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224 results about "Polymer scaffold" patented technology
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Method for preparing porous polymer scaffold for tissue engineering using gel spinning molding technique
InactiveUS20070009570A1Uniform pore sizeImprove interconnectivitySuture equipmentsCeramic shaping apparatusPolymer scienceSpinning
The present invention relates to a method of preparing a porous polymer scaffold for tissue engineering using a gel spinning molding technique. The method of the present invention can prepare a porous polymer scaffold having a uniform pore size, high interconnectivity between pores and mechanical strength, as well as high cell seeding and proliferation efficiencies, which can be effectively used in tissue engineering applications. Further, the method of the present invention can easily mold a porous polymer scaffold in various types such as a tube type favorable for regeneration of blood vessels, esophagus, nerves and the like, as well as a sheet type favorable for regeneration of skins, muscles and the like, by regulating the shape and size of a template shaft.
Owner:KOREA INST OF SCI & TECH
Methods for making and using composites, polymer scaffolds, and composite scaffolds
InactiveUS20070187857A1Promote safe productionTime-consumeDomestic articlesProsthesisOrganic solventTissue repair
The present invention relates to methods of making and using composites and scaffolds as implantable devices useful for tissue repair, guided tissue regeneration, and tissue engineering. In particular, the present invention relates to methods of making and using compression molded resorbable thermoplastic polymer composites which can be subsequently processed with non-organic solvents to create porous, resorbable thermoplastic polymer scaffolds or composite scaffold with interconnected porosity. Furthermore, these composites or scaffolds can be coated with an organic and / or inorganic material.
Owner:LOREM VASCULAR PTE LTD
Implants and methods for treating bone
This invention relates to biomedical implants for filling, supporting or treating bone. In one embodiment, the implant comprises an electrospun polymer scaffold that is thereafter plated with a metal to provide a selected high modulus. Such an implant can be fabricated with a selected porosity for tissue ingrowth. The implant can be further provided with a varied modulus along the length of the implant body for inducing bending of the implant for packing in a bone. In another embodiment, the implant is fabricated in an elongated configuration for introducing into bone to treat a vertebral fracture. In another embodiment, the implant can be configured with helical threads for helically driving the implant into a bone.
Owner:DFINE INC
Crush Recoverable Polymer Scaffolds
ActiveUS20110190871A1Improves deployment uniformityReduce fracturesStentsSurgeryPolymer scaffoldMedical device
A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells.
Owner:ABBOTT CARDIOVASCULAR
Reducing Crimping Damage to Polymer Scaffold
ActiveUS20120042501A1Reduce harmImprove batch yieldStentsLarge fixed membersCatheterPolymer scaffold
A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the catheter by a multi-step process for increasing scaffold-catheter yield following a crimping sequence. Damage reduction during a crimping sequence includes modifying blades of a crimper, adopting a multi-step crimping sequence, and inflating a supporting balloon to support the scaffold during crimping.
Owner:ABBOTT CARDIOVASCULAR
Protein-Polymer-Drug Conjugates
ActiveUS20130101546A1Improve drug bioavailabilityImprove bioavailabilityPharmaceutical non-active ingredientsSynthetic polymeric active ingredientsDrug conjugationPharmaceutical drug
A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight≦5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
Owner:MERSANA THERAPEUTICS INC
Methods of producing three-dimensional objects from materials having multiple mechanisms of hardening
ActiveUS20160136889A1Increased formationEnhance or speed the refilling of the build regionManufacturing enclosuresOptical articlesPolymer scaffoldChemistry
A method of forming a three-dimensional object is carried out by: (a) providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; (b) filling the build region with a polymerizable liquid, the polymerizable liquid including a mixture of (i) a light polymerizable liquid first component, and (ii) a second solidifiable component that is different from the first component; (c) irradiating the build region with light through the optically transparent member to form a solid polymer scaffold from the first component and also advancing the carrier away from the build surface to form a three-dimensional intermediate having the same shape as, or a shape to be imparted to, the three-dimensional object, and containing the second solidifiable component carried in the scaffold in unsolidified and / or uncured form; and (d) concurrently with or subsequent to the irradiating step, solidifying and / or curing the second solidifiable component in the three-dimensional intermediate to form the three-dimensional object.
