperproliferationBiocideInorganic active ingredientsZinc hydroxideT cell
This invention provides a novel method of treating psoriasis in humans by topical administration of a mixture consisting of copper lactate [Cu (C3, H5 O3)2. 2H2O], zinc hydroxide Zn(OH)2, trace amounts of cupric oxide and purified water by blunting the action of T cells present in the bleeding points located in and around the psoriatic lesions. When the bleeding points are absent in psoriatic lesions, this composition eliminates primary psoriatic symptoms such as inflammation, itching, rete ridges and tough red skin patches without curing psoriasis. The size and population of psoriatic lesions is also reduced. This composition is also very effective for providing instant relief from skin rash and itching.
Owner:SUNDAE LAXMAN S
Bifidobacterium animalis capable of relieving psoriasis and application of bifidobacterium animalis
ActiveCN112159778ARelieve psoriasisInhibit hyperproliferationCosmetic preparationsBacteriaBiotechnologyMicroorganism
The invention discloses bifidobacterium animalis capable of relieving psoriasis and application of the bifidobacterium animalis, and belongs to the technical field of microorganisms and medicines. Theinvention provides a bifidobacterium animalis CCFM1148, and the bifidobacterium animalis CCFM1148 can alleviate psoriasis, which is specifically reflected in that the bifidobacterium animalis CCFM1148 inhibits the excessive proliferation of psoriasis-like cortical forming cells, inhibits activation of an NF-kB signal path in psoriasis-like cortical forming cells, reduces the level of proinflammatory factor IL-6 in psoriasis-like cortical forming cells, and reduces the level of a proinflammatory factor IL-8 in psoriasis-like cortical cells, so that the bifidobacterium animalis CCFM1148 has a huge application prospect in preparation of products (such as daily chemical products or medicines) for preventing and / or treating psoriasis.
Owner:JIANGNAN UNIV
Retina pigment epithelial cell culture medium and application thereof
InactiveCN104178452AProtects against oxidative damageIncrease vitalityArtificial cell constructsVertebrate cellsCell culture mediaBiology
The invention relates to a retina pigment epithelial cell culture medium and an application thereof. The retina pigment epithelial cell culture medium comprises a first RPE (Retinal Pigment Epithelium) cell culture medium and a second RPE cell culture medium, wherein the first RPE cell culture medium and the second RPE cell culture medium are respectively used in 1.5 weeks, a RPE monolayer cell needed for cell replacement therapy can be quickly cultured; and the cultured RPE is polygonal, embedded and polarly-arranged monolayer cell and has the normal biological functions. Compared with the prior art, the RPE monolayer cell needed for cell replacement therapy can be quickly cultured in 1.5 weeks under the precondition that the conventional laboratory consumables are used; and the retina pigment epithelial cell culture medium is relatively low in cost and high in proliferation speed.
Owner:TONGJI UNIV
Apogossypolone and the uses thereof
InactiveUS20060178435A1Toxic reductionMore tolerableBiocideOrganic compound preparationSensitized cellApogossypolone
The invention relates to the compound apogossypolone and salts and prodrugs thereof. Apogossypolone functions as an inhibitor of Bcl-2 family proteins. The invention also relates to the use of apogossypolone for inhibiting hyperproliferative cell growth, for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
Owner:RGT UNIV OF MICHIGAN
Application of M2 pyruvate kinase as drug target in preparation of drugs for prevention and treatment of psoriasis
InactiveCN108653736AInhibit hyperproliferationStop progressOrganic active ingredientsDermatological disorderMedicineDrug target
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Novel prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
InactiveUS20070015246A1Inhibit hyperproliferationCell receptors/surface-antigens/surface-determinantsSugar derivativesTestis specificTesticle
The invention provides novel STAMP2 nucleic acid molecules, polypeptides, antibodies, and modulatory compounds for use in methods of diagnosing, treating, and preventing diseases and conditions of the prostate and testis, such as cancer.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE
Traditional Chinese medicine preparation for treating gastro-esophageal reflux disease
InactiveCN102512553APromote peristalsisPromote emptyingHeavy metal active ingredientsDigestive systemDiseaseEsophageal disease
The invention discloses traditional Chinese chinese preparation for treating gastro-esophageal reflex disease. Raw materials include, by weight part, from 10 to 15 parts of inula flower, from 5 to 10 parts of ruddle, from 10 to 15 parts of dry radix ginseng, from 5 to 10 parts of rhizoma pinelliae preparata, from 5 to 10 parts of radix glycyrrhizae preparate, from 12 to 18 parts of Sichuan coptischinensis, from 3 to 6 parts of fructus evodiae, from 15 to 20 parts of western tangkuei, from 10 to 15 parts of loquat leaves and from 1 to 3 parts of bitter platycodon grandiflorum. Efficiency of the traditional Chinese medicine preparation reaches 92.7%, and a good curative effect is obtained.
