148 results about "Biomedical implant" patented technology

This invention relates to biomedical implants for filling, supporting or treating bone. In one embodiment, the implant comprises an electrospun polymer scaffold that is thereafter plated with a metal to provide a selected high modulus. Such an implant can be fabricated with a selected porosity for tissue ingrowth. The implant can be further provided with a varied modulus along the length of the implant body for inducing bending of the implant for packing in a bone. In another embodiment, the implant is fabricated in an elongated configuration for introducing into bone to treat a vertebral fracture. In another embodiment, the implant can be configured with helical threads for helically driving the implant into a bone.

The present invention relates to biomedical implants for bone substitution and replacement applications. The implant includes a strong, porous polymeric or thermoplastic compositions and growth-enhancing compositions.

The use of collagen as a biomedical implant raises safety issues towards viruses and prions. The physicochemical changes and the in vitro and in vivo biocompatibility of collagen treated with heat, and by formic acid (FA), trifluoroacetic acid (TFA), tetrafluoroethanol (TFE) and hexafluoroiso-propanol (HFIP) were investigated. FA and TFA resulted in extensive depurination of nucleic acids while HFIP and TFE did so to a lesser degree. The molecules of FA, and most importantly of TFA, remained within collagen. Although these two acids induced modification in the secondary structure of collagen, resistance to collagenase was not affected and, in vitro, cell growth was not impaired. Severe dehydrothermal treatment, for example 110° C. for 1-3 days under high vacuum, also succeeded in removing completely nucleic acids. Since this treatment also leads to slight cross-linking, it could be advantageously used to eliminate prion and to stabilize gelatin products. Finally, prolonged treatment with TFA provides a transparent collagen, which transparency is further enhanced by adding glycosaminoglycans or proteoglycans, particularly hyaluronic acid. All the above treatments could offer a safe and biocompatible collagen-derived material for diverse biomedical uses, by providing a virus or prion-free product.

The present invention relates to improved biomedical implantable material comprising a plurality of pores, of which one or more of the pores are interconnected below the surface of the material. The improved biomedical implantable material may be used in biomedical implant devices such as orthopedic implants, spinal implants, neurocranial implants, maxillofacial implants, and joint replacement implants. The present invention also relates to a method of preparing an improved biomedical implantable material, comprising subjecting an implantable material to a pore-forming treatment and optionally further subjecting the material to a surface-modifying treatment. The biomedical implantable material may be used in other applications, which as applications where two surfaces are contacted and bonding between the surfaces is required.

A novel BC fermentation technique for controlling 3D shape, thickness and architecture of the entangled cellulose nano-fibril network is presented. The resultant nano-cellulose based structures are useful as biomedical implants and devices, are useful for tissue engineering and regenerative medicine, and for health care products. More particularly, embodiments of the present invention relate to systems and methods for the production and control of 3-D architecture and morphology of nano-cellulose biomaterials produced by bacteria using any biofabrication process, including the novel 3-D Bioprinting processes disclosed. Representative processes according to the invention involve control of the rate of production of biomaterial by bacteria achieved by meticulous control of the addition of fermentation media using a microfluidic system. In exemplary embodiments, the bacteria gradually grew up along the printed alginate structure that had been placed into the culture, incorporating it. After culture, the printed alginate structure was successfully removed revealing porosity where the alginate had been placed. Porosity and interconnectivity of pores in the resultant 3-D architecture can be achieved by porogen introduction using, e.g., ink-jet printer technology.

Structural inorganic cellular materials with controlled open porosity are produced by foaming fine particulate-laden aqueous solutions into stable, uniform, dodecahedral froth structures which are dried and sintered by microwave energy or high voltage instant electrical discharge. Porous open cell biomedical implants such as niobium or tantalum acetabular caps with engineered osteoconductive porosity are among the products achievable.

Methods are provided to produce optimal fractionations of charged keratins that have superior biomedical activity. Also provided are medical implants coated with these keratin preparations. Further provided are methods of treating blood coagulation in a patient in need thereof.

Hydroxyapatite is treated by a combination of nitridation and the application of bone morphogenetic protein to improve the tissue compatibility and affinity of the hydroxyapatite, rendering the hydroxyapatite more useful as a material for biomedical implants.

The invention discloses a Zn-Mn series zinc alloy and a preparing method and application thereof. The Zn-Mn series zinc alloy comprises Zn and Mn, wherein by weight percent, the mass percent of Mn in the zinc alloy ranges from 0% to 30%, however the mass percent of the Mn cannot be 0. The preparing method comprises following steps: firstly, Zn and Mn are mixed, and a mixture is obtained; secondly, the mixture is treated according to the step of a or b, cooling is carried out, and the zinc alloy is obtained, wherein under the CO2 and SF6 atmosphere protection, the mixture is smelted or sintered, and under the vacuum atmosphere protection, hydrogen is dissolved in the mixture to be smelted. The prepared Zn-Mn series zinc alloy is excellent in mechanical property, long-term effective mechanical support is provided in the machine body, the excellent cellular biocompatibility, blood compatibility and tissue and organ compatibility can be achieved, and the alloy can be used for preparing of biomedical implant materials.