Owner:CARBON INC
Stents
Owner:NANOVASC
Crush Recoverable Polymer Scaffolds Having a Low Crossing Profile
A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile.
Owner:ABBOTT CARDIOVASCULAR
Polymeric Stent and Method of Making Same
A stent may be formed from a PLLA tubular polymer construct that is deformed in a blow mold. A desirable polymer morphology resulting in improved stent performance is obtained with a selected radial axial expansion ratio from about 20% to about 70%, a selected radial expansion ratio from about 400% to about 500%, a selected axial rate of deformation propagation at or about 0.3 mm / minute, a selected expansion pressure at or about 130 psi, and a selected expansion temperature that does not exceed 200 deg F. The tubular polymer construct may also be made of PLGA, PLLA-co-PDLA, PLLD / PDLA stereocomplex, and PLLA-based polyester block copolymer containing a rigid segment of PLLA or PLGA and a soft segment of PCL or PTMC.
Owner:ABBOTT CARDIOVASCULAR
Multi-layer polymer scaffolds
Three-dimensional single or multilayer polymer scaffolds for use in tissue engineering and other applications are provided. These scaffolds typically include at least two layers of biodegradable polymer of similar thickness, wherein each layer of polymer further includes a plurality of substantially uniform structural features having predetermined geometries, and wherein each layer of polymer is attached to the other layers of polymer to form predefined spatial relationships between the structural features of each layer.
Owner:THE OHIO STATE UNIV RES FOUND
Methods of producing polyurethane three-dimensional objects from materials having multiple mechanisms of hardening
ActiveUS20160137838A1Increased formationEnhance or speed the refilling of the build regionManufacturing enclosuresOptical articlesEndcappingPolymer science
A method of forming a three-dimensional object of polyurethane, polyurea, or copolymer thereof is carried out by: (a) providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; (b) filling the build region with a polymerizable liquid, the polymerizable liquid including at least one of: (i) a blocked or reactive blocked prepolymer, (ii) a blocked or reactive blocked diisocyanate, or (iii) a blocked or reactive blocked diisocyanate chain extender; (c) irradiating the build region with light through the optically transparent member to form a solid blocked polymer scaffold and advancing the carrier away from the build surface to form a three-dimensional intermediate having the same shape as, or a shape to be imparted to, the three-dimensional object, with the intermediate containing the chain extender; and then (d) heating or microwave irradiating the three-dimensional intermediate sufficiently to form from the three-dimensional intermediate the three-dimensional object of polyurethane, polyurea, or copolymer thereof.
Owner:CARBON INC
Removable sheath assembly for a polymer scaffold
ActiveUS20140379065A1Easy to disassembleMinimize damageStentsBalloon catheterHealth professionalsCatheter
A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A sheath is placed over the crimped scaffold after crimping to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body. The sheath is removed by a health professional either by removing the sheath directly or using a tube containing the catheter.
Owner:ABBOTT CARDIOVASCULAR
Polymer-based stent assembly
Methods for preparing a polymer-based stent assembly comprising an inflatable balloon catheter and a polymer-based stent resistant to relaxation-related negative recoil are provided. The methods comprise heating a polymeric cylindrical device which is at a final predetermined shape and diameter to a temperature sufficiently above the glass transition temperature (Tg) of the polymer and for a time sufficient to erase any memory of previous processing of the polymeric cylindrical device and then quenching the polymeric cylindrical device to provide an educated polymeric cylindrical device having a memory of the final predetermined diameter and shape, mounting the educated cylindrical device on an inflatable balloon catheter, reducing the diameter of the educated cylindrical device by heating to a temperature at or slightly above the Tg of the polymer while evenly applying pressure on the exterior surface of the wall of the cylindrical device, and then cooling the cylindrical device below the Tg of the polymer to provide a stent assembly comprising an inflatable balloon catheter and an expandable, educated, polymeric stent snugly and stably disposed thereon. Assemblies comprising an inflatable balloon and a polymer based stent that is substantially resistant to relaxation related recoil mounted snugly on the balloon are also provided.