Owner:TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
Low-molecular-weight fucoidan and effect thereof on diabetic nephropathy
InactiveCN103804504AImprove kidney functionGood effectOrganic active ingredientsMetabolism disorderFucoidanIon exchange
The invention discloses a process for preparing low-molecular-weight fucoidan, wherein the low-molecular-weight fucoidan is prepared through the process steps of hydrochloric acid degradation, desalination, ion exchange column elution and the like. Proved by pharmacological activity experiments, the low-molecular-weight fucoidan prepared by adopting the method disclosed by the invention is capable of obviously improving renal function, reducing proteinuria, slowing glomerular sclerosis and playing a role of protecting kidney. Proved by animal experiments, the effect of the low-molecular-weight fucoidan is obviously better than that of fucoidan with the same dose, so that the low-molecular-weight fucoidan disclosed by the invention can be used for preparing drugs for treating diabetic nephropathy or can be directly used as a drug for treating the diabetic nephropathy.
Owner:SHANDONG UNIV
Probiotics ice cream and preparation method thereof
InactiveCN107173516AMeet your own health needsAvoid destructionFrozen sweetsFood ingredient functionsFlavorIce cream
The invention discloses probiotics ice cream and a preparation method thereof and belongs to the technical field of probiotics ice cream. The probiotics ice cream is prepared by mixing and sterilizing non-probiotics materials and sequentially performing homogenization, inoculation with probiotics, aging, congelation and hardening. The probiotics ice cream has stable quality, cannot prone to creaming, layering, flavor loss and the like in the aging and congelation processes and is suitable for production of the probiotics ice cream.
Owner:大庆市红宝石冰淇淋有限公司
Preparation method and application of amino-rich stent material modified by copper 4-carboxyphenyl porphyrin, blood vessel stent material and application
ActiveCN109663151APromotes endothelial cell adhesion and proliferationInhibits smooth muscle cell proliferationSurgeryPharmaceutical delivery mechanismLeiomyocyteCarboxylic group
The invention relates to a preparation method and application of an amino-rich stent material modified by copper 4-carboxyphenyl porphyrin, a blood vessel stent material and application, and belongs to the technical field of biological material surface modification. The preparation method of the amino-rich stent material modified by copper 4-carboxyphenyl porphyrin includes the steps that copper 4-carboxyphenyl porphyrin is dissolved in an organic solvent, the pH value of a solution is adjusted to be 7+ / -0.5, so that a copper 4-carboxyphenyl porphyrin solution is obtained. After an activatingagent and copper 4-carboxyphenyl porphyrin are mixed, the amino-rich stent material is put into a mixed solution for a reaction, taken out, flushed and sterilized. The surface of the blood vessel stent material is modified with copper 4-carboxyphenyl porphyrin, in this way, good biological compatibility is realized, repairing of endothelial cells can be promoted, and excessive proliferation of smooth muscle cells can be inhibited.
Owner:SOUTHWEST JIAOTONG UNIV
Self-assembly short-chain peptide and application of short-chain peptide in treatment of acne
ActiveCN111253469ALittle side effectsInhibit hyperproliferationCosmetic preparationsPeptide/protein ingredientsTreatment acneHormones levels
The invention discloses a self-assembly short-chain peptide and an application of the short-chain peptide in treatment of acne. The self-assembled short-chain peptide in the invention is a self-assembled short-chain peptide composed of 10 amino acid residues, and the amino acid sequence is shown as FFLQLQAEER. The self-assembled short-chain peptide can inhibit excessive proliferation of sebaceousglands and reduce secretion of skin oil, has smaller toxicity and side effects, is suitable for a wider population, has better transdermal properties, and can be used for acne resistance, especially for treatment of acne generated by changes in hormone levels during adolescence and pregnancy; and because the self-assembled short-chain peptide has only 10 amino acids, the short-chain peptide is self-assemble into nanospheres through modification, so that the self-assembled short-chain peptide has better stability, can continuously act on a treatment site, and has a significant effect.
