120 results about "Cell replacement" patented technology

In a pattern correction method, design layout data of a pattern designed by an automated layout unit is entered. An environmental profile is determined based on whether or not another graphics pattern exists at the surroundings of each correction target cell included in the entered design layout data. A target cell name is replaced with a prescribed cell name of correction pattern corresponding to the determined environmental profile by referencing a cell replacement table. An OPC correction pattern corresponding to the replaced cell name is imported from a cell library.

The present invention is directed to methods for altering the fate of a cell, tissue or organ type by altering Notch pathway function in the cell. The invention is further directed to methods for altering the fate of a cell, tissue or organ type by simultaneously changing the activation state of the Notch pathway and one or more cell fate control gene pathways. The invention can be utilized for cells of any differentiation state. The resulting cells may be expanded and used in cell replacement therapy to repopulate lost cell populations and help in the regeneration of diseased and / or injured tissues. The resulting cell populations can also be made recombinant and used for gene therapy or as tissue / organ models for research. The invention is directed to methods for of treating macular degeneration comprising altering Notch pathway function in retinal pigment epithelium cells or retinal neuroepithelium or both tissues. The present invention is also directed to kits utilizing the methods of the invention to generate cells, tissues or organs of altered fates. The invention also provides methods for screening for agonists or antagonists of Notch or cell fate control gene pathway functions.

The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.

The invention provides pluripotent cells modified to overexpress Pdx1 and Ngn3. Pluripotent cells include embryonic stem cells and induced pluripotent stem cells. Methods of producing pancreatic endocrine progenitor cells from ES cells or from iPS cells by forced expression of Pdx1 and Ngn3 are provided. Pancreatic endocrine progenitor cells are useful for drug discovery and cell replacement therapy.

Method of differentiating ex vivo expanded stem cells in-tissue anti in vivo are provided. Also provided are method of treating individuals suffering from a disorder necessitating cell replacement or tissue replacement therapy using ex vivo expanded stem cells.

In a pattern correction method, design layout data of a pattern designed by an automated layout unit is entered. An environmental profile is determined based on whether or not another graphics pattern exists at the surroundings of each correction target cell included in the entered design layout data. A target cell name is replaced with a prescribed cell name of correction pattern corresponding to the determined environmental by referencing a cell replacement table. An OPC correction pattern corresponding to the replaced cell name is imported from a cell library.

The present disclosure is directed to improved methods for efficiently producing neuroprogenitor cells and differentiated neural cells such as dopaminergic neurons and serotonergic neurons from pluripotent stem cells, for example human embryonic stem cells. Using the disclosed methods, cell populations containing a high proportion of cells positive for tyrosine hydroxylase, a specific marker for dopaminergic neurons, have been isolated. The neuroprogenitor cells and terminally differentiated cells of the present disclosure can be generated in large quantities, and therefore may serve as an excellent source for cell replacement therapy in neurological disorders such as Parkinson's disease.

A battery pack having a function for preventing operation of the battery pack when an abnormal replacement of a battery cell is detected or preventing a use of the battery pack in which a cap has been removed. The battery pack generates an encryption code and writes the encryption code to data flash when a battery cell is normally discharged according to a first voltage, and if an abnormal power-on reset is detected on the battery cell, the battery pack may check the stored encryption code to a second encryption code generated upon power-on reset. If the codes do not match, firmware of the battery pack is deleted and / or a fuse is blown, making it is possible to prevent the battery pack from being re-used when the battery cell has been replaced or in which a cap has been removed.

The invention discloses a wireless sensor network (WSN) node self-powered system based on solar energy-wind energy complementation. The system mainly comprises a solar energy acquisition module, a piezoelectric type vertical axis wind energy acquisition module, a super-capacitor energy storage module and an interface circuit, wherein the solar energy acquisition module acquires luminous energy in the environment through a solar cell panel, the piezoelectric type vertical axis wind energy acquisition module acquires wind energy in the environment, the super-capacitor energy storage module stores the acquired energy into a super capacitor, and the interface circuit provides a channel for energy storage and WSN node power supply. In addition, in order to improve acquisition efficiency of the wind energy acquisition module and reduce influences of a wind direction, a vertical axis piezoelectric type scheme is adopted by the wind energy acquisition module. Due to the facts that rechargeable times of a lithium cell are limited, and in the process of acquisition of environmental energy, charging and discharging are frequent, the super capacitor in the system is used for replacing the lithium cell to serve as a system energy storage unit, and the service life of the energy storage unit can be prolonged. The WSN node self-powered system can collect energy in the environment, does not need to conduct maintenance on a cell, such as cell replacement and charging, therefore prolongs service life of a node, and solves the energy supply problem of a WSN.

Method and system for providing a computer implemented process of performing design for testability analysis and synthesis in an integrated circuit design includes partitioning each logic block in an integrated circuit design based on one or more boundaries of multi-cycle initial setup sequence, excluding one or more partitioned logic blocks with multi-cycle initial setup sequence from valid candidate blocks, selecting a constraint setting set, extracting a subset of constraint settings from the selected constraint setting set, applying the extracted subset of constraint settings to the integrated circuit design, performing design for testability analysis and synthesis on the valid candidate blocks, performing scan cell replacement. The scan cell replacement may include performing class selection from a cell library and a gate-level netlist based on affinity between cells, determining a target characterization, such as timing, power, area, for example, for the scan cell replacement, and replacing one or more cells with a corresponding one or more scan cells having the closest target characteristics.

A method of replacing standard cells with high speed cells in the design of a circuit using a computer program, said application specific integrated circuit design comprising a plurality of high speed cells and a plurality of standard cells, said high speed cells and standard cells being arranged to form a plurality of paths on said application specific integrated circuit, said method comprising the steps of: timing said plurality of paths identifying cells occurring on paths for which timing targets are not met; upgrading at least one of said identified cells to a high speed cell.