Owner:SAHAJANAND TECHNOLOGIES PRIVATE LTD
Wash liquids for use in additive manufacturing with dual cure resins
ActiveUS10343331B2Enhance or speed the refilling of the build regionIncreased formationAdditive manufacturing apparatus3D object support structuresDual curePolymeric liquid
Owner:CARBON INC
Continuous Cell Programming Devices
ActiveUS20120100182A1Easy to controlClinical effectiveness of has been limitedOrganic active ingredientsPeptide/protein ingredientsDendritic cellProtective immunity
The present invention comprises compositions, methods and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE +1
Wash liquids for use in additive manufacturing with dual cure resins
ActiveUS20170173872A1Increased formationEnhance or speed the refilling of the build regionAdditive manufacturing apparatus3D object support structuresDual curePolymeric liquid
A method of forming a three-dimensional object, which method includes a cleaning or washing step, is carried out by: (a) providing a carrier and a fill level, and optionally an optically transparent member having a build surface defining the fill level, the carrier and the fill level having a build region therebetween; (b) filling the build region with a polymerizable liquid, the polymerizable liquid comprising a mixture of (i) a light polymerizable liquid first component, and (ii) a second solidifiable component that is different from the first component; (c) irradiating the build region with light, to form a solid polymer scaffold from the first component and also advancing the carrier away from the build surface to form a three-dimensional intermediate having the same shape as, or a shape to be imparted to, the three-dimensional object and containing the second solidifiable component carried in the scaffold in unsolidified and / or uncured form; (d) washing the three-dimensional intermediate; and (e) concurrently with or subsequent to the irradiating step, and / or the washing step, solidifying and / or curing the second solidifiable component in the three-dimensional intermediate to form the three-dimensional object.
Owner:CARBON INC
Macroporous polymer scaffold containing calcium phosphate particles
A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a range of about 1.0-2.0 mm. The polymer scaffold is prepared using a novel process which advantageously combines the techniques of particulate leaching and phase inversion to render a process that provides amplified means by which to control the morphology of the resulting polymer scaffold. The polymer scaffold has utility in the area of tissue engineering, particularly as a scaffold for both in vitro and in vivo cell growth. The polymer scaffold may be produced using pure polymer or alternatively a composite material may be formed consisting of a macroporous polymer scaffold and osteoclast-resorbable calcium phosphate particles with a binding agent binding the calcium phosphate particles to the polymer scaffold.
Owner:GUAN LIMIN +3
Uniform Crimping and Deployment Methods for Polymer Scaffold
A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes one or more balloon pressurization steps. The balloon pressurization steps are selected to enhance scaffold retention to the balloon and maintain a relatively uniform arrangement of balloon folds about the inner surface of the crimped scaffold so that the scaffold expands in a uniform manner when the balloon is inflated.
Owner:ABBOTT CARDIOVASCULAR
Porous biodegradable polymer scaffolds for in situ tissue regeneration and method for the preparation thereof
The present invention relates to an intelligent porous biodegradable polymer scaffold for in situ tissue regeneration in which two kinds of physiologically active substances having high differentiation potential and biocompatibility are introduced into the polymer scaffold and conjugated to the surface thereof, respectively, and a method for the preparation thereof. Since the intelligent porous biodegradable polymer scaffold exhibits improved biocompatibility and differentiation potential due to the introduction of physiologically active substances capable of efficiently inducing cell proliferation and differentiation into both the surface and the inside thereof, it can directly induce in situ tissue regeneration of the musculoskeletal system from stem cells in a living tissue after transplanting the polymer scaffold and stem cells into a human body without additional in vitro cultivation. Therefore, the intelligent porous biodegradable polymer scaffold according to the present invention can be effectively used in the regeneration of various kinds of tissues and organs including the musculoskeletal system.
Owner:KOREA INST OF SCI & TECH
Processes for making crush recoverable polymer scaffolds
ActiveUS20120073733A1Improves deployment uniformityReduce fracturesStentsDomestic articlesBalloon catheterPolymer scaffold
Methods for making scaffolds for delivery via a balloon catheter are described. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold structure has patterns that include an asymmetric or symmetric closed cell, and links connecting such closed cells.
Owner:ABBOTT CARDIOVASCULAR
Fiber scaffolds for use creating implantable structures
A synthetic construct suitable for implantation into a biological organism that includes at least one polymer scaffold; wherein the at least one polymer scaffold includes at least one layer of polymer fibers that have been deposited by electrospinning; wherein the orientation of the fibers in the at least one polymer scaffold relative to one another is generally parallel, random, or both; and wherein the at least one polymer scaffold has been adapted to function as at least one of a substantially two-dimensional implantable structure and a substantially three-dimensional implantable tubular structure.
Owner:NFS IP HLDG LLC
Sheaths Used in Polymer Scaffold Delivery Systems
A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A sheath is placed over the crimped scaffold after crimping to reduce recoil of the crimped polymer scaffold. The sheath is removed before the medical device is implanted within the body.
Owner:ABBOTT CARDIOVASCULAR
Protein-polymer-drug conjugates
ActiveUS20150104407A1Improve drug bioavailabilityImprove bioavailabilityOrganic active ingredientsPharmaceutical non-active ingredientsDrug conjugationPharmaceutical drug
A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
Owner:MERSANA THERAPEUTICS INC
Methods for Increasing a Retention Force Between a Polymeric Scaffold and a Delivery Balloon
ActiveUS20120261858A1Increase retention forceReduce diameterStentsSurgeryPolymeric scaffoldMedical treatment
A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes inflating the delivery balloon during a diameter reduction to improve scaffold retention and maintaining an inflated balloon during the diameter reduction and prior and subsequent dwell periods.
Owner:ABBOTT CARDIOVASCULAR
Protein-Polymer-Drug Conjugates
ActiveUS20120321583A1High drug loadingImprove bindingPeptide/protein ingredientsAntibody ingredientsDrug conjugationPharmaceutical drug
A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
Owner:MERSANA THERAPEUTICS INC
Methods for Crimping a Polymeric Stent Scaffold Onto a Delivery Balloon
ActiveUS20110271513A1Easy alignmentEliminates static buildupStentsMetal working apparatusInsertion stentPolymer scaffold
A medical device includes a polymer stent scaffold crimped to a catheter having an expansion balloon. A process for forming the medical device includes placing the scaffold on a support supported by an alignment carriage, and deionizing the scaffold to remove any static charge buildup on the scaffold before placing the scaffold within a crimper to reduce the scaffold's diameter. The polymer scaffold is heated to a temperature below the polymer's glass transition temperature to improve scaffold retention without adversely affecting the mechanical characteristics of the scaffold when deployed to support a body lumen.
Owner:ABBOTT CARDIOVASCULAR
Reducing crimping damage to polymer scaffold
A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the catheter by a multi-step process for increasing scaffold-catheter yield following a crimping sequence. Damage reduction during a crimping sequence includes modifying blades of a crimper, adopting a multi-step crimping sequence, and inflating a supporting balloon to support the scaffold during crimping.
Owner:ABBOTT CARDIOVASCULAR
Sheaths Used With Polymer Scaffold
InactiveUS20120324696A1Easy to disassembleIncrease propensityStentsBalloon catheterPolymer scaffoldMedical device
A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A sheath pair is placed over the crimped scaffold after crimping to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body. The sheath pair is removed by a health professional before placing the scaffold within the body.
Owner:ABBOTT CARDIOVASCULAR
Polymer-based stent assembly
InactiveUS20060058863A1Reduce the overall diameterStablyStentsSurgeryPolymer scienceBalloon catheter
Methods for preparing a polymer-based stent assembly comprising an inflatable balloon catheter and a polymer-based stent resistant to relaxation-related negative recoil are provided. The methods comprise heating a polymeric cylindrical device which is at a final predetermined shape and diameter to a temperature sufficiently above the glass transition temperature (Tg) of the polymer and for a time sufficient to erase any memory of previous processing of the polymeric cylindrical device and then quenching the polymeric cylindrical device to provide an educated polymeric cylindrical device having a memory of the final predetermined diameter and shape, mounting the educated cylindrical device on an inflatable balloon catheter, reducing the diameter of the educated cylindrical device by heating to a temperature at or slightly above the Tg of the polymer while evenly applying pressure on the exterior surface of the wall of the cylindrical device, and then cooling the cylindrical device below the Tg of the polymer to provide a stent assembly comprising an inflatable balloon catheter and an expandable, educated, polymeric stent snugly and stably disposed thereon. Assemblies comprising an inflatable balloon and a polymer based stent that is substantially resistant to relaxation related recoil mounted snugly on the balloon are also provided.
Owner:SAHAJANAND TECHNOLOGIES PRIVATE LTD
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