Owner:JINAN UNIVERSITY
Biological preparation for treating xanthan gum fermentation process wastewater
ActiveCN110092526AHigh porosityChemically stableSpecific water treatment objectivesWater contaminantsWastewaterBacillus perfringens
The invention belongs to the technical field of organisms, and discloses a biological preparation for treating xanthan gum fermentation process wastewater. The biological preparation includes a combination of any two or more of Paracoccus denitrificans, Clostridium perfringens and Halomonas elogata. The bacteria in the biological preparation can form shortcut positive cycle, so the biological preparation has good synergistic performances, and can effectively treat pollutants in the wastewater.
Owner:内蒙古阜丰生物科技有限公司
Dressing composition used for inhibiting scars and accelerating wound healing and application thereof
InactiveCN101897990BInhibit hyperproliferationPromote growthAbsorbent padsBandagesCarboxymethyl-chitosanSodium hyaluronate
Owner:DALIAN UNIV OF TECH
Arginyl-glutamine dipeptide for treatment of pathological vascular proliferation
InactiveUS20050089547A1Inhibit hyperproliferationEasy to prepareDipeptide ingredientsMetabolism disorderVascular proliferationAqueous solution
The subject invention provides dipeptides useful in preventing pathological proliferation of blood vessels. The dipeptides of the subject invention are particularly advantageous because they are stable, bioavailable, and can be formulated in an aqueous solution, and in particular, into infant formulations.
Owner:BRISTOL MYERS SQUIBB CO
Anti-fam19a5 antibodies and uses thereof
ActiveUS20200299373A1Many formatsDelay progressNervous disorderImmunoglobulins against cytokines/lymphokines/interferonsAntiendomysial antibodiesFibrosis
Owner:NEURACLE SCI CO LTD
Lactobacillus paracasei capable of inhibiting abnormal proliferation of HaCaT cells
ActiveCN112094784ARelieve psoriasisInhibit hyperproliferationCosmetic preparationsBacteriaBiotechnologyChemical products
The invention discloses lactobacillus paracasei capable of inhibiting abnormal proliferation of HaCaT cells, and belongs to the technical field of microorganisms and medicines. The invention providesa lactobacillus paracasei CCFM1147, and the lactobacillus paracasei CCFM1147 can alleviate psoriasis, which is specifically embodied in that the excessive proliferation of psoriasis-like cortical forming cells is inhibited; the activation of an NF-kB signal path in psoriasis-like cortical forming cells is inhibited; the level of proinflammatory factor IL-6 in psoriasis-like cortical forming cellsis reduced; the level of proinflammatory factor IL-8 in psoriasis-like cortical forming cells is reduced; and therefore, the lactobacillus paracasei CCFM1147 has a huge application prospect in the preparation of products (such as daily chemical products or medicines) for preventing and / or treating psoriasis.
Owner:JIANGNAN UNIV
Application of small-molecule oligopeptide in preparing product for treating acnes
PendingCN111249440AInhibit hyperproliferationInhibit excessive value-addedCosmetic preparationsPeptide/protein ingredientsSide effectOligopeptide
The invention discloses application of small-molecule oligopeptide in preparing a product for treating acnes. The small-molecule oligopeptide disclosed by the invention is bFGF (basic fibroblalst growth factor) derived degraded oligopeptide consisting of 8 amino acid residues, and the amino acid sequence of the small-molecule oligopeptide is LQLQAEER. The invention finds that the small-molecule oligopeptide is capable of inhibiting excessive proliferation of sebaceous gland and reducing grease secretion of skin, in addition, is high in stability, small in toxicity and side effect, applicable to massive people, good in percutaneous permeability and capable of continuously acting on treatment parts, therefore, can be applied to antiacne aspects, particularly can be used for treating acnes caused by variation of hormonal levels in the puberty period and the gestation period.
