167 results about "Bioactive coating" patented technology

The present invention provides a bioactive coating composition, method and devices for bodily fluid-contacting surfaces. The coating comprises a complex of Formula II: wherein R1 is an C1-18alkyl or C6-32aryl group, each R2 is independently selected from the group consisting of C1-18alkyl and C6-32aryl, R3 is N or O, n is a number from 1 to 10, and x in a number from 1 to about 30, directly bound to a heparin-activity molecule via covalent bonding, with one or more bioactive molecules bound to the heparin-activity molecule. The bioactive molecule may be an adhesive molecule such as fibronectin, a growth factor such as basic fibroblast growth factor, or any other bioactive molecule that binds, by any mechanism, to a heparin-activity molecule

Devices and methods are directed to improving the gaseous exchange in a lung of an individual having, for instance, chronic obstructive pulmonary disease. More particularly, conduits may be deployed in the lung to maintain collateral openings (or channels) surgically created through airway walls. This tends to facilitate both the exchange of oxygen ultimately into the blood and decompress hyper-inflated lungs. The conduit includes a radially expandable center section having a first end, a second end, and a passageway extending from the first end to the second end. A control segment may be associated with the conduit to limit the degree of radial expansion. The conduit further includes a plurality of deflectable members extending from the ends of the center section. A tissue barrier may coaxially surround the conduit such that tissue ingrowth is prevented. The conduits may also include hold-down members and bioactive coatings that serve to prevent ejection of the conduit as well as prevent narrowing of the passageway due to tissue ingrowth.

Stent grafts are provided comprising an endoluminal stent and a graft, wherein the stent graft releases an agent which induces the in vivo adhesion of the stent graft to vessel walls, or, otherwise induces or accelerates an in vivo fibrotic reaction causing said stent graft to adhere to vessel wall. Also provided are methods for making and using such stent grafts.

A graftless spinal implant for mechanically attaching two adjacent vertebrae includes a body having first and second opposite surfaces. The first and second surfaces include at least one protruding member for securing the body to adjacent vertebrae, wherein the exterior surfaces of the body and the first and second protruding members include a bioactive coating. The bioactive coating can be selected from coatings such as for example, hydroxyapatite. The exterior bioactive coating facilitates the ongrowth / ingrowth of vertebral bone between the implantable spinal fusion device and adjacent vertebrae. Advantageously, spinal fusion may be achieved without the use of a bone graft and / or bone growth agents.

Disclosed herein are novel coatings and paints comprising a biomolecule composition, wherein the biomolecule composition comprises a phosphoric triester hydrolase. Also disclosed herein are methods of detoxification of a surface contaminated with an organophosphorus compound by contacting the surface with such a coating or paint. Also disclosed herein are novel coating and paint components derived from microorganisms.

Stent grafts are provided comprising an endoluminal stent and a graft, wherein the stent graft releases an agent which induces the in vivo adhesion of the stent graft to vessel walls, or, otherwise induces or accelerates an in vivo fibrotic reaction causing said stent graft to adhere to vessel wall. Also provided are methods for making and using such stent grafts.

The invention relates to a new method for preparing an antibiotic bioactive coating material on the surface of titanium alloy and magnesium alloy by ultrasonic-microarc oxidation composite technology, which can be used for obtaining a biological coating material which is compact at the bottom layer and is porous at the surface layer, wherein Ca, P and Ag contained in the coating can improve the bioactivity and the corrosion resistance of magnesium and titanium, and reduce bacterial infection caused by implantation. The invention can meet the requirements of bearing bones of human beings for mechanical properties of implanted materials, and can overcome disadvantages of the traditional surface modification method for biologic materials. In the coating composite material, the coating thickness of titanium alloy is 50-85 mu m, the surface hole diameter is 4-25 mu m, the porosity is 20-30%, and the bonding strength between the coating and the matrix is 23-40 MPa. The coating thickness of magnesium alloy is 16-22 mu m, the surface hole diameter is 5-28 mu m, the porosity is 21-30%, and the bonding strength between the coating and the matrix is 8-20 MPa.

A composite expandable stent for delivery into a vessel carrying blood comprising an expandable support frame having first and second end portions. A porous imprevious polymer sleeve having inner and outer surfaces extending over the support frame. A coating is disposed on at least one of the inner and outer surfaces of the polymer sleeve for enhancing endothelial cell growth on the device and polymer sleeve. The stent can be cylindrical or tapered.

The invention discloses a preparation method and application of a wear-resistant antibacterial bioactive ceramic film for a titanium or titanium alloy surface, belonging to the technical field of metal material surface treatment. The method comprises the following steps: preparing a bottom passivating film, preparing a porous hard ceramic film containing Zn, Ca and P under the ultrasonic conditions in combination with forward square wave pulse voltage, and carrying out hydrothermal treatment to finally obtain the wear-resistant antibacterial bioactive ceramic film. Compared with the bioactive coating obtained by other methods, the ceramic film prepared by the method disclosed by the invention has the advantages of high combination firmness with the base, favorable wear resistance and favorable corrosion resistance, and has the antibacterial effect due to the introduction of Zn on the premise of implementing bioactivity. The dental implant for the field of oral cavity manufactured on the basis of the wear-resistant antibacterial bioactive ceramic film shortens the combination time between the traditional dental implant and the bone.

The invention discloses pure-titanium metal surface micro-arc oxidation treatment electrolyte and an antimicrobial bioactive coating preparation method thereof, belongs to a medical titanium metal surface modification technology, and aims to provide a micro-arc oxidation treatment electrolyte which can remarkably improve pure-titanium metal surface bioactivity and coating bonding strength and a coating preparation method thereof. The electrolyte comprises a compound system including the components of calcium acetate, sodium phosphate and a zinc oxide precursor, wherein the phosphorous ion concentration is 0.5 to 1.0 M, the molar ratio of Ca to P is 0.2 to 1.0, and the designed Zn<2+> concentration accounts for 10 to 20 percent of the total concentration. A biological composite coating is directly generated on the surface of a titanium metal surface in-situ by adopting the electrolyte and a micro-arc oxidation technology. The coating has high bonding strength with a substrate, dense inner layer, coarse and porous outer layer, high bioactivity and high antibacterial property; moreover, the used raw materials are easy to obtain; the process is simple and easy to operate; and the electrolyte has stability, reusability, and low production cost and is suitable for industrial production.

A composite expandable device for delivery into a vessel carrying blood comprising an expandable support frame having first and second end portions. An impervious polymer sleeve having inner and outer surfaces extending over the support frame. A coating is disposed on at least one of the inner and outer surfaces of the polymer sleeve for enhancing endothelial cell growth on the device and polymer sleeve.

The invention discloses a micro-arc oxidation-electrodeposition preparation method of a magnesium-based bioactive coating. The preparation method comprises the following steps: putting a magnesium-based base material in micro-arc oxidation electrolyte after pretreatment to perform micro-arc oxidation reaction to obtain a micro-arc oxidation coating sample; then, putting the micro-arc oxidation coating sample in electrodeposition electrolyte to perform electrodeposition reaction; and after electrodeposition, taking the sample out, and washing and drying the sample. The micro-arc oxidation-electrodeposition preparation method has the advantages that a biologic coating prepared by the method has high binding property with a base material; and the entire biologic coating has excellent corrosion resistance, bioactivity and compatibility; moreover, the formed bioactive coating is a composite coating (comprising HA, OCP, Mg3(PO3)2 and MgO); and because the composite coating comprises OCP, problems that the degradation of pure HA is difficult are avoided and only an HA crust is left after the degradation of formed magnesium alloy can be avoided.

Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.

The invention provides a method for preparing a hydroxyapatite / titanium dioxide composite bioactive coating on the surfaces of medical metals such as a titanium alloy, and the like, and belongs to the technical field of the preparation of bioactive coatings on the surface of the titanium alloy. The composite coating is prepared by preparing precursor sols of HA and TiO2 respectively, then mixing the precursor sols of the HA and the TiO2, and performing aging, coating, drying and heat treatment. The coating has high bioactivity, low cost of preparation technology, and high bonding strength with a matrix, is applicable to the preparation of surface coatings of various complicated geometric structures, and can be used for surface modification of surgical implants such as artificial hip joints and dental implants as well as orthopedic instrument products.

This invention relates generally to methods and apparatus for the detoxification of fluid streams, for example, wastewater contaminated with neurotoxins, particularly organophosphorous compounds, and comprises contacting the fluid stream with a bioactive coating. More particularly, the invention relates to chemical reactors for detoxifying fluid streams and also, bioactive coated support components comprising rigid, semi-rigid, or flexible support materials coated with a bioactive coating compriseing dessicated whole cells, whole cell fragments, enzymes, and combinations thereof that are capable of hydrolizing neurotoxic organophosphorous chemical compounds. Organophosphorus hydrolases that are capable of detoxifying organophosphorus compounds that are: chemical weapons agents, in particular, tabun (“GA”), sarin (“GB”), soman (“GD”), cyclosarin, VX, and its isometric analog Russian VX (“VR” or “R-VX”); chemical weapons agent analogs, chemical weapons surrogates; and pesticides are most preferred. The process and apparatus embodiments of the present invention are designed to detoxify organophosphorus compounds continuously, semi-continuously and and in batch operation.

The invention discloses a method for coating the surface of titanium materials, which comprises the following steps: cooling an alkali heat treated titanium disc, putting the titanium disc in a 12-hole plate, respectively adding 5ml of 1.5 times of bionic liquid to each hole, standing the bionic liquid for 2 to 14 days at a temperature of 37 DEG C, and changing 1.5*CSBF liquid every 12h; taking out the titanium disc for washing with deionized water, and naturally drying the titanium disc to acquire a bioactive coating on the titanium surface. The coating is a composite coating of recombined collagen and hydroxyapatite. The coating formed by the method is a composite of nano-hydroxyapatite crystals and the recombined collagen, has two key components of a natural bone, and has the function of promoting cell adhesion, proliferation and differentiation. The prepared titanium composite materials can be applied in bone tissue engineering as bone repair or substitute materials.

The invention discloses a method for preparing a hydroxyapatite bioactive coating, and aims to solve the technical problem that the bonding strength of carbon nano-tubes and a matrix material in a hydroxyapatite bioactive coating prepared by the conventional preparation method is low. The technical scheme is that the method comprises the following steps of: introducing the carbon nano-tubes onto the surface of the matrix material in an in-situ growth mode, and electrodepositing a hydroxyapatite coating, so that the bottoms of the carbon nano-tubes are combined with the matrix material in the in-situ growth mode, and the carbon nano-tubes are distributed in the hydroxyapatite coating to achieve a wild phase effect. A method for forming effective combination of the carbon nano-tubes and the matrix material in the hydroxyapatite coating is constructed.

The invention discloses bone-like bioactive coating medical material which is prepared by adopting an electrochemical method. The invention adopts an electrolytic deposition method and imitates the forming process of a natural bone. Electrolyte solution contains calcium, a phosphorous compound and bone matrix collagen, a medical metal transplant body is taken as a working electrode, platinum is taken as a reference electrode, the electrode reaction causes partial pH value of the electrolyte solution around the medical metal transplant body to ascend, thereby leading collagen to be gelatinized, in cooperation with the deposition of calcium phosphate mineral, the bone-like bioactive coating is formed on the medical metal surface. Through the adoption of the invention method, the bioactive coating acquired on the surface of the metal transplant body is similar to the natural bone in the component and the structure, and has favorable biological activity, thus the disadvantages that the biological activity of the business use hydroxyapatite coating is limited, the required curing time is long, etc. are solved. The preparation process of the invention is simple, highly effective and easy to be industrialized.

The invention discloses a method for plasma spraying of a Ca-P bioactive coating on the surface of a magnesium alloy. The method comprises the following steps of: preheating the magnesium alloy to 130-250 DEG C by using a plasma torch before spraying, wherein the spraying parameters are that: the main gas Ar is 40-50 L / min, the auxiliary gas He is 10-20L / min, the spraying power is 15-35kW, the moving speed of a spray gun is 300-500mm / s, the spraying distance is 80-150mm, the powder feed rate is 5-12g / min and cooling air is not used in the spraying process; and heating to about 100-120 DEG C for 2-4 hours by using steam after spraying. By adopting the process disclosed by the invention, the Ca-P coating can be prepared on the surface of the magnesium alloy through spraying, so that the degradation rate of the magnesium alloy is reduced and the bioactivity of a magnesium alloy material is improved; the process is easy to control; and the method is easy and convenient to operate and easy to popularize.

A method of forming a bioactive coating on a biomedical implant, the method including the step of contacting at least part of the surface of the implant prior to implantation with a plasma gas containing a reactive hydroxylating oxidant species. The step of contacting the surface of the implant prior to implantation with a plasma gas containing a reactive hydroxylating oxidant species may be preceded by a step of exposing the implant to an organosilane or organosilicate species to form a silica coating on at least part of the implant prior to contact with the oxidant species.

A process for preparing a composite coating of hydroxyapatite and porous titanium dioxide on the biomedical titanium metal surface belongs to the technical field of metal surface modification. Compared with other technologies of coating titanium surface bioactive coating, the process prepares the a composite coating of hydroxyapatite and porous titanium dioxide on the biomedical titanium matrix surface in situ, thereby the adhesion of titanium matrix substitutes implanted into the body and bone tissues is remarkably improved. The process includes the following steps of, firstly, placing titanium or titanium alloy into a stainless steel groove containing an alkaline electrolyte, using a bipolar impulsing power source, controlling micro-arc oxidation electrical parameters and micro-arc oxidation time, enabling the titanium surface to form a porous titanium dioxide coating by a disruptive discharge of the titanium surface; secondly, putting the coating into a reactor containing liquid through a hydro-thermal method, thereby the hydroxyapatite can grow in situ of the biomedical titanium matrix surface in situ. The process for preparing a composite coating of hydroxyapatite and porous titanium dioxide on the biomedical titanium metal surface is simple in operation, high in controllability and low in manufacturing cost, and can introduce non-toxic substances into the coating.

The invention belongs to the technical field of biomedical composite materials, in particular to a preparation method of a hydroxyapatite bioactive bionic coating containing trace elements. The method comprises the following steps of: firstly, reacting raw materials for preparing hydroxyapatite containing the trace elements according to the proportion at a certain temperature to obtain a suspension; and then transmitting the suspension as a precursor liquid to a high-temperature area of plasma flame and directly spraying the suspension on a biomedical metal substrate to form the hydroxyapatite coating containing the trace elements. The invention has simple process and low production cost; and the obtained hydroxyapatite coating contains the trace elements such as silicon, magnesium and the like closer to human bony bionic components and has better osteogenesis capability and important application value.

The present invention relates to bioactive coating on the surface of titanium or titanium alloy and its preparation process. The process includes the following steps: the first anode oxidation, alkali treatment and heat treatment of titanium or titanium alloy to form surface gradient coating in the thickness of 3 micron and comprising one inner thin and compact titania film and one outer porous titania film; introducing Ca element by means of the electrolyte solution into the coating to raise the biocompatibility; boiling in NaOH solution for 1-5 hr to form thin surface sodium titanate and calcium titanate layer; and final depositing a bone-like hydroxyapatite layer. The present invention raises the bioactivity of titanium or titanium alloy surface, and has high binding force of hydroxyapatite layer and high cell adhering capacity.

The invention relates to a composite medicament stent for inhibiting cardiovascular restenosis and a preparation method. The stent is prepared by performing laser cutting on a metal tube; the surface of the stent is corroded by electrochemical acid solution so as to form nanopores; the surface of a main body is coated with a nondegradable bioactive coating with thickness of 10 to 50 microns; a degradable biocompatible polymer medicament coating with thickness of 10 to 100 microns are coated outside the nondegradable bioactive coating; the nondegradable bioactive coating is prepared by mixing a nondegradable biocompatible high polymer, active biological components, an organic solvent and the like to form solution and spraying and drying the solution and the like; and the medicament coating is prepared by mixing a degradable biocompatible high polymer, anti-restenosis medicament ingredients, an organic solvent and the like to form solution and spraying and drying the solution and the like. The composite medicament stent has the characteristics of slow medicament release and capability of effectively reducing restenosis and thrombosis at the later stage of stent implantation.

The invention discloses a method for preparing a bioactive coating on a titanium alloy surface, which comprises the following steps of: taking the titanium alloy as a matrix, and then putting titanium alloy into micro-arc oxidation electrolyte for micro-arc oxidation, later implementing alkali heat treatment on the titanium alloy after micro-arc oxidation treatment, and finally obtaining the titanium alloy with the bioactive coating attached on the surface. The method has the advantages that by learning from the strong points of others and making up self-deficiencies, and then directly preparing a film with high matrix combination strength on the titanium alloy surface by micro-arc oxidation, and later conducting alkali heat treatment for improving the biological activity of the micro-arc oxidation film, the coating better solves the problems of combination strength, wear resistance, decay resistance, biological activity and the like.

The invention provides a preparation method of a magnesium surface ultrasonic micro-arc oxidation-HF-silane coupling agent multistage compound bioactive coating, relates to a method for preparing a pure magnesium bioactive coating composite material, and aims to solve the problems of low bonding strength and poor biocompatibility of a coating and a base in a bioactive coating composite material. The method comprises the following steps: 1, roughly grinding and cleaning a pure magnesium sample; 2, preparing an Na2SiO3 electrolyte A and a KOH electrolyte B, mixing the two electrolytes, and adding KF to obtain a micro-arc oxidation electrolyte; 3, regulating parameters of micro-arc oxidation equipment, and performing micro-arc oxidation on the sample to prepare a coating composite material; and 4, sequentially soaking the rinsed coating composite material in an HF solution and a silane coupling agent, thus completing preparation of the bioactive coating. According to the invention, the bonding strength of the coating and the base in the obtained bioactive coating is high; and meanwhile, magnesium fluoride and magnesium silicate in the oxidation layer ensure favorable biocompatibility.

The invention relates to a method for spraying suspending liquid plasma to prepare hydroxyapatite bioactive coating, which comprises following steps: adopting hydroxyapatite suspending liquid as plasma spraying raw materials, adopting a pressure tank or an electronic peristaltic pump as a power transmitting device to transmit the hydroxyapatite suspending liquid, adopting an atomizing nozzle with a small angle to inject the hydroxyapatite suspending liquid into a central region of plasma flame directly and radially or adopting a duct with small diameter to inject the hydroxyapatite suspending liquid into the central region of the plasma flame directly and radially in a linear type jet-flow mode, exchanging heat between the suspending liquid and high temperature plasma flame through transmitting and injecting the suspending liquid, and directly generating the hydroxyapatite bioactive coating on the surface of a biological medical metal base through vaporizing liquid in the suspending liquid, crushing particles, smelting and depositing. The method simplifies a tedious technological link for preparing the spraying raw materials in a method for spraying powder plasma, the spraying raw materials and energy are saved, and the structural homogeneity of the hydroxyapatite bioactive coating which is prepared is good.

Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.

A preparation method of a medicinal silver-loaded metal bioactive coating, which is characterized by adopting a magnetron sputtering process, and comprises the following steps of: (1) processing a metallic matrix; (2) processing the metallic matrix before sputtering; (3) preparing the medicinal silver-loaded metal bioactive coating through the magnetron sputtering process, and obtaining the medicinal silver-loaded metal bioactive coating by controlling the precipitating time under the following conditions: a cathode is a high-purity silver target, a working gas is argon, the vacuum of a substrate in a vacuum chamber is 2.0*10<-3>Pa, the power of the target is 40 to 80 W, the frequency is 13.0 to 15.6MHz, and the flow is 30 SCCM. The medicinal silver-loaded metal bioactive coating provided by the invention is stable in property, free from biological toxicity and good in biocompatibility, and realizes antibiosis.