The invention discloses a preparation method of a titanium surface porous structure layer bioactive ceramic membrane with low elasticity modulus, and relates to the field of biomedical implant, especially the preparation technology of a biomedical implant made of a titanium or titanium alloy material. The method comprises steps of: first preparing a porous structure layer on a matrix structure of a pure titanium or titanium alloy implant with a solid structure by using a powder metallurgy method; then forming a titanium dioxide membrane containing calcium and phosphorus on a hole surface of the porous structure layer by a micro-arc oxidation method; and finally, preparing a hydroxyl apatite layer on a hole external surface of the porous structure layer by an electrodeposition method. The invention can realize formation of porous structure layer on the surface of the pure titanium or titanium alloy implant with solid structure, and reduce elastic modulus on the implant surface; meanwhile, the implant is endowed with high biological activity through implantation of a hydroxyapatite layer, and can be used in the field of biological medicine.

The invention provides a method of preparing a biomedical implant comprising the steps of providing a biomedical implant comprising a metal and having a surface, wherein the surface comprises a metal oxide layer, contacting the biomedical implant with a composition comprising an alkaline earth element, disrupting the metal oxide layer on the surface of the biomedical implant, and adhering the alkaline earth element to the surface of the biomedical implant.

The invention discloses a Zn-Li-Mg-system zinc alloy and a preparation method and application thereof. The zinc alloy comprises, by weight, 0-1% of Li, 0-1% of Mg and the balance Zn, wherein the masspercents of Li and Mg are not zero. The zinc alloy prepared by the preparation method is excellent in mechanical performance, can provide long-term and effective supporting force in a body, has excellent cellular and blood compatibility, and can be applied to preparation of biomedical implants.

The invention relates to a medical implanted titanium alloy with low elastic modulus and high fatigue strength and a preparation method. The medical implanted titanium alloy comprises, by weight, 30-33% of Nb, 1-6% of Zr, 2-4% of Mo, 0.20-0.40% of O, and the balance Ti. The preparation method of the medical implanted titanium alloy specifically comprises the steps that smelting is conducted by using a vacuum non-consumable electric-arc furnace to obtain an alloy ingot with uniform ingredients, solution treatment is conducted at 850-950 DEG C after the alloy ingot is subjected to hot forging into bar materials, and water cooling is conducted to the room temperature; then cold rolling deformation processing is conducted, and the deformation quantity is 80-90%; and finally, aging heat treatment is conducted, the heating temperature of the aging heat treatment is 400-500 DEG C, and the heat preservation time is 1-12 h. According to the medical implanted titanium alloy with the low elasticmodulus and the high fatigue strength and the preparation method, after cold rolling and heat treatment, the strength is significantly higher than that of a current most-widely-applied medical implanted titanium alloy Ti-6Al-4V, the fatigue strength is comparable to Ti-6Al-4V, the elastic modulus is only 52% of Ti-6Al-4V, the biocompatibility and the mechanical compatibility are more excellent, and the medical implanted titanium alloy can be applied to preparation of biomedical implants.

The invention discloses a method for preparing a hydroxylapatite coating by cold spraying, which belongs to the field of implant processing and preparation in biomedical material engineering. The method adopts cold spraying equipment to spray dried hydroxylapatite powder onto a matrix of a biomedical implant metal material with the surface subjected to sand blasting treatment, thereby obtaining the hydroxylapatite coating with high crystallinity and good biological stability. The method can effectively avoid the thermal decomposition of sprayed powder, namely hydroxylapatite during the processing, can reduce the non-crystallization and hydroxyl loss, has small influence on an organization structure of the material, retains a structure of the originally spayed HA powder, and does not generate impurity phases. The hydroxylapatite powder used by the sprayed powder can realize the full recovery, which saves the powder for spraying in a large quantity. The method can prepare the hydroxylapatite coating on the surfaces of implant metal materials to ensure that the surfaces of biologically inert metal matrixes have biological activity, and can prepare medical implant devices such as dental roots, artificial joints and the like.

The invention relates to a high strength high elasticity titanium alloy and a preparation method. The alloy comprises the following components in percentages by weight: 31-33wt% of Nb, 4-8wt% of Zr, 2-4wt% of Sn, 0.30-0.55wt% of O (0.3wt% endpoint value is not contained) and the balance of Ti. The preparation method of the alloy comprises the follow specific steps: adopting a vacuum nonconsumableelectric-arc furnace to smelt to obtain a uniform alloy ingot, performing solution treatment at 850-950 DEG C after hot forging of a rod, and performing water cooling to room temperature; then performing cold rolling deformation processing, wherein the deformation is 80-90%; and finally, performing ageing thermal treatment, wherein the heating temperature is 400-500 DEG C and the insulating time is 1-24h. The titanium alloy provided by the invention has high strength and relatively low elasticity modulus. The elastic deformability is superior to those of various beta-titanium alloys high in elasticity. The titanium alloy is quite suitable for preparing ultralight small-sized elastic parts in the fields of aerospace, machinery and the like, and also can be applied to preparing biomedical implants.

The invention discloses a Zn-Li-Mn-based zinc alloy and a preparation method and application thereof. The Zn-Li-Mn-based zinc alloy comprises, by mass, greater than 0 and less than or equal to 1% of Li, greater than 0 and less than or equal to 1% of Mn and the balance of Zn. The Zn-Li-Mn-based zinc alloy has excellent mechanical properties, can provide long-term effective support in the human body, has excellent cell compatibility and blood compatibility and can be used for preparation of biomedical implants.