Owner:JINAN UNIVERSITY
Surface modification method for improving corrosion resistance of magnesium alloy intravascular stent
ActiveCN108014379AImprove corrosion resistanceEasy to captureSurgeryCoatingsEndothelial regenerationStent implantation
The invention relates to the field of interventional medical devices, and especially relates to a surface modification method for improving the corrosion resistance of a magnesium alloy intravascularstent. The method is suitable for a novel dual-drug degradable magnesium alloy intravascular stent for treating intraluminal stenosis, carrying a smooth muscle proliferation inhibitor and promoting endothelialization. The method is characterized in that a drug coating with an endothelialization promoting function is prepared on a magnesium alloy stent to accelerate the endothelialization process after stent implantation and improve the service environment of the stent, so the corrosion resistance of the magnesium alloy intravascular stent is improved. The magnesium alloy intravascular stent carries a drug for inhibiting intimal hypertrophy, and also carries a drug for promoting endothelialization. The stent can realize rapid endothelial regeneration of damaged parts through the action of the drug for promoting endothelialization after being implanted into a diseased blood vessel, so the service environment of the magnesium alloy stent is improved, and the corrosion resistance of the degradable magnesium alloy intravascular stent is improved.
Owner:INST OF METAL RESEARCH - CHINESE ACAD OF SCI
Anti human gas6 monoclonal antibody
ActiveCN107148474AInhibit bindingInhibit hyperproliferationMetabolism disorderBiological material analysisTransformed cellBase sequence
The present invention pertains to a monoclonal antibody, or an antibody fragment thereof, that binds specifically to human growth arrest-specific 6 (hGas6) and binds to at least one amino acid residue among the 314th, 315th, and 316th amino acid residues of human Gas6. The present invention also pertains to: a nucleic acid containing a base sequence that codes for the antibody or the antibody fragment; a transformed cell containing a vector that contains the nucleic acid; a method for producing the antibody or the antibody fragment; reagents for detecting or measuring Gas6 that contain the antibody or the antibody fragment; therapeutic or diagnostic agents for Gas6-related diseases that contain the antibody or the antibody fragment as an active ingredient; and a use of the antibody or the antibody fragment for producing the therapeutic or diagnostic agents for Gas6-related diseases.
Owner:KYOWA HAKKO KIRIN CO LTD
Baicalin-modified amino-rich scaffold material as well as preparation method and application thereof
InactiveCN108096635AGood biocompatibilityEasy to prepareCoatingsProsthesisAntioxidative stressBiocompatibility Testing
The invention relates to a baicalin-modified amino-rich scaffold material as well as a preparation method and an application thereof and belongs to the technical field of medical scaffolds. The preparation method of the baicalin-modified amino-rich scaffold material comprises steps as follows: a baicalin solution is mixed with an activating agent to be activated, an amino-rich scaffold material and the activated baicalin solution are mixed, and grafting is performed. The method adopts a simple process and is simple to operate and wide in application range. The baicalin-modified amino-rich scaffold material prepared with the method simultaneously has multiple functions of anti-oxidative stress, anti-inflammation, endothelial apoptosis inhibition, inhibition of excessive proliferation of smooth muscle cells and the like. The baicalin-modified amino-rich scaffold material is used for improving the microenvironment of blood vessels, can notably improve the biocompatibility of the scaffoldmaterial and can inhibit adverse reactions such as oxidative stress, inflammation, restenosis and the like after the scaffold is implanted into the body of a patient.
Owner:SOUTHWEST JIAOTONG UNIV
Application of gensenoside C-K to preparing medicines for treating psoriasis
InactiveCN106924271ANo side effectsInhibit hyperproliferationOrganic active ingredientsDermatological disorderPsoriasisDrug
The invention provides application of gensenoside C-K and pharmacologically acceptable solvates or hydrates of the gensenoside C-K to preparing medicines for treating psoriasis, a medicine box and a medicine composition with the gensenoside C-K for treating the psoriasis and a method for preparing the medicine composition.
Owner:SHANGHAI INST OF PHARMA IND +1
Environmentally-friendly technology for treating xanthan gum fermentation wastewater
ActiveCN110092527AHigh porosityStrong adsorption performanceSpecific water treatment objectivesWater contaminantsChemistryPollutant
The invention belongs to the technical field of environmental protection, and discloses an environmentally-friendly technology for treating xanthan gum fermentation wastewater. Biological preparationsare used in the invention, and include Paracoccus denitrificans, Clostridium perfringens and Halomonas elogata. The technology is simple to operate, and can thoroughly degrade pollutants such as ammonia nitrogen quickly and efficiently.
Owner:内蒙古阜丰生物科技有限